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公开(公告)号:US20220084858A1
公开(公告)日:2022-03-17
申请号:US17456338
申请日:2021-11-23
Applicant: Micron Technology, Inc.
Inventor: David Palsulich , Nicholas A. Wieber
Abstract: A method of contaminant detection comprises exposing a wafer comprising one or more contaminants to microdroplets of an oxidizer to form an oxide on a surface of the wafer, exposing the oxide to an etchant to remove the oxide and leave the one or more contaminants on the surface of the wafer, and determining a composition of the one or more contaminants. Additional methods and related tools are also disclosed.
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公开(公告)号:US11264222B2
公开(公告)日:2022-03-01
申请号:US16993832
申请日:2020-08-14
Applicant: Elemental Scientific, Inc.
Inventor: Kyle W. Uhlmeyer , Tyler Yost , Jacob Unnerstall , Aaron Williams
Abstract: Systems and methods are described for heating sample transfer lines between a source of a sample and a detection system to detect analytes of interest in the sample, where the sample is maintained in a heated state to maintain dissolved analytes of interest in solution.
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公开(公告)号:US11264221B2
公开(公告)日:2022-03-01
申请号:US17253538
申请日:2019-06-18
Applicant: Fluidigm Canada Inc. , Paul Corkum
Inventor: Paul Corkum , Alexander V. Loboda
IPC: H01J49/04 , G01N33/68 , G02B21/33 , H01J37/20 , H01J37/28 , H01J49/00 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/40 , H01J49/16 , H01J49/14
Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMCTM) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.
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公开(公告)号:US20220057363A1
公开(公告)日:2022-02-24
申请号:US16998174
申请日:2020-08-20
Applicant: Bruker Daltonik GmbH
Inventor: Aneesh PRABHAKARAN
Abstract: An ion mobility separator includes an ion path with a central axis along which ions travel, the ion path containing a gas. A first force is applied to the ions in a first axial direction, and a second force that varies spatially along the ion path is applied to the ions in second axial direction opposite the first axial direction. A rotating confinement field has a radially-inhomogeneous electric potential with relative maxima and minima that rotate about the central axis as a function of time, the confinement field exerting a radial confinement force on the ions in a radial direction toward the central axis. The ion mobility separator may be operated at elevated pressures including ambient pressure and higher. The first and/or second axial forces may be a constant or gradient gas flow, a constant or gradient electric field or an axial component of the rotating confinement field.
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公开(公告)号:US11217438B2
公开(公告)日:2022-01-04
申请号:US15555758
申请日:2016-03-07
Applicant: Micromass UK Limited
Inventor: Emrys Jones , Tamas Karancsi , Steven Derek Pringle , Julia Balog , Daniel Simon , Lajos Godorhazy , Daniel Szalay , Zoltan Takats
IPC: H01J49/00 , H01J49/04 , A61B90/13 , A61B1/04 , A61B1/273 , A61B5/00 , A61B5/01 , A61B5/0507 , A61B5/055 , A61B6/03 , A61B8/13 , A61B10/00 , A61B10/02 , A61B17/00 , A61B17/32 , A61B18/00 , A61B18/04 , A61B18/14 , A61B18/18 , A61B18/20 , A61F13/38 , C12Q1/02 , C12Q1/04 , C12Q1/18 , C12Q1/24 , G01N1/22 , G01N3/00 , G01N9/00 , G01N27/622 , G01N27/624 , G01N30/72 , G01N33/487 , G01N33/68 , G01N33/92 , H01J49/02 , H01J49/06 , H01J49/10 , H01J49/14 , H01J49/16 , H01J49/24 , H01J49/26 , G16H10/40 , G16H15/00 , G16H50/20 , G16B20/00 , A61B1/00 , A61B1/31 , A61B5/145
Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing an analyte; supplying a matrix compound to said analyte such that said analyte dissolves in said matrix; forming first droplets of the dissolved analyte; and colliding said first droplets with a collision surface. The use of matrix improves the analyte ion signal.
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公开(公告)号:US11215583B2
公开(公告)日:2022-01-04
申请号:US16093681
申请日:2017-04-12
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor: John Lawrence Campbell
Abstract: Methods and systems for separating, detecting, and/or quantifying sample enantiomers using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of racemic or non-racemic mixtures of sample enantiomers that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), by reacting the sample enantiomers with an enantiomerically-pure compound to form diastereomers separable by DMS.
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公开(公告)号:US20210375606A1
公开(公告)日:2021-12-02
申请号:US16886288
申请日:2020-05-28
Applicant: Thermo Finnigan LLC
Inventor: Jesse D. CANTERBURY , Graeme C. McALISTER
Abstract: A mass spectrometer system, comprises: an ion source; a first and a second multipole apparatus; one or more ion gates or ion lenses between the first and second multipole apparatuses; at least one power supply configured to provide voltages to electrodes of the ion source, the mass analyzer, the first and second multipole apparatuses and the one or more ion gates or ion lenses; and a computer or electronic controller electrically coupled to the at least one power supply, wherein the computer or electronic controller comprises computer-readable instructions that are operable to cause the at least one power supply to supply voltages to the electrodes that cause transfer of ions from the first multipole apparatus to the second multipole apparatus, wherein a duration of a time allotted for completion of the transfer of the ions is dependent upon one or more properties of the ions being transferred.
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公开(公告)号:US11189478B2
公开(公告)日:2021-11-30
申请号:US16771397
申请日:2018-02-07
Applicant: SHIMADZU CORPORATION
Inventor: Manabu Ueda , Kota Nagasao
Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). The fixation band (53) has a coating film layer (532) formed by a black nickel plating process on the entire surface of a main member (531) made from phosphor bronze. The coating film layer (532) has high emissivity, and thus heat transferred from the rod holder (51) to the fixation band (53) is efficiently radiated into the vacuum housing (1). Therefore, heat generated in the rod holder (51) due to dielectric loss is efficiently dissipated, and deformation of the rod holder can be reduced.
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公开(公告)号:US11189475B2
公开(公告)日:2021-11-30
申请号:US16976211
申请日:2018-12-20
Applicant: SHIN-ETSU HANDOTAI CO., LTD.
Inventor: Kenji Araki
Abstract: A desolvation unit performs desolvation by heating after a sample solution is turned to sample mist by a nebulizer. A sample gas that contains the desolvated sample mist and a carrier gas is introduced through a sample introduction tube to a plasma torch. An addition unit for adding, to the sample introduction tube, a water-containing gas is provided. The addition unit includes a container that contains ultrapure water, a gas tube for introducing the carrier gas into the ultrapure water to cause bubbling, and a gas tube for adding the water-containing gas, to the sample introduction tube. The plasma torch generates an inductively coupled plasma under the condition that supplied power is set to a range of 550 W to 700 W. Generation of interfering molecule ions due to an element having a high ionization potential is inhibited when an element in a sample ionized by the plasma is analyzed.
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70.
公开(公告)号:US20210310911A1
公开(公告)日:2021-10-07
申请号:US17215711
申请日:2021-03-29
Applicant: TOKYO OHKA KOGYO CO., LTD.
Inventor: Kohei SUZUKI , Isao NOUCHI , Toshio NOMURA
IPC: G01N1/38 , H01J49/10 , G01N27/623 , G01N33/44
Abstract: A method of analyzing a metal component contained as an impurity in a polymer composition that contains a polymer and an organic solvent including a step (i) of preparing a dispersion by mixing the polymer composition with an acid aqueous solution, a step (ii) of separating the dispersion prepared in the step (i) into a dispersoid layer containing the polymer and a dispersion medium layer containing the metal component, and a step (iii) of quantifying the metal component contained in the dispersion medium layer separated in the step (ii).
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