公开(公告)号：US06967323B2

公开(公告)日：2005-11-22

申请号：US10868933

申请日：2004-06-17

Applicant: Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

Inventor： Yuichiro Hashimoto ,  Takashi Baba ,  Hideki Hasegawa ,  Izumi Waki

IPC: G01N27/62 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/063 ,  H01J49/004 ,  H01J49/0481

Abstract: An ion mass spectrometer comprising an ionization source for generating ions, a linear trap region for accumulation and dissociation of ions, and a time-of-flight mass spectrometer for mass spectroscopy of ions based on the flying time, and having a collision damping region introduced with a buffer gas for reducing the kinetic energy of ions ejected from the linear trap region and converting the ion packet into continuous beam and provided with plural electrodes for generating multipole electric fields in the inside between the linear trap region and the time-of-flight mass spectrometer, and having an ion transmission control mechanism for allowing or inhibiting incidence of ion from the linear trap region to the collision damping region between the linear trap region and the collision damping region.

Abstract translation: 一种离子质谱仪，包括用于产生离子的电离源，用于离子的聚集和离解的线性捕获区域，以及用于基于飞行时间的离子质谱的飞行时间质谱仪，并且具有引入的碰撞阻尼区域 使用缓冲气体，用于降低从线性捕获区域排出的离子的动能，并将离子包转换为连续光束，并设置有多个电极，用于在线性捕获区域和飞行时间之间的内部产生多极电场 并且具有用于允许或抑制从线性捕获区域到线性捕获区域和碰撞阻尼区域之间的碰撞阻尼区域的入射的离子传输控制机构。

公开(公告)号：US06960762B2

公开(公告)日：2005-11-01

申请号：US10691661

申请日：2003-10-24

Applicant: Eizo Kawato ,  Shinichi Yamaguchi

Inventor： Eizo Kawato ,  Shinichi Yamaguchi

IPC: G01N27/62 ,  H01J49/10 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/424 ,  H01J49/005 ,  H01J49/0481 ,  H01J49/24

Abstract: A mass spectroscope includes an ion source for generating ions, a mass spectrometry portion, and an ion retention portion arranged between the ion source and mass spectrometry portion for storing, cooling and/or dissociating the ions before the ions are discharged into the mass spectrometry portion. The mass spectroscope further includes a flow adjusting device for adjusting a gas flowing into the ion retention portion from an outside, and a control device for controlling the flow adjusting device in order to appropriately set a gas pressure in the ion retention portion according to an operation mode such as an introducing operation, a retention operation, and a discharging operation.

Abstract translation: 质谱仪包括用于产生离子的离子源，质谱分析部分和设置在离子源和质谱部分之间的离子保留部分，用于在将离子排放到质谱部分之前存储，冷却和/或解离离子 。 该质谱仪还包括用于调节从外部流入离子保持部的气体的流量调节装置，以及用于控制流量调节装置的控制装置，以便根据操作来适当地设定离子保持部的气体压力 模式，例如导入操作，保持操作和放电操作。

公开(公告)号：US20040238754A1

公开(公告)日：2004-12-02

申请号：US10489305

申请日：2004-03-17

Inventor： Vladimir I. Baranov ,  Alexandre V. Loboda ,  Christopher M. Lock

IPC: H01J027/00

CPC classification number: H01J49/0418 ,  H01J49/0481

Abstract: Collisional cooling of ions in mass spectrometry has been known for sometime. It is known that collisional cooling can promote focusing of ions along the axis of an ion guide. A similar technique has been used to enhance coupling of a pulsed ion source such as a MALDI source to a Time of Flight instrument. It is now realized that it is desirable to provide, immediately adjacent to a MALDI or other ion source, a low-pressure region to promote ionization conditions most favorable for the particular ion source. Then, with the ions released and free, the ions are subjected to relatively rapid collisional cooling in a high pressure region adjacent to the ionization region. This will dissipate excess of internal energy in the ions, so as to substantially reduce the incidence of metastable fragmentation of the ions. The ions can then be subjected to conventional mass analysis steps.

Abstract translation: 质谱中离子的碰撞冷却已经有一段时间了。 众所周知，碰撞冷却可促进离子沿离子导向轴的聚焦。 已经使用类似的技术来增强诸如MALDI源的脉冲离子源与飞行时间仪器的耦合。 现在认识到，期望提供紧邻MALDI或其它离子源的低压区域，以促进对于特定离子源最有利的电离条件。 然后，离子释放并游离，离子在与电离区相邻的高压区域进行相对快速的碰撞冷却。 这将消散离子中的过量的内部能量，从而显着降低离子的亚稳碎裂的发生率。 然后可以对离子进行常规的质量分析步骤。

公开(公告)号：US06809318B2

公开(公告)日：2004-10-26

申请号：US10657580

申请日：2003-09-08

Applicant: Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

Inventor： Andrew Krutchinsky ,  Herbert Cohen ,  Markus Kalkum ,  Vadim Sherman ,  Brian Chait

IPC: B01D5944

CPC classification number: H01J49/063 ,  H01J49/0481 ,  H01J49/161 ,  H01J49/164

Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

公开(公告)号：US06744047B2

公开(公告)日：2004-06-01

申请号：US10164724

申请日：2002-06-07

Applicant: Craig M. Whitehouse ,  Erol Gulcicek

Inventor： Craig M. Whitehouse ,  Erol Gulcicek

IPC: H01J4900

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and qn values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.

Abstract translation: 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入到大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 多极离子导向DC补偿电位可用于调整平均离子能量和离子导向器a和qn值可以设置为减小或扩大将通过离子导向器传输的离子质量到充电的范围。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。

公开(公告)号：US06710334B1

公开(公告)日：2004-03-23

申请号：US10347988

申请日：2003-01-20

Applicant: Damian Twerenbold

Inventor： Damian Twerenbold

IPC: B01D5944

CPC classification number: H01J49/424 ,  H01J49/025 ,  H01J49/0481

Abstract: This invention relates to a quadrupol ion trap mass spectrometer with improved sensitivity for massive molecules by using cryogenic particle detectors as molecule detectors. Cryogenic particle detectors have a mass independent detection efficiency and do not show a decrease of detection efficiency for increasing molecule mass as compared to ionizing detectors which are used in common quadrupol ion trap mass spectrometers.

Abstract translation: 本发明涉及通过使用低温颗粒检测器作为分子检测器，对大分子具有改进的灵敏度的四极离子阱质谱仪。 与普通四极离子阱质谱仪中使用的电离检测器相比，低温颗粒检测器具有质量独立的检测效率，并且不显示提高分子质量的检测效率的降低。

公开(公告)号：US06403953B2

公开(公告)日：2002-06-11

申请号：US09727285

申请日：2000-11-30

Applicant: Craig M. Whitehouse ,  Erol Gulcicek

Inventor： Craig M. Whitehouse ,  Erol Gulcicek

IPC: B01D5944

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and qn values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.

Abstract translation: 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入到大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 多极离子导向DC补偿电位可用于调整平均离子能量和离子导向器a和qn值可以设置为减小或扩大将通过离子导向器传输的离子质量到充电的范围。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。

公开(公告)号：US20010038069A1

公开(公告)日：2001-11-08

申请号：US09727285

申请日：2000-11-30

Inventor： Craig M. Whitehouse ,  Erol Gulcicek

IPC: H01J049/00 ,  B01D059/44

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide an and q values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.

Abstract translation: 在一个泵送阶段开始并连续延伸到一个或多个后续泵送阶段的多极离子导向器已经被并入到大气压离子源质谱仪系统中。 从电喷雾，大气压化学电离或电感耦合等离子体离子源进入真空的离子被引导并且使用多极离子导向器以高效率聚焦到质量分析器中。 多极离子导向器长度的一部分上的背景压力足够高，由于与中性背景气体分子的离子碰撞而导致横过离子导向器长度的离子的动能冷却。 这种离子动能冷却降低了穿过多极离子导向器长度的离子的能量扩散。 多极离子导向器DC偏置电位可用于调节平均离子能量和离子导向器a和q值，以减小或扩大将通过离子导向器传输的离子质量至电荷的范围。 多极离子导向器和多泵级多极离子导向器的这些特性用于提高大气压离子源质谱仪器的性能和降低成本。

公开(公告)号：US06222185B1

公开(公告)日：2001-04-24

申请号：US08866524

申请日：1997-05-30

Applicant: James Speakman ,  Raymond Clive Haines ,  Patrick James Turner ,  Thomas Oliver Merren ,  Stuart Alan Jarvis

Inventor： James Speakman ,  Raymond Clive Haines ,  Patrick James Turner ,  Thomas Oliver Merren ,  Stuart Alan Jarvis

IPC: B01D5944

CPC classification number: H01J49/063 ,  H01J49/0481 ,  H01J49/105

Abstract: A plasma mass spectrometer comprises a plasma torch (1) for generating ions from a sample introduced into a plasma (2), a nozzle-skimmer interface (3,5) for transmitting said ions into a first evacuated chamber (11), ion guiding means (12), an apertured diaphragm (18) dividing said first evacuated chamber (11) from a second evacuated chamber, and an ion mass-to-charge ratio analyzer in the second chamber for producing a mass spectrum. The ion guiding means comprises a multipole rod-set (13,14,15), means for applying an AC voltage between rods in the set, and means (22) for introducing into said ion guiding means an inert gas selected from the group comprising helium, neon, argon, krypton, xenon and nitrogen so that the partial pressure of said inert gas inside said rod-set is at least 10−3 torr. Interfering peaks in the spectrum, such as Ar, are thereby reduced.

Abstract translation: 等离子体质谱仪包括用于从引入等离子体（2）中的样品产生离子的等离子体焰炬（1），用于将所述离子传输到第一抽真空室（11）中的喷嘴 - 撇渣器界面（3,5），离子导向 装置（12），在第二室中将所述第一抽真空室（11）与第二抽空室分开的有孔隔膜（18）和离子质荷比分析器产生质谱。 离子引导装置包括多极杆组（13,14,15），用于在组中的杆之间施加AC电压的装置和用于将所述离子引导装置引入到惰性气体的装置（22），所述惰性气体选自包括 氦气，氖气，氩气，氪气，氙气和氮气，使得所述棒组件内的所述惰性气体的分压至少为10 -3乇。 从而降低光谱中的干扰峰如Ar。

公开(公告)号：US5962851A

公开(公告)日：1999-10-05

申请号：US794970

申请日：1997-02-05

Applicant: Craig M. Whitehouse ,  Erol Gulcicek

Inventor： Craig M. Whitehouse ,  Erol Gulcicek

IPC: G01N27/62 ,  H01J49/04 ,  H01J49/16 ,  H01J49/26 ,  H01J49/40 ,  H01J49/42 ,  G01D59/44 ,  H01J49/00

CPC classification number: B01D59/44 ,  H01J49/0481 ,  H01J49/063

Abstract: A multipole ion guide which begins in one pumping stage and extends continuously into one or more subsequent pumping stages has been incorporated into an atmospheric pressure ion source mass spectrometer system. Ions delivered into vacuum from an Electrospray, Atmospheric Pressure Chemical Ionization or Inductively Coupled Plasma ion source are guided and focused into a mass analyzer with high efficiency using the multipole ion guide. The background pressure over a portion of the multipole ion guide length is high enough to cause kinetic energy cooling of ions traversing the ion guide length due to ion collisions with neutral background gas molecules. This ion kinetic energy cooling lowers energy spread of ions traversing the multipole ion guide length. The multipole ion guide DC offset potential can be used to adjust the mean ion energy and the ion guide a.sub.n and q.sub.n values can be set to reduce or expand the range of ion mass to charge which will be transmitted through the ion guide. These features of multipole ion guides and multiple pumping stage multipole ion guides are used to improve performance and lower the cost of Atmospheric Pressure Ion source mass spectrometer instruments.