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    페남 유도체 및 이의 제조 방법
    101.
    发明公开
    페남 유도체 및 이의 제조 방법 失效
    苯衍生物及其制备方法

    公开(公告)号：KR1019990032285A

    公开(公告)日：1999-05-15

    申请号：KR1019970053270

    申请日：1997-10-17

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  고훈영 ,  최경일 ,  하영진 ,  차주환 ,  장문호 ,  배애님 ,  김명주

    IPC: C07D499/887

    Abstract: 본 발명은 일반식( III )의 알데히드와 일반식( II )의 아민 유도체를 용매 존재하에 축합반응시켜 중간체인 일반식( IV )의 이민화합물을 제조하고 카르복시 보호기를 제거하여 일반식(I)로 표시되는 페남 유도체를 제조하는 것으로 일반식(I)은 이성체를 포함한다. 일반식(I)의 화합물은 베타락타마제 저해제로서 기존의 항생제와 일정 비율로 병용하면 항균작용을 증진시키는 유용한 화합물이다.

    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물
    106.
    发明公开
    칼슘 채널에 활성을 지닌 신규 피라조일 피페라진 화합물 有权
    吡唑基哌嗪化合物作为钙通道拮抗剂

    公开(公告)号：KR1020120125098A

    公开(公告)日：2012-11-14

    申请号：KR1020110043180

    申请日：2011-05-06

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  배애님 ,  이재균 ,  서선희 ,  송치만 ,  신선미 ,  아미드,압둘와히드

    IPC: C07D403/12 ,  A61K31/496 ,  A61P25/00

    Abstract: PURPOSE: A pyrazolyl piperazine compound with a pharmaceutical activity to a calcium channel and a pharmaceutical composition containing the same are provided to be used as a pharmaceutical composition for preventing or treating diseases of brain diseases, heart diseases, cancer, and pain. CONSTITUTION: A pyrazolyl piperazine compound is denoted by chemical formula 1. The compound of chemical formula 1 is prepared by binding piperazine compounds of chemical formula 2 and chloride compounds of chemical formula 3 under the presence of a base at 20-30 Deg. C. The base includes an organic base such as an amine-based base and an inorganic base. The reaction solvent is dichloromethane, tetrahydrofurane(THF), dimethyl formamide(DMF), dimethyl aceteamide(DMAC), and dioxane. A pharmaceutical composition for preventing brain diseases, cancer, heart diseases, or pain contains the compound of chemical formula 1.

    Abstract translation: 目的：提供对钙通道具有药学活性的吡唑基哌嗪化合物和含有该通道的药物组合物作为预防或治疗脑疾病，心脏病，癌症和疼痛疾病的药物组合物。 构成：化学式1表示吡唑基哌嗪化合物。化学式1的化合物是通过在20-30度的碱存在下将化学式2的哌嗪化合物和化学式3的氯化合物结合而制备的。 C.碱包括有机碱如胺基和无机碱。 反应溶剂为二氯甲烷，四氢呋喃（THF），二甲基甲酰胺（DMF），二甲基乙酰胺（DMAC）和二恶烷。 用于预防脑疾病，癌症，心脏病或疼痛的药物组合物含有化学式1的化合物。

    입체선택성 3,4―다이메틸렌옥세페인 화합물과 이의 제조방법
    107.
    发明公开
    입체선택성 3,4―다이메틸렌옥세페인 화합물과 이의 제조방법 有权
    选择性的3,4-二甲氧基苯酚化合物的制备及其制备方法

    公开(公告)号：KR1020120095252A

    公开(公告)日：2012-08-28

    申请号：KR1020110014803

    申请日：2011-02-18

    Applicant: 한국과학기술연구원

    Inventor： 조용서 ,  민선준 ,  이재균 ,  배애님 ,  울라프,푼나레디

    IPC: C07D313/04 ,  C07D409/04 ,  C07D407/04

    Abstract: PURPOSE: A stereoselectivity 3,4-die methylene jade force pane compound and a manufacturing method thereof are provided to be useful as intermediate which synthesizes the various multicyclic compounds. CONSTITUTION: A stereoselectivity 3,4-die methylene jade force pane compound is represented by chemical formula 1. A manufacturing method of the 3,4-die methylene jade force pane compound comprises the following step: performing Prins cyclization of solvents selected from diethyl ether and tetrahydrofuran under existence of trimethylsilyl trifluoro methansulfonate(TMSOTf) or tin tetrachloride(TiCl4) using aldehyde compound represented by chemical formula 3 as a starting material. The manufacturing method uses 1-2 equivalent weight range of Lewis acid based the alcoholates represented. The Prins reaction temperature is in a range of -78-30 deg. Celsius.

    Abstract translation: 目的：提供立体选择性3,4- die亚甲基ade力玻璃化合物及其制备方法，可用作合成各种多环化合物的中间体。 构成：立体选择性3,4- die亚甲基ade pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane pane 1. ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether ether 和三甲基甲硅烷基三氟甲烷磺酸盐（TMSOTf）或四氯化锡（TiCl 4）存在下的四氢呋喃，使用由化学式3表示的醛化合物作为起始原料。 该制造方法使用1-2当量重量范围的路易斯酸所代表的醇化物。 Prins反应温度在-78-30度的范围内。 摄氏度。

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