公开(公告)号：US09921170B2

公开(公告)日：2018-03-20

申请号：US14898077

申请日：2014-06-12

Applicant: University of Virginia Patent Foundation

Inventor： Brooks Hart Pate ,  Amanda Steber ,  Brent Harris ,  Kevin K. Lehmann

IPC: G01J5/02 ,  G01N22/00 ,  G01J3/453 ,  G01N21/3586

CPC classification number: G01N22/00 ,  G01J3/453 ,  G01N21/3586

Abstract: Examples herein include apparatus and techniques that can be used to perform rotational spectroscopy on gas-phase samples. Such techniques can include using a spectrometer providing frequency synthesis and pulse modulation to provide excitation (e.g., pump or probe pulses) of a gas-phase sample at mm-wave frequencies. Synthesis of such mm-wave frequencies can include use of a frequency multiplier, such as an active multiplier chain (AMC). A free induction decay (FID) elicited by the excitation or other time-domain information can be obtained from the sample, such as down-converted and digitized. A frequency domain representation of the digitized information, such as a Fourier transformed representation, can be used to provide a rotational spectrum.

公开(公告)号：US09861286B1

公开(公告)日：2018-01-09

申请号：US15686198

申请日：2017-08-25

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J3/00 ,  A61B5/00 ,  G01N33/49 ,  G01N33/44 ,  G01N33/15 ,  G01N33/02 ,  G01N21/88 ,  G01N21/3563 ,  G01N21/359 ,  G01J3/453 ,  A61B5/145 ,  A61B5/1455 ,  H01S3/30 ,  G01N21/39 ,  G01M3/38 ,  G01J3/28 ,  G01J3/10 ,  G01J3/18 ,  G01J3/14

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A wearable device for use with a smart phone or tablet includes LEDs for measuring physiological parameters by modulating the LEDs and generating a near-infrared multi-wavelength optical beam. At least one LED emits at a first wavelength having a first penetration depth and at least another LED emits at a second wavelength having a second penetration depth into tissue. The device includes lenses that deliver the optical beam to the tissue, which reflects the first and second wavelengths. A receiver is configured to capture light while the LEDs are off and while at least one of the LEDs is on and to difference corresponding signals to improve a signal-to-noise ratio of the optical beam reflected from the tissue. The signal-to-noise ratio is further increased by increasing light intensity of at least one of the LEDs. The device generates an output signal representing a non-invasive measurement on blood within the tissue.

公开(公告)号：US09857225B2

公开(公告)日：2018-01-02

申请号：US14663882

申请日：2015-03-20

Applicant: IMACC, LLC

Inventor： William F. Pearman ,  Scott A. Evans ,  Daniel J. Pearson

IPC: G01J3/45 ,  G01B9/02 ,  G01J3/453 ,  G01N21/3504 ,  H04B1/403

CPC classification number: G01J3/453 ,  G01J2003/4534 ,  G01N21/3504 ,  G01N2201/06113 ,  H04B1/406

Abstract: A system. The system includes a first beam path configured to transmit a first light beam having a first optical wavelength and a second beam path configured to transmit a second light beam having a second optical wavelength distinct from the first optical wavelength. A first beam splitter disposed at an intersection of the first beam path and the second beam path. The first beam splitter is configured to superimpose the first and second light beams to form a third light beam, the third light beam impinging on a first window of a sample cell. The sample cell defines an interior volume and is configured to transfer the third light beam from the first window to a second window along a light path within the interior volume. The light path comprises a plurality of segments. The third light beam undergoes at least one reflection at an end of each segment, wherein the light path passes through a gas sample disposed within the interior volume.

公开(公告)号：US09709440B2

公开(公告)日：2017-07-18

申请号：US14325502

申请日：2014-07-08

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Dirk Robert Englund ,  Edward H. Chen ,  Fan Meng ,  Tim Schroder ,  Noel Heng Loon Wang ,  Ren-Jye Shiue

IPC: G01J3/02 ,  G01J3/453 ,  G02B6/42 ,  G02B6/293

CPC classification number: G01J3/0205 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/453 ,  G02B6/29344 ,  G02B6/4287

Abstract: Multimode interference can be used to achieve ultra-high resolving powers (e.g., Q>105) with linewidths down to 10 pm at 1500 nm and a broad spectroscopy range (e.g., 400-2400 nm) within a monolithic, millimeter-scale device. For instance, multimode interference (MMI) in a tapered waveguide enables fine resolution and broadband spectroscopy in a compact, monolithic device. The operating range is limited by the transparency of the waveguide material and the sensitivity of the camera; thus, the technique can be easily extended into the ultraviolet and mid- and deep-infrared spectrum. Experiments show that a tapered fiber multimode interference spectrometer can operate across a range from 500 nm to 1600 nm (B=1.0576) without moving parts. The technique is suitable for on-chip tapered multimode waveguides, which could be fabricated in high volume by printing or optical lithography, for applications from biochemical sensing to the life and physical sciences.

公开(公告)号：US09683891B2

公开(公告)日：2017-06-20

申请号：US12935772

申请日：2009-03-17

Applicant: Yassine Hadjar ,  Sylvain Blaize ,  Aurelien Bruyant ,  Gilles Lerondel ,  Pascal Royer

Inventor： Yassine Hadjar ,  Sylvain Blaize ,  Aurelien Bruyant ,  Gilles Lerondel ,  Pascal Royer

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/453 ,  G01J3/45

CPC classification number: G01J3/0205 ,  G01J3/02 ,  G01J3/021 ,  G01J3/2803 ,  G01J3/45 ,  G01J3/453

Abstract: A spectrometer for sampling interferograms in two dimensions offering a large spectral band and high spectral resolution with a relative compactness. The spectrometer includes a refracting surface, an array of detecting elements and an array of diffusion elements capturing means at the refracting surface of an interferogram delivered from two interference beams (F1, F2) and forming interference lines parallel to each other along the transverse axis (Ox) of the interferogram within the plane (xOy) of the refracting surface, the array of detection elements being parallel to the plane of the refracting surface and arranged to detect the spatial distribution of the interferogram, wherein the array is a two-dimensional array over an entirety of which the detections elements are disposed equidistantly, and wherein interference lines exhibit an angular shift with the capturing means.

公开(公告)号：US09671287B2

公开(公告)日：2017-06-06

申请号：US14762179

申请日：2014-01-24

Applicant: LAMBDA-X

Inventor： Didier Beghuin

IPC: G01J3/02 ,  G01J3/28 ,  G01J3/45 ,  G01J3/453

CPC classification number: G01J3/2823 ,  G01J3/0208 ,  G01J3/0224 ,  G01J3/45 ,  G01J3/4537

Abstract: Described herein is a hyperspectral imaging system in which a polarizing beam splitter, a Wollaston prism, an optical system, and a plane mirror are arranged on an optical axis of the imaging system. An imaging detector is provided on which radiation is focused by an imaging lens. The Wollaston prism is imaged on itself by the optical system and the plane mirror so that translation of the Wollaston prism in a direction parallel to a virtual split plane of the prism effectively provides an optical path length difference that is the same for all points in the object field.

公开(公告)号：US09651533B2

公开(公告)日：2017-05-16

申请号：US14875709

申请日：2015-10-06

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J5/20 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.

公开(公告)号：US09588099B2

公开(公告)日：2017-03-07

申请号：US13760193

申请日：2013-02-06

Applicant: Cambridge Research & Instrumentation, Inc.

Inventor： Richard Levenson ,  Paul J. Cronin

IPC: G01N21/64 ,  A61B5/00 ,  G01N33/483 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/44 ,  G01J3/453 ,  G01N21/25

CPC classification number: G01N33/4833 ,  A61B5/0059 ,  B82Y5/00 ,  B82Y10/00 ,  G01J3/32 ,  G01J3/4406 ,  G01J3/453 ,  G01N21/255 ,  G01N21/6486 ,  G01N2201/062 ,  G01N2201/125

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract translation: 提供了设备和方法，用于使用光谱成像提供高度敏感的检测来生物样本中深层组织中的结构成像。 通过获取提供具有不同光谱加权的样本的多个图像的数据和随后的光谱分析，来自目标化合物的光发射与样品中的自发荧光分离。 随着自发荧光降低或消除，获得目标化合物的改进的测量。

公开(公告)号：US09557555B2

公开(公告)日：2017-01-31

申请号：US14117396

申请日：2012-04-04

Applicant: Yoshihisa Warashina ,  Tomofumi Suzuki ,  Kohei Kasamori

Inventor： Yoshihisa Warashina ,  Tomofumi Suzuki ,  Kohei Kasamori

IPC: G02B26/00 ,  G02B26/08 ,  G01B9/02 ,  G02B5/08 ,  G01J3/453

CPC classification number: G02B26/001 ,  G01B9/02051 ,  G01B9/02056 ,  G01J3/4535 ,  G01J3/4537 ,  G02B5/08 ,  G02B26/0833

Abstract: An optical module includes a first plate-shaped member having a light transmissive optical component which is formed by applying etching to a silicon region, and a second plate-shaped member having light reflective optical components (mirrors) for reflecting light transmitting through the light transmissive optical component. The first and second plate-shaped members are bonded to one another, and an optical path for light transmitting through the light transmissive optical component is along a component forming surface of the first plate-shaped member and a principal surface of the second plate-shaped member. Thereby, realizing an optical module in which it is possible to dispose the light reflective optical component and the light transmissive optical component close to one another, and a manufacturing method for the optical module.

Abstract translation: 光学模块包括具有通过对硅区域进行蚀刻形成的透光光学部件的第一板状部件和具有反射透过透光性的光的反射光学部件（反射镜）的第二板状部件 光学元件。 第一和第二板状构件彼此接合，并且用于透过透光性光学构件的光的光路沿着第一板状构件的构件形成表面，并且第二板状构件的主表面 会员。 由此，实现了可以将光反射型光学部件和透光性光学部件配置成彼此靠近的光学模块，以及光学模块的制造方法。

公开(公告)号：US20170016770A1

公开(公告)日：2017-01-19

申请号：US15124600

申请日：2015-03-12

Applicant: National University of Singapore

Inventor： Sascha Pierre Heussler ,  Herbert Oskar Moser ,  Alok Pathak

IPC: G01J3/453 ,  G01J3/02

Abstract: An optical interference device 100 is disclosed herein. In a described embodiment, the optical interference device 100 comprises a phase shifter array 108 for receiving a collimated beam of light. The phase shifter array 108 includes an array of cells 128 for producing optical light channels from respective rays of the collimated beam of light, with at least some of the optical light channels having varying phase shifts. The optical interference device 100 further includes a focusing lens 110 having a focal distance and arranged to simultaneously produce, from the optical light channels, a focused beam of light in its focal plane and an image downstream the phase shifter array 108 for detection by an optical detector 116. The optical interference device 100 also includes an optical spatial filter 112 arranged at the focal distance of the focusing lens 110 and arranged to filter the focused beam of light to produce a spatially distributed interference light pattern in zeroth order for detection by the optical detector 116. A method for producing a spatially distributed interference light pattern is also disclosed.

Abstract translation: 本文公开了光学干涉装置100。 在所描述的实施例中，光学干涉装置100包括用于接收准直光束的移相器阵列108。 移相器阵列108包括用于从准直光束的各个光线产生光学光通道的单元阵列128，其中至少一些光学光通道具有不同的相移。 光学干涉装置100还包括聚焦透镜110，该聚焦透镜110具有焦距并被布置成从光学光通道同时产生在其焦平面上的聚焦光束和在移相器阵列108下游的图像，用于通过光学 光学干涉装置100还包括布置在聚焦透镜110的焦距处的光学空间滤光器112，并布置成滤光聚焦光束，以产生空间分布的干涉光图案，用于由光学器件检测 还公开了一种用于产生空间分布的干涉光图案的方法。