公开(公告)号：US06859275B2

公开(公告)日：2005-02-22

申请号：US09798860

申请日：2001-03-01

Applicant: William G. Fateley ,  Ronald R. Coifman ,  Frank Geshwind ,  Richard A. DeVerse

Inventor： William G. Fateley ,  Ronald R. Coifman ,  Frank Geshwind ,  Richard A. DeVerse

IPC: G01J3/02 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/28 ,  G01J3/32 ,  G01J3/457 ,  G01N21/39 ,  G02B26/08 ,  G02B27/10 ,  G01J3/04

CPC classification number: G02B27/1013 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0232 ,  G01J3/027 ,  G01J3/06 ,  G01J3/10 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/2846 ,  G01J3/2889 ,  G01J3/32 ,  G01J3/42 ,  G01J3/433 ,  G01J3/457 ,  G01J2003/2866 ,  G01N21/39 ,  G01N2021/393 ,  G01N2021/6463 ,  G02B26/0833 ,  G02B26/0841 ,  G02B27/1086 ,  G02B27/126

Abstract: Encoded spatio-spectral information processing is performed using a system having a radiation source, wavelength dispersion device and two-dimensional switching array, such as digital micro-mirror array (DMA). In one aspect, spectral components from a sample are dispersed in space and modulated separately by the switching array, each element of which may operate according to a predetermined encoding pattern. The encoded spectral components can then be detected and analyzed. In a different aspect, the switching array can be used to provide a controllable radiation source for illuminating a sample with radiation patterns that have predetermined characteristics and separately encoded components. Various applications are disclosed.

Abstract translation: 使用具有辐射源，波长色散器件和二维开关阵列（例如数字微镜阵列（DMA））的系统执行编码空间光谱信息处理。 在一个方面，来自样本的频谱分量被分散在空间中，并且由开关阵列分开调制，开关阵列的每个元件可以根据预定的编码模式进行操作。 然后可以检测和分析编码的光谱分量。 在不同的方面，开关阵列可以用于提供用于利用具有预定特征的辐射图案和分开编码的部件来照射样本的可控辐射源。 公开了各种应用。

公开(公告)号：US20040007665A1

公开(公告)日：2004-01-15

申请号：US10453717

申请日：2003-06-03

Applicant: Baker Hughes Incorporated

Inventor： Rocco DiFoggio ,  Arnold Walkow ,  Paul Bergren

IPC: G01N021/64 ,  G01V005/08

CPC classification number: G01J3/26 ,  E21B49/08 ,  E21B2049/085 ,  G01J3/0202 ,  G01J3/0262 ,  G01J3/06 ,  G01J3/433 ,  G01J3/4406 ,  G01N21/0317 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/64 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2021/855

Abstract: The invention comprises an apparatus and method for simple fluorescence spectrometry in a down hole environment. The apparatus and method utilization of two UV light bulbs and an optically clear UV coupler and a fluid containment system. The optically clear UV coupler and fluid containment system are made of sapphire. The apparatus is attached in a manner that enables light transmitted from a light source on the far side of the fluid containment system to pass through a pathway in a plate holding the UV bulbs. UV light illuminates the fluid, which in turn fluoresces light. The fluoresced light is transmitted back towards the UV bulb mount and through the pathway towards an optical spectrum analyzer.

Abstract translation: 本发明包括在井下环境中简单荧光光谱法的装置和方法。 两种紫外灯泡和光学透明UV耦合器和流体容纳系统的装置和方法利用。 光学透明的UV耦合器和流体容纳系统由蓝宝石制成。 该装置以使得能够从流体容纳系统的远侧上的光源透射的光通过保持UV灯泡的板中的路径的方式附接。 紫外线照射流体，这又使荧光发光。 荧光的光被传输回到UV灯座并通过光谱分析仪。

公开(公告)号：US20030205682A1

公开(公告)日：2003-11-06

申请号：US10429426

申请日：2003-05-05

Inventor： Rakesh Kapoor ,  Martin Casstevens

IPC: G01J001/58

CPC classification number: G01J3/433 ,  G01J3/4406 ,  G01N21/6408

Abstract: A method of analyzing sample material having more than one fluorescing species comprises the steps of providing a plurality of intensity-modulated excitation light beams each being modulated at a respective unique frequency; directing the intensity-modulated excitation light beams to interact with the sample material; detecting fluorescence emission light from the sample material to provide signal information representative of detected light intensity versus time; and extracting a plurality of component emission signals from the signal information, wherein each component emission signal corresponds to a respective one of the modulated excitation light beams. Apparatus for implementing the method include flow cytometers and bulk sample analytical optical systems. The invention is helpful in determining species concentrations in cases where the fluorescing species have overlapping or substantially the same emission spectra.

Abstract translation: 分析具有多于一种荧光物质的样品材料的方法包括以下步骤：提供多个强度调制的激发光束，每个激发光束以相应的唯一频率被调制; 引导强度调制的激发光束与样品材料相互作用; 检测来自样品材料的荧光发射光，以提供表示检测到的光强度对时间的信号信息; 以及从所述信号信息提取多个分量发射信号，其中每个分量发射信号对应于调制的激发光束中的相应一个。 用于实施该方法的装置包括流式细胞仪和散装样品分析光学系统。 在荧光物质具有重叠或基本上相同的发射光谱的情况下，本发明有助于确定物质浓度。

公开(公告)号：US06549861B1

公开(公告)日：2003-04-15

申请号：US09636041

申请日：2000-08-10

Applicant: Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

Inventor： Howard Mark ,  Emil Ciurczak ,  Gary Ritchie

IPC: G01R2316

CPC classification number: G01J3/28 ,  G01J3/0264 ,  G01J3/433 ,  G01J2003/2866

Abstract: An automated method for modeling spectral data is provided, wherein the spectral data generated by one of diffuse reflectance, clear transmission, or diffuse transmission. The method includes accessing a set of spectral data, the set of spectral data including, corresponding spectral data for each of a plurality of samples, the spectral data for each of the plurality of samples having associated therewith at least one constituent value, the at least one constituent value being a reference value for a target substance in the sample which is measured by a independent measurement technique. A plurality of data transforms are applied to the set of spectral data to generate, for each sample, a set of transformed and untransformed spectral data. The set of transformed and untransformed spectral data, with its associated constituent values, is divided into a calibration sub-set and a validation sub-set, and one or more of a partial least squares, a principal component regression, a neural net, or a multiple linear regression analysis is applied to the transformed and untransformed calibration data sub-sets to obtain corresponding modeling equations for predicting the amount of the target substance in a sample. The modeling equation which provides the best correlation between the spectral data in the validation sub-set and the corresponding constituent values in the validation sub-set is identified, preferably as a function of the SEE and SEP.

Abstract translation: 提供了一种用于建模光谱数据的自动化方法，其中由漫反射，透明或漫射传输之一产生的光谱数据。 该方法包括访问一组光谱数据，该光谱数据集合包括多个样本中的每一个的对应光谱数据，多个样本中的每一个的光谱数据与其相关联，至少一个成分值，至少 一个成分值是通过独立测量技术测量的样品中的目标物质的参考值。 将多个数据变换应用于该光谱数据集合，以针对每个样本生成一组经变换和未转换的光谱数据。 具有其相关联的成分值的经转换和未转换的光谱数据的集合被分成校准子集和确认子集，以及一个或多个偏最小二乘法，主成分回归，神经网络或 将多元线性回归分析应用于转化和未转换的校准数据子集，以获得用于预测样品中目标物质的量的相应建模方程。 确定在验证子集中的光谱数据与验证子集中的相应组成值之间提供最佳相关性的建模方程，优选地作为SEE和SEP的函数。

公开(公告)号：US20030048449A1

公开(公告)日：2003-03-13

申请号：US10147009

申请日：2002-05-16

Inventor： Peter G. Vander Jagt ,  Steven H. Peterson

IPC: G01N021/59

CPC classification number: G01N21/255 ,  G01J3/10 ,  G01J3/433 ,  G01J3/50 ,  G01J3/501 ,  G01J3/524 ,  G01J2001/4242 ,  G01N2201/0625 ,  G01N2201/0627 ,  G01N2201/0691

Abstract: An instrument and method for measuring light or color using modulated illumination. The system includes an LED illuminator modulated at a specific frequency for illuminating the sample, and a sensor capable of differentiating between the modulated light from the sample and unmodulated ambient light. The instrument is therefore capable of nullseeingnull only light from the sample, while ignoring ambient light. In a second embodiment, the system includes multiple illuminators of different colors each modulated at a unique frequency so that the sample can be measured at multiple at each of the different frequencies.

Abstract translation: 一种使用调制照明测量光或颜色的仪器和方法。 该系统包括以特定频率调制以照亮样品的LED照明器，以及能够区分来自样品的调制光和未调制的环境光的传感器。 因此，仪器只能“看到”来自样品的光，同时忽略环境光。 在第二实施例中，系统包括多个不同颜色的照明器，每个照明器以独特的频率进行调制，使得可以在不同频率的每一个处以多个测量样本。

公开(公告)号：US20030030001A1

公开(公告)日：2003-02-13

申请号：US09804828

申请日：2001-03-13

Inventor： David E. Cooper ,  Pajo Vujkovic-Cvijin

IPC: G01N021/35 ,  G02F001/01

CPC classification number: G01J3/433 ,  G01N21/39 ,  G01N21/538 ,  G01N2021/1793

Abstract: This specification discloses a method and apparatus for the mobile and remote detection of a gas, such as methane, in the atmosphere. The apparatus includes a TDL based Light Detection and Ranging (LIDAR) driven at carrier frequency lying within the absorption line of the gas. The apparatus also drives the TDL with a modulation frequency to generate upper and lower sidebands in the output of the TDL and with a low ramp frequency to sweep the output of the TDL across twice the width of the pressure-broadened absorption line of the gas, preferably the first overtone absorption line in the case of methane detection. Suitable power for remote detection through use of the TDL is provided by a master oscillator/fiber amplifier transmitter has no moving or adjustable parts at all. An all-solid-state monolithic and integrated amplifier is achieved, which leads to a compact and virtually maintenance-free LIDAR system. The remote detection apparatus includes reference and calibration cells or chambers, and includes a light collector and detectors to detect the quantity and modulation of the light that passes the reference or calibration cells and that is received by the apparatus after reflection back toward the apparatus from an uncooperative target. The apparatus further includes a signal processor that applies a derivative spectroscopy technique, such as frequency modulation spectroscopy or wavelength modulation spectroscopy, to determine the presence of the gas in the atmosphere.

Abstract translation: 本说明书公开了一种用于在大气中移动和远程检测诸如甲烷的气体的方法和装置。 该装置包括在位于气体的吸收线内的载波频率下驱动的基于TDL的光检测和测距（LIDAR）。 该装置还驱动具有调制频率的TDL，以在TDL的输出中产生上边带和下边带，并具有低斜坡频率，以扫过TDL的输出跨过气体的加压扩大吸收线的两倍宽度， 在甲烷检测的情况下，优选地是第一泛音吸收线。 通过使用TDL进行远程检测的合适电源由主振荡器/光纤放大器发射器完全没有移动或可调部分提供。 实现了全固态单片和集成放大器，从而实现了紧凑且几乎无需维护的激光雷达（LIDAR）系统。 远程检测设备包括参考和校准单元或室，并且包括光收集器和检测器，用于检测通过参考或校准单元的光的量和调制，并且由反射器从反射器 不合作目标。 该装置还包括信号处理器，其应用衍生光谱技术，例如频率调制光谱或波长调制光谱，以确定气体在大气中的存在。

公开(公告)号：US06473632B1

公开(公告)日：2002-10-29

申请号：US09595148

申请日：2000-06-16

Applicant: Dean E. Myers

Inventor： Dean E. Myers

IPC: A61B500

CPC classification number: A61B5/7239 ,  A61B5/1455 ,  G01J3/433 ,  G01N21/35 ,  G01N21/3504

Abstract: A method for operating a spectrophotometric instrument of the type for measuring the oxygenation state of hemoglobin in tissue. The method includes the use of stored hemoglobin concentration relationship data characterizing the relationship between second derivative absorbance values at a hemoglobin-absorbing wavelength and hemoglobin concentration in a tissue as a function of hemoglobin oxygenation state. Data representative of a second derivative absorbance value of tissue being analyzed is received. The hemoglobin oxygenation state of the tissue is determined as a function of the second derivative absorbance value. The hemoglobin concentration in the tissue is then determined as a function of the hemoglobin concentration relationship data, the second derivative absorbance value and the hemoglobin oxygenation state. The accuracy of the hemoglobin oxygenation state can be determined as a function of the hemoglobin concentration value.

Abstract translation: 一种用于测量组织中血红蛋白氧合状态类型的分光光度仪的方法。 该方法包括使用存储的血红蛋白浓度关系数据，其表征血红蛋白吸收波长的二次导数吸光度值与组织中的血红蛋白浓度之间的关系作为血红蛋白氧合状态的函数。 接收表示正在分析的组织的二阶导数吸光度值的数据。 确定组织的血红蛋白氧合状态作为二阶导数吸光度值的函数。 然后根据血红蛋白浓度关系数据，二阶导数吸光度值和血红蛋白氧合状态确定组织中的血红蛋白浓度。 可以将血红蛋白氧合状态的准确度确定为血红蛋白浓度值的函数。

公开(公告)号：US20010032923A1

公开(公告)日：2001-10-25

申请号：US09782440

申请日：2001-02-13

Inventor： Katsue Koashi

IPC: G01J003/50

CPC classification number: G01J3/433 ,  G01N21/31

Abstract: As for the specific analyzed object, the spectral profile is prepared. The spectral profile is differentiated and the two-dimensional derivative plot wherein at least one axis denotes the differentiated value is prepared, and at least one component band is estimated based on the characteristic information including the local minimum and the local maximum in the said two-dimensional derivative plot. The component bands are estimated which construct spectral profile of the analyzed object by iterating the estimation of other component bands in the same procedure and by estimating component bands in order as for the profile with estimated component bands removed from the original spectral profile or the two-dimensional derivative plot. Further, after estimating the component bands, the band parameter values are so improved as to coincide the specific estimated component bands with complementary estimated component bands with all the component bands removed except for the specific component bands estimated from the original spectral data. The total sum of the distances of the iso-wavenumber lines and the symmetry of the two-dimensional derivative plot are employed as criteria of the coincidence.

Abstract translation: 对于具体分析对象，准备光谱分布。 光谱分布被区分，并且准备其中至少一个轴表示微分值的二维导数图，并且基于包括所述二维图像中的局部最小值和局部最大值的特征信息来估计至少一个单位频带， 三维导数图。 估计分量频带，其通过在相同的过程中迭代其他分量频带的估计来估计分析对象的频谱分布，并且通过按照关于从原始频谱分布中去除估计分量带的分布的顺序估计分量带， 三维导数图。 此外，在估计分量频带之后，频带参数值被如此改进，以便除了除了从原始频谱数据估计的特定分量频带之外，除去具有所有分量频带的互补估计分量频带的特定估计分量频带。 作为符号的标准，使用等波数线的距离和二维导数图的对称性的总和。

公开(公告)号：US06271917B1

公开(公告)日：2001-08-07

申请号：US09105279

申请日：1998-06-26

Applicant: Thomas W. Hagler

Inventor： Thomas W. Hagler

IPC: G01J304

CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0213 ,  G01J3/0229 ,  G01J3/0289 ,  G01J3/12 ,  G01J3/18 ,  G01J3/32 ,  G01J3/433 ,  G01J2001/4242 ,  G01J2003/2866

Abstract: A disc serving as a spatial radiation modulator has dispersed radiation filters thereon. Each filter has a transmittance or reflectance modulation function of the form sin2(m&thgr;+p&pgr;/4), where m is a positive integer and p has one of the four values 0, 1, 2, 3. A radiation beam including selected wavelength components is diffracted into an elongated image dispersed according to wavelength. Different wavelength components are focused onto different filters on the modulator and are encoded by correspond filters. Since the modulation functions of the filters are orthogonal to one another, it is possible to extract the amplitude of each wavelength component after it has been encoded or modulated by corresponding filter from the total detected signal during one measurement.

Abstract translation: 用作空间辐射调制器的盘在其上具有分散的辐射滤波器。 每个滤波器具有形式为sin2（mtata + ppi / 4）的透射率或反射率调制函数，其中m是正整数，p具有四个值0,1,2,3中的一个。包括选择的波长分量 衍射成根据波长分散的细长图像。 不同的波长分量聚焦在调制器上的不同滤波器上，并由相应的滤波器编码。 由于滤波器的调制功能彼此正交，因此可以在一次测量期间从总检测信号对相应的滤波器进行编码或调制之后提取每个波长分量的振幅。

公开(公告)号：US6040914A

公开(公告)日：2000-03-21

申请号：US872617

申请日：1997-06-10

Applicant: Michael L. Bortz ,  Asif A. Godil

Inventor： Michael L. Bortz ,  Asif A. Godil

IPC: G01J3/433 ,  G01N21/39 ,  G01N21/31

CPC classification number: G01N21/39 ,  G01J3/433

Abstract: A laser absorption sensor system for performing optical measurements on a sample is described. The sensor system includes a tunable laser, capable of being tuned at rates exceeding 1 KHZ, and with a tuning range approaching 1 GHz. The laser beam is modulated at a modulation frequency between 1 and 100 KHz. Modulation in this frequency range is termed wavelength modulation. The beam is split into two beams, a signal beam and a reference beam. The signal beam traverses the sample where characteristic absorption takes place and is incident on a signal photodetector. The reference beam is incident directly on a reference photodetector. A noise cancellation circuit combines signal and reference photo-currents from signal and reference photodetectors reducing signal noise and increasing system sensitivity. The combination of wavelength modulation and the noise cancellation scheme provide a highly sensitive simple, rugged, low cost laser absorption sensor system.

Abstract translation: 描述了用于对样品进行光学测量的激光吸收传感器系统。 传感器系统包括可调谐激光器，能够以超过1 KHZ的速率调谐，并且调谐范围接近1 GHz。 激光束以1和100KHz之间的调制频率进行调制。 该频率范围内的调制称为波长调制。 光束被分成两个光束，一个信号光束和一个参考光束。 信号光束穿过特征吸收发生并入射到信号光电检测器上的样品。 参考光束直接入射到参考光电检测器上。 噪声消除电路组合信号和参考光电检测器的信号和参考光电流，从而降低信号噪声并提高系统灵敏度。 波长调制和噪声消除方案的组合提供了高灵敏度的简单，坚固，低成本的激光吸收传感器系统。