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    FLUORESCENCE REMOVAL FROM RAMAN SPECTRA BY POLARIZATION SUBTRACTION
    41.
    发明申请
    FLUORESCENCE REMOVAL FROM RAMAN SPECTRA BY POLARIZATION SUBTRACTION 审中-公开
    通过极化分离从拉曼光谱中去除荧光

    公开(公告)号：US20160103073A1

    公开(公告)日：2016-04-14

    申请号：US14883269

    申请日：2015-10-14

    Applicant: Alakai Defense Systems, Inc.

    Inventor： Alan R. Ford ,  Adam J. Hopkins

    IPC: G01N21/65 ,  G01N33/22

    CPC classification number: G01N21/65 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0262 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/4424 ,  G01N33/227 ,  G01N2021/1793 ,  G01N2201/0683 ,  G01N2201/121

    Abstract: A method for utilizing polarization as a scheme for fluorescence removal from UV Raman spectra collected in a standoff detection scheme has been invented. In this scheme, a linearly polarized ultraviolet (UV) laser interacts with a material on a surface or in a container. The material generates Raman scattering with polarization contributions relative to that of the laser. The material possibly fluoresces as well, but the fluorescence is generally unpolarized. By subtracting a scaled version of the perpendicular component from the parallel component of the returned signal both relative to the laser source polarization—it is possible to generate a spectrum that is fluorescence free and contains the strongest features of the Raman scattered light.

    Abstract translation: 已经发明了利用偏振作为在间隔检测方案中收集的UV拉曼光谱进行荧光去除的方案的方法。 在该方案中，线偏振紫外（UV）激光与表面或容器中的材料相互作用。 该材料产生相对于激光的偏振贡献的拉曼散射。 该材料也可能发荧光，但荧光通常是非极化的。 通过从相对于激光源极化的返回信号的并行分量中减去垂直分量的缩放版本，可以产生无荧光的光谱，并且包含拉曼散射光的最强特征。

    Object observing apparatus, object observing method, and storage medium
    42.
    发明授权
    Object observing apparatus, object observing method, and storage medium 有权
    物体观测装置，物体观察方法和存储介质

    公开(公告)号：US09297752B2

    公开(公告)日：2016-03-29

    申请号：US14388358

    申请日：2013-04-04

    Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL

    Inventor： Takeaki Shimokawa ,  Takashi Kosaka ,  Okito Yamashita ,  Masaaki Sato

    IPC: G01D18/00 ,  G01N21/47 ,  A61B10/00 ,  A61B5/00

    CPC classification number: G01N21/4785 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/0091 ,  A61B10/0041 ,  G01N2201/121 ,  G01N2201/12753

    Abstract: In order to solve a problem that a local optical characteristic-changed region inside an object cannot be accurately estimated, an object observing apparatus includes: a light intensity information acquiring unit that acquires light intensity information received by each light-receiving probe; a light intensity change information acquiring unit that acquires, for each probe set, light intensity change information, from reference light intensity information and light intensity information; an estimating unit that acquires three-dimensional optical characteristic-changed region information, using the light intensity change information; and an output unit that outputs the optical characteristic-changed region information; the estimating unit including a correcting part that performs correction according to sensitivity attenuation in accordance with a depth; and a sparseness applying part that introduces sparseness for improving a space resolution, thereby acquiring the optical characteristic-changed region information. Accordingly, it is possible to accurately estimate a local optical characteristic-changed region inside an object.

    Abstract translation: 为了解决不能准确地估计对象内的局部光学特性变化区域的问题，物体观测装置包括：光强度信息获取单元，其获取由各受光探针接收的光强度信息; 光强度变化信息获取单元，对于每个探针组，从参考光强度信息和光强度信息获取光强度变化信息; 估计单元，使用光强度变化信息获取三维光学特性变化区域信息; 以及输出单元，其输出所述光学特性变化区域信息; 所述估计单元包括根据深度执行根据灵敏度衰减的校正的校正部分; 以及引入稀疏性以提高空间分辨率的稀疏性施加部，从而获取光学特性变化区域信息。 因此，可以精确地估计物体内部的局部光学特性变化区域。

    Method and System for Correcting Incident Light Fluctuations in Absorption Spectroscopy
    43.
    发明申请
    Method and System for Correcting Incident Light Fluctuations in Absorption Spectroscopy 有权
    用于校正吸收光谱中入射光波动的方法和系统

    公开(公告)号：US20150268095A1

    公开(公告)日：2015-09-24

    申请号：US14662307

    申请日：2015-03-19

    Applicant: Servomex Group Limited

    Inventor： Richard P. Kovacich ,  Bahram Alizadeh ,  Ian C. Gaskin ,  James D. Hobby ,  Martin Lopez

    IPC: G01J3/02 ,  G01N21/39

    CPC classification number: G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/423 ,  G01N21/274 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/121 ,  G01N2201/1215

    Abstract: A method and system for correcting the effect of intensity fluctuations of the transmitted light in an absorption spectroscopy system used for the detection or measurement of chemical species in a medium, whereby one or more modulation bursts are imposed onto a light beam that passes through the medium. This burst signal may be obtained by modulating the bias current of a tunable diode laser, and the modulation burst signal may be optimally at the second harmonic of the modulation frequency of a wavelength modulated beam to allow usage of the same signal path processing used for the spectroscopic detection of the measurand for a second harmonic detection system. The burst signal can be controlled using a smooth window function to minimise the effects of non-linear perturbations that are inherent in tunable diode laser wavelength modulation spectroscopy systems, of optical interference fringes (etalons) and of the residual light absorption by background chemical species or the measurand at the wavelength coinciding with the modulation burst.

    Abstract translation: 一种用于校正用于检测或测量介质中的化学物质的吸收光谱系统中的透射光的强度波动的影响的方法和系统，由此一个或多个调制脉冲串被施加到通过介质的光束 。 可以通过调制可调谐二极管激光器的偏置电流来获得该脉冲串信号，并且调制脉冲串信号可以在波长调制波束的调制频率的二次谐波处最佳地进行，以允许使用与 用于二次谐波检测系统的被测量的光谱检测。 可以使用平滑窗函数来控制突发信号，以最小化可调谐二极管激光波长调制光谱系统固有的非线性扰动，光学干涉条纹（标准具）和背景化学物质的残余光吸收的影响， 在波长上的被测量与调制脉冲串一致。

    Determining percent solids in suspension using raman spectroscopy
    44.
    发明授权
    Determining percent solids in suspension using raman spectroscopy 有权
    使用拉曼光谱法测定悬浮液中的固体百分数

    公开(公告)号：US09140651B2

    公开(公告)日：2015-09-22

    申请号：US13696650

    申请日：2011-05-04

    Applicant: Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    IPC: G01J3/44 ,  G01N21/65

    CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a Partial Least Squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

    Abstract translation: 提供了使用拉曼光谱测定悬浮液中固体重量百分比的方法和装置。 这些方法可用于从悬浮液中获得拉曼光谱数据，并确定例如在容器中进行的方法中固体的重量百分比，而不需要除去样品进行分析。 固体的重量百分比可以在相对较短的时间（通常为10分钟或更短）内以期望的精度确定。 获得的拉曼光谱数据可以通过化学计量学软件使用例如部分最小二乘算法和数据预处理来提供重量百分比固体的预测值。 在一些实施方案中，本发明用于测定水溶液中二酮哌嗪微粒的重量百分比。

    IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD
    45.
    发明申请
    IMAGE PROCESSING APPARATUS AND IMAGE PROCESSING METHOD 有权
    图像处理装置和图像处理方法

    公开(公告)号：US20150139527A1

    公开(公告)日：2015-05-21

    申请号：US14522814

    申请日：2014-10-24

    Applicant: Sony Corporation

    Inventor： Yuichiro Ikenaga ,  Toru Shiono ,  Tetsuro Hoshino

    IPC: H04N1/60 ,  G01N21/64 ,  G06K9/00

    CPC classification number: H04N1/603 ,  G01J3/4406 ,  G01J3/46 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/6458 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/121 ,  G02B21/365 ,  G06K9/00127

    Abstract: An image processing apparatus includes: an interface unit configured to input an image signal from an imaging apparatus that exposes a specimen dyed with a fluorescent dye to excitation light and images fluorescence by a color imaging element; and a color correction circuit configured to retain information on a percentage of each of a component of a second color and a component of a third color with respect to a component of a first color corresponding to the excitation light in the image signal, which is determined in advance based on color filter spectral characteristics of the color imaging element, and reduce each of an amount corresponding to the percentage of the component of the second color and an amount corresponding to the percentage of the component of the third color from the input image signal.

    Abstract translation: 一种图像处理装置，包括：接口单元，被配置为从成像装置输入图像信号，所述成像装置将用荧光染料染色的样本曝光到激发光，并通过彩色成像元件对荧光图像进行成像; 以及颜色校正电路，被配置为相对于所确定的图像信号中与激发光对应的第一颜色的分量，保持关于第二颜色和第三颜色的分量的分量中的每一个的百分比的信息 基于彩色成像元件的滤色器光谱特性预先提取，并且减少对应于第二颜色的分量的百分比的量和对应于来自输入图像信号的第三颜色的分量的百分比的量 。

    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY
    46.
    发明申请
    DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY 有权
    使用拉曼光谱法测定悬浮液中的固体含量

    公开(公告)号：US20130050696A1

    公开(公告)日：2013-02-28

    申请号：US13696650

    申请日：2011-05-04

    Applicant: Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

    IPC: G01J3/44

    CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a Partial Least Squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

    Abstract translation: 提供了使用拉曼光谱测定悬浮液中固体重量百分比的方法和装置。 这些方法可用于从悬浮液中获得拉曼光谱数据，并确定例如在容器中进行的方法中固体的重量百分比，而不需要除去样品进行分析。 固体的重量百分比可以在相对较短的时间（通常为10分钟或更短）内以期望的精度确定。 获得的拉曼光谱数据可以通过化学计量学软件使用例如部分最小二乘算法和数据预处理来提供重量百分比固体的预测值。 在一些实施方案中，本发明用于测定水溶液中二酮哌嗪微粒的重量百分比。

    ACTUATION AND EVALUATION CIRCUIT, MEASURING DEVICE AND METHOD FOR MEASURING THE CONCENTRATION OF A GAS
    47.
    发明申请
    ACTUATION AND EVALUATION CIRCUIT, MEASURING DEVICE AND METHOD FOR MEASURING THE CONCENTRATION OF A GAS 有权
    启动和评估电路，测量装置和测量气体浓度的方法

    公开(公告)号：US20120281220A1

    公开(公告)日：2012-11-08

    申请号：US13266610

    申请日：2010-04-14

    Applicant: Helmut Scherer ,  Dieter Schrader ,  Stefan Menninger

    Inventor： Helmut Scherer ,  Dieter Schrader ,  Stefan Menninger

    IPC: G01N21/59

    CPC classification number: G01N21/39 ,  G01J1/42 ,  G01J1/4257 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/61 ,  G01N21/8507 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/121 ,  G01N2201/1245 ,  G01N2201/12753

    Abstract: The invention relates to an actuation and evaluation circuit for a laser diode (1) and a photodiode (3) for determining the concentration of a gas. The laser diode can generate light in the range of an absorption line of the gas. The circuit comprises a driver (10, 11, 12, 13) for generating a driving signal (17) for the laser diode (1), an assembly (8, 9) for generating a reference signal (20), and a subtractor (5) for subtracting the reference signal (20) from the signal (21) supplied by the photodiode. The invention further relates to a measuring device for determining the concentration of a gas by means of such an actuation and evaluation circuit. Finally, the invention relates to a corresponding method.

    Abstract translation: 本发明涉及用于确定气体浓度的激光二极管（1）和光电二极管（3）的致动和评估电路。 激光二极管可以在气体的吸收线的范围内产生光。 电路包括用于产生用于激光二极管（1）的驱动信号（17）的驱动器（10,11,12,13），用于产生参考信号（20）的组件（8,9）和减法器 5），用于从由光电二极管提供的信号（21）中减去参考信号（20）。 本发明还涉及一种用于通过这种致动和评估电路确定气体浓度的测量装置。 最后，本发明涉及一种相应的方法。

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