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    4.
    发明专利
    未知

    公开(公告)号：BR0215370A

    公开(公告)日：2004-12-07

    申请号：BR0215370

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Sistema y procedimiento de diagnóstico por imagen microscópica multifotónica fibrada de una muestra
    5.
    发明专利
    Sistema y procedimiento de diagnóstico por imagen microscópica multifotónica fibrada de una muestra 未知

    公开(公告)号：ES2396426T3

    公开(公告)日：2013-02-21

    申请号：ES05812037

    申请日：2005-10-21

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： VIELLEROBE BERTRAND ,  LACOMBE FRANCOIS ,  LOISEAU ALEXANDRE ,  LOURADOUR FREDERIC ,  LELEK MICHAEL ,  BARTHELEMY ALAIN

    IPC: G02B21/00 ,  G02B21/16

    Abstract: Sistema de diagnóstico por imagen multifotónica fibrada de una muestra (10), este sistema consta de: - un láser (2) pulsado para generar un haz láser de excitación multifotónica, - una guía de imagen (8) constituida por una pluralidad de fibras ópticas, que permiten iluminar la muestra(10) por un barrido punto por punto, y - medios de barrido (5) para dirigir por turno el haz láser de excitación en una fibra de la guía de imagen (8),Sistema caracterizado porque consta además de: - medios de compensación (4) para compensar efectos de dispersión de velocidad de grupo y efectos nolineales de los impulsos de excitación en la guía de imagen (8), estos medios están dispuestos entre elláser pulsado (2) y la guía de imagen (8) la dispersión lineal y los efectos no lineales en la guía de imagen(8) modifican el perfil temporal y espectral del impulso de excitación que vuelve a ser sensiblementeidéntico al perfil (18) del impulso saliente del láser, de modo que los medios de compensación que constan de un trozo de fibra óptica seguido por una línea dispersiva, eltrozo de fibra óptica está constituido por una única fibra óptica monomodo, el diámetro del modo de estafibra monomodo es superior al diámetro del modo de los núcleos de la guía de imagen, este trozo de fibraestá dispuesto para hacer aparecer efectos no lineales de ensanchamiento espectral, la línea dispersivaestá dispuesta para introducir un índice de dispersión de velocidad anormal de grupo, retrasando losfotones más rojos del espectro láser de modo que el impulso (19) saliente de la línea dispersiva sea máslargo que el del (18) saliente del láser.

    6.
    发明专利
    未知

    公开(公告)号：FR2871358B1

    公开(公告)日：2007-02-09

    申请号：FR0406396

    申请日：2004-06-14

    Applicant: MAUNA KEA TECHNOLOGIES SOC PAR

    Inventor： VIELLEROBE BERTRAND ,  JEAN FLORENCE ,  BOURG HECKLY GENEVIEVE ,  LOISEAU ALEXANDRE

    IPC: A61B5/00 ,  G01N21/64 ,  G02B21/00 ,  G02B23/26

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    8.
    发明专利
    未知

    公开(公告)号：AT320614T

    公开(公告)日：2006-04-15

    申请号：AT02801158

    申请日：2002-12-20

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  G02B23/24 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

    Multimarking fiber fluorescence microscopic imagery system and method
    9.
    发明专利
    Multimarking fiber fluorescence microscopic imagery system and method 未知

    公开(公告)号：AU2005256758A1

    公开(公告)日：2006-01-05

    申请号：AU2005256758

    申请日：2005-06-09

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BOURG-HECKLY GENEVIEVE ,  VIELLEROBE BERTRAND ,  JEAN FLORENCE ,  LOISEAU ALEXANDRE

    IPC: G01N21/64 ,  A61B5/00 ,  G02B21/00 ,  G02B23/26

    Abstract: The invention relates to a method for producing a fluorescent fiber image of a sample, wherein a sample is scanned with the aid of an excitation signal; the fluorescent signal emanating from the sample is detected, wherein the excitation signal and fluorescent signal use the same optical path; the optical path is used to excite at least two fluorophores contained in the sample; a final image is produced, including areas that are colored according to the at least two fluorophores. The multimarking according to the invention makes it possible to simultaneously acquire two images in two different wavelength bands. The system according to the invention can comprise a spectrometer for spectral quantification of the fluorescent signal.

    10.
    发明专利
    未知

    公开(公告)号：FR2834348A1

    公开(公告)日：2003-07-04

    申请号：FR0116979

    申请日：2001-12-28

    Applicant: MAUNA KEA TECHNOLOGIES

    Inventor： BERIER FREDERIC ,  BOURRIAUX STEPHANE ,  GENET MAGALIE ,  VIELLEROBE BERTRAND ,  LOISEAU ALEXANDRE ,  ABRAT BENJAMIN

    IPC: G02B23/26 ,  A61B1/00 ,  G02B21/02 ,  A61B1/07

    Abstract: An optical head for equipping the distal end of a flexible optical fiber bundle, designed to be urged into contact with an analyzing surface and including optical elements for focusing an excitation signal into a so-called excitation focal point located at a specific depth beneath the analyzing surface and for sampling a signal backscattered by the excitation focal point which is carried back by the fiber bundle. The head includes an optics-holder tube wherein are inserted on one side the distal end portion of the fiber bundle and on the other optical elements, the latter including a plate placed in contact with the end of the fiber bundle whereof the index is close to that of the fiber core and a focusing optical block, an output window being further provided adapted to provide index adaptation so as to eliminate parasitic reflection occurring on the analyzing surface.

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