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公开(公告)号：CA3112257A1
公开(公告)日：2020-03-19
申请号：CA3112257
申请日：2019-09-10
Applicant: FLUIDIGM CANADA INC
Inventor： SANDKUIJL DAAF , LOBODA ALEXANDER , CAREW ADAM , ASKARPOUR KHASHAYAR
Abstract: The invention relates to systems and methods for autofocusing in imaging mass spectrometry. The present invention provides improvements over current IMS and IMG apparatus and methods through an autofocus component including plurality of apertures in the autofocus system, such as a plurality of apertures arranged in 2 dimensions. As a plurality of apertures is used the autofocus system provides redundancy in the event that measurement of focus on the sample from the illuminating radiation passed through one or more of the apertures fails so reducing the number of unsuccessful autofocus attempts.
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公开(公告)号：HK1214650A1
公开(公告)日：2016-07-29
申请号：HK16102364
申请日：2016-03-01
Applicant: FLUIDIGM CANADA INC
Inventor： SCOTT TANNER
IPC: C12M20060101 , G01N20060101 , C40B20060101 , H01J20060101
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公开(公告)号：CA2888308A1
公开(公告)日：2014-05-01
申请号：CA2888308
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
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公开(公告)号：WO2021108584A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062268
申请日：2020-11-25
Applicant: FLUIDIGM CANADA INC.
Inventor： SANDKUIJL, Daaf , LOBODA, Alexander , YEH, Vincent Yi-Ching , GHEIRATMAND, Ladan
Abstract: Methods and systems for automated slide handling for imaging applications are described herein. In certain aspects, an automated slide handler may be operatively coupled to a slide hotel and/or one or more imaging systems described herein. The automated slide handler may be a robotic arm with up to 6 degrees of freedom. Automated slide handling may include sample preparation, such as sectioning and staining. Suitable imaging systems include a fluorescence microscope or an imaging mass cytometer. Methods and systems disclosed herein enable high throughput profiling of tissue sections.
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公开(公告)号：WO2020198614A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025296
申请日：2020-03-27
Applicant: FLUIDIGM CANADA INC. , FLUIDIGM CORPORATION
Inventor： LI, Stephen K.H. , MAJONIS, Daniel , BARANOV, Vladimir , ORNATSKY, Olga , ALLO, Bedilu , BANDURA, Dmitry , THOM, Colin , STELZER, Greg , LOBODA, Alexander
Abstract: A lyophilized antibody panel is disclosed for interrogation using elemental analysis. The antibody panel includes multiple antibodies each element-tagged or element-labelled with one or more isotopes such that each different antibody is isotopically distinguishable from the other antibodies. Each element tag can include one or more unique isotopes or unique combinations of isotopes. The set of element-tagged antibodies can be lyophilized in admixture. Thus, the lyophilized element-tagged antibody panel can be easily and efficiently resuspended and mixed with a sample prior to interrogation with an elemental analyzer, such as a mass spectrometer. This lyophilized element-tagged antibody panel can provide the benefits of an element-tagged assay while also being easy to use and remaining stable for long durations.
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Patent Agency Ranking
公开(公告)号：WO2016090356A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/064226
申请日：2015-12-07
Applicant: FLUIDIGM CANADA INC.
Inventor： LOBODA, Alexander V.
IPC: H01J49/00 , G01N33/60 , G01N33/68 , H01J49/40 , G01N33/574
CPC classification number: H01J49/105 , H01J49/0004 , H01J49/0463
Abstract: The inventor has improved LA-ICP-MS to facilitate its use for imaging of biological samples. Additionally, mass cytometry systems having imaging capability less than 1 micron and high sensitivity are disclosed.
Abstract translation: 发明人已经改进了LA-ICP-MS，以便于其用于生物样品的成像。 此外，公开了具有小于1微米和高灵敏度的成像能力的质量细胞计量系统。
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公开(公告)号：WO2014169394A1
公开(公告)日：2014-10-23
申请号：PCT/CA2014/050387
申请日：2014-04-17
Applicant: FLUIDIGM CANADA INC.
Inventor： LOBODA, Alexandre
CPC classification number: G01N15/10 , G01N2015/0065 , G01N2015/1006 , H01J49/0463 , H01J49/105 , H01J49/40
Abstract: The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). The invention provides methods and devices in which individual ablation plumes are distinctively captured and transferred to the ICP, followed by analysis by mass cytometry.
Abstract translation: 本发明涉及使用激光烧蚀电感耦合等离子体质谱（LA-ICP-MS）分析样品的方法和装置。 本发明提供方法和装置，其中个体消融羽流被明显地捕获并转移到ICP，随后通过质谱法分析。
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公开(公告)号：WO2014063247A1
公开(公告)日：2014-05-01
申请号：PCT/CA2013/050798
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC.
Inventor： BARANOV, Vladimir
CPC classification number: G01N15/10 , C12M1/343 , G01N1/04 , G01N33/4833 , G01N33/569 , G01N2001/045 , G01N2015/1006 , G01N2015/1093
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
Abstract translation: 相互排斥的基于细胞的分析技术的组合可以应用于同一组细胞用于分析。 可以通过用针对质粒细胞分析的候选细胞产生的每种技术来制备相同组的细胞用于分析。 该配置允许每个技术之间的信息的相关性，以产生具有相同组的单元的蜂窝信息的多维矩阵。
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公开(公告)号：CA2888308C
公开(公告)日：2021-01-19
申请号：CA2888308
申请日：2013-10-22
Applicant: FLUIDIGM CANADA INC
Inventor： BARANOV VLADIMIR
Abstract: A combination of mutually exclusive cell-based analytical techniques can be applied to the same group of cells for analysis. The same group of cells can be prepared for analysis by each technique resulting with candidate cells targeted for mass cytometry analysis. This configuration allows for the correlation of the information between each technique to produce a matrix of multi dimension of cellular information with the same group of cells.
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公开(公告)号：CA3081543A1
公开(公告)日：2019-05-09
申请号：CA3081543
申请日：2018-06-08
Applicant: FLUIDIGM CANADA INC
Inventor： CHANG QING , ALLO BEDILU , LOU XUDONG , BOUZEKRI ALEXANDER , ORNATSKY OLGA
Abstract: The present disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.
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