公开(公告)号：JPH0753359A

公开(公告)日：1995-02-28

申请号：JP11809894

申请日：1994-05-31

Applicant: KAO CORP

Inventor： MURASE TAKATOSHI ,  HASE TADASHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI ,  YADA YUKIHIRO ,  IMOKAWA GENJI

IPC: A61K31/015 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/12 ,  A61K31/22 ,  A61P11/00 ,  A61P17/00 ,  A61P27/16 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00

Abstract: PURPOSE:To provide a lipoxygenase inhibitor having excellent lipoxygenase inhibiting action and useful as an anti-inflammatory agent, anti-allergic agent, etc., by using piceatannol existing in flat-sedge belonging to the family Cyperaceae or its derivative as the active component. CONSTITUTION:Dried flat-sedge is crushed and extracted with methanol, the extracted liquid is concentrated under reduced pressure, the concentrated liquid is subjected to liquid-liquid partition with ethyl acetate-water, the obtained organic layer is concentrated under reduced pressure and partitioned with hexane-90% methanol, the 90% methanol layer is concentrated, dried and subjected to silica gel chromatography, the adsorbed material is eluted with chloroform-methanol and the eluate is collected and subjected to high- performance liquid chromatography to obtain piceatannol of the formula (R to R are each OH, an alkyl, alkoxy, alkanoyl, etc.) or its derivative. The compound is used as an active component, compounded with a carrier and formed in the form of a pharmaceutical preparation to obtain the objective preparation for anti-inflammatory agent, anti-allergic agent, etc., having excellent lipoxygenase inhibiting action.

公开(公告)号：JPH06321873A

公开(公告)日：1994-11-22

申请号：JP3948094

申请日：1994-03-10

Applicant: KAO CORP

Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KUSUOKU HIROSHI ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/41 ,  C07C217/28 ,  C07C233/18 ,  C07F7/10 ,  A61K7/00

Abstract: PURPOSE:To obtain a new compound excellent in anti-dandruff effect, beautifully whitening effect after sunburn, etc., and capable of preventing and improving creases and maintaining a normal function of skin. CONSTITUTION:This new compound is an amine derivative or its acid adduct salt of the formula (R1 is 7-40C hydrocarbon containing a heteroatom (preferably, oxygen atom); R2-R6 are H or 1--10C hydrocarbon which can have 1 or >=2 hydroxyl groups), e.g. 1-(2-hydroxyethylamino)-3-(12-hydroxyoctadecyloxy)-2- propanol, etc. An amino derivative of the formula can be obtained by bringing an alcohol having a heteroatom to an glycol ether derivative, and then adding an amine thereto.

公开(公告)号：JPH06321765A

公开(公告)日：1994-11-22

申请号：JP11600393

申请日：1993-05-18

Applicant: KAO CORP

Inventor： YADA YUKIHIRO ,  KIMURA MITSUTOSHI ,  MORIZAKI NAOKO ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/33 ,  A61K31/19 ,  A61K31/235 ,  A61P17/00 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain a skin beautifying agent containing a diphenyl ether derivative as an active component, having excellent skin beautifying effect and preventing and dissipating effect on pigmentation and useful for the prevention and treatment of spots and freckles caused by sunburn, etc. CONSTITUTION:This skin beautifying agent contains 0.00001-10wt.%, preferably 0.0001-5wt.% of a compound of the formula (R and R are H or lower alkyl; R is H or methyl; R and R are H or Cl) as an active component. A cosmetics is provided which is properly incorporated, in addition to the compound of the formula, with oil, humectant, thickener, antiseptic, emulsifier, pigment, powder, pH modifier, medicinal component, ultraviolet absorber, antioxidant, perfume, etc., and prepared in the form of cream, milky lotion, face lotion, foundation, pack, lotion, gel, solution, stick, etc. The compound of the formula suppresses melanogenesis of melanocyte, dissipates the deposited melanin pigment formed by the stimulation of ultraviolet rays and has high safety.

公开(公告)号：JPH06321764A

公开(公告)日：1994-11-22

申请号：JP11490593

申请日：1993-05-17

Applicant: KAO CORP

Inventor： YADA YUKIHIRO ,  AZUMA SEISHI ,  IMOKAWA GENJI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/33 ,  A61K31/12 ,  A61K36/48 ,  A61P17/00 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00 ,  A61K35/78

Abstract: PURPOSE:To obtain a skin beautifying agent containing a chalcone derivative as an active component, having excellent skin beautifying effect and effective for preventing and treating spots and freckles caused by sunburn, etc. CONSTITUTION:This skin beautifying agent contains 0.0001-10wt.%, preferably 0.001-5wt.% of a chalcone derivative of the formula (R is H or OH) as an active component. The compound of the formula exhibits excellent preventing and dissipating effect on the deposition of melanin pigment by the suppression of melanogenesis of melanocyte and a skin cosmetic compounded with the compound exhibits excellent skin beautifying effect. This cosmetic is properly incorporated, in addition to the compound of the formula, with oil, humectant, thickener, antiseptic, emulsifier, pigment, powder, pH modifier, antioxidant, perfume, emulsion stabilizer, etc., and prepared in the form of lotion, milky lotion, cream, ointment, stick, solution, pack or gel.

公开(公告)号：JPH06321760A

公开(公告)日：1994-11-22

申请号：JP11048293

申请日：1993-05-12

Applicant: KAO CORP

Inventor： MURASE TAKATOSHI ,  YADA YUKIHIRO ,  IMOKAWA GENJI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

IPC: A61K8/96 ,  A61K8/00 ,  A61K8/97 ,  A61K36/18 ,  A61P17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00 ,  A61K35/78

Abstract: PURPOSE:To obtain a skin beautifying agent having excellent melanogenesis suppressing effect and capable of effectively preventing and dissipating the pigmentation of skin. CONSTITUTION:A skin beautifying agent composed of an extract of a plant belonging to the genus Cyperus, especially umbrella sedge, and a skin cosmetic containing the extract. The extract can be produced by directly squeezing the plant to obtain juice or by thoroughly crushing the plant in the presence of an extraction solvent and filtering the crushed product to remove the plant pieces. The amount of the extract to be compounded to the skin cosmetic is preferably 0.001-20wt.%, especially 0.005-5wt.% (in terms of dried solid). The skin cosmetic includes quasi-drugs and medicines for external use, etc., as well as common skin cosmetics. It is used in various forms such as lotion, milky lotion, cream, ointment, stick, organic solvent solution, pack or gel.

公开(公告)号：JPH06321749A

公开(公告)日：1994-11-22

申请号：JP10672493

申请日：1993-05-07

Applicant: KAO CORP

Inventor： YADA YUKIHIRO ,  KIMURA MITSUTOSHI ,  MORIZAKI NAOKO ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61K31/16 ,  A61P17/00 ,  A61P43/00 ,  A61Q1/00 ,  A61Q1/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  A61K7/48 ,  A61K7/00 ,  A61K7/42

Abstract: PURPOSE:To obtain a whitening agent capable of preventing formation of melanin, having an effect on improvement of pigmentation caused by stimulation of ultraviolet rays, etc., and capable of providing a skin care cosmetic exhibiting an excellent whitening effect and excellent in prevention and improvement of a spot or a freckle caused by sunburn, etc. CONSTITUTION:There are provided whitening agent composed of a styrylamine derivative of the formula [R and R are each H or a lower alkyl; (n) is 1 to 3) and a skin care cosmetic containing this compound. The compound of the formula can be obtained by culturing an Actinomyces and separating it from the culture supernatant. The mixture ratio of the compound of the formula in this skin care cosmetic is preferably 0.00001 to 10wt.%, especially 0.0001 to 5wt.%. In the skin care cosmetic, not only a general skin care cosmetic but a quasi drug, a medicine for external use, etc., are included. The dosage form can be freely selected from cream, milky lotion, toilet water, foundation, pack, lotion, get, stick, etc. according to the purpose.

公开(公告)号：JPH06271449A

公开(公告)日：1994-09-27

申请号：JP6060493

申请日：1993-03-19

Applicant: KAO CORP

Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  FUJIMURA TSUTOMU ,  IMOKAWA GENJI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/40 ,  A61K8/41 ,  A61P17/16 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain a wrinkle improver and a keratinization improver excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin hyperplasia of epidermis and abnormality of lipometabolism and excellent in recovery of normal function and retention of homeostasis. CONSTITUTION:The wrinkle improver and keratinization improver consist of an amine derivative of formula I [R is H or 1-40C straight-chain, branched chain or cyclic hydrocarbon group; R is H or 1-5C hydrocarbon group which may have OH or alkoxy; R IS H or 1-22C hydrocarbon which may have OH or alkoxy; R are H or 1-7C hydrocarbon group which may have OH; R is 2-6C hydrocarbon group which may have OH; X is H, OH or OP(=0) (OH)2; Y is X except OH] or its acid addition salt or quaternary compound, e.g. 1-(2- hydroxyethylamino)-2-octadecanol. This compound has action capable of suppressing DNA synthesis of an epidermic cell, promoting differential induction and suppressing hyperplasia of epidermis. The compound of formula I wherein X is OH and Y is H is obtained by adding an amine of formula 3 to an epoxide of formula 2.

公开(公告)号：JPH06271443A

公开(公告)日：1994-09-27

申请号：JP5724893

申请日：1993-03-17

Applicant: KAO CORP

Inventor： OHASHI YUKIHIRO ,  FUJIMORI TAKETOSHI ,  KAWAMATA AKIRA ,  YADA YUKIHIRO ,  HIGUCHI KAZUHIKO ,  TAKEMA YOSHINORI ,  OSU HIROYUKI ,  IMOKAWA GENJI

IPC: A61K8/49 ,  A61K8/00 ,  A61K8/41 ,  A61K31/13 ,  A61Q5/00 ,  A61Q19/00 ,  C07D311/72 ,  C07D319/06 ,  A61K7/48 ,  A61K7/00 ,  A61K7/06

Abstract: PURPOSE:To obtain a skin external preparation excellent in action capable of suppressing occurrence of wrinkle and removing wrinkle and suppressing parakeratosis of skin, hyperplasia of epidermis and abnormality of lipometabolism and excellent in the recovery of normal function and retention of homeostasis. CONSTITUTION:The skin external preparation contains a compound of formula I (R is 7-40C hydrocarbon group having a ring structure and containing a hetero atom; R to R are 1-10C hydrocarbon group whose hydrogen may be substituted with OH) or its acid addition salt, e.g. 1-(2-hydroxyethylamino)-3- tocopheryloxy-2-propanol. This compound has action capable of suppressing DNA synthesis of an epidermic cell and promoting differential induction and suppressing hyperplasia of epidermis and is blended in the skin external preparation in an amount of 0.0001-5wt.% in the case of emulsion system or 0.0001-10wt.% in the case of an oil system using a liquid hydrocarbon such as squalane as a base. The compound of formula I is obtained by adding an amine derivative of formula 3 to a glycidyl ether derivative of formula 2.

公开(公告)号：JPH0632727A

公开(公告)日：1994-02-08

申请号：JP18819892

申请日：1992-07-15

Applicant: KAO CORP

Inventor： KITAYAMA TAKASHI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI ,  IMOKAWA GENJI ,  KIMURA MITSUTOSHI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/44 ,  A61K31/195 ,  A61K31/198 ,  A61K31/215 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07C229/36 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To obtain an external preparation for skin having inhibitory action on melanism, excellent preventing effects on stain, freckle and pigmentation on skin after sunburn and high stability and safety. CONSTITUTION:This external preparation for skin comprises 0.01-50wt.%, especially 0.1-20wt.% based on the whole amount of the ternal preparation for skin of a BETA-branched phenylalanine derivative of the formula (R is H or OH; R is lower alkyl; R is H or lower alkyl) or its salt, preferably BETA- methylphenylalanine. The external preparation for skin is prepared in a lotion state, milky lotion state, creamy state, ointment state, stick state, solution state with an organic solvent, pack state or gelatinous state.

公开(公告)号：JPH05345713A

公开(公告)日：1993-12-27

申请号：JP15523992

申请日：1992-06-15

Applicant: KAO CORP

Inventor： KITAYAMA TAKASHI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI ,  IMOKAWA GENJI ,  KIMURA MITSUTOSHI

IPC: A61K8/49 ,  A61K8/00 ,  A61K31/415 ,  A61K31/4166 ,  A61P17/00 ,  A61P43/00 ,  A61Q19/00 ,  A61Q19/02 ,  C07D233/78 ,  A61K7/48 ,  A61K7/00

Abstract: PURPOSE:To provide hydantoin derivatives (including new compounds) having pigmentation preventing and improving effects and excellent safety and stability and easily miscible to a cosmetic base, etc. CONSTITUTION:The objective melanogenesis suppressing agent is composed of a compound of formula I [R is H, lower alkyl or aralkyl; R is H, alkyl (which may contain epoxy group or ketone group), lower alkoxycarbonyl or lower alkoxycarbonylalkyl; dotted line represents the presence or absence of double bond], e.g. 5-(p-methoxybenzylidene)hydantoin. Compounds of formula wherein R is not aralkyl and R is not H are new compounds. The compound strongly inhibits the activity of tyrosinase which is an essential enzyme for melanin synthesis and suppresses the melanogenesis in the artificially formed pigment freckle. The amount of the compound to be compounded to the total external agent is 0.01-50wt.%, especially 0.1-20wt.%.