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    피리딜이미다졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 신경 염증 질환의 예방 및 치료용 조성물
    94.
    发明公开
    피리딜이미다졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 신경 염증 질환의 예방 및 치료용 조성물 有权
    用于预防和治疗含有作为活性成分的吡啶并咪唑衍生物的神经酰胺性疾病的药物组合物

    公开(公告)号：KR1020100130390A

    公开(公告)日：2010-12-13

    申请号：KR1020090049056

    申请日：2009-06-03

    Applicant: 한국화학연구원

    Inventor： 이규양 ,  김낙정 ,  서지희 ,  임채조 ,  석경호 ,  옥지연

    IPC: C07D403/10 ,  C07D403/08 ,  C07D487/04 ,  C07D257/06

    Abstract: PURPOSE: A composition containing pyridylimidazole derivatives for preventing and treating nerve inflammation is provided to use as a therapeutic agent for Alzheimer disease, Parkinson's disease, Huntington disease, amyotrophic lateral sclerosis, creutzfeldt-Jakob disease, multiple sclerosis. CONSTITUTION: A pharmaceutical composition for preventing and treating nerve inflammation contains pyridylimidazole derivative of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The pyridylimidazole derivative of chemical formula 1 suppresses TNF-alpha, IL-beta, and iNOS gene expression.

    Abstract translation: 目的：提供含有用于预防和治疗神经炎症的吡啶基咪唑衍生物的组合物，用作阿尔茨海默病，帕金森病，亨廷顿疾病，肌萎缩性侧索硬化症，克罗伊茨菲尔特 - 雅各布病，多发性硬化症的治疗剂。 构成：用于预防和治疗神经炎症的药物组合物含有化学式1的吡啶基咪唑衍生物或其药学上可接受的盐作为活性成分。 化学式1的吡啶基咪唑衍生物抑制TNF-α，IL-β和iNOS基因表达。

    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물
    95.
    发明公开
    페닐테트라졸 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 포함하는 골다공증 또는 비만의 예방 또는 치료용 약학적 조성물 失效
    用于预防或治疗包含苯并噻唑衍生物的药物或药物的药物组合物或其作为活性成分的药物可接受的盐

    公开(公告)号：KR1020100130139A

    公开(公告)日：2010-12-10

    申请号：KR1020090121291

    申请日：2009-12-08

    Applicant: 한국화학연구원

    Inventor： 김낙정 ,  배명애 ,  유성은 ,  강남숙 ,  허정녕 ,  이규양 ,  서지희 ,  장성연 ,  황은숙 ,  홍정호

    IPC: C07D487/04 ,  A61K31/437 ,  A61P19/08 ,  A61P3/04

    Abstract: PURPOSE: A pharmaceutical composition containing phenyltetrazole derivatives for preventing or treating osteoporosis, obesity, diabetes or hyperlipidemia is provided to control TAZ(transcriptional coactivator with PDZbinding motif) protein. CONSTITUTION: A pharmaceutical composition for preventing or treating osteoporosis contains a compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A pharmaceutical composition for preventing or treating obesity, diabetes or hyperlipidemia contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The compound is phenyltetrazole derivatives.

    Abstract translation: 目的：提供含有苯基四唑衍生物用于预防或治疗骨质疏松症，肥胖症，糖尿病或高脂血症的药物组合物以控制TAZ（具有PDZ结合基序的转录共激活物）蛋白质。 构成：用于预防或治疗骨质疏松症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 用于预防或治疗肥胖症，糖尿病或高脂血症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。 该化合物是苯基四唑衍生物。

    항진균 활성을 갖는 플루오로페닐 벤조옥사졸 유도체, 이의제조방법 및 이의 용도
    96.
    发明公开
    항진균 활성을 갖는 플루오로페닐 벤조옥사졸 유도체, 이의제조방법 및 이의 용도 有权
    氟代苯并噻唑衍生物抑制肽合成具有抗真菌活性，其制备方法和包含其的用途

    公开(公告)号：KR1020100093946A

    公开(公告)日：2010-08-26

    申请号：KR1020090013114

    申请日：2009-02-17

    Applicant: 순천대학교 산학협력단 ,  한국화학연구원

    Inventor： 최상기 ,  이규양 ,  백형록 ,  오재현 ,  정상철 ,  김낙정 ,  채종학 ,  김선우

    IPC: C07D261/20 ,  C07D263/54

    Abstract: PURPOSE: A fluorophenyl benzoxazole derivative with antifungal activity is provided to selectively suppress protein synthesis of pathogenic fungus and to use as an antifungal agent. CONSTITUTION: A fluorophenyl benzoxazole derivative or pharmaceutically acceptable salt thereof is denoted by chemical formula 1. The fluorophenyl benzoxazole derivatie is 3-[2-(4-fluorophenyl)-6-methyl-benzoxazole-5-yl]-3-oxo-propyonic acid methylester; 1-(2-(4-fluorophenyl)-6-methylbenzo[d]oxazole-5-yl)hexane-1,5-dion; 3-(2-(4-fluorophenyl)-6-methylbenzo[d]oxazole-5-yl)-3-oxopropionic acid ethyl ester; or 3-(6-ethyl-2-(4-fluorophenyl)benzo[d]oxazole-5-yl)-3-oxopropionic acid methyl ester. The compound of chemical formula 1 is prepared by reacting the compound of chemical formula 3 with a compound of chemical formula 2.

    Abstract translation: 目的：提供具有抗真菌活性的氟苯基苯并恶唑衍生物，以选择性抑制病原真菌的蛋白质合成并用作抗真菌剂。 构成：氟苯并苯并恶唑衍生物或其药学上可接受的盐由化学式1表示。氟苯基苯并恶唑衍生物是3- [2-（4-氟苯基）-6-甲基 - 苯并恶唑-5-基] -3-氧代 - 丙基 酸甲酯; 1-（2-（4-氟苯基）-6-甲基苯并[d]恶唑-5-基）己烷-1,5-二酮; 3-（2-（4-氟苯基）-6-甲基苯并[d]恶唑-5-基）-3-氧代丙酸乙酯; 或3-（6-乙基-2-（4-氟苯基）苯并[d]恶唑-5-基）-3-氧代丙酸甲酯。 化学式1的化合物通过使化学式3的化合物与化学式2的化合物反应来制备。

    아마이드로 치환된 벤조퓨란 및 벤조싸이오펜 유도체, 이의제조 방법 및 이를 포함하는 약학적 조성물
    99.
    发明公开
    아마이드로 치환된 벤조퓨란 및 벤조싸이오펜 유도체, 이의제조 방법 및 이를 포함하는 약학적 조성물 失效
    酰胺取代的苯并呋喃衍生物及其制备方法以及含有它们的药物组合物

    公开(公告)号：KR1020090037744A

    公开(公告)日：2009-04-16

    申请号：KR1020070103244

    申请日：2007-10-12

    Applicant: 한국화학연구원

    Inventor： 서지희 ,  유성은 ,  이규양 ,  김낙정 ,  김은희 ,  정용삼 ,  이윤숙 ,  서해영

    IPC: C07D307/85 ,  C07D405/12 ,  C07D491/048 ,  C07D413/04

    CPC classification number: C07D307/85 ,  C07D333/70 ,  C07D401/12 ,  C07D409/12 ,  C07D413/04 ,  C07D491/048 ,  C07D495/04

    Abstract: Benzofuran and bezothiophene derivatives substituted with amide, a preparation process thereof, and a pharmaceutical composition containing the same are provided to prevent and treat ischemic diseases such as cerebral ischemia mediated by ischemic cell death. Benzofuran and bezothiophene derivatives substituted with amide are represented by the chemical formula 1. The benzofuran and bezothiophene derivatives substituted with amide of the chemical formula 1 is obtained by reacting a compound of the chemical formula 2 and a compound of the chemical formula 3. The benzofuran and bezothiophene derivatives substituted with amide or their pharmaceutically acceptable salts is contained as an active ingredient of a pharmaceutical composition for preventing and treating ischemic diseases.

    Abstract translation: 提供了被酰胺取代的苯并呋喃和噻唑并噻吩衍生物及其制备方法和含有它们的药物组合物，以预防和治疗缺血性疾病如缺血性细胞死亡介导的脑缺血。 由酰胺取代的苯并呋喃和噻唑并噻吩衍生物由化学式1表示。化学式1的被酰胺取代的苯并呋喃和异噻吩衍生物是通过使化学式2的化合物与化学式3的化合物反应得到的。苯并呋喃 作为预防和治疗缺血性疾病的药物组合物的活性成分，含有被酰胺取代的噻唑并噻吩衍生物或其药学上可接受的盐。

    아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물
    100.
    发明公开
    아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 失效
    具有芳基哌啶取代基的咪唑衍生物，其制备方法和含有它们的药物组合物

    公开(公告)号：KR1020080100022A

    公开(公告)日：2008-11-14

    申请号：KR1020070046064

    申请日：2007-05-11

    Applicant: 한국화학연구원

    Inventor： 김낙정 ,  유성은 ,  이규양 ,  서지희 ,  이병호 ,  오광석 ,  천혜경 ,  이상달 ,  정원훈

    IPC: C07D401/06 ,  C07D471/04 ,  A61K31/454

    Abstract: An imidazol derivative having an aryl piperidine substituent is provided to prevent and cure diseases relating to MCH by acting on an antagonist to a melanin-concentrating hormone receptor. An imidazole derivative or a salt pharmaceutically allowable is indicated as a chemical formula 1. In the chemical formula 1: R1 is a group 1 or a group 2; X is H, halogen, OR4, C1~C4 of straight-chain or side chain alkyl, CF3, phenyl, CN, NO2, -CO2R5 or -CONR6R7; R4, R5, R6 and R7 are independently H, halogen, C1~C3 of straight-chain or side chain alkyl or phenyl; R2 is H, halogen, C1~C3 of straight-chain or side chain alkyl, phenyl, OR4, NO2, CN, pyridyl or -CONR6R7; R3 is C1~C3 of straight-chain or side chain alkyl and phenyl substituted into halogen or methyl; A is CH or N; and n is an integer of 2 - 5.

    Abstract translation: 提供具有芳基哌啶取代基的咪唑衍生物，以通过作用于黑色素浓缩激素受体的拮抗剂来预防和治愈与MCH相关的疾病。 咪唑衍生物或药学上允许的盐表示为化学式1.在化学式1中：R1是1或2组; X是直链或侧链烷基，CF 3，苯基，CN，NO 2，-CO 2 R 5或-CONR 6 R 7的H，卤素，OR 4，C 1 -C 4; R4，R5，R6和R7独立地为H，卤素，C1-C3直链或侧链烷基或苯基; R2是H，卤素，C1-C3直链或侧链烷基，苯基，OR4，NO2，CN，吡啶基或-CONR6R7; R3是直链或侧链烷基的C1〜C3，被卤素或甲基取代的苯基; A是CH或N; n为2〜5的整数。

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