-
81.
公开(公告)号:US20210310949A1
公开(公告)日:2021-10-07
申请号:US17219108
申请日:2021-03-31
Inventor: Kamal Priya SINGH , Mehra Singh SIDHU , Biswajit PANDA
IPC: G01N21/64 , C09K11/06 , C07K14/435
Abstract: Disclosed herein is a novel phenomenon to create a nano-confined, dopant-free, electron spin-dependent fluorescence (SDF) in spider silk by fundamentally transforming its local molecular structure with femtosecond-pulses (206), having fluence below an ablation threshold. Electron-spin dependence of the fluorescent patterns created on the silk sample are confirmed by measuring the fluorescence intensity at different microwave frequencies. The fluorescent intensity exhibits microwave magnetic resonances at 2.88 GHz and 1.44 GHz at room-temperature. The SDF in laser-transformed silk can thereby enable a new-class of tough yet elastic silk-based quantum sensor and hybrid nano-mechanical ultrasensitive cantilevers on a micro-chip. X-ray diffraction (XRD), Raman-spectroscopy, direct atomistic imaging with high-resolution transmission electron microscopy (HR-TEM) and model-building studies are carried out to exhibit the change in the molecular structure and unveil creation of crown-ring like structure in nanocrystals of fluorescent silk with localized electrons possessing mid-gap states.
-
公开(公告)号:US11091434B2
公开(公告)日:2021-08-17
申请号:US16553647
申请日:2019-08-28
Inventor: Bernard Lerer , Mugesh Govindasamy , Tzuri Lifschytz
IPC: A61K31/40 , C07D207/456 , C07D405/06 , C07D517/04 , A61P25/24 , A61P35/00 , A61K31/4015 , A61K31/4025 , A61K31/402
Abstract: The present invention relates to compounds that inhibit the activity of Type III deiodinase (DIO3). The present invention further relates to methods for treating or preventing depression, depression associated with other psychiatric or general medical diseases or conditions, condition amenable to treatment with known anti-depressants and cancer, particularly by using the compounds of the invention.
-
公开(公告)号:US20210162410A1
公开(公告)日:2021-06-03
申请号:US16954140
申请日:2018-12-14
Applicant: Indian Institute of Science
Inventor: Jatin Panwar , Rahul Roy , Usama Ahmed Abbasi , Prakhar Jain , Viswanathan Kumaran
Abstract: The present disclosure provides a microfluidic device comprising a set of micro-structured electrodes. The electrodes are made of a fusible alloy such as Field's Metal and are patterned on a layer of PDMS. The molten fusible alloy is poured over the patterned PDMA layer and a suction force is applied to ensure uniformity of flow of the molten metal. A second layer comprising a flow channel orthogonal to the direction of the micro-structured electrodes is disposed under the first layer to form the microfluidic device. The device shows enhanced sensitivity to RBC detection at high frequencies that are also bio-compatible (above 2 MHz). Multiple layers of the micro-structures electrodes can be sandwiched between layers of flow channels to provide a 3D microfluidic device.
-
84.
公开(公告)号:US20200299676A1
公开(公告)日:2020-09-24
申请号:US15779800
申请日:2016-11-18
Applicant: Indian Institute of Science
Inventor: Varadarajan RAGHAVAN , Anusmita SAHOO , Shruti KHARE , Pankaj JAIN , Shahbaz AHMED , Kritika GUPTA
IPC: C12N15/10
Abstract: The present disclosure relates to a method of protein structure and amino acid residue interaction prediction based on saturation suppressor mutagenesis screening of a protein of interest. The method of the instant disclosure can be adapted for multi-protein complexes, and is useful where crystal structure of a protein of interest is not available.
-
85.
公开(公告)号:US20200072850A1
公开(公告)日:2020-03-05
申请号:US16467229
申请日:2017-12-08
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor: Raghavan Varadarajan , Tariq Ahmad Najar , Rohini Datta
Abstract: The present disclosure provides a rapid, scalable, and high-throughput method of identifying the precise regions in a receptor protein which are involved in binding of a molecule of interest. The method of the instant disclosure is useful where the crystal structure of a protein of interest is not available. Also provided are surface display libraries, and methods of making the same.
-
公开(公告)号:US10535762B2
公开(公告)日:2020-01-14
申请号:US15899102
申请日:2018-02-19
Applicant: Indian Institute of Science
Inventor: Mayank Shrivastava , Milova Paul , Harald Gossner
Abstract: SCRs are a must for ESD protection in low voltage—high speed I/O as well as ESD protection of RF pads due to least parasitic loading and smallest foot print offered by SCRs. However, conventionally designed SCRs in FinFET and Nanowire technology suffer from very high turn-on and holding voltage. This issue becomes more severe in sub-14 nm non-planar technologies and cannot be handled by conventional approaches like diode- or transient-turn-on techniques. Proposed invention discloses SCR concept for FinFET and Nanowire technology with diffused junction profiles with sub-3V trigger and holding voltage for efficient and robust ESD protection. Besides low trigger and holding voltage, the proposed device offers a 3 times better ESD robustness per unit area.
-
公开(公告)号:US20190236227A1
公开(公告)日:2019-08-01
申请号:US16319221
申请日:2017-07-18
Applicant: INDIAN INSTITUTE OF SCIENCE , ROBERT BOSCH ENGINEERING AND BUSINESS SOLUTIONS PRIVATE LIMITED
Inventor: Dipanjan GOPE , Gourav CHATTERJEE , Arkaprovo DAS , Sreenivasulu Reddy VEDICHERLA
CPC classification number: G06F17/5018 , G06F2217/16 , G06T17/20
Abstract: Techniques for electromagnetic modelling of EM structures are described. Krylov subspace of a second EM structure is augmented with Eigen vectors of a first EM structure to form an augmented space. The second EM structure is a design variant of the first EM structure and the first EM structure is already EM modelled and simulated. Thereafter, Maxwell's equations for the second EM structure are solved using the augmented space.
-
公开(公告)号:US10319662B2
公开(公告)日:2019-06-11
申请号:US15883749
申请日:2018-01-30
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor: Mayank Shrivastava , Milova Paul , Christian Russ , Harald Gossner
IPC: H01L23/367 , H01L27/088 , H01L29/423 , H01L29/74 , H01L29/861 , H01L29/06 , H01L27/02 , H01L29/735
Abstract: The present disclosure relates to a thermal management solution for ESD protection devices in advanced Fin- and/or Nanowire-based technology nodes, by employing localized nano heat sinks, which enable heat transport from local hot spots to surface of chip, which allows significant reduction in peak temperature for a given ESD current. In an aspect, the proposed semiconductor device can include at least one fin having a source and a drain disposed over a p-well or a n-well in a substrate; an electrically floating dummy metal gate disposed close to drain or hot spot over at least a portion of the at least one fin, and an electrical metal gate is disposed close to the source; and a nano-heat sink operatively coupled with the dummy metal gate and terminating at the surface of chip in which the semiconductor device is configured so as to enable transfer of heat received from the at least one fin through the dummy metal gate to the surface of the chip.
-
公开(公告)号:US20190067440A1
公开(公告)日:2019-02-28
申请号:US16114650
申请日:2018-08-28
Applicant: INDIAN INSTITUTE OF SCIENCE
Inventor: Mayank Shrivastava , Sayak Dutta Gupta , Ankit Soni , Srinivasan Raghavan , Navakanta Bhat
IPC: H01L29/49 , H01L29/778 , H01L21/02
Abstract: The present disclosure provides an improved enhancement mode field effect transistor (FET) having an oxide (AlxTi1-xO) emulating p-type gate. The present disclosure provides a novel enhancement mode High Electron Mobility Transistor (HEMT) structure with AlxTi1-xO Gate Oxide Engineering as Replacement of p-GaN Gate. In an aspect, the present disclosure provides a hybrid gate stack that combines p-GaN technology with the proposed oxide for e-mode operation. The HEMT structure with AlxTi1-xO Gate oxide provides a threshold voltage tuning from negative to positive by changing p-doping composition. Using a developed p-type oxide, e-mode device shows ON current ˜400 mA/mm, sub-threshold slope of 73 mV/dec, Ron=8.9 Ωmm, interface trap density
-
公开(公告)号:US20180354066A1
公开(公告)日:2018-12-13
申请号:US16103751
申请日:2018-08-14
Inventor: Kamal Priya SINGH , Mehra Singh Sidhu , Bhupesh Kumar
IPC: B23K26/00 , B29C65/00 , B29C65/16 , G01Q40/00 , G01Q70/16 , B23K26/046 , B23K26/0622 , B23K26/06 , B23K26/03 , B23K26/22 , A61L27/22
CPC classification number: B23K26/0006 , A61L27/227 , B23K26/032 , B23K26/046 , B23K26/0624 , B23K26/0626 , B23K26/22 , B29C65/1616 , B29C66/0224 , B29C66/0324 , B29C66/69 , B29C66/712 , B29C66/729 , B29K2033/12 , B29K2083/00 , B29K2089/00 , B29L2011/0041 , B29L2031/40 , B81C1/00126 , B81C2201/038 , G01Q40/00 , G01Q70/16
Abstract: The present invention relates to nanoprocessing and heterostructuring of silk. It has been shown that few-cycle femtosecond pulses are ideal for controlled nanoprocessing and heterostructuring of silk in air. Two qualitatively different responses, ablation and bulging, were observed for high and low laser fluence, respectively. Using this approach, new classes of silk-based functional topological microstructures and heterostructures which can be optically propelled in air as well as on fluids remotely with good control have been fabricated.
-
-
-
-
-
-
-
-
-