公开(公告)号：BR9810852A

公开(公告)日：2000-07-25

申请号：BR9810852

申请日：1998-07-21

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  BREITENBACH J RG

IPC: A23K40/10 ,  A23K40/20 ,  A23K50/80 ,  A23K1/18

Abstract: The invention relates to slow sinking, porous granules or pellets with a density of greater than 1 g/cm for use in fish breeding. The inventive granules or pellets are obtained by solvent-free melt extrusion of mixtures consisting of biologically active substances, matrix support substances and a solid gas producer.

公开(公告)号：DE19855440A1

公开(公告)日：2000-06-08

申请号：DE19855440

申请日：1998-12-01

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  KOTHRADE STEPHAN ,  KESLER THOMAS ,  LANGE ARMIN ,  HOFMANN JUERGEN ,  REINHOLD ULRICH

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

Abstract: The invention relates to a method for producing solid forms of administration by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).

公开(公告)号：CA2352874A1

公开(公告)日：2000-06-08

申请号：CA2352874

申请日：1999-11-30

Applicant: BASF AG

Inventor： REINHOLD ULRICH ,  HOFMANN JURGEN ,  KESSLER THOMAS ,  KOTHRADE STEPHAN ,  LANGE ARMIN ,  BERNDL GUNTHER

IPC: A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  B29C47/42

Abstract: The invention relates to a method for producing solid forms of administratio n by means of melt extrusion. A polymer binder, at least one pharmaceutical active agent and optionally, other additives are mixed and the mixture is melted in an extruder and then extruded in the form of a continuous plastic product strand. The inventive method is characterised in that the extruder used is a planetary roller extruder (10) which preferably has one central spindle (13) and six planetary spindles (14).

公开(公告)号：AU8632298A

公开(公告)日：1999-02-22

申请号：AU8632298

申请日：1998-07-21

Applicant: BASF AG

Inventor： ZEIDLER JUERGEN ,  NEUMANN JOERG ,  LIEPOLD BERND ,  ROSENBERG JOERG ,  BERNDL GUNTHER ,  BREITENBACH JOERG ,  VOLLGRAF CHRISTIANE

IPC: A61K9/20 ,  A61K31/192 ,  A61K47/02 ,  A61K47/32 ,  A61P29/00 ,  A61K31/19

Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.

公开(公告)号：ZA9706363B

公开(公告)日：1999-01-19

申请号：ZA9706363

申请日：1997-07-18

Applicant: BASF AG

Inventor： BERNDL GUNTHER ,  ROSENBERG JOERG ,  SANNER AXEL

IPC: A61K9/16 ,  A61K9/20 ,  A61K36/00 ,  A61K36/16 ,  A61K36/38 ,  A61K36/48 ,  A61K36/61 ,  A61K

CPC classification number: A61K9/2095 ,  A61K9/1694 ,  A61K36/16 ,  A61K36/38 ,  A61K36/48 ,  A61K36/61 ,  A61K2300/00

公开(公告)号：CA2229621A1

公开(公告)日：1998-09-12

申请号：CA2229621

申请日：1998-03-11

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  ROSENBERG JOERG ,  BERNDL GUNTHER

IPC: A61K9/00 ,  A61K9/24 ,  A61K9/52 ,  A61K31/485 ,  A61J3/06 ,  A61K9/22

Abstract: A solid, at least two-phase formulation of at least one opioid analgesic in a matrix, where each of the two phases contains at least one opioid with an in vitro release rate by the Ph.Eur. paddle method of more than 50% by weight of active ingredient after one hour.