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    OPTICAL APPARATUS AND FOCUS CORRECTION METHOD
    41.
    发明公开
    OPTICAL APPARATUS AND FOCUS CORRECTION METHOD 审中-公开

    公开(公告)号：US20240280502A1

    公开(公告)日：2024-08-22

    申请号：US18581794

    申请日：2024-02-20

    Applicant: Lasertec Corporation

    Inventor： Minoru HOSOMI

    IPC: G01N21/88

    CPC classification number: G01N21/8806 ,  G01N21/8851 ,  G01N2201/06113 ,  G01N2201/0636 ,  G01N2201/12753

    Abstract: An optical apparatus according to the present embodiment includes a detector for detecting detection light of illumination light reflected by a sample, an optical system for illuminating the sample with the illumination light and guiding the detection light reflected by the sample to the detector, a displacement measurement unit for measuring a displacement drift indicating the amount of drift in the position of an optical element included in the optical system, a storage unit for storing the correlation between the displacement drift and a focus drift indicating the amount of drift in the distance between the sample and the optical system when the detection light detected by the detector is brought into focus, and a prediction unit for predicting a focus drift from the measured displacement drift by using the correlation.

    ANALOG LIGHT MEASURING AND PHOTON COUNTING IN CHEMILUMINESCENCE MEASUREMENTS
    42.
    发明公开
    ANALOG LIGHT MEASURING AND PHOTON COUNTING IN CHEMILUMINESCENCE MEASUREMENTS 审中-公开

    公开(公告)号：US20240272080A1

    公开(公告)日：2024-08-15

    申请号：US18542333

    申请日：2023-12-15

    Applicant: Beckman Coulter, Inc.

    Inventor： Richard Wolf ,  David Sorrentino ,  Takayuki Mizutani ,  Glenn Davis

    IPC: G01N21/76 ,  G01J1/44 ,  G01N21/27

    CPC classification number: G01N21/76 ,  G01J1/44 ,  G01N21/27 ,  G01N21/272 ,  G01J2001/444 ,  G01N2201/022 ,  G01N2201/12753

    Abstract: A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).

    CALIBRATION FOR GAS DETECTION
    46.
    发明申请
    CALIBRATION FOR GAS DETECTION 审中-公开
    气体检测校准

    公开(公告)号：US20160349226A1

    公开(公告)日：2016-12-01

    申请号：US15116436

    申请日：2015-02-04

    Applicant: DETECTOR ELECTRONICS CORPORATION

    Inventor： Jitendra S. Chauhan

    IPC: G01N33/00 ,  G01N21/3504 ,  G01N21/27

    CPC classification number: G01N33/0006 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/3504 ,  G01N2201/12753

    Abstract: Embodiments are directed to controlling a flow of a mixture of gas at a plurality of concentrations, controlling a temperature of a chamber over a temperature range, reading, by a computing device comprising a processor, gas absorbance values from a first detector included in the chamber over the plurality of concentrations and over the temperature range, generating at least one of a look-up table and a mathematical formula for the first detector based on the gas absorbance values, and causing the at least one of the look-up table and the mathematical formula to be stored in a second detector.

    Abstract translation: 实施例涉及控制多个浓度的气体混合物的流动，在温度范围内控制室的温度，通过包括处理器的计算装置读取包括在室中的第一检测器的气体吸收值 在多个浓度和温度范围内，基于气体吸光度值生成用于第一检测器的查找表和数学公式中的至少一个，并且使查找表和 要存储在第二个检测器中的数学公式。

    Object observing apparatus, object observing method, and storage medium
    47.
    发明授权
    Object observing apparatus, object observing method, and storage medium 有权
    物体观测装置，物体观察方法和存储介质

    公开(公告)号：US09297752B2

    公开(公告)日：2016-03-29

    申请号：US14388358

    申请日：2013-04-04

    Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL

    Inventor： Takeaki Shimokawa ,  Takashi Kosaka ,  Okito Yamashita ,  Masaaki Sato

    IPC: G01D18/00 ,  G01N21/47 ,  A61B10/00 ,  A61B5/00

    CPC classification number: G01N21/4785 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/0091 ,  A61B10/0041 ,  G01N2201/121 ,  G01N2201/12753

    Abstract: In order to solve a problem that a local optical characteristic-changed region inside an object cannot be accurately estimated, an object observing apparatus includes: a light intensity information acquiring unit that acquires light intensity information received by each light-receiving probe; a light intensity change information acquiring unit that acquires, for each probe set, light intensity change information, from reference light intensity information and light intensity information; an estimating unit that acquires three-dimensional optical characteristic-changed region information, using the light intensity change information; and an output unit that outputs the optical characteristic-changed region information; the estimating unit including a correcting part that performs correction according to sensitivity attenuation in accordance with a depth; and a sparseness applying part that introduces sparseness for improving a space resolution, thereby acquiring the optical characteristic-changed region information. Accordingly, it is possible to accurately estimate a local optical characteristic-changed region inside an object.

    Abstract translation: 为了解决不能准确地估计对象内的局部光学特性变化区域的问题，物体观测装置包括：光强度信息获取单元，其获取由各受光探针接收的光强度信息; 光强度变化信息获取单元，对于每个探针组，从参考光强度信息和光强度信息获取光强度变化信息; 估计单元，使用光强度变化信息获取三维光学特性变化区域信息; 以及输出单元，其输出所述光学特性变化区域信息; 所述估计单元包括根据深度执行根据灵敏度衰减的校正的校正部分; 以及引入稀疏性以提高空间分辨率的稀疏性施加部，从而获取光学特性变化区域信息。 因此，可以精确地估计物体内部的局部光学特性变化区域。

    Optical filling control of pharmaceutical capsules in capsule filling machines
    50.
    发明授权
    Optical filling control of pharmaceutical capsules in capsule filling machines 有权
    胶囊灌装机中胶囊的光学灌装控制

    公开(公告)号：US08584715B2

    公开(公告)日：2013-11-19

    申请号：US12668350

    申请日：2008-07-07

    Applicant: Peter Stoeckel ,  Frank Biedenbender ,  Thomas Kruger

    Inventor： Peter Stoeckel ,  Frank Biedenbender ,  Thomas Kruger

    IPC: B67C3/02

    CPC classification number: G01N21/9508 ,  A61J3/074 ,  B07C5/3425 ,  G01F17/00 ,  G01N15/1463 ,  G01N21/274 ,  G01N2015/0096 ,  G01N2015/1497 ,  G01N2201/0694 ,  G01N2201/124 ,  G01N2201/12753 ,  G06T7/0006 ,  G06T2207/10024

    Abstract: The present invention relates to a method for monitoring the filling of a capsule with a medicament, to a corresponding filling method, to the associated apparatuses, and to a computer program for controlling the method and the apparatus. In the monitoring method, after at least part of the capsule has been filled with a predefined filling mass of a predefined closed contour of the medicament, at least the filling mass in the part of the capsule after the filling operation is recorded using digital imaging in a first step, the contour of the filling mass in the part of the capsule is determined from the digital imaging recording in a second step, and the contour is analysed in a third step in order to assess the filling operation in comparison with the predefined contour. The invention provides for external influences on the image properties to be compensated for by controlling the optical system.

    Abstract translation: 本发明涉及一种用于通过药物，相应的填充方法，相关装置以及用于控制该方法和装置的计算机程序来监测胶囊的填充的方法。 在监测方法中，在胶囊的至少一部分已经填充有药物的预定义的闭合轮廓的预定填充物质之后，至少填充操作之后的胶囊部分中的填充质量使用数字成像记录在 第一步骤，在第二步骤中从数字成像记录确定胶囊部分中的填充质量的轮廓，并且在第三步骤中分析轮廓，以便与预定轮廓相比较，评估填充操作 。 本发明通过控制光学系统来提供对补偿图像特性的外部影响。

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