公开(公告)号：US11982624B2

公开(公告)日：2024-05-14

申请号：US17079609

申请日：2020-10-26

Applicant: BATTELLE SAVANNAH RIVER ALLIANCE, LLC

Inventor： Amanda L. Houk ,  Matthew S. Wellons ,  Ross J. Smith ,  Joshua T. Hewitt

IPC: G01N21/65 ,  D01F9/12 ,  G01J3/28 ,  G01J3/44

CPC classification number: G01N21/65 ,  D01F9/12 ,  G01J3/4412 ,  G01J2003/283 ,  G01J2003/2869 ,  G01J2003/2873

Abstract: Carbon fiber characterization processes are described that include multi-condition Raman spectroscopy-based examination combined with multivariate data analyses. Methods are a nondestructive material characterization approach that can provide predictions as to carbon fiber bulk physical properties, as well as identification of unknown carbon fiber materials for quality control purposes. The framework of the multivariate analysis methods includes a principal component-based identification protocol including comparison of Raman spectral data from an unknown carbon fiber with a data library of multiple principal component spaces.

公开(公告)号：US20240130677A1

公开(公告)日：2024-04-25

申请号：US18365932

申请日：2023-08-03

Applicant: ROCKLEY PHOTONICS LIMITED

Inventor： Aaron John ZILKIE ,  Hooman ABEDIASL ,  Cristiano DALVI ,  Jeffrey DRISCOLL ,  Alexander GONDARENKO ,  Richard GROTE ,  Haydn Frederick JONES ,  Sean MERRITT ,  Roozbeh PARSA ,  Philip PEREA ,  Andrew George RICKMAN ,  Adam SCOFIELD ,  Guomin YU

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/024 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/44 ,  G02B6/12

CPC classification number: A61B5/6801 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/02427 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/683 ,  G01J3/4412 ,  G02B6/12004 ,  G02B6/12007 ,  A61B2562/0238 ,  G02B2006/12061 ,  G02B2006/12121 ,  G02B2006/12142

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

公开(公告)号：US11879780B2

公开(公告)日：2024-01-23

申请号：US17598211

申请日：2019-11-21

Applicant: WEIPENG (SUZHOU) MEDICAL DEVICES CO., LTD.

Inventor： Yan Xia ,  Bin Yang ,  Rui Li

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/10 ,  G01N21/65 ,  G02B21/00 ,  G02B21/18

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/10 ,  G01N21/65 ,  G02B21/006 ,  G02B21/008 ,  G02B21/0048 ,  G02B21/18 ,  G01N2021/653

Abstract: A coherent anti-Stokes Raman scattering microscope imaging apparatus, comprising: a laser light source (21), a two-dimensional oscillating mirror assembly (22), a first light dichroic mirror plate (23), an objective lens (24), a sample translation platform (25), a collection device (26), and a data processing module; the laser light source (21) is used for producing a first laser beam and a second laser beam; the first laser beam and the second laser beam are coaxially emitted and are incident on the two-dimensional oscillating mirror assembly (22); the first laser beam and the second laser beam leaving the two-dimensional oscillating mirror assembly pass through the first light dichroic mirror plate (23) and the objective lens (24); the objective lens (24) focuses the first laser beam and the second laser beam onto the sample translation platform; the signal light produced on the sample translation platform (25) passes through the objective lens (24).

公开(公告)号：US20240019375A1

公开(公告)日：2024-01-18

申请号：US18245161

申请日：2021-09-14

Applicant: NOVA LTD.

Inventor： Eyal Hollander ,  Gilad BARAK ,  Elad Schleifer ,  Yonatan OREN ,  Amir Shayari

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC classification number: G01N21/65 ,  G01J3/0205 ,  G01J3/027 ,  G01J3/4412 ,  G01N2201/0636 ,  G01N2201/06113

Abstract: A method, a system, and a non-transitory computer readable medium for Raman spectroscopy. The method may include determining first acquisition parameters of a Raman spectroscope to provide a first acquisition set-up, the determining is based on at least one expected radiation pattern to be detected by a sensor of the Raman spectroscope as a result of an illumination of a first area of a sample, the first area comprises a first nano-scale structure, wherein at least a part of the at least one expected radiation pattern is indicative of at least one property of interest of the first nano-scale structure of the sample; wherein the first acquisition parameters belong to a group of acquisition parameters; setting the Raman spectroscope according to the first acquisition set-up; and acquiring at least one first Raman spectrum of the first nano-scale structure of the sample, while being set according to the first acquisition set-up.

公开(公告)号：US11846545B2

公开(公告)日：2023-12-19

申请号：US17288035

申请日：2019-10-22

Applicant: Specto S.r.L. ,  Fondazione Istituto Italiano di Tecnologia

Inventor： Giuseppe Antonacci

IPC: G01J3/44 ,  G01J3/02 ,  G01N21/63

CPC classification number: G01J3/4412 ,  G01J3/0218 ,  G01N2021/638

Abstract: Spectrometer for analyzing the spectrum of a Brillouin scattered light including input means receiving the scattered light, and selecting means for selecting and separating specific multiple frequency components of the scattered light. The selecting means has at least one main input, and at least an optical detector is coupled to the selecting means for measuring the intensity of the different frequency components and reconstructing the spectrum profile of the scattered light. The selecting means include an optical integrated circuit having at least one optical ring resonator of a first type having an input waveguide for receiving the light from the input means, a closed loop waveguide having an effective refractive index neff, and an output waveguide. The selecting means further have at least a modulator element of the effective refractive index neff coupled to the closed loop waveguide of the optical ring resonator of the first type.

公开(公告)号：US20230358611A1

公开(公告)日：2023-11-09

申请号：US17939334

申请日：2022-09-07

Applicant: AGENCY FOR DEFENSE DEVELOPMENT

Inventor： Jae Hwan LEE ,  Young Soo CHUNG ,  Hyung Bin SON ,  Se Kyu SHIM ,  Jung Taek HONG

IPC: G01J3/18 ,  G01J3/44 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01J3/4412 ,  G01J3/0208 ,  G01J3/18 ,  G01N21/65

Abstract: A spectroscopy system that includes a light source portion configured to generate light having a plurality of wavelengths, a light transmitter configured to transmit the light to a target analyte, a light receiving portion configured to receive Raman-scattered light scattered from the target analyte, and a multi-wavelength spectroscopy portion that may acquire a spectrum by splitting the Raman-scattered light transmitted from the light receiving portion. The multi-wavelength spectroscopy portion includes a single diffraction grating configured to diffract the Raman-scattered light and a single concave mirror configured to focus the Raman-scattered light.

公开(公告)号：US20230296439A1

公开(公告)日：2023-09-21

申请号：US18123488

申请日：2023-03-20

Applicant: The United States of America, as represented by the Secretary of the Navy

Inventor： Kin Chiu Ng ,  Subrata Sanyal

IPC: G01J3/44 ,  G06V40/13 ,  G01J3/02

CPC classification number: G01J3/4412 ,  G06V40/1318 ,  G01J3/0286 ,  G01J3/0272 ,  G01J3/0229 ,  G01J3/0202 ,  G01J3/0227 ,  G01J3/0275

Abstract: Provided is a portable biosensor that includes a sample filter cartridge, a filter collector, an optical sphere, an electromagnetic radiation emitter, a photo-detector, a processor, a signal display, a vacuum pump, and a power supply. The sample filter cartridge selectively removes small molecules to minimize spectral interference in the detection signal. The sample is concentrated onto the filter collector and subjected to illumination by the electromagnetic radiation emitter, producing Raman-scattering. The optical sphere collects and distributes the Raman-scattering shifts, which then pass through a spectral filter to produce spectral filtered scattering, which is then reflected by the concave holographic flat-field grating onto the photo-detector. The data is displayed graphically to provide the Raman-scattering shift data. The data is compared with a database for sample identification. The device is contained within a housing that is small enough to be easily transported for field use.

公开(公告)号：US11740128B2

公开(公告)日：2023-08-29

申请号：US16927804

申请日：2020-07-13

Applicant: Sanguis Corporation

Inventor： Jeffrey Owen Katz

IPC: G01J3/02 ,  G01J3/44 ,  G01N21/65 ,  G01J3/06 ,  G01N33/49

CPC classification number: G01J3/4412 ,  G01J3/021 ,  G01J3/0202 ,  G01J3/0218 ,  G01J3/0275 ,  G01J3/06 ,  G01N21/65 ,  G01N33/492 ,  G01J2003/062 ,  G01J2003/064

Abstract: A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

公开(公告)号：US11719642B2

公开(公告)日：2023-08-08

申请号：US17527844

申请日：2021-11-16

Applicant: OndaVia, Inc.

Inventor： Mark C. Peterman ,  Merwan Benhabib ,  Samuel Kleinman

IPC: G01N21/65 ,  G01J3/02 ,  G01J3/18 ,  G01J3/44 ,  G01N21/47 ,  G01N21/63 ,  G01N21/66 ,  G01N21/68 ,  G01N27/44 ,  G01N30/60 ,  B01D15/08 ,  B01D43/00 ,  B01D57/02 ,  B01L3/00 ,  G01N27/447 ,  G01N21/49 ,  C02F1/28 ,  B01D35/30 ,  G01N33/18 ,  G01N30/00 ,  G01J3/28

CPC classification number: G01N21/65 ,  B01D15/08 ,  B01D35/30 ,  B01D43/00 ,  B01D57/02 ,  B01L3/502761 ,  C02F1/28 ,  G01J3/02 ,  G01J3/0256 ,  G01J3/0291 ,  G01J3/18 ,  G01J3/44 ,  G01J3/4412 ,  G01N21/47 ,  G01N21/4785 ,  G01N21/49 ,  G01N21/63 ,  G01N21/658 ,  G01N21/66 ,  G01N21/68 ,  G01N27/44704 ,  G01N27/44791 ,  G01N30/6095 ,  G01N33/18 ,  B01L2200/04 ,  B01L2200/0652 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/087 ,  B01L2300/0867 ,  B01L2400/0418 ,  B01L2400/0421 ,  G01J2003/2866 ,  G01J2003/2879 ,  G01N30/6065 ,  G01N2021/651 ,  G01N2021/656 ,  G01N2030/0095 ,  G01N2201/0221 ,  G01N2201/13

Abstract: A hand-held microfluidic testing device is provided that includes a housing having a cartridge receiving port, a cartridge for input to the cartridge receiving port having a sample input and a channel, where the channel includes a mixture of Raman-scattering nanoparticles and a calibration solution, where the calibration solution includes chemical compounds capable of interacting with a sample under test input to the cartridge and the Raman-scattering nanoparticles, and an optical detection system in the housing, where the optical detection system is capable of providing an illuminated electric field, where the illuminating electric field is capable of being used for Raman spectroscopy with the Raman-scattering nanoparticles and the calibration solution to analyze the sample under test input to the cartridge.

公开(公告)号：US20230194339A1

公开(公告)日：2023-06-22

申请号：US17994387

申请日：2022-11-28

Applicant: Shimadzu Corporation

Inventor： Naoya FUJIWARA ,  Yuka MORITANI

IPC: G01J3/02 ,  G01J3/10 ,  G01J3/44 ,  G01J3/28

CPC classification number: G01J3/0237 ,  G01J3/108 ,  G01J3/4412 ,  G01J3/2823 ,  G01J2003/106

Abstract: In a Raman microscope, a depth measurement processor performs depth measurement by changing a focal position of laser light along a depth direction of a sample which is an irradiation direction of the laser light with respect to the sample, and meanwhile, acquiring a Raman spectrum of the sample at a plurality of points in the depth direction. A display processor displays an input screen used to input a parameter at a time of performing the depth measurement on the sample in association with a surface image of the sample on a stage. The parameter includes a range in which the focal position of the laser light is changed along the depth direction and an interval between the plurality of points within the range.