公开(公告)号：DK0931069T3

公开(公告)日：2001-02-19

申请号：DK97918992

申请日：1997-08-21

Applicant: BASF AG

Inventor： SCHAEFER BERND ,  ZIERKE THOMAS

IPC: C07D213/81 ,  C07B43/00 ,  C07C257/10 ,  C07D213/73 ,  C07D213/78 ,  C07D271/06 ,  C07D401/12 ,  C07D413/12 ,  C07K1/06 ,  C07K5/062

Abstract: A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or absence of an in-organic or organic ammonium salt.

公开(公告)号：BG104089A

公开(公告)日：2000-12-29

申请号：BG10408900

申请日：2000-01-17

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TEREZA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: The invention relates to inhibitors of the cellular growth and to their adjunctive to acid salts which are peptides with the formula A - B - D - E - F - (G)r - (K)s - L (I) where A, B, D, E, F, G. and K are -aminoacid residues and s and r are, individually, 0 or 1. L is univalent radical, such as aminogroup, N-substituted aminogroup, beta-hydroxyaminogroup, beta-hydroxyaminogroup, hydrasidogroup, alkoxygroup, thioalkoxygroup, aminooxygroup or oximatogroup. The invention also relates to a method for the treatment of cancer in mammals, including humans which includes the administration of an effective quantity of the above compound in a pharmaceutically acceptable composition. 6 claims

公开(公告)号：DE59702414D1

公开(公告)日：2000-11-02

申请号：DE59702414

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083

Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.

公开(公告)号：HRP950271B1

公开(公告)日：2000-08-31

申请号：HRP950271

申请日：1995-05-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  HARALD BERNARD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：NO20000231D0

公开(公告)日：2000-01-17

申请号：NO20000231

申请日：2000-01-17

Applicant: BASF AG

Inventor： JANSSEN BERND ,  BARLOZZARI TERESA ,  HAUPT ANDREAS ,  ZIERKE THOMAS ,  KLING ANDREAS

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34 ,  C07K

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：AT185349T

公开(公告)日：1999-10-15

申请号：AT96925744

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：NZ333679A

公开(公告)日：1999-09-29

申请号：NZ33367997

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07D417/12 ,  C07D409/12 ,  C07D413/12 ,  C07D407/12 ,  C07D401/12

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：PL331540A1

公开(公告)日：1999-07-19

申请号：PL33154097

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K5/02

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：HU9900089A2

公开(公告)日：1999-05-28

申请号：HU9900089

申请日：1996-10-30

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  DE ARRUDA MONIKA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ROBINSON SIMON ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  A61K38/08

Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.

公开(公告)号：AU705143B2

公开(公告)日：1999-05-13

申请号：AU6615496

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MULLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.