公开(公告)号：US20160370262A1

公开(公告)日：2016-12-22

申请号：US15120897

申请日：2015-02-27

Applicant: David DIAZ ,  Jonathan HEIN ,  Kyle W. UHLMEYER ,  Daniel R. WIEDERIN ,  Tyler YOST ,  Kevin WIEDERIN ,  Elemental Scientific, Inc.

Inventor： David Diaz ,  Jonathan Hein ,  Kyle W. Uhlmeyer ,  Daniel R. Wiederin ,  Tyler Yost ,  Kevin Wiederin

IPC: G01N1/10 ,  G01N35/10 ,  H01J49/04 ,  G01N35/00

CPC classification number: G01N1/10 ,  G01N1/14 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/1097 ,  G01N2001/002 ,  H01J49/045

Abstract: A system includes an analysis system at a first location and one or more remote sampling systems at a second location remote from the first location. A sampling system can be configured to receive a remote liquid sample. The system also includes a sample transfer line configured to transport gas from the second location to the first location. The sample transfer line is configured to selectively couple with a remote sampling system for supplying a continuous liquid sample segment to the sample transfer line. The system can further include a sample receiving line at the first location. The sample receiving line is configured to selectively couple with the sample transfer line and the analysis system to receive the continuous liquid sample segment and supply the sample to an analysis device.

Abstract translation: 系统包括在第一位置处的分析系统和在远离第一位置的第二位置处的一个或多个远程采样系统。 采样系统可以被配置为接收远程液体样品。 该系统还包括被配置为将气体从第二位置输送到第一位置的样品传送管线。 样品传输线被配置为选择性地与远程采样系统耦合，以将连续的液体样品段供应到样品传送线。 该系统还可以包括在第一位置处的样本接收线。 样品接收管线被配置为选择性地与样品传送管线和分析系统连接以接收连续液体样品段并将样品供应到分析装置。

公开(公告)号：US20160365232A1

公开(公告)日：2016-12-15

申请号：US15121508

申请日：2015-02-26

Applicant: Micromass UK Limited

Inventor： Stevan Bajic

IPC: H01J49/04 ,  H01J49/14 ,  H01J49/00

CPC classification number: H01J49/045 ,  H01J49/0031 ,  H01J49/0445 ,  H01J49/142 ,  H01J49/16

Abstract: An ion source is provided comprising one or more nebulisers and one or more targets, wherein the one or more nebulisers are arranged and adapted to emit, in use, a stream predominantly of droplets which are caused to impact upon the one or more targets and to ionise the droplets to form a plurality of ions. The ion source further comprises one or more electrodes arranged adjacent to and/or attached to the one or more targets wherein the one or more electrodes comprise one or more apertures, notches or cut-outs wherein at least some of the plurality of ions pass, in use, through the one or more apertures, notches or cut-outs.

Abstract translation: 提供了包括一个或多个雾化器和一个或多个靶的离子源，其中所述一个或多个雾化器被布置和适于在使用中发射主要由液滴引起的流动，所述液滴被流过所述一个或多个靶，并且 电离液滴以形成多个离子。 离子源还包括一个或多个电极，其布置成邻近于和/或连接到一个或多个靶，其中一个或多个电极包括一个或多个孔，切口或切口，其中多个离子中的至少一些通过， 在使用中，通过一个或多个孔，切口或切口。

公开(公告)号：US20150364310A1

公开(公告)日：2015-12-17

申请号：US14738899

申请日：2015-06-14

Applicant: IONSENSE INC.

Inventor： BRIAN D. MUSSELMAN

IPC: H01J49/16 ,  H01J49/00

CPC classification number: H01J49/165 ,  G01N1/4022 ,  G01N2001/028 ,  G01N2030/009 ,  G01N2030/062 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/16

Abstract: The present invention is directed to a method and device to generate a chemical signature for a mixture of analytes. The present invention involves using a SPME surface to one or both absorb and adsorb the mixture of analytes. In an embodiment of the invention, the surface is then exposed to different temperature ionizing species chosen with appropriate spatial resolution to desorb a chemical signature for the mixture of analytes.

Abstract translation: 本发明涉及一种生成分析物混合物的化学特征的方法和装置。 本发明涉及使用SPME表面吸收和吸附分析物混合物中的一种或两种。 在本发明的一个实施方案中，然后将表面暴露于用适当的空间分辨率选择的不同温度的离子化物质以解吸分析物混合物的化学特征。

公开(公告)号：US09177772B1

公开(公告)日：2015-11-03

申请号：US13656978

申请日：2012-10-22

Applicant: Elemental Scientific, Inc.

Inventor： Daniel R. Wiederin ,  Austin Schultz

IPC: H01J49/04 ,  H01J49/10

CPC classification number: G05D11/02 ,  H01J49/0413 ,  H01J49/045 ,  H01J49/105

Abstract: A sample introduction system providing intermittent or discontinuous supply of liquid to a nebulizer is described. In one or more implementations, the sample introduction system includes a nebulizer configured to receive a fluid sample and a nebulizer gas and aerosolize the fluid sample with the nebulizer gas. The sample introduction system also includes a sample pump configured to supply a first aliquot of a sample to the nebulizer during a first time interval, stop supplying the first aliquot of the sample at the end of the first time interval, supply at least substantially no sample to the nebulizer during a second time interval subsequent to the first time interval, and supply a second aliquot of a sample to the nebulizer during a third time interval subsequent to the second time interval.

Abstract translation: 描述了向雾化器提供间歇或不连续供应液体的样品引入系统。 在一个或多个实施方案中，样品引入系统包括构造成接收流体样品和喷雾器气体并且用喷雾器气雾化流体样品的雾化器。 样品引入系统还包括样品泵，其构造成在第一时间间隔期间将样品的第一等分试样提供给喷雾器，停止在第一时间间隔结束时提供样品的第一等分试样，至少基本上不提供样品 在所述第一时间间隔之后的第二时间间隔期间到所述雾化器，并且在所述第二时间间隔之后的第三时间间隔期间将样品的第二等分试样提供给所述雾化器。

公开(公告)号：US20150206729A1

公开(公告)日：2015-07-23

申请号：US14597727

申请日：2015-01-15

Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  S.T. JAPAN INC.

Inventor： Kazumi INAGAKI ,  Shin-ichiro FUJII ,  Shin-ichi MIYASHITA ,  Koichi CHIBA ,  Takao NAKAGAWA ,  Masaaki ABE ,  Nobuyoshi KITAGAWA ,  Yosuke NAKAGAWA

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/045 ,  H01J49/105

Abstract: An object is to mix multiple liquids sufficiently and then nebulize the mixed liquids while maintaining the nebulizing efficiency. A nebulizer includes a first inner tube disposed inside an outer tube and having therein a first sample passage through which a first liquid sample flows, a second inner tube disposed inside the outer tube in parallel with the first inner tube and having therein a second sample passage through which a second liquid sample flows, a membranous member disposed with a gap between the membranous member and sample outlets formed at respective ends of the inner tubes. The gap forms mixing space in which a gas passing through a gas passage converts the first and second liquid samples flowing out of the sample outlets into droplets and mixes the droplets and the membranous member has multiple holes through which the mixed liquid samples pass along with the gas.

Abstract translation: 目的是充分混合多种液体，然后使混合液体雾化，同时保持喷雾效率。 喷雾器包括设置在外管内的第一内管，其中具有第一液体样品流过的第一样品通道，与第一内管平行设置在第二内管内的第二内管，其中具有第二样品通道 第二液体样品通过其流动，膜构件设置在膜构件和形成在内管的各个端部处的样品出口之间的间隙。 间隙形成混合空间，其中通过气体通道的气体将从样品出口流出的第一和第二液体样品转化成液滴并混合液滴，并且膜构件具有多个孔，混合液体样品通过该孔与 加油站。

公开(公告)号：US20150021469A1

公开(公告)日：2015-01-22

申请号：US14367647

申请日：2012-12-21

Applicant: Micromass UK Limited

Inventor： Stevan Bajic

IPC: H01J49/04 ,  H01J49/00 ,  H01J49/10

CPC classification number: G01N30/7266 ,  G01N27/44704 ,  G01N27/622 ,  H01J49/0031 ,  H01J49/045 ,  H01J49/0454 ,  H01J49/10 ,  H01J49/16 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising a separation device arranged and adapted to emit an eluent over a period of time. The separation device preferably comprises a Capillary Electrophoresis (“CE”) separation device. The mass spectrometer further comprises a nebuliser and a target. Eluent emitted by the separation device is nebulised, in use, by the nebuliser wherein a stream of analyte droplets are directed to impact upon the target so as to ionise the analyte to form a plurality of analyte ions.

Abstract translation: 公开了一种质谱仪，其包括布置并适于在一段时间内发射洗脱液的分离装置。 分离装置优选包括毛细管电泳（“CE”）分离装置。 质谱仪还包括雾化器和靶。 由分离装置发射的洗脱液在使用中由雾化器喷雾，其中分析物液滴流被引导以撞击靶，以便离子化分析物以形成多个分析物离子。

公开(公告)号：US20140216177A1

公开(公告)日：2014-08-07

申请号：US14245324

申请日：2014-04-04

Applicant: UT-BATTELLE, LLC

Inventor： Gary J. VAN BERKEL ,  Vilmos KERTESZ

IPC: G01N1/20

CPC classification number: H01J49/0431 ,  G01N35/1095 ,  G01N2001/1031 ,  H01J49/045 ,  H01J49/0463 ,  H01J49/167

Abstract: A method and system for formation and withdrawal of a sample from a surface to be analyzed utilizes a collection instrument having a port through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.

Abstract translation: 用于从待分析的表面形成和取出样品的方法和系统利用采集仪器，其具有将液体溶液通过该端口传导到要分析的表面上。 端口定位在待分析表面附近，并且液体溶液通过端口传导到表面上，使得被引导到表面上的液体溶液与包含表面的材料相互作用。 此后从表面取出一定量的材料。 可以使用压力控制来操纵表面处的溶液平衡，从而控制从表面撤出的材料量。 此外，这种压力控制可以与表面相对于收集仪器在X-Y平面内的端口的运动相配合。

公开(公告)号：US20140001280A1

公开(公告)日：2014-01-02

申请号：US13926075

申请日：2013-06-25

Applicant: Christopher Field ,  Alexander V. Terray ,  Sean J. Hart ,  Duane A. Rogers ,  Adam Lubrano ,  Michael P. Malito

Inventor： Christopher Field ,  Alexander V. Terray ,  Sean J. Hart ,  Duane A. Rogers ,  Adam Lubrano ,  Michael P. Malito

IPC: B05B12/08

CPC classification number: B05B12/087 ,  G01N21/714 ,  H01J49/045

Abstract: A method and system for generating vapors of liquid solutions where a pneumatically modulated liquid delivery system maintains a defined flow rate for a liquid solution. The pneumatically modulated liquid delivery system includes a flow meter configured to measure a flow rate for the liquid solution flowing from a pressure vessel; a microcontroller configured to determine a pressure necessary to achieve the defined flow rate; and an electronic pressure control unit configured to adjust the pressure inside the pressure vessel. The system includes a nebulizer coupled to the pneumatically modulated liquid delivery system configured to receive the liquid solution from the pneumatically modulated liquid delivery system at the defined flow rate and configured to generate an aerosol of the liquid solution. A heat tube can vaporize the aerosol generated by the nebulizer.

Abstract translation: 一种用于产生液体溶液的蒸气的方法和系统，其中气动调制的液体输送系统维持液体溶液的限定流速。 气动调制液体输送系统包括：流量计，被配置为测量从压力容器流出的液体溶液的流量; 微控制器，其被配置为确定实现所述限定流量所需的压力; 以及电子压力控制单元，被配置为调节压力容器内的压力。 该系统包括耦合到气动调制的液体输送系统的雾化器，其配置成以限定的流速从气动调制的液体输送系统接收液体溶液，并且被配置为产生液体溶液的气溶胶。 热管可以蒸发由喷雾器产生的气溶胶。

公开(公告)号：US20130341503A1

公开(公告)日：2013-12-26

申请号：US13959243

申请日：2013-08-05

Applicant: PerkinElmer Health Sciences, Inc.

Inventor： Craig M. Whitehouse ,  Victor Laiko

IPC: H01J49/14

CPC classification number: H01J49/145 ,  H01J49/045 ,  H01J49/168

Abstract: An Atmospheric Pressure Chemical Ionization (APCI) source interfaced to a mass spectrometer is configured with a corona discharge needle positioned inside an APCI inlet probe assembly. Liquid sample flowing into the APCI inlet probe is nebulized and vaporized prior to passing through the corona discharge region all contained in the APCI inlet probe assembly. The APCI probe is configured to shield the electric field from the corona discharge region while allowing penetration of an external electric field to focus APCI generated ions into an orifice into vacuum for mass to charge analysis. Ions that exit the APCI probe are directed only by external electric fields and gas flow maximizing ion transmission into a mass to charge analyzer. Sample ions and gas phase reagent ions are generated in the APCI probe from liquid or gas inlet species or mixtures of both.

Abstract translation: 与质谱仪接口的大气压化学电离（APCI）源配置有位于APCI入口探针组件内的电晕放电针。 流入APCI入口探针的液体样品在通过包含在APCI入口探针组件中的电晕放电区域之前被雾化和蒸发。 APCI探针被配置为屏蔽来自电晕放电区域的电场，同时允许穿透外部电场以将APCI产生的离子聚焦到孔中以进行质量电荷分析。 离开APCI探头的离子仅由外部电场和气流引导，将离子传输最大化成质量计量分析仪。 样品离子和气相试剂离子在APCI探针中从液体或气体入口物质或两者的混合物中产生。

公开(公告)号：US20130181126A1

公开(公告)日：2013-07-18

申请号：US13661686

申请日：2012-10-26

Applicant: DVS Sciences Inc.

Inventor： Raymond Jong

IPC: G01N35/10 ,  H01J49/04

CPC classification number: H01J49/0445 ,  G01N15/06 ,  G01N15/10 ,  G01N35/10 ,  G01N2015/0065 ,  G01N2015/1006 ,  H01J49/045 ,  H01J49/105

Abstract: In a mass cytometer or mass spectrometer, a sample of elemental tagged particles is transferred from a dispersion to a gas flow through a carrier aerosol spray for atomization and ionization by inductively coupled plasma (ICP) source. The configuration of the sample transfer apparatus allow for total consumption of the sample by passing the sample spray through a deceleration stage to decelerate the spray of particles from its high velocity expansion. Following the deceleration stage, the decelerated sample of particles can be accelerated and focused through an acceleration stage for transferring into the ICP. This effectively improves the particle transfer between the sample spray and the ICP.

Abstract translation: 在质谱仪或质谱仪中，将元素标记的颗粒的样品从分散体转移到通过载体气溶胶喷雾的气流中，以通过电感耦合等离子体（ICP）源进行雾化和电离。 样品转印装置的结构允许通过使样品喷雾通过减速阶段来使样品总消耗，以使颗粒从其高速膨胀中的喷雾减速。 在减速阶段后，减速的颗粒样品可以通过加速阶段加速和聚焦，以转移到ICP中。 这有效地改善了样品喷雾和ICP之间的颗粒转移。