公开(公告)号：US11674897B2

公开(公告)日：2023-06-13

申请号：US17698215

申请日：2022-03-18

Applicant: Purdue Research Foundation

Inventor： Delong Zhang ,  Ji-Xin Cheng

IPC: G01N21/3563 ,  G01N21/17 ,  C12Q1/02 ,  G01J5/22 ,  G01J5/00 ,  G02B21/02 ,  G02B21/06 ,  G02B21/18 ,  H01S5/34

CPC classification number: G01N21/3563 ,  C12Q1/02 ,  G01J5/22 ,  G01N21/171 ,  G01J2005/0077 ,  G01N2021/1712 ,  G01N2201/0612 ,  G01N2201/0697 ,  G02B21/02 ,  G02B21/06 ,  G02B21/18 ,  H01S5/3401

Abstract: Systems and methods for sensing vibrational absorption induced photothermal effect via a visible light source. A Mid-infrared photothermal probe (MI-PTP, or MIP) approach achieves 10 mM detection sensitivity and sub-micron lateral spatial resolution. Such performance exceeds the diffraction limit of infrared microscopy and allows label-free three-dimensional chemical imaging of live cells and organisms. Distributions of endogenous lipid and exogenous drug inside single cells can be visualized. MIP imaging technology may enable applications from monitoring metabolic activities to high-resolution mapping of drug molecules in living systems, which are beyond the reach of current infrared microscopy.

公开(公告)号：US20180283847A1

公开(公告)日：2018-10-04

申请号：US15938591

申请日：2018-03-28

Applicant: SHIMADZU CORPORATION

Inventor： Takahide HATAHORI ,  Yuya NAGATA ,  Kenji TAKUBO

IPC: G01B9/02 ,  G01M7/02 ,  G01N21/88 ,  G01B11/24

CPC classification number: G01B9/02096 ,  G01B9/02098 ,  G01B11/2441 ,  G01M7/025 ,  G01N21/1717 ,  G01N21/45 ,  G01N21/8806 ,  G01N29/00 ,  G01N2021/1706 ,  G01N2021/8809 ,  G01N2201/0697

Abstract: A vibration measurement device includes: a vibration-inducing section; a laser source; a scanning section for illuminating a partial area of a measurement area on an object with laser light and moving the illumination area; an illumination control section for sequentially illuminating each point within the measurement area with an illuminating duration equal to or shorter than one third of the vibration period; a displacement measurement section for measuring, for each point within the measurement area, an interfering light obtained by splitting an object light from the object into two bundles of light to measure a relative displacement in a back-and-forth direction between two closely-located points within the measurement area; and a vibration state determination section for determining the state of vibration of the entire measurement area, based on the relative displacement in the back-and-forth direction between two closely-located points at each point within the measurement area.

公开(公告)号：US20180202941A1

公开(公告)日：2018-07-19

申请号：US15564154

申请日：2016-12-19

Applicant: NIPPON STEEL & SUMITOMO METAL CORPORATION

Inventor： Yusuke KONNO ,  Takamichi KOBAYASHI ,  Toshio AKAGI ,  Atsuhiro HIBI ,  Nobuhiro FURUYA ,  Akihito NAKAZAKI

IPC: G01N21/88 ,  G01N21/892

CPC classification number: G01N21/8806 ,  G01N15/06 ,  G01N21/00 ,  G01N21/359 ,  G01N21/88 ,  G01N21/8851 ,  G01N21/892 ,  G01N21/94 ,  G01N21/952 ,  G01N2201/0697

Abstract: [Object] To find, with high sensitivity, an unevenness defect or the like that has occurred on the surface of an inspection object having a surface roughness comparable to wavelengths of visible light and is comparable to several times the surface roughness, and accurately distinguish between dirt and an unevenness flaw present on the surface of the inspection object, and also enable a reduction in the size of an apparatus.[Solution] An inspection object imaging apparatus according to the present invention includes: a light source configured to produce a light beam belonging to an infrared wavelength band and having a predetermined spread half-angle on a surface of an inspection object; a projection optical system configured to project the light beam on the surface of the inspection object at a predetermined projection angle; and an imaging unit configured to image reflected light from the surface of the inspection object. The imaging unit includes an imaging optical system including at least one convex lens, configured to condense reflected light and branch the reflected light to two different directions, and a first image sensor and a second image sensor each configured to image the reflected light that has passed through the imaging optical system. The first image sensor is positioned on the inspection object side with respect to a position of the imaging optical system that is conjugate with the surface of the inspection object, along an optical axis of the reflected light. The second image sensor is positioned on the reflected-light travel direction side with respect to the conjugate position.

公开(公告)号：US09981266B2

公开(公告)日：2018-05-29

申请号：US14803594

申请日：2015-07-20

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller

IPC: G01N35/08 ,  B01L3/00 ,  G01N21/59 ,  G01N33/543 ,  G01N33/574 ,  B01L7/00

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.

公开(公告)号：US20180134973A1

公开(公告)日：2018-05-17

申请号：US15870864

申请日：2018-01-13

Applicant: Honeywell Limited

Inventor： Markku Kellomaki

IPC: C10G47/36 ,  G01N15/06 ,  C10G47/02 ,  G01N15/02

CPC classification number: C10G47/36 ,  C10G47/00 ,  C10G47/02 ,  C10G47/26 ,  G01N15/0205 ,  G01N15/0227 ,  G01N15/06 ,  G01N21/21 ,  G01N21/23 ,  G01N33/2835 ,  G01N2015/0053 ,  G01N2015/0693 ,  G01N2021/216 ,  G01N2021/479 ,  G01N2021/4792 ,  G01N2201/0612 ,  G01N2201/0697

Abstract: On-line detection of mesophase particles employs a laser diode light source to illuminate a target area with a pulsed laser linearly or circularly polarized probe beam. Analysis of images determines extent of presence the birefringent mesophase particles, which are precursors to coking in catalytic hydrocracking processes. The inherently polarized low-coherence, unfocused but sufficiently collimated, pulsed laser beam yield sharp imaging with high depth of field of very small mesophase particles that are present in a moving, dark reactor liquid environment.

公开(公告)号：US09927417B2

公开(公告)日：2018-03-27

申请号：US15001238

申请日：2016-01-20

Applicant: The Texas A&M University System

Inventor： Vladislav Victorovich Yakovlev ,  Edward S. Fry ,  John David Mason ,  Joel Nathan Bixler ,  Michael Thomas Cone ,  Brett Harrison Hokr

IPC: G01N21/25 ,  G01N33/18 ,  G01N21/64 ,  G01N21/39

CPC classification number: G01N33/1826 ,  G01N21/39 ,  G01N21/645 ,  G01N2021/6469 ,  G01N2201/065 ,  G01N2201/0697

Abstract: Disclosed is a high reflectivity integrating cavity and device to amplify and detect luminescent emissions produced by small concentrations of materials to be analyzed. Femto or nano molar concentrations of a material can be placed within the high reflectivity integrating cavity. At least the interior surface of the high reflectivity integrating cavity can comprise a coating that, at a designated wavelength of electromagnetic radiation, is transparent and non-absorbing to such designated wavelengths of electromagnetic radiation. In addition to the isotropic field induced by the interior surface of the high reflectivity integrating cavity, the high reflectivity of the interior surface of the high reflectivity integrating cavity leads to very large effective optical path lengths within the interior of the high reflectivity integrating cavity, thereby amplifying the luminescent emissions produced by the sample.

公开(公告)号：US09880095B2

公开(公告)日：2018-01-30

申请号：US14360813

申请日：2012-11-29

Applicant: CiDRA Corporate Services Inc.

Inventor： Michael A. Davis ,  Mark R. Fernald

IPC: G01N21/3563 ,  G01N33/24 ,  G01N21/39 ,  G01N21/84

CPC classification number: G01N21/3563 ,  G01N21/39 ,  G01N21/84 ,  G01N33/24 ,  G01N33/241 ,  G01N2201/0691 ,  G01N2201/0697 ,  G01N2201/12

Abstract: The present invention provides a technique that uses discrete wavelengths of illumination of an ore sample, and through the use of optical filters and laser illumination the signal-to-noise ratio of the measurement can be greatly improved, and may take the form of apparatus featuring a signal processor configured to: receive signaling containing information about a spectral reflectance caused by discrete wavelengths illuminating an ore sample; and determine information about a bitumen content of the ore sample based at least partly on the signaling. The signal processor may provide corresponding signaling containing information about the bitumen content of the ore sample, including for further processing, printing or displaying.

公开(公告)号：US09851248B2

公开(公告)日：2017-12-26

申请号：US14961872

申请日：2015-12-07

Applicant: EMX International, LLC

Inventor： Daniel Lee Graybeal ,  Alan Carey Rogers ,  Andrey Muraview ,  Charles Mark Carnifax ,  Robert E. Peale

IPC: G01J5/02 ,  G01J3/10 ,  G01J3/42 ,  G01J3/02 ,  G01N21/3504 ,  G01N21/39 ,  H01S5/34

CPC classification number: G01J3/10 ,  G01J3/0205 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0245 ,  G01J3/108 ,  G01J3/42 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/06113 ,  G01N2201/0612 ,  G01N2201/0691 ,  G01N2201/0697 ,  G01N2201/08 ,  H01S5/3401

Abstract: An intracavity laser absorption infrared spectroscopy system for detecting trace analytes in vapor samples. The system uses a spectrometer in communications with control electronics, wherein the control electronics contain an analyte database that contains absorption profiles for each analyte the system is used to detect. The system can not only detect the presence of specific analytes, but identify them as well. The spectrometer uses a hollow cavity waveguide that creates a continuous loop inside of the device, thus creating a large path length and eliminating the need to mechanically adjust the path length to achieve a high Q-factor. In a preferred embodiment, the laser source may serve as the detector, thus eliminating the need for a separate detector.

公开(公告)号：US20170303789A1

公开(公告)日：2017-10-26

申请号：US15497407

申请日：2017-04-26

Applicant: Kenneth M. Tichauer ,  Jovan G. Brankov ,  Lagnojita Sinha

Inventor： Kenneth M. Tichauer ,  Jovan G. Brankov ,  Lagnojita Sinha

IPC: A61B5/00 ,  G06F17/50 ,  G01N21/64

CPC classification number: A61B5/0073 ,  A61B5/0071 ,  A61B2562/0233 ,  A61B2576/00 ,  G01N21/6456 ,  G01N2201/06113 ,  G01N2201/0697 ,  G01N2201/12 ,  G06F17/5009

Abstract: A system and method for optical tomography including illuminating an object with pulsing stimulus light and pulsing the stimulus light at a repetition frequency having a pulse period that is greater than a dead-time of a detector. Coordinating the pulse with the dead-time of the detector allows for higher powered light source and improves early photon detection.

公开(公告)号：US20170239656A1

公开(公告)日：2017-08-24

申请号：US15588548

申请日：2017-05-05

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: B01L3/00 ,  G01N21/05 ,  G01N21/64 ,  G01N21/76 ,  G01N33/543 ,  G01N21/59

CPC classification number: B01L3/502746 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/52 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2200/143 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/027 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/12 ,  B01L2300/14 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1894 ,  B01L2400/0475 ,  B01L2400/049 ,  B01L2400/0666 ,  B01L2400/082 ,  G01N21/05 ,  G01N21/59 ,  G01N21/64 ,  G01N21/76 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/57434 ,  G01N2201/02 ,  G01N2201/0612 ,  G01N2201/062 ,  G01N2201/0621 ,  G01N2201/0697 ,  G01N2333/96433 ,  Y10T137/0324 ,  Y10T436/12

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.