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公开(公告)号：US11197842B2
公开(公告)日：2021-12-14
申请号：US15527531
申请日：2015-11-19
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a bead and comprise (i) an inert core; (ii) a first layer surrounding the inert core, wherein the first layer comprises dimethyl fumarate; and (iii) an enteric coating surrounding the first layer. Also provided are pharmaceutical compositions in the form of a bead comprising a core and an enteric coating surrounding the core, wherein the core comprises dimethyl fumarate. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US20210369629A1
公开(公告)日：2021-12-02
申请号：US17319694
申请日：2021-05-13
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi , Ivan Nestorov
IPC: A61K9/50 , A61K31/225 , A61K9/48
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US20200062705A1
公开(公告)日：2020-02-27
申请号：US16610817
申请日：2018-05-18
Applicant: Biogen MA Inc.
Inventor： Nishanth Gopinathan , Erwin Irdam , William Kiesman , Daw-long A. Kwok , Yiqing Lin , Frederick Osei-Yeboah , Matthew Peterson , Kenny Tran , Kalyan Vasudevan
IPC: C07D207/16
Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
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公开(公告)号：US20190175510A1
公开(公告)日：2019-06-13
申请号：US16275739
申请日：2019-02-14
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Yiqing Lin
IPC: A61K9/20 , A61K9/28 , A61K31/225 , A61K9/48 , A61K45/06
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a tablet and comprise one or more extended release polymer matrix. Also provided are pharmaceutical compositions in the form of a capsule comprising one or more tablets of the present invention. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US20190083404A1
公开(公告)日：2019-03-21
申请号：US15527539
申请日：2015-11-19
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Yiqing Lin
IPC: A61K9/20 , A61K31/225 , A61K45/06 , A61K9/28 , A61K9/48
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a tablet and comprise one or more extended release polymer matrix. Also provided are pharmaceutical compositions in the form of a capsule comprising one or more tablets of the present invention. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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Patent Agency Ranking
公开(公告)号：US11820760B2
公开(公告)日：2023-11-21
申请号：US17283301
申请日：2019-10-15
Applicant: BIOGEN MA INC.
Inventor： Fengmei Zheng , Anton Peterson , Kalyan Vasudevan , Chaomin Li , Daniel B. Patience , Yiqing Lin
IPC: C07D405/14
CPC classification number: C07D405/14 , C07B2200/13
Abstract: Provided are crystalline forms of (R)-1-(tert-butyl)-N-(8-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-2-(oxetan-3-yl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-5-yl)-1H-1,2,3-triazole-4-carboxamide, pharmaceutical compositions, methods of use and methods of making thereof.
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公开(公告)号：US20220098150A1
公开(公告)日：2022-03-31
申请号：US17322382
申请日：2021-05-17
Applicant: Biogen MA Inc.
Inventor： Nishanth Gopinathan , Erwin Irdam , William Kiesman , Daw-long A. Kwok , Yiqing Lin , Frederick Osei-Yeboah , Matthew Peterson , Kenny Tran , Kalyan Vasudevan
IPC: C07D207/16
Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[2-fluorophenyl)methyl]oxy}phenyl-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.
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公开(公告)号：US20190046456A1
公开(公告)日：2019-02-14
申请号：US16076849
申请日：2017-02-08
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi , Ivan Nestorov
IPC: A61K9/50 , A61K31/225 , A61K9/48
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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9.发明公开公开(公告)号：US20230286972A1
公开(公告)日：2023-09-14
申请号：US18019270
申请日：2021-08-03
Applicant: BIOGEN MA INC.
Inventor： Asmerom Weldeab , Tae Kim Correia , Aireal Diane Jenkins , Yiqing Lin , Chaomin Li
IPC: C07D417/14
CPC classification number: C07D417/14 , C07B2200/13
Abstract: Described herein are solid forms of N-(4-fluoro-5-(((2S,4R)-4-46-methoxypyrimidin-4-yl)oxy)-2-methylpyrrolidin-1-yl)methyl)thiazol-2-yl)acetamide, compound (I): (I) and the process of making said solid forms of compound (I). The present invention further relates to a pharmaceutical composition comprising crystalline Form A and Form B of compound (I), and methods of using said form and pharmaceutical composition in the treatment and prevention of Alzheimer's disease and related neurological disorders.
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公开(公告)号：US11291642B2
公开(公告)日：2022-04-05
申请号：US15737011
申请日：2016-06-15
Applicant: BIOGEN MA INC.
Inventor： Pierre Boulas , Erwin Irdam , Shyam B. Karki , William F. Kiesman , Cheuk-Yui Leung , Yiqing Lin , Andrea Trementozzi , Peter Zawaneh
IPC: A61K31/225 , A61K9/00 , A61K9/50 , A61K9/14 , A61K9/48 , A61K9/16 , A61K47/10 , A61K47/14 , A61K47/42 , A61P25/00
Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).
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