公开(公告)号：US08917390B2

公开(公告)日：2014-12-23

申请号：US13531128

申请日：2012-06-22

Applicant: Bradford B. Behr ,  Jeffrey T. Meade

Inventor： Bradford B. Behr ,  Jeffrey T. Meade

IPC: G01J3/28 ,  G01J3/02 ,  G02B27/09

CPC classification number: G01J3/28 ,  G01J3/0205 ,  G01J3/021 ,  G02B27/0911

Abstract: A spectrograph including light beam reformatting element(s), beam expander(s), dispersive element(s) and light receiving element(s). The light beam reformatting element(s) reformat a received light beam into a reformatted light beam having a first dimension along a first axis that is larger than a dimension of the received light beam along the first axis and a second dimension along a second axis substantially orthogonal to the first axis that is smaller than a dimension of the received light beam along the second axis. The beam expander(s) anamorphically expand the reformatted light beam along the second axis into an expanded light beam. The dispersive element(s) disperse the expanded light beam along the second axis, resulting in a dispersed light beam. The light receiving element(s) receive the dispersed light beam. The light receiving element(s) may include one or more detectors to measure spectral intensity of the dispersed light beam.

Abstract translation: 包括光束重新格式化元件，光束扩展器，分散元件和光接收元件的光谱仪。 光束重新格式化元件将接收的光束重新格式化成具有沿着第一轴的第一尺寸的重新格式化的光束，该第一尺寸大于沿着第一轴线的接收光束的尺寸，并且基本上沿第二轴线的第二尺寸 与第一轴正交，其小于沿着第二轴的接收光束的尺寸。 光束扩展器将重新格式化的光束沿第二轴变形扩展成扩展的光束。 分散元件沿着第二轴分散扩展的光束，导致分散的光束。 光接收元件接收分散的光束。 光接收元件可以包括一个或多个检测器，以测量分散的光束的光谱强度。

公开(公告)号：US08913241B2

公开(公告)日：2014-12-16

申请号：US13555428

申请日：2012-07-23

Applicant: Vikram Bhatia ,  Carl Edgar Crossland ,  Paul G Dewa ,  Michael Lucien Genier

Inventor： Vikram Bhatia ,  Carl Edgar Crossland ,  Paul G Dewa ,  Michael Lucien Genier

IPC: G01J3/28

CPC classification number: G01J3/021 ,  G01J3/0294 ,  G01J3/04 ,  G01J3/08 ,  G01J3/2823 ,  G01J3/36

Abstract: A hyperspectral imaging system and method are described herein for providing a hyperspectral image of an area of a remote object (e.g., scene of interest). The hyperspectral imaging system includes at least one optic, a scannable slit mechanism, a spectrometer, a two-dimensional image sensor, and a controller. The scannable slit mechanism can be a micro-electromechanical system spatial light modulator (MEMS SLM), a diffractive Micro-Opto-Electro-Mechanical Systems (MOEMS) spatial light modulator (SLM), a digital light processing (DLP) system, a liquid crystal display, a rotating drum with at least one slit formed therein, or a rotating disk with at least one slit formed therein.

Abstract translation: 本文描述了一种用于提供远程对象（例如，感兴趣的场景）的区域的高光谱图像的高光谱成像系统和方法。 高光谱成像系统包括至少一个光学元件，可扫描狭缝机构，光谱仪，二维图像传感器和控制器。 可扫描狭缝机构可以是微机电系统空间光调制器（MEMS SLM），衍射微光电机械系统（MOEMS）空间光调制器（SLM），数字光处理（DLP）系统，液体 晶体显示器，其中形成有至少一个狭缝的旋转滚筒或其中形成有至少一个狭缝的旋转盘。

公开(公告)号：US08885162B2

公开(公告)日：2014-11-11

申请号：US13669634

申请日：2012-11-06

Applicant: Olympus Corporation

Inventor： Masaharu Tomioka

IPC: G01J3/28 ,  G01J3/18 ,  G02B21/00 ,  G01J3/06 ,  G01J3/02 ,  G01J3/44

CPC classification number: G02B21/0076 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/06 ,  G01J3/1838 ,  G01J3/4406 ,  G02B21/0064

Abstract: Provided is a detection optical system that is provided with a dispersed-light detection function and that can increase the amount of detected light by enhancing the diffraction efficiency. A detection optical system is employed which includes a transmissive VPH diffraction grating that disperses fluorescence from a specimen into a plurality of wavelength bands; a rotating mechanism that rotates the VPH diffraction grating about an axial line that is perpendicular to an incident optical axis of the fluorescence from the specimen and an emission optical axis from the VPH diffraction grating; a light detection portion that detects the fluorescence from the specimen that has been dispersed by the VPH diffraction grating; and a correcting portion that corrects an incident position on the light detection portion in accordance with a displacement of the optical axis caused by the rotation of the VPH diffraction grating in synchronization with the rotating mechanism.

Abstract translation: 提供了一种具有分散光检测功能并且可以通过提高衍射效率来增加检测光量的检测光学系统。 使用检测光学系统，其包括将来自样本的荧光分散到多个波长带中的透射VPH衍射光栅; 围绕垂直于来自样本的荧光的入射光轴的轴线和来自VPH衍射光栅的发射光轴旋转VPH衍射光栅的旋转机构; 光检测部，其检测由所述VPH衍射光栅分散的所述样本的荧光; 以及校正部，其根据与旋转机构同步的VPH衍射光栅的旋转引起的光轴的位移校正光检测部上的入射位置。

公开(公告)号：US08885160B2

公开(公告)日：2014-11-11

申请号：US12866078

申请日：2009-02-25

Applicant: Dominik Rabus ,  Michael Winkler ,  Christian Oberndorfer

Inventor： Dominik Rabus ,  Michael Winkler ,  Christian Oberndorfer

IPC: G01J3/00 ,  G01J3/28 ,  G01J3/02 ,  G01N21/25 ,  G01J3/04 ,  G01N21/53

CPC classification number: G01N21/255 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0291 ,  G01J3/04 ,  G01N21/532 ,  G01N2201/0628

Abstract: The compact microspectrometer for fluid media has, in a fixed spatial coordination in a housing, a light source, a fluid channel, a reflective diffraction grating, and a detector. The optical measuring path starting from the light source passes through the fluid channel and impinges on the diffraction grating. The spectral light components reflected by the diffraction grating impinge on the detector.

Abstract translation: 用于流体介质的紧凑型微光谱仪在外壳中具有固定的空间配合，光源，流体通道，反射衍射光栅和检测器。 从光源开始的光学测量路径通过流体通道并撞击在衍射光栅上。 由衍射光栅反射的光谱光分量撞击检测器。

公开(公告)号：US20140303463A1

公开(公告)日：2014-10-09

申请号：US14250125

申请日：2014-04-10

Applicant: M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

Inventor： M. Ries Robinson ,  Russell E. Abbink ,  Robert D. Johnson

IPC: A61B5/1455 ,  A61B5/145

CPC classification number: A61B5/14552 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14558 ,  A61B5/7257 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0262 ,  G01N21/21 ,  G01N21/49 ,  G01N2021/4792

Abstract: The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.

Abstract translation: 本发明提供用于精确无创确定组织性质的方法和装置。 本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。 极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。 作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

公开(公告)号：US20140268137A1

公开(公告)日：2014-09-18

申请号：US14212779

申请日：2014-03-14

Applicant: Prior Scientific Instruments, Ltd.

Inventor： Thomas FREDA ,  Dennis DOHERTY

IPC: G01J3/28

CPC classification number: G01J3/0291 ,  G01J3/0202 ,  G01J3/021 ,  G01J3/0218 ,  G01J3/0256 ,  G02B21/0096 ,  G02B21/06

Abstract: A compact spectrometer apparatus for characterizing a microscope illumination source in real time, and without interfering with the observation and/or characterization of a sample under observation with the microscope. The spectrometer apparatus is comprised of a light probe comprising a mirror disposed in a housing, the mirror positioned to reflect light from the illumination source into an optical coupling; an optical waveguide receiving reflected light into the optical coupling; and a spectrometer comprising a light sensor receiving reflected light directed by the optical waveguide from the optical coupling of the light probe, the sensor adapted to sense light over a range of wavelengths and output a signal indicative of the intensity of the light at any wavelength over the range.

Abstract translation: 用于实时表征显微照明源的紧凑型光谱仪装置，并且不会干扰用显微镜观察的样品的观察和/或表征。 光谱仪装置由光探针组成，该探针包括设置在壳体中的反射镜，该反射镜被定位成将来自照明源的光反射到光耦合器中; 将反射光接收到光耦合器中的光波导; 以及光谱仪，其包括从光探针的光耦合器接收由光波导引导的反射光的光传感器，该传感器适于感测波长范围上的光并输出指示任何波长的光的强度的信号 范围。

公开(公告)号：US20140268127A1

公开(公告)日：2014-09-18

申请号：US13826102

申请日：2013-03-14

Applicant: SCIAPS, INC.

Inventor： David Day

IPC: G01N21/25 ,  G02B26/08

CPC classification number: G01J3/0229 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0291 ,  G01J3/14 ,  G01J3/16 ,  G02B26/0833

Abstract: Featured is a spectral analysis method and a wide spectral range spectrometer including a source of electromagnetic radiation and an optical subsystem configured to disperse radiation into a plurality of wavelengths. A pixilated light modulator receives the radiation wavelengths and is configured to direct one or more selective wavelengths to a sample.

Abstract translation: 特征是光谱分析方法和包括电磁辐射源的宽光谱范围光谱仪和被配置为将辐射分散成多个波长的光学子系统。 像素化光调制器接收辐射波长并且被配置为将一个或多个选择波长指向样品。

公开(公告)号：US08830475B1

公开(公告)日：2014-09-09

申请号：US13969634

申请日：2013-08-19

Applicant: National Cheng Kung University

Inventor： Wei-Chih Wang ,  Benjamin Estroff ,  Chih-Han Chang ,  Fong-Chin Su

IPC: G01J3/45 ,  G01B9/02

CPC classification number: G01J3/45 ,  G01J3/021 ,  G01J3/4531 ,  G01J3/4532

Abstract: Disclosed is an interferometer comprising a light source, a reflective element, and a photodetector. The light source is configured to emit a light beam, and an angle is formed by inclusion between a direction to which the light beam travels and the reflective element, the photodetector is configured to be substantially perpendicular to the reflective element. The light beam is halved into a first light beam propagating by the included angle, and a second light beam reflected off the reflective element, the first light beam and the second light beam interfere each other to form an interferogram on the photodetector, which detects the interferogram. By benefit of above, the interferometer does not need to reposition its parts in order to make adjustment to interferogram, thereby simplifying optical element setup and minimizing physical volume of the interferomger. Also disclosed is a spectrometer including the same interferometer and a Fourier-transform-capable analyzer.

Abstract translation: 公开了一种包括光源，反射元件和光电检测器的干涉仪。 光源被配置为发射光束，并且通过在光束行进的方向与反射元件之间包含形成角度，光电检测器被配置为基本上垂直于反射元件。 光束被分成一个以夹角传播的第一光束，并且从反射元件反射的第二光束，第一光束和第二光束彼此相互干涉以在光电检测器上形成干涉图，该光检测器检测 干涉图。 受益于上述，干涉仪不需要重新定位其部件以便调整干涉图，从而简化了光学元件的设置并使干涉仪的体积最小化。 还公开了包括相同干涉仪和具有傅里叶变换的分析仪的光谱仪。

公开(公告)号：US08824042B2

公开(公告)日：2014-09-02

申请号：US13564461

申请日：2012-08-01

Applicant: James M. Tedesco ,  Joseph B. Slater

Inventor： James M. Tedesco ,  Joseph B. Slater

IPC: H01S3/30 ,  G02B5/10

CPC classification number: G01N21/65 ,  G01J3/021 ,  G01J3/44 ,  H01S3/08 ,  H01S3/08095 ,  H01S3/305 ,  H01S3/307

Abstract: Raman signal amplification apparatus comprises an ellipsoidal reflector providing a first real focus f1, and second real or virtual focus f2, both foci being situated within a sample volume. When an input laser excitation beam having an initial numerical aperture (NA) is focused onto one of the foci, the beam is reflected by the reflector and refocused onto alternating foci, such that the NA of the reflected optical path progressively increases for higher efficiency collection of Raman emissions from the multiple foci. The ellipsoidal reflector may be a half section providing a single real focus f1, with a flat reflector producing a mirror image of the ellipsoidal reflector, such that f2 is a virtual focus occupying the same point as f1. Alternatively, the ellipsoidal reflector may have a first half section with a first real focus f1 and a second half section with a second real focus f2.

Abstract translation: 拉曼信号放大装置包括提供第一实际焦点f1的椭球反射器和第二实际或虚拟焦点f2，两个焦点位于样本体积内。 当具有初始数值孔径（NA）的输入激光激发光束聚焦到焦点之一时，光束被反射器反射并重新聚焦到交替的焦点上，使得反射光路的NA逐渐增加以获得更高的效率 的多焦点的拉曼散射。 椭圆反射器可以是提供单个实际焦点f1的半部分，平面反射器产生椭圆反射体的镜像，使得f2是与f1相同的点。 或者，椭球反射器可以具有带有第一实际焦点f1的第一半部分和具有第二实心f2的第二半部分。

公开(公告)号：US20140204373A1

公开(公告)日：2014-07-24

申请号：US14221418

申请日：2014-03-21

Applicant: Hologic, Inc.

Inventor： Victor Mazzio

IPC: G01J3/02 ,  G01J3/44

CPC classification number: G01J3/0218 ,  G01J3/02 ,  G01J3/0202 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0256 ,  G01J3/027 ,  G01J3/0291 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/65 ,  G01N21/95 ,  G02B21/24

Abstract: A Raman microspectrometer system extends the optical reach and analysis range of an existing Raman microspectrometer to allow analysis and/or repair of an oversized sample. The Raman microspectrometer system includes an extender for extending the optical reach of the existing microspectrometer and a supplemental stage which extends the analysis range of the existing microspectrometer by providing travel capabilities for non-destructive analysis of an entire oversized sample. Such an arrangement decreases manufacturing costs associated with testing oversized samples such as mammography panels, enabling analysis and/or repair to be performed without destruction.

Abstract translation: 拉曼显微光谱仪系统扩展了现有拉曼显微光谱仪的光学范围和分析范围，以便对超大样品进行分析和/或修复。 拉曼显微光谱仪系统包括扩展器，用于扩展现有微光谱仪的光学范围，以及补充级，通过提供用于整个超大样本的非破坏性分析的行进能力来扩展现有微光谱仪的分析范围。 这样的布置降低了与测试超大样本（例如乳房X线照相面板）相关联的制造成本，使得能够进行分解和/或修复而不破坏。