公开(公告)号：AU1128002A

公开(公告)日：2002-04-08

申请号：AU1128002

申请日：2001-10-01

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SU TING ,  LI WENHAO ,  GOLDMAN ERICK A ,  ZHANG PENGLIE ,  JIA ZHAOZHONG JON ,  SCARBOROUGH ROBERT M JR

IPC: C07D241/06 ,  A61K31/438 ,  A61K31/495 ,  A61K31/496 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  C07D241/08 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D491/10 ,  C07D491/113 ,  C07D221/00 ,  C07D317/00 ,  C07D401/12

公开(公告)号：NO20021230D0

公开(公告)日：2002-03-12

申请号：NO20021230

申请日：2002-03-12

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  JIA ZHAOZHONG JON ,  HUANG WENRONG ,  SONG YONGHONG ,  KANTER JAMES ,  SCARBOROUGH ROBERT M

IPC: C07D231/14 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/426 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K31/551 ,  A61P7/02 ,  A61P7/04 ,  A61P43/00 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D277/20 ,  C07D277/56 ,  C07D333/38 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07D

公开(公告)号：AU3660501A

公开(公告)日：2001-08-14

申请号：AU3660501

申请日：2001-02-01

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT

IPC: A61K31/4184 ,  A61K31/42 ,  A61P7/02 ,  C07D475/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D235/16 ,  C07D209/10

Abstract: Novel compounds of formula I: including its pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa is described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

公开(公告)号：AU1770001A

公开(公告)日：2001-06-04

申请号：AU1770001

申请日：2000-11-17

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  WANG LINGYAN ,  HUANG WENRONG ,  WU YANHONG ,  FAN JINGMEI ,  SU TING ,  SCARBOROUGH ROBERT

IPC: C07D213/75 ,  A61K31/18 ,  A61K31/198 ,  A61K31/223 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4545 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  C07C311/16 ,  C07C311/18 ,  C07C311/19 ,  C07C311/46 ,  C07D207/04 ,  C07D213/81 ,  C07D295/185 ,  C07D295/18 ,  C07D409/12

公开(公告)号：AU5283900A

公开(公告)日：2000-12-12

申请号：AU5283900

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SU TING ,  ZHAOZHONG JON JIA ,  SCARBOROUGH ROBERT M JR ,  SONG YONGHONG

IPC: A61P7/02 ,  A61K31/167 ,  A61K31/18 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C311/16 ,  C07C311/18 ,  C07C311/40 ,  C07C311/44 ,  C07C311/46 ,  C07D207/16 ,  C07D217/22 ,  C07D401/06 ,  C07C311/00

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：AU5155500A

公开(公告)日：2000-12-12

申请号：AU5155500

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SU TING ,  ZHAOZHANG JON JIA ,  SCARBOROUGH ROBERT M JR ,  SONG YONGHONG

IPC: A61P7/02 ,  A61K31/167 ,  A61K31/18 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C311/16 ,  C07C311/18 ,  C07C311/40 ,  C07C311/44 ,  C07C311/46 ,  C07D207/16 ,  C07D217/22 ,  C07D401/06

Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：CA2374646A1

公开(公告)日：2000-11-30

申请号：CA2374646

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SU TING ,  SCARBOROUGH ROBERT M ,  SONG YONGHONG ,  ZHAOZHONG JON JIA

IPC: A61P7/02 ,  A61K31/167 ,  A61K31/18 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C311/16 ,  C07C311/18 ,  C07C311/40 ,  C07C311/44 ,  C07C311/46 ,  C07D207/16 ,  C07D217/22 ,  C07D401/06

Abstract: Novel compounds, their salts and compositions related thereto having activit y against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：CA2371904A1

公开(公告)日：2000-11-30

申请号：CA2371904

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： ZHU BING-YAN ,  SCARBOROUGH ROBERT M ,  WANG LINGYAN

IPC: A61K31/155 ,  A61K31/18 ,  A61K31/275 ,  A61K31/401 ,  A61K31/402 ,  A61K31/451 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C311/46 ,  C07D207/16 ,  C07D211/60 ,  C07D241/04 ,  C07D243/08 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  A61K31/40 ,  A61P7/00 ,  C07C311/39

Abstract: Compounds, e.g. described in claim 5, formula (I) and formula (II), where A- B is (1), their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：AU3857300A

公开(公告)日：2000-08-29

申请号：AU3857300

申请日：2000-02-11

Applicant: COR THERAPEUTICS INC

Inventor： SONG YONGHONG ,  ZHU BING-YAN ,  SCARBOROUGH ROBERT M JR ,  CLIZBE LANE ,  JIA ZHAOZHONG JON ,  SU TING ,  TENG WILLY

IPC: C07D295/14 ,  A61K31/18 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/341 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/505 ,  A61K31/517 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07D213/56 ,  C07D213/58 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D217/22 ,  C07D231/12 ,  C07D233/61 ,  C07D239/42 ,  C07D239/94 ,  C07D257/04 ,  C07D295/16 ,  C07D307/54 ,  C07D401/12 ,  C07D521/00 ,  A61K31/16 ,  A61K31/33 ,  C07D231/56

公开(公告)号：NZ312840A

公开(公告)日：1999-11-29

申请号：NZ31284096

申请日：1996-06-05

Applicant: COR THERAPEUTICS INC

Inventor： MARLOWE CHARLES K ,  SCARBOROUGH ROBERT M ,  LAIBELMAN ALAN M ,  SINHA UMA ,  ZHU BING-YAN

IPC: C07D277/24 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61K38/00 ,  A61P7/02 ,  A61P9/00 ,  C07C311/64 ,  C07D263/14 ,  C07D263/56 ,  C07D277/68 ,  C07K5/06 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/08

Abstract: The present invention relates to ketoheterocyclic containing compounds of the formula 1 which are inhibitors of the isolated factor Xa which treats a condition in a mammal characterised by undesired thrombosis. Also claimed is a pharmaceutical composition caused by thrombosis, and a method for inhibiting the coagulation of biological samples.