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公开(公告)号：US20240410864A1
公开(公告)日：2024-12-12
申请号：US18694904
申请日：2022-09-23
Applicant: SOCIETE DES PRODUITS NESTLE S.A.
IPC: G01N30/88 , A61K31/198 , A61K35/00 , A61K35/741 , G01N30/02 , G01N30/72 , G01N33/53 , H01J49/00
Abstract: The present invention relates to the use of glycine-conjugated bile acids as biomarker for detecting and/or quantifying improvements of the mood disorder status and/or excessive emotional reaction of a subject. It also relates to a method for detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or excessive emotional reaction of a subject, in particular for monitoring the progress of an intervention to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject, wherein the intervention comprises the administration of a probiotic. It also relates to an improved method to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject in need, comprising administering to the subject, an effective amount of a composition combining a probiotic with glycine or derivative thereof.
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公开(公告)号：US20240404812A1
公开(公告)日：2024-12-05
申请号：US18704299
申请日：2021-10-25
Applicant: SHIMADZU CORPORATION
Inventor： Aleksandr RUSINOV
IPC: H01J49/00
Abstract: A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (ω) within an ion analyser apparatus. The method comprises acquiring a data set comprising a first measured signal frequency (ω1) associated with a first part of a measured image-charge/current signal of an ion and a second measured signal frequency (ω2) associated with a subsequent second part of the measured image-charge/current signal of the ion. The method includes estimating a charge state (Q) of the ion undergoing oscillatory motion of said first measured signal frequency (ω1) and subsequently of said second measured signal frequency (ω2) and therewith estimating the value of a mass change Δm to substantially match a reference mass corresponding to a mass of one or more neutral loss. The method includes estimating the mass (M) of a deprotonated molecule forming a part of the ion according to the estimated charge state (Q) of the ion, the first measured signal frequency (ω1), the quantified mass change value Δm, and the mass-to-charge ratio (mp/e) of a protonating proton.
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43.发明授权公开(公告)号：US12159778B2
公开(公告)日：2024-12-03
申请号：US18473991
申请日：2023-09-25
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Michael Krummen , Jens Radke , Johannes Schwieters , Nils Stöebener , Ronald Seedorf
Abstract: A gas transfer system for transferring gas into an analytical instrument for isotope ratio analysis comprises a capillary for delivering sample and/or reference gas from a gas source, a first connector for connecting the capillary to the gas source, a second connector for connecting the capillary to the analytical instrument, a crimping device, wherein the internal surface of the capillary comprises a coating material to prevent or minimize adsorption of water to the surface. Also provided is a device for regulating gas flow in a gas inlet system of an analytical instrument, comprising a body member having an internal gas flow channel, and a clamping member for attachment to the body member such that when the clamping member is tightened onto the body member, the internal gas flow channel is adjustably and reversibly crimped, to adjust gas flow therethrough.
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公开(公告)号：US12159777B2
公开(公告)日：2024-12-03
申请号：US18385656
申请日：2023-10-31
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Dalton Snyder , Lucas Szalwinski
IPC: H01J49/00
Abstract: The invention generally relates to two-dimensional mass spectrometry using ion micropacket detection. In certain aspects, the invention provides systems including a mass spectrometer having an ion trap and one or more detectors. The system includes a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to: apply one or more scan functions to the ion trap that excite a precursor ion and eject a product ion from the ion trap; and determine a secular frequency of the product ion by detecting micropackets of the product ion as the micropackets are ejected from the ion trap.
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公开(公告)号：US20240387160A1
公开(公告)日：2024-11-21
申请号：US18293245
申请日：2023-01-27
Applicant: KIMIA ANALYTICS INC. , QUADROCORE CORP.
Inventor： Gholamreza JAVAHERY , Sina ALAVI , Javad MOSTAGHIMI , Kaveh KAHEN
Abstract: A collision cell is disclosed that comprises of a support and a target material. The parent ions entering the cell are accelerated and collide with the target material resulting in their fragmentation. The target material can be made from any suitable materials such as graphene, carbon, silicon, a combination of these materials, or alloys which have an atomic or molecular structure. The target material and the support are so selected to optimize the fragmentation process for a particular range of molecules and ions. The fragmented ions produced within the collision or fragmentation zone are focused and collected by a set of lenses positioned on the downstream side of the cell.
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Patent Agency Ranking
公开(公告)号：US12148606B2
公开(公告)日：2024-11-19
申请号：US17768089
申请日：2020-10-13
Applicant: University of South Florida
Inventor： Theresa Evans-Nguyen , Linxia Song , Yi You
Abstract: Provided herein are systems and methods for sampling analytes into an atmospheric pressure inlet mass spectrometer using ultrasonic nebulization-assisted atmospheric pressure chemical ionization. The systems can include a mass spectrometer having an input and an ultrasonic nebulizer chip. The ultrasonic nebulizer chip can be operatively coupled to the mass spectrometer, such that when the ultrasonic nebulizer chip nebulizes the analyte to provide a nebulized analyte, at least some of the nebulized analyte enters the input of the mass spectrometer.
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公开(公告)号：US12148605B2
公开(公告)日：2024-11-19
申请号：US17441857
申请日：2020-03-26
Applicant: Thermo Fisher Scientific (Bremen) GmbH
Inventor： Mikhail Belov , Lothar Rottman
Abstract: A method of operating a collision cell (10) in a mass spectrometer is disclosed. The collision cell comprises an entrance aperture (116), an exit aperture (117) and electrodes (113, 114) for producing electric fields. The method comprises feeding ions in a forward axial direction (LD) through the entrance aperture into the collision cell, producing a first electric field to trap ions, and subsequently producing a second electric field to accelerate trapped ions in the forward axial direction. The method further comprises producing a gas flow (G1) which is, at least at the entrance aperture (116) of the collision cell, contrary to the forward axial direction (LD), so as to reduce the kinetic energy of ions in dependence on their collisional cross sections. A collision cell arranged for carrying out the method is also disclosed, as well as a mass spectrometer comprising such a collision cell.
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公开(公告)号：US12148602B2
公开(公告)日：2024-11-19
申请号：US17638640
申请日：2020-08-28
Applicant: Micromass UK Limited
Inventor： Keith George Richardson , Martin Raymond Green , John Brian Hoyes , Richard Denny , Peter Nixon , Richard Chapman
IPC: H01J49/00
Abstract: A method of correcting mass spectral data comprises making calibration measurements of first intrinsic components (A, B, C) at one or more calibration times (t1) using calibrants which have known mass to charge ratio (m/z) values or previously mass measured mass to charge ratio (m/z) values, making a list of second intrinsic components (D, E, F) which are present during more than one acquisition periods, wherein the second intrinsic components have mass to charge ratio (m/z) values that were not present or observed during or close to the one or more calibration times (t1) but which do overlap in time with the first intrinsic components (A, B, C), and utilising the list to calculate a mass or mass to charge ratio (m/z) correction factor for one or more acquisition periods which are not close or adjacent in time to an acquisition period containing a directly calibrated mass to charge ratio (m/z) value.
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公开(公告)号：US20240379337A1
公开(公告)日：2024-11-14
申请号：US18780251
申请日：2024-07-22
Applicant: Zeteo Tech, Inc.
Inventor： Michael MCLOUGHLIN , Nathaniel K. JONES , Daniel Jeffrey GUSSIN
Abstract: Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.
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公开(公告)号：US20240371622A1
公开(公告)日：2024-11-07
申请号：US18610570
申请日：2024-03-20
Applicant: Standard BioTools Canada Inc. , University of Ottawa
Inventor： Paul Corkum , Alexander V. Loboda
IPC: H01J49/04 , G01N33/68 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/40
Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC®) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
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