公开(公告)号：US07932491B2

公开(公告)日：2011-04-26

申请号：US12365354

申请日：2009-02-04

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/00

CPC classification number: H01J3/14 ,  H01J49/004 ,  H01J49/061 ,  H01J49/40

Abstract: A mass spectrometer includes a pulsed ion source that generates an ion beam comprising a plurality of ions. A first timed ion selector passes a first group of ions. A first ion mirror generates a reflected ion beam comprising the first group of ions that at least partially compensates for an initial kinetic energy distribution of the first group of ions. A second timed ion selector passes a second group of ions. A second ion mirror generates a reflected ion beam comprising the second group of ions that at least partially compensates for an initial kinetic energy distribution of the second group of ions. A timed ion deflector deflects the second group of ions to a detector assembly comprising at least two ion detectors which detects the deflected ion beam.

Abstract translation: 质谱仪包括产生包含多个离子的离子束的脉冲离子源。 第一定时离子选择器通过第一组离子。 第一离子镜产生包含至少部分地补偿第一组离子的初始动能分布的第一组离子的反射离子束。 第二个定时离子选择器通过第二组离子。 第二离子镜产生包含至少部分地补偿第二组离子的初始动能分布的第二组离子的反射离子束。 定时离子偏转器将第二组离子偏转到包括至少两个检测偏转离子束的离子检测器的检测器组件。

公开(公告)号：USRE42111E1

公开(公告)日：2011-02-08

申请号：US10351965

申请日：2003-01-27

Applicant: Melvin A. Park ,  Claus Koester

Inventor： Melvin A. Park ,  Claus Koester

IPC: H01J3/30 ,  H01J49/40 ,  H01J49/28

CPC classification number: H01J49/061 ,  H01J49/40

Abstract: A method and apparatus to direct ions away from their otherwise intended or parallel course. Deflectors are used to establish electric fields in regions through which ions are to pass. With such electric fields, ions may be deflected to a desired trajectory. According to the present invention, a multideflector, in the form of a series of bipolar plates spaced evenly across the ion beam path, is used as an ion deflector. A multideflector, including at least three bipolar deflection plates each of which includes a pair of electrically conducting electrodes separated from one another by an insulator, where each electrically conducting electrode in each pair of electrically conducting electrodes has a uniform lengthwise curvature and the electrically conducting electrodes in each pair of electrically conducting electrodes are parallel with one another, with each of the electrically conducting electrodes of the at least three bipolar deflection plates being energized to a potential, with each bipolar deflection plate of the at least three bipolar deflection plates having a first electrode of the pair of electrically conducting electrodes which has a first potential and a second electrode of the pair of electrically conducting electrodes which has a second potential, the first potential and the second potential are of opposite polarities.

Abstract translation: 一种将离子远离其他预期或平行过程的方法和装置。 偏转器用于在离子通过的区域建立电场。 通过这样的电场，离子可以被偏转到期望的轨迹。 根据本发明，以离子束路径均匀间隔开的一系列双极板的形式的多重反射器被用作离子偏转器。 一种多重反射器，包括至少三个双极偏转板，每个偏转板包括通过绝缘体彼此分离的一对导电电极，其中每对导电电极中的每个导电电极具有均匀的纵向曲率，并且导电电极 在每对导电电极中彼此平行，其中至少三个双极偏转板的导电电极中的每一个被激发到电位，所述至少三个双极偏转板的每个双极偏转板具有第一 所述一对导电电极的电极具有具有第二电位的所述一对导电电极的第一电位和第二电极，所述第一电位和所述第二电位具有相反的极性。

公开(公告)号：US07838824B2

公开(公告)日：2010-11-23

申请号：US11742709

申请日：2007-05-01

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/40

CPC classification number: H01J49/004 ,  H01J49/0495 ,  H01J49/061 ,  H01J49/164 ,  H01J49/40

Abstract: The present invention comprises apparatus and methods for rapidly and accurately determining mass-to-charge ratios of molecular ions produced by a pulsed ionization source, and for fragmenting substantially all of the molecular ions produced while rapidly and accurately determining the intensities and mass-to-charge ratios of the fragments produced from each molecular ion.

Abstract translation: 本发明包括用于快速且准确地确定由脉冲电离源产生的分子离子的质荷比的装置和方法，并且用于基本上全部分解所产生的分子离子，同时快速准确地确定强度和质量 - 从每个分子离子产生的片段的电荷比。

公开(公告)号：US07829843B2

公开(公告)日：2010-11-09

申请号：US11571860

申请日：2005-06-22

Applicant: Andrei Burnin ,  Joseph J. Belbruno

Inventor： Andrei Burnin ,  Joseph J. Belbruno

IPC: H01J49/00

CPC classification number: H01J49/061 ,  H01J49/40

Abstract: A method of selecting ions includes generating a group of ions, accelerating the group of ions through a flight region towards an electronic mass selector grid, and selectively varying a voltage applied to the electronic mass selector grid, such that only a selected subset of the group of ions passes through the grid. An apparatus for selecting ions includes an ion generator, an ion accelerator for accelerating ions into a flight region, and an electronic mass selector grid responsive to an applied voltage to pass a subset of the ions from the flight region. An apparatus for detecting a threat molecule includes an ion generator for generating ions from a mixed gas stream, an ion accelerator for accelerating the ions into a flight region, and an electronic mass selector grid. The grid passes only a subset of the ions, such as ions and/or ionized fragments of the threat molecule.

Abstract translation: 选择离子的方法包括产生一组离子，通过飞行区域朝向电子质量选择器网格加速离子组，并且选择性地改变施加到电子质量选择器网格的电压，使得仅仅选择组的选定子集 的离子通过网格。 用于选择离子的装置包括离子发生器，用于将离子加速到飞行区域中的离子加速器，以及响应于所施加的电压的电子质量选择器格栅，以使来自飞行区域的离子的子集通过。 用于检测威胁分子的装置包括用于从混合气流产生离子的离子发生器，用于将离子加速到飞行区域中的离子加速器和电子质量选择器格栅。 网格仅通过离子的一部分，例如威胁分子的离子和/或离子化碎片。

公开(公告)号：US20100224774A1

公开(公告)日：2010-09-09

申请号：US12429460

申请日：2009-04-24

Applicant: Jens Griep-Raming ,  Wilko Balschun ,  Alexander Makarov ,  Eduard V. Denisov ,  Joachim Muller

Inventor： Jens Griep-Raming ,  Wilko Balschun ,  Alexander Makarov ,  Eduard V. Denisov ,  Joachim Muller

IPC: H01J49/26 ,  H01J49/40 ,  H01J49/06

CPC classification number: H01J49/067 ,  H01J49/061

Abstract: An electrode for influencing ion motion in mass spectrometers, having a dielectric substrate and a conducting layer on portions of the substrate, wherein peripheral borders, edges or convex shapes of the conducting layer adjoin free regions of the substrate. According to the invention, a dielectric layer is provided on transitions from the conducting layer to the adjoining free regions of the substrate such that at least some of the peripheral borders, edges or convex shapes of the conducting layer are covered.

Abstract translation: 一种用于影响质谱仪中的离子运动的电极，其具有介电衬底和在衬底的部分上的导电层，其中导电层的周边边界，边缘或凸形形状与衬底的自由区域相邻。 根据本发明，在从导电层到基板的相邻自由区的过渡处提供介电层，使得覆盖导电层的周边边界，边缘或凸形的至少一些。

公开(公告)号：US07667195B2

公开(公告)日：2010-02-23

申请号：US11742714

申请日：2007-05-01

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: H01J49/40

CPC classification number: H01J49/40 ,  H01J49/0495 ,  H01J49/061 ,  H01J49/164

Abstract: The invention comprises apparatus and methods for rapidly and accurately determining mass-to-charge ratios of molecular ions produced by a pulsed ionization source, and for fragmenting all of the molecular ions produced and rapidly and accurately determining the intensities and mass-to-charge ratios of the fragments produced from each molecular ion.

Abstract translation: 本发明包括用于快速且准确地确定由脉冲电离源产生的分子离子的质荷比的装置和方法，并且用于使所产生的所有分子离子碎裂，并快速且准确地确定强度和质荷比 的每个分子离子产生的片段。

公开(公告)号：US20100019144A1

公开(公告)日：2010-01-28

申请号：US12179548

申请日：2008-07-24

Applicant: Jae C. Schwartz ,  Viatcheslav V. Kovtoun

Inventor： Jae C. Schwartz ,  Viatcheslav V. Kovtoun

IPC: H01J49/26

CPC classification number: H01J49/061 ,  H01J49/4265

Abstract: An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques can be achieved by using an ion optical gating element and applying a desired signal waveform (e.g., a square wave) having a predetermined duty cycle. The applied voltage amplitude of such a signal can be configured to switch between a voltage which fully transmits the ions, and a voltage which does not transmit any ions. The frequency is chosen to result in a period which is significantly lower than the smallest non-uniformity period. Techniques of the present invention can also be extended to methods of AGC which can use a single ion injection event from the ion source to avoid variations in ion numbers from an unstable ion source.

Abstract translation: 本文中引入了用于任何时间不均匀离子束（例如由MALDI离子源产生的离子束）的自动增益控制（AGC）技术和装置，以最小化空间电荷效应。 所公开的配置和技术可以通过使用离子光学门控元件并施加具有预定占空比的期望信号波形（例如，方波）来实现。 这种信号的施加电压幅度可以被配置为在完全透射离子的电压和不透射任何离子的电压之间切换。 选择频率以产生明显低于最小不均匀周期的周期。 本发明的技术也可以扩展到AGC的方法，AGC方法可以使用来自离子源的单一离子注入事件来避免离不开离子源的离子数的变化。

公开(公告)号：US07534996B2

公开(公告)日：2009-05-19

申请号：US11676882

申请日：2007-02-20

Applicant: Arthur Suits ,  Myung Hwa Kim ,  Brian D. Leskiw

Inventor： Arthur Suits ,  Myung Hwa Kim ,  Brian D. Leskiw

IPC: H01J49/40

CPC classification number: H01J49/40 ,  H01J49/004 ,  H01J49/061 ,  H01J49/443

Abstract: A mass spectrometer that employs ion velocity mapping. The mass spectrometer includes velocity mapping ion optics that focus the ions based on their velocity. The focused ions are then directed into a deflection region between two deflection plates. A pulse is applied to the deflection plates that deflect the ions in a transverse direction also according to their mass. The pulse is turned on before the first ion in an ion packet reaches the deflection region, and is turned off before the first ion exits the deflection region. The focused and deflected ions are then reflected by a reflecting device that directs the ions along separate paths to a detector. The detector provides an image of the ion paths, where the location of a spot on the image represents ions of a certain mass and the size of the spot indicates the various velocities of the ions of that mass.

Abstract translation: 使用离子速度映射的质谱仪。 质谱仪包括速度映射离子光学，其基于它们的速度聚焦离子。 然后将聚焦离子导入两个偏转板之间的偏转区域。 一个脉冲被施加到偏转板上，它们也根据它们的质量沿横向偏转离子。 在离子包中的第一离子到达偏转区域之前，脉冲被打开，并且在第一离子离开偏转区域之前被关闭。 聚焦和偏转的离子然后被反射装置反射，反射装置将离子沿着分离的路径引导到检测器。 检测器提供离子路径的图像，其中图像上的点的位置表示一定质量的离子，斑点的大小表示该质量的离子的各种速度。

公开(公告)号：US07465919B1

公开(公告)日：2008-12-16

申请号：US11386628

申请日：2006-03-22

Applicant: Kiki H. Hosea ,  Matthew L. Breuer

Inventor： Kiki H. Hosea ,  Matthew L. Breuer

IPC: H01J37/244 ,  H01J49/26

CPC classification number: H01J49/025 ,  H01J49/061

Abstract: An ion detection system includes a mass analyzer generating an ion beam along an ion beam longitudinal axis. A field generator generates a field for altering the direction of ions in the ion beam away from the ion beam longitudinal axis. A conversion dynode includes an ion collision region on a conversion dynode surface. A conversion dynode axis passes through the ion collision region perpendicular to the conversion dynode surface, the conversion dynode axis being offset from and not intersecting the ion beam longitudinal axis. An electron multiplier receives secondary charged particles from the conversion dynode generated in response to the ion collision with the conversion dynode surface.

Abstract translation: 离子检测系统包括沿着离子束纵轴产生离子束的质量分析器。 场发生器产生用于改变远离离子束纵轴的离子束中离子的方向的场。 转换倍增电极包括转换倍增极面上的离子碰撞区域。 转换倍增极轴通过垂直于转换倍增极面的离子碰撞区域，转换倍增极轴偏离离子束纵向轴线并且不与离子束纵向轴线相交。 电子倍增器从响应于与转换倍增极面的离子碰撞产生的转换倍增器接收二次带电粒子。

公开(公告)号：US20080265173A1

公开(公告)日：2008-10-30

申请号：US12082452

申请日：2008-04-11

Applicant: Rosemary Smith ,  Scott Collins ,  Brian G. Frederick ,  Lawrence J. LeGore

Inventor： Rosemary Smith ,  Scott Collins ,  Brian G. Frederick ,  Lawrence J. LeGore

IPC: H01J49/06

CPC classification number: H01J9/14 ,  H01J49/0018 ,  H01J49/061 ,  H01L2924/0002 ,  Y10S438/977 ,  H01L2924/00

Abstract: A grid structure and method for manufacturing the same. The grid is used for gating a stream of charged particles in certain types of particle measurement instruments, such as ion mobility spectrometers and the like. The methods include various microfabrication techniques for etching and/or depositing grid structure materials on a silicon substrate.