公开(公告)号：US20240355611A1

公开(公告)日：2024-10-24

申请号：US18685534

申请日：2022-08-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： David M. COX ,  Mircea GUNA ,  Yang KANG ,  Mircea MANOLESCU ,  Andrei SONOC

IPC: H01J49/42

CPC classification number: H01J49/421

Abstract: An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to generate an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto, and at least two pairs of auxiliary electrodes interspersed between the plurality of multipole rods, where one pair forms a first pole of the auxiliary electrodes and the other pair forms a second pole of the auxiliary electrodes. A controller can provide one or more control signals to the DC voltage source so as to switch the polarity of the DC voltage differential between the two poles according to a predefined criterion.

公开(公告)号：US20250125136A1

公开(公告)日：2025-04-17

申请号：US18696002

申请日：2022-09-26

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea GUNA ,  Yves LE BLANC

IPC: H01J49/00 ,  H01J49/42

Abstract: In one aspect, a method for fragmenting ions in a mass spectrometer is disclosed, which includes introducing a plurality of precursor ions into a collision cell of a mass spectrometer, generating a potential barrier in the collision cell to cause at least a portion of ions in the collision cell to be trapped within a region in proximity of said potential barrier, and applying ultraviolet (UV) radiation to said trapped ions so as to cause fragmentation of at least a portion of any of said precursor ions and fragment ions thereof to generate a plurality of product ions such that a space charge generated in said region in proximity of said potential barrier due to accumulation of ions will impart sufficient kinetic energy to at least a portion of the product ions so as to overcome said potential barrier, thereby exiting said region.

公开(公告)号：US20250069877A1

公开(公告)日：2025-02-27

申请号：US18718871

申请日：2022-12-13

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea GUNA ,  William LOYD

IPC: H01J49/06

Abstract: A method of performing mass spectrometry is disclosed. which comprises introducing a plurality of ions into an ion guide of a mass spectrometer via an inlet orifice thereof. where the ion guide includes a plurality of rods arranged in a multipole configuration and spaced from one another to provide a passageway for transit of the ions therethrough. applying RF voltages to the rods so as to generate an electromagnetic field within the passageway for providing radial confinement of the ions passing through the passageway, identifying a space charge effect, which can adversely affect operation of the mass spectrometer, based on detection of a variation of an intensity of an ion detection signal associated with at least one ion population transmitted through said ion guide and having an m/z ratio greater than a threshold, and in response to said identification of the adverse space charge effect. adjusting at least one of frequency and amplitude of the RF voltages to counteract said space charge effect.

公开(公告)号：US20240355612A1

公开(公告)日：2024-10-24

申请号：US18685356

申请日：2022-08-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： David M. COX ,  Manuel FAUR ,  Mircea GUNA ,  Yang KANG ,  Andrei SONOC

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4215 ,  H01J49/004

Abstract: In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to provide an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto. At least two pairs of auxiliary electrodes are interspersed between the plurality of rods and are configured for application of a DC bias voltage with one polarity to one of said pairs and a DC bias voltage with an opposite polarity to the other one of said pairs to provide a DC potential difference between the auxiliary electrodes and the plurality of rods.

公开(公告)号：US20240128069A1

公开(公告)日：2024-04-18

申请号：US18276609

申请日：2022-02-08

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Mircea GUNA ,  Andrei SONOC

IPC: H01J49/00 ,  H01J49/06

CPC classification number: H01J49/005 ,  H01J49/0031 ,  H01J49/062

Abstract: In one aspect, a method of performing mass spectrometry is disclosed, which comprises introducing a plurality of ions into a mass spectrometer, selecting a portion of the precursor ions having m/z ratios within a first desired range to provide a plurality of precursor ions, causing fragmentation of at least a portion of the precursor ions to generate a plurality of product ions, selecting a portion of the product ions having m/z ratios within a second desired range, and performing mass analysis of the selected productions.