公开(公告)号：US08790594B2

公开(公告)日：2014-07-29

申请号：US13093769

申请日：2011-04-25

Applicant: Dennis W. Hess ,  Balamurali Balu ,  Victor Breedveld

Inventor： Dennis W. Hess ,  Balamurali Balu ,  Victor Breedveld

IPC: B01L99/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B82Y30/00 ,  B01L3/502707 ,  B01L3/502792 ,  B01L2300/0816 ,  B01L2300/166 ,  B01L2400/0427 ,  B81B2201/058 ,  B81C1/00206 ,  B82Y40/00 ,  D21H21/16

Abstract: Systems and methods to pattern surfaces to create regions of variable adhesive force on a superhydrophobic paper surface. By taking advantage of high surface energy sticky islands on a non-sticky superhydrophobic surface, microliter water drops can be registered or confined at specific locations; selected drops can then be transferred to another patterned substrate and the drops mixed and/or allowed to react without the need for pipettes or other fluid transfer tool.

Abstract translation: 在超疏水纸表面上形成表面以形成可变粘合力区域的系统和方法。 通过利用非粘性超疏水表面上的高表面能粘性岛，可以将微滴水滴注册或限制在特定位置; 然后可以将所选择的液滴转移到另一个图案化的基底上，并且液滴被混合和/或允许反应，而不需要移液管或其它流体转移工具。

公开(公告)号：US08747778B2

公开(公告)日：2014-06-10

申请号：US12677042

申请日：2008-09-10

Applicant: Toshinobu Tokita

Inventor： Toshinobu Tokita

IPC: B01L99/00 ,  B29C35/08

CPC classification number: B81C1/00071 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B81B2201/058

Abstract: There is provided a method of producing a microfluidic device including a substrate having a depressed portion and a cover member, whereby to reduce the dispersion of a geometric individual difference and the possibility that a non-joint area can occur in a joint portion between the substrate and the cover member. At the time of producing the microfluidic device, the depressed portion serving as a channel, a chamber and a reservoir is formed in advance in the substrate and a liquid-state energy ray curable resin is applied to the surface of the substrate in which the depressed portion is formed. The energy ray curable resin is cured by an energy ray irradiation unit and caused to serve as the cover on the depressed portion of the substrate, thereby to form the channel, chamber and reservoir.

Abstract translation: 提供了一种制造微流体装置的方法，该微流体装置包括具有凹陷部分和覆盖部件的基板，从而减小几何个体差异的分散，以及在基板之间的接合部分中可能发生非接合区域的可能性 和盖构件。 在制造微流体装置时，预先在基板中形成用作通道的凹陷部分，腔室和储存器，并且将液态能量射线固化树脂施加到基板的表面，其中凹陷 形成部分。 能量射线固化树脂通过能量射线照射单元固化，并用作衬底的凹陷部分上的盖，从而形成通道，室和储存器。

公开(公告)号：US08716050B2

公开(公告)日：2014-05-06

申请号：US13721496

申请日：2012-12-20

Applicant: The Hong Kong University of Science and Technology

Inventor： Man Wong ,  Fan Zeng

IPC: H01L21/00 ,  H01L29/82

CPC classification number: H01L21/461 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00822 ,  B01J2219/00828 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01L3/502707 ,  B01L2300/0816 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00071 ,  B81C2201/0116 ,  B81C2201/0178 ,  H01L29/16

Abstract: Described herein is a microchannel that is formed beneath and parallel to a surface of a silicon substrate. Silicon migration technology is utilized to form a microchannel that is buried beneath the surface of the silicon substrate. Etching opens at least one end of the microchannel. Oxidization is utilized through the open end of the microchannel to facilitate a controlled diameter of the microchannel.

Abstract translation: 这里描述的是形成在硅衬底的表面下方并平行于其的表面的微通道。 利用硅迁移技术形成埋在硅衬底表面下方的微通道。 蚀刻打开微通道的至少一端。 通过微通道的开口端利用氧化，以促进微通道的受控直径。

公开(公告)号：US20140030811A1

公开(公告)日：2014-01-30

申请号：US13675685

申请日：2012-11-13

Applicant: Princeton University

Inventor： Han Cao ,  Jonas O. Tegenfeldt ,  Stephen Chou ,  Robert H. Austin

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/027 ,  B01L2200/0663 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/086 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/0157 ,  B81C2201/0159 ,  B82Y30/00 ,  G01N33/48721 ,  G03F7/2008 ,  Y10T436/143333

Abstract: The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient lithography (DGL) is used to form a gradient interface between a microfluidic area and a nanofluidic area. The gradient interface area reduces the local entropic barrier to nanochannels formed in the nanofluidic area. In one embodiment, the gradient interface area is formed of lateral spatial gradient structures for narrowing the cross section of a value from the micron to the nanometer length scale. In another embodiment, the gradient interface area is formed of a vertical sloped gradient structure. Additionally, the gradient structure can provide both a lateral and vertical gradient.

Abstract translation: 本发明涉及适用于进行高通量大分子分析的纳米流体和微流体组分的界面装置。 衍射梯度光刻（DGL）用于在微流体区域和纳流体区域之间形成梯度界面。 梯度界面面积减小了在纳米流体区域形成的纳米通道的局部熵阻挡。 在一个实施例中，梯度界面区域由横向空间梯度结构形成，用于使从微米到纳米长度尺度的值的横截面变窄。 在另一个实施例中，梯度界面区域由垂直倾斜梯度结构形成。 此外，梯度结构可以提供横向和垂直梯度。

公开(公告)号：US08636022B2

公开(公告)日：2014-01-28

申请号：US12374180

申请日：2007-07-16

Applicant: Vincent Studer ,  Denis Bartolo ,  Guillaume Degre

Inventor： Vincent Studer ,  Denis Bartolo ,  Guillaume Degre

IPC: B81B7/00 ,  B29C35/08 ,  B32B9/04

CPC classification number: B81C1/00119 ,  B81B2201/058 ,  B81B2203/0323 ,  B81C2201/036 ,  B81C2203/032 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10T137/0491 ,  Y10T137/2224 ,  Y10T137/598 ,  Y10T428/31504 ,  Y10T428/31663

Abstract: Method for producing a microfluidic device comprising a step in which a stamp made of elastomeric material is used for printing a photo-curable and/or heat-curable liquid disposed on a support.

Abstract translation: 用于制造微流体装置的方法包括以下步骤：由弹性体材料制成的印模用于印刷设置在载体上的可光固化和/或热固化液体。

公开(公告)号：US20140001149A1

公开(公告)日：2014-01-02

申请号：US13536915

申请日：2012-06-28

Applicant: Jingwei Bai ,  Stefan Harrer ,  Stanislav Polonsky ,  Stephen M. Rossnagel

Inventor： Jingwei Bai ,  Stefan Harrer ,  Stanislav Polonsky ,  Stephen M. Rossnagel

IPC: B44C1/22 ,  H01B13/00

CPC classification number: B81C1/00087 ,  B81B2201/058 ,  H01L21/0337 ,  Y10T428/24322

Abstract: For a cross slit structure that contains a nanopore, a layer is produced including a first spacer that penetrates through the layer. A subsequent layer over, and in direct contact with, the layer is also produced. The subsequent layer includes a second spacer penetrating through the subsequent layer. The first spacer and the second spacer are selectively etched away, creating a first slit and a second slit. Respective projections of these slits are crossing one another at an angle. At such a crossing an opening is formed which provides for fluid connectivity through the two layers.

公开(公告)号：US20130331528A1

公开(公告)日：2013-12-12

申请号：US13876583

申请日：2011-10-03

Applicant: Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

Inventor： Carl Fredrik Carlborg ,  Tommy Haraldsson ,  Kim Öberg ,  Michael Malkoch

IPC: C08G75/04 ,  C08G77/392

CPC classification number: C08G77/392 ,  B81B2201/058 ,  B81B2201/06 ,  B81C3/001 ,  C08G75/045 ,  C08G75/12 ,  C09D181/02

Abstract: A method for the manufacture of articles of thiol-ene polymers comprises the steps: a) reacting a compound comprising at least two thiol groups and a compound comprising at least two carbon-carbon double bonds, in off stochiometry ratios to obtain a first intermediate article, wherein said first intermediate article comprises at least one unreacted group selected from an unreacted thiol group and an unreacted carbon-carbon double bond, and b) contacting said first intermediate article with a second article, wherein the surface of said second article at least partially comprises reactive groups and reacting at least a part of said unreacted groups on said first intermediate article with chemical groups on said second article to obtain covalent bonds and forming a final article.

Abstract translation: 一种用于制备硫醇 - 烯聚合物制品的方法包括以下步骤：a）以脱硫方法比例使包含至少两个硫醇基团的化合物和包含至少两个碳 - 碳双键的化合物反应，以获得第一中间制品 其中所述第一中间制品包含至少一种选自未反应的硫醇基团和未反应的碳 - 碳双键的未反应基团，和b）使所述第一中间制品与第二制品接触，其中所述第二制品的表面至少部分地 包括反应性基团并使所述第一中间体上的所述未反应基团的至少一部分与所述第二制品上的化学基团反应，以获得共价键并形成最终制品。

公开(公告)号：US20130244181A1

公开(公告)日：2013-09-19

申请号：US13888563

申请日：2013-05-07

Applicant: GEORGIA TECH RESEARCH CORPORATION

Inventor： Paul A. Kohl ,  Sue Ann Bidstrup-Alllen ,  Clifford Lee Henderson

IPC: G03F7/004

CPC classification number: G03F7/004 ,  B81B2201/058 ,  B81B2203/0338 ,  B81B2203/0384 ,  B81C1/00103 ,  B81C2201/0108 ,  C08J3/28 ,  C08K5/0041 ,  G03F7/40 ,  Y10T428/24479

Abstract: Polymers, methods of use thereof, and methods of decomposition thereof, are provided. One exemplary polymer, among others, includes, a photodefinable polymer having a sacrificial polymer and a photoinitiator.

Abstract translation: 提供聚合物，其使用方法及其分解方法。 一个示例性聚合物，其中包括具有牺牲聚合物和光引发剂的光可定义聚合物。

公开(公告)号：US20130220810A1

公开(公告)日：2013-08-29

申请号：US13781181

申请日：2013-02-28

Applicant: Gary Chorng-Jyh Wang

Inventor： Gary Chorng-Jyh Wang

IPC: B01L3/00 ,  B81B1/00

CPC classification number: G01N27/44791 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502715 ,  B01L3/502792 ,  B01L3/563 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0427 ,  B81B1/00 ,  B81B2201/0214 ,  B81B2201/058

Abstract: A three-dimensional digital microfluidic system comprises a first plate with a first electrode, a second plate with a second electrode, and a microfluidic drop in between the first and the second electrode. The electrodes are able to be actuated in sequence such that the microfluidic drop is able to be transported. A bridge plate is able to be included.

Abstract translation: 三维数字微流体系统包括具有第一电极的第一板，具有第二电极的第二板和在第一和第二电极之间的微流体液滴。 电极能够依次致动，使得微流体液滴能够被输送。 可以包括桥板。

公开(公告)号：US08501029B2

公开(公告)日：2013-08-06

申请号：US11554537

申请日：2006-10-30

Applicant: Timothy Beerling ,  Hongfeng Yin

Inventor： Timothy Beerling ,  Hongfeng Yin

IPC: C23F1/00

CPC classification number: B81C1/00063 ,  B01L3/5027 ,  B81B2201/058 ,  B81C2201/0132 ,  G01N30/6095

Abstract: In accordance with the invention, a method for making microfluidic structures in bulk titanium is disclosed. Specific microfluidic structures include HPLC structures.

Abstract translation: 根据本发明，公开了一种在体积钛中制造微流体结构的方法。 特定的微流体结构包括HPLC结构。