公开(公告)号：KR1020110039069A

公开(公告)日：2011-04-15

申请号：KR1020090096346

申请日：2009-10-09

Applicant: (주)아모레퍼시픽

Inventor： 안은정 ,  김형준 ,  김수나 ,  김용진 ,  김미진 ,  김진웅 ,  심종원

IPC: A61K8/55 ,  A61Q7/00 ,  A61K8/49 ,  A61K8/73

CPC classification number: A61K8/553 ,  A61K8/14 ,  A61K8/4953 ,  A61Q7/00

Abstract: PURPOSE: A composition containing phosphatidic acid for promoting hair growth is provided to form liposome and to effectively deliver hair growth promoting ingredients to hair follicle. CONSTITUTION: A composition for promoting hair growth contains phosphatidic acid as an active ingredient. The phosphatidic acid is contained as a functional group of lecithin. The lecithin includes phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanol amine, or phosphatidyl glycol. The composition further contains 0.1-20.0 weight% of lecithin.

Abstract translation: 目的：提供含有用于促进毛发生长的磷脂酸的组合物以形成脂质体并有效地将毛发生长促进成分递送至毛囊。 构成：用于促进头发生长的组合物含有磷脂酸作为活性成分。 磷脂酸作为卵磷脂的官能团含有。 卵磷脂包括磷脂酰胆碱，磷脂酰丝氨酸，磷脂酰乙醇胺或磷脂酰乙二醇。 组合物还含有0.1-20.0重量％的卵磷脂。

公开(公告)号：KR1020110019571A

公开(公告)日：2011-02-28

申请号：KR1020090077158

申请日：2009-08-20

Applicant: (주)아모레퍼시픽

Inventor： 박종희 ,  박신영 ,  신홍주 ,  김도훈 ,  이창근 ,  박원석 ,  고현주 ,  김정환 ,  김형준

IPC: A61K31/155 ,  A61P17/10 ,  A61P17/08 ,  A61K31/203

CPC classification number: A61K31/155 ,  A61K31/203

Abstract: PURPOSE: A composition containing hexamidine and retinoid is provided to prevent skin pigmentation and control sebum and pore. CONSTITUTION: A compositioin contains 0.0001-15 weight% of hexamidine, derivative thereof, or pharmaceutically acceptable salt thereof; and 0.0001-15 weight% of retinoid, derivative thereof, or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for controlling sebum and pore and preventing skin pigmentation. The composition further contains 0.001-10 weight% of ceramide.

Abstract translation: 目的：提供含有己脒和类视色素的组合物，以防止皮肤色素沉淀和控制皮脂和毛孔。 组成：组合物含有0.0001-15重量％的己脒，其衍生物或其药学上可接受的盐; 和0.0001-15重量％的类视黄醇，其衍生物或其药学上可接受的盐作为活性成分。 该组合物用于控制皮脂和毛孔并防止皮肤色素沉着。 组合物还含有0.001-10重量％的神经酰胺。

公开(公告)号：KR1020110017660A

公开(公告)日：2011-02-22

申请号：KR1020090075242

申请日：2009-08-14

Applicant: (주)아모레퍼시픽

Inventor： 김정환 ,  박원석 ,  고현주 ,  신홍주 ,  김도훈 ,  박종희 ,  이창근 ,  김형준 ,  서정아

IPC: A61K8/97 ,  A61Q19/02 ,  A23L1/30 ,  A61K36/254

CPC classification number: A61K8/97 ,  A23L33/105 ,  A61K36/254 ,  A61Q19/02 ,  Y10S514/859

Abstract: PURPOSE: A composition containing Acanthopanax senticosus extract is provided to suppress pigmentation by acne and to be sued in cosmetic product or medical field. CONSTITUTION: A composition for suppressing pigmentation by acne contains Acanthopanax senticosus extract as an active ingredient. The Acanthopanax senticosus extract is isolated using distilled water and C1-C5 organic solvent of hydrous or anhydrous low alcohol. An external use composition contains the composition for suppressing acne. The conten of the Acanthopanax senticosus extract is contained 0.5-20 weight% based on total weight. The external use skin composition is a cosmetic formulation.

Abstract translation: 目的：提供含有刺五加提取物的组合物，以抑制痤疮的色素沉着，并在化妆品或医疗领域起诉。 构成：抑制痤疮色素沉着的组合物含有刺五加提取物作为活性成分。 使用蒸馏水和含水或无水低醇的C1-C5有机溶剂分离刺五加提取物。 外用组合物含有抑制痤疮的组合物。 刺五加提取物的含量为0.5-20重量％，基于总重量。 外用皮肤组合物是化妆品制剂。

公开(公告)号：KR1020110017645A

公开(公告)日：2011-02-22

申请号：KR1020090075219

申请日：2009-08-14

Applicant: (주)아모레퍼시픽

Inventor： 김정환 ,  박원석 ,  고현주 ,  신홍주 ,  김도훈 ,  박종희 ,  이창근 ,  김형준 ,  서정아

IPC: A61K8/97 ,  A61Q19/02 ,  A23L1/30 ,  A61K36/708

Abstract: PURPOSE: A composition containing Rheum undulatum extract is provided to suppress pigmentation due to acne and to be used in a cosmetic field or medical field. CONSTITUTION: A composition for suppressing pigmentation due to acne contains Rheum undulatum extract as an active ingredient. An external use skin composition contains the composition for suppressing pigmentation. The content of the Rheum undulatum extract is 0.5-20 weight%. The composition is a cosmetic formulation. An aftercare composition for acne contains Rheum undulatum extract as an active ingredient.

Abstract translation: 目的：提供含有大黄精华提取物的组合物以抑制由于痤疮引起的色素沉着并用于化妆品领域或医疗领域。 构成：用于抑制由于痤疮引起的色素沉着的组合物含有作为有效成分的无色杜鹃花提取物。 外用皮肤组合物含有抑制色素沉着的组合物。 大黄精华提取物的含量为0.5〜20重量％。 组合物是化妆品制剂。 用于痤疮的保健用组合物含有作为活性成分的大黄精华提取物。

公开(公告)号：KR1020110017566A

公开(公告)日：2011-02-22

申请号：KR1020090075085

申请日：2009-08-14

Applicant: (주)아모레퍼시픽

Inventor： 김정환 ,  박원석 ,  고현주 ,  신홍주 ,  김도훈 ,  박종희 ,  이창근 ,  김형준 ,  서정아

IPC: A61K8/97 ,  A61Q19/02 ,  A23L1/30 ,  A61K36/738

Abstract: PURPOSE: A composition containing Rosa spp. extract is provided to suppress pigmentation by acne and to be used in food or cosmetic field. CONSTITUTION: A composition for suppressing pigmentation by acne contains 0.5-20 weight% of Rosa spp. extract as an active ingredient. An external use skin composition contains the composition for suppressing pigmentation. The composition is a cosmetic formulation. A food additive or health food composition contains the composition for suppressing pigmentation or aftercare composition.

Abstract translation: 目的：含有罗莎属的组合物。 提取物以抑制痤疮的色素沉着，并用于食品或化妆品领域。 构成：用于抑制痤疮色素沉着的组合物含有0.5-20重量％的罗莎属。 提取物作为活性成分。 外用皮肤组合物含有抑制色素沉着的组合物。 组合物是化妆品制剂。 食品添加剂或保健食品组合物含有抑制色素沉着或后处理组合物的组合物。

公开(公告)号：KR1020110017563A

公开(公告)日：2011-02-22

申请号：KR1020090075082

申请日：2009-08-14

Applicant: (주)아모레퍼시픽

Inventor： 김정환 ,  박원석 ,  고현주 ,  신홍주 ,  김도훈 ,  박종희 ,  이창근 ,  김형준 ,  서정아

IPC: A61K8/97 ,  A61Q19/02 ,  A23L1/30 ,  A61K36/481

Abstract: PURPOSE: A composition containing Astraglus membranaceus extract is provided to prevent acne pigmentation and/or scar and to be used in cosmetic, food, or medial field. CONSTITUTION: A composition for suppressing acne pigmentation contains Astraglus membranaceus extract as an active ingredient. The Astraglus membranaceus extract suppresses gelatinase. The composition is used in the form of cosmetic product. A composition for aftercare of acne contains Astraglus membranaceus extract as an active ingredient. A food additive or health food contains Astraglus membranaceus extract.

Abstract translation: 目的：提供含有黄芪提取物的组合物，以防止痤疮色素沉着和/或疤痕，并用于化妆品，食品或内部领域。 构成：抑制痤疮色素沉着的组合物含有黄芪提取物作为活性成分。 黄芪提取物抑制明胶酶。 该组合物以化妆品的形式使用。 用于治疗痤疮的组合物含有黄芪提取物作为活性成分。 食品添加剂或保健食品含有黄芪提取物。

公开(公告)号：KR1020100122455A

公开(公告)日：2010-11-22

申请号：KR1020100043804

申请日：2010-05-11

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  박원석 ,  고현주 ,  박필준 ,  김수나 ,  최강열 ,  윤주용 ,  이성훈

IPC: A61K8/36 ,  A61Q7/00 ,  A61K31/19 ,  A61P17/14

CPC classification number: A61K31/19 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/361 ,  A61Q7/00 ,  A23V2200/318

Abstract: PURPOSE: A composition containing valproic acid for promoting hair growth or preventing hair loss is provided to apply in pharmaceutical and cosmetic field. CONSTITUTION: A composition for preventing hair loss or promoting hair growth contains valproic acid or pharmaceutically acceptable salt thereof as an active ingredient. The salt is sodium valproate. The composition is manufactured in a percutaneous administration. The composition is also manufactured hypodermic injection or external use formulation. A pharmaceutical or cosmetic composition contains the composition for preventing hair loss or promoting hair growth.

Abstract translation: 目的：提供一种用于促进头发生长或预防脱发的含有丙戊酸的组合物，用于制药和美容领域。 构成：用于预防脱发或促进毛发生长的组合物含有丙戊酸或其药学上可接受的盐作为活性成分。 盐是丙戊酸钠。 组合物经皮给药制成。 该组合物还制造皮下注射或外用制剂。 药物或化妆品组合物含有用于防止脱发或促进毛发生长的组合物。

公开(公告)号：KR1020090032372A

公开(公告)日：2009-04-01

申请号：KR1020070097553

申请日：2007-09-27

Applicant: 한국화학연구원 ,  (주)아모레퍼시픽

Inventor： 공영대 ,  조희영 ,  전문국 ,  이태호 ,  최길돈 ,  공재양 ,  정대영 ,  황순희 ,  김정주 ,  이창훈 ,  고재영 ,  노민수 ,  한은실 ,  김형준 ,  김혁 ,  윤준원 ,  모주현 ,  김도훈

IPC: C07D277/44 ,  C07D417/04 ,  C07D417/12 ,  A61K31/426

CPC classification number: C07D277/46 ,  C07D417/04 ,  C07D417/12

Abstract: Provided is 2,4,5-trisubstituted-1,3-thiazole derivatives having excellent inhibiting activity about SPC(sphingosylphosphorylcholine) receptor to treat inflammatory diseases caused by activity of the SPC acceptor. A therapeutic agent for treating inflammatory diseases caused by activity of SPC acceptor comprises a 2,4,5-trisubstituted-1,3-thiazole derivative represented by the formula 1 and pharmaceutically allowable salts thereof. A method for preparing the 2,4,5-trisubstituted-1,3-thiazole derivative consists of the following steps of: reacting methyl cyanocarbonimidodithionate represented by the formula 2 to 2-haloacetophenone in order to synthesize 4-amino-1,3-thiazol represented by the formula 3; and polymerizing chloridation carboxylic acid to 4-amino group of the 4-amino-1,3-thiazol to synthesize 4-N-acyl-1,3-thiazole represented by the formula 4.

Abstract translation: 提供对SPC（鞘氨基磷酰胆碱）受体具有优异抑制活性的2,4,5-三取代-1,3-噻唑衍生物，用于治疗由SPC受体的活性引起的炎性疾病。 用于治疗由SPC受体的活性引起的炎性疾病的治疗剂包括由式1表示的2,4,5-三取代-1,3-噻唑衍生物及其药学上允许的盐。 制备2,4,5-三取代-1,3-噻唑衍生物的方法包括以下步骤：使由式2表示的氰基羰基亚氨基二硫代乙酸甲酯与2-卤代苯乙酮反应，以合成4-氨基-1,3- 由式3表示的噻唑; 并将氯化羧酸聚合成4-氨基-1,3-噻唑-4-氨基，合成由式4表示的4-N-酰基-1,3-噻唑。

公开(公告)号：KR1020090016595A

公开(公告)日：2009-02-16

申请号：KR1020087030865

申请日：2006-12-08

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  김혁 ,  성기사 ,  김대권 ,  성대석 ,  박종희 ,  조선아 ,  김광미 ,  이창훈 ,  김정주

IPC: A61K31/661 ,  C07K14/47 ,  C12Q1/68 ,  A61P17/00

CPC classification number: C12Q1/18 ,  G01N33/92 ,  G01N2405/08 ,  G01N2800/202 ,  A61K31/661 ,  C07K14/47

Abstract: A sphingosylphosphorylcholine(SPC) antagonist is provided to prevent and treat diseases related to the expression decrease of anti-bacterial peptide such as atopic dermatitis, and screen the SPC antagonist by analyzing the expression recover of gene or protein of the anti-bacterial peptide. The sphingosylphosphorylcholine(SPC) antagonist manufactures the medicine for restoring the expression of anti-bacterial peptide back to the normal level in mammal requiring the expression restoration of anti-bacterial peptide. The screening method of the sphingosylphosphorylcholine(SPC) antagonist comprises the steps of: treating the object with sphingosylphosphorylcholine or its derivative to inhibit expression of anti-bacterial peptide; and treating the object with the SPC antagonist candidate material, and analyzing the expression restoration level of the anti-bacterial peptide in the object.

Abstract translation: 提供鞘糖基磷酰胆碱（SPC）拮抗剂以预防和治疗与抗细菌肽如特应性皮炎的表达降低相关的疾病，并通过分析抗细菌肽的基因或蛋白质的表达恢复来筛选SPC拮抗剂。 鞘氨醇磷酰胆碱（SPC）拮抗剂在需要抗菌肽表达恢复的哺乳动物中制备了将抗菌肽的表达恢复至正常水平的药物。 鞘氨醇磷酰胆碱（SPC）拮抗剂的筛选方法包括以下步骤：用鞘糖基磷酰胆碱或其衍生物处理物体以抑制抗菌肽的表达; 并用SPC拮抗剂候选物质处理对象，分析对象中抗菌肽的表达恢复水平。

公开(公告)号：KR1020080050760A

公开(公告)日：2008-06-10

申请号：KR1020060121432

申请日：2006-12-04

Applicant: (주)아모레퍼시픽

Inventor： 조선아 ,  이창훈 ,  김광미 ,  김대권 ,  김형준 ,  성기사 ,  김혁 ,  김정주 ,  김수열

IPC: A61K31/351 ,  A61P41/00

CPC classification number: A61K31/7008 ,  A61K9/06 ,  A61K9/10 ,  A61K9/20 ,  A61K9/48

Abstract: A hexosamine derivative is provided to show excellent intra-abdominal fibrinous adhesion inhibitory activity, thereby being usefully used for preventing or treating post-operative adhesion. A pharmaceutical composition for preventing or treating post-operative adhesion such as intra-abdominal fibrinous adhesion comprises a hexosamine compound represented by a formula(1) or a pharmaceutically acceptable salt thereof as an active ingredient, wherein the active ingredient is selected from the group consisting of galactosamine, D-(+)-glucosamine hydrochloride, and D-(+)-galactosamine hydrochloride.

Abstract translation: 提供了一种己糖胺衍生物以显示优异的腹内纤维粘附抑制活性，从而有效地用于预防或治疗术后粘连。 用于预防或治疗术后粘连（例如腹内纤维粘连）的药物组合物包含由式（1）表示的己糖胺化合物或其药学上可接受的盐作为活性成分，其中活性成分选自 的半乳糖胺，D - （+） - 葡糖胺盐酸盐和D - （+） - 半乳糖胺盐酸盐。