公开(公告)号：ZA824438B

公开(公告)日：1983-05-25

申请号：ZA824438

申请日：1982-06-23

Applicant: BASF AG

Inventor： THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LENKE DIETER ,  ROSSY PHILLIP A ,  LEHMANN HANS DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  A61K ,  C07C

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：CA1145749A

公开(公告)日：1983-05-03

申请号：CA341754

申请日：1979-12-12

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10 ,  C07D207/30

Abstract: O.Z. 0050/033576 2-Aryl-3,4-diaza-bicyclo-¢4.1.0!hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：FI823217L

公开(公告)日：1983-03-19

申请号：FI823217

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MYLLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GYNTHER ,  MYLLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：ZA82293B

公开(公告)日：1982-12-29

申请号：ZA82293

申请日：1982-01-18

Applicant: BASF AG

Inventor： THIEME PETER C ,  STEINER GERD ,  ROHR WOLFGANG ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  TESCHENDORF HANS JUERGEN ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  A61K ,  C07C ,  C07D

Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula where R1 is hydrogen or alkyl of 1 to 4 carbon atoms, R2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.

公开(公告)号：ZA8200293B

公开(公告)日：1982-12-29

申请号：ZA8200293

申请日：1982-01-18

Applicant: BASF AG

Inventor： THIEME PETER C ,  STEINER GERD ,  ROHR WOLFGANG ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  TESCHENDORF HANS JUERGEN ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D249/08 ,  A61K31/495 ,  A61K31/496 ,  A61P9/02 ,  A61P11/00 ,  A61P25/20 ,  C07D231/12 ,  C07D233/60 ,  C07D233/61 ,  C07D271/10 ,  C07D295/06 ,  C07D295/067 ,  C07D295/096 ,  C07D521/00 ,  A61K ,  C07C ,  C07D

CPC classification number: C07D271/10 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D295/067 ,  C07D295/096

公开(公告)号：HU179676B

公开(公告)日：1982-11-29

申请号：HUBA003887

申请日：1979-11-16

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS D

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12 ,  C07D233/16

公开(公告)号：NO821085L

公开(公告)日：1982-10-11

申请号：NO821085

申请日：1982-03-31

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C

公开(公告)号：ZA814688B

公开(公告)日：1982-08-25

申请号：ZA814688

申请日：1981-07-10

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  WEIFENBACH HARALD ,  HOFMANN HANS PETER ,  KREISKOTT HORST

IPC: C07D295/08 ,  A61K31/495 ,  A61P9/12 ,  A61P25/20 ,  C07C45/70 ,  C07D295/092 ,  C07D303/22 ,  A61K ,  C07C

公开(公告)号：HU178989B

公开(公告)日：1982-07-28

申请号：HUBA003778

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  THEOBALD HANS ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：NO810480L

公开(公告)日：1981-08-14

申请号：NO810480

申请日：1981-02-12

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: A61K31/495 ,  C07D413/12 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12 ,  C07D

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.