公开(公告)号：US09787815B2

公开(公告)日：2017-10-10

申请号：US14804386

申请日：2015-07-21

Applicant: Cornell University

Inventor： David Erickson ,  Seoho Lee ,  Dakota O'Dell ,  Saurabh Mehta ,  Vlad-Victor Oncescu ,  Matthew Mancuso

IPC: H04M1/725 ,  G01N33/487 ,  G01N21/77 ,  G01N21/78 ,  G01N21/80 ,  G01N21/84 ,  H04N5/225

CPC classification number: H04M1/72527 ,  G01N21/78 ,  G01N21/80 ,  G01N21/8483 ,  G01N33/48785 ,  G01N2021/7759 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/127 ,  H04N5/2251

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

公开(公告)号：US20160080548A1

公开(公告)日：2016-03-17

申请号：US14804386

申请日：2015-07-21

Applicant: Cornell University

Inventor： David Erickson ,  Seoho Lee ,  Dakota O'Dell ,  Saurabh Mehta ,  Vlad-Victor Oncescu ,  Matthew Mancuso

IPC: H04M1/725 ,  H04N5/225 ,  G01N21/80 ,  G01N33/487 ,  G01N21/78 ,  G06K9/46 ,  G06T7/40

CPC classification number: H04M1/72527 ,  G01N21/78 ,  G01N21/80 ,  G01N21/8483 ,  G01N33/48785 ,  G01N2021/7759 ,  G01N2201/0221 ,  G01N2201/062 ,  G01N2201/127 ,  H04N5/2251

Abstract: A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications.

Abstract translation: 使用智能手机获得测试条上的分析物的收集点的选定定量标记的方法涉及对由于智能手机的测试条照明而在其上发生目标样品的比色反应的测试条进行成像。 智能手机包括智能手机应用程序和智能手机附件，可提供独立于所使用智能手机平台的外部环境独立/内部无光环境的成像环境。 然后可以将结果定量呈现或变成更为消费者友好的测量（正，负，高于平均水平等），显示给用户，存储供以后使用，并传达到从业者可以提供额外审查的位置。 此外，社交媒体整合可以允许将设备结果广播给特定的受众，将健康生活与他人进行比较，以竞争健康的游戏，创建映射和其他应用程序。

公开(公告)号：US11668711B2

公开(公告)日：2023-06-06

申请号：US16763707

申请日：2018-11-13

Applicant: CORNELL UNIVERSITY

Inventor： Saurabh Mehta ,  David Erickson ,  Zhengda Lu

IPC: G01N33/543 ,  G01N21/64 ,  G01N33/58 ,  G01N33/68 ,  G01N33/82 ,  G01N33/84

CPC classification number: G01N33/54388 ,  G01N21/6428 ,  G01N33/54386 ,  G01N33/582 ,  G01N33/6803 ,  G01N33/82 ,  G01N33/84 ,  G01N2021/6441 ,  G01N2333/4737 ,  G01N2333/705 ,  G01N2458/00 ,  G01N2470/04 ,  G01N2470/10

Abstract: A diagnostic assay strip includes a first layer that includes an iron mobile labelled specific binding partner that will bind to and iron biomarker from a sample and produce an iron complex and a vitamin A mobile labelled specific binding partner that will bind to a vitamin A biomarker from the sample and produce a vitamin A complex. A second layer includes iron and vitamin A test regions, and a control region. The iron test region has immobilized specific binding partners that will bind to the iron complex. The vitamin A test region has immobilized vitamin A biomarker that will bind to vitamin A mobile labelled specific binding partner, which is not bound to the vitamin A biomarker, passing from the first layer to the second layer. The control region has a moiety which will non-specifically bind to and immobilize the iron and vitamin A labelled specific binding partners. Methods of using the diagnostic assay strip are also discussed.

公开(公告)号：US20180196041A1

公开(公告)日：2018-07-12

申请号：US15875686

申请日：2018-01-19

Applicant: CORNELL UNIVERSITY

Inventor： Saurabh Mehta ,  David Erickson ,  Seoho Lee

IPC: G01N33/543 ,  B01L3/00 ,  C12Q1/18

CPC classification number: G01N33/54366 ,  B01L3/5023 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/0887 ,  C12Q1/18 ,  G01N33/558 ,  G01N2333/4737 ,  G01N2333/5753 ,  G01N2800/26

Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.

公开(公告)号：US10345295B2

公开(公告)日：2019-07-09

申请号：US15875686

申请日：2018-01-19

Applicant: CORNELL UNIVERSITY

Inventor： Saurabh Mehta ,  David Erickson ,  Seoho Lee

IPC: G01N33/543 ,  G01N33/558 ,  B01L3/00 ,  C12Q1/18

Abstract: A device for detecting the presence of a target in a sample including a first port configured to receive a multi-layered substrate having a sample inlet and a reagent inlet. The sample inlet is connected to a first microfluidic channel and the reagent inlet is connected to both the first microfluidic channel and a second microfluidic channel. The second microfluidic channel has a longer pathway than the first microfluidic channel. A first test strip and a second test strip are each connected to both the first microfluidic channel and the second microfluidic channel, while a third test strip is connected only to the first microfluidic channel. Each test strip includes a conjugate section, a detection section, and a collection section.