中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

213 records (took 0.022 seconds)

    Fluidic structures including meandering and wide channels
    112.
    发明专利
    Fluidic structures including meandering and wide channels 未知

    公开(公告)号：AU2006236410B2

    公开(公告)日：2012-11-01

    申请号：AU2006236410

    申请日：2006-04-19

    Applicant: HARVARD COLLEGE

    Inventor： LINDER VINCENT ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  NAROVLYANSKY MAX ,  SIA SAMUEL K

    IPC: B01L3/00 ,  G01N21/59 ,  G01N33/543 ,  G01N33/553

    Abstract: The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    Assay device and method
    114.
    发明专利
    Assay device and method 未知

    公开(公告)号：AU2004312893B2

    公开(公告)日：2010-06-17

    申请号：AU2004312893

    申请日：2004-12-29

    Applicant: HARVARD COLLEGE

    Inventor： LINDER VINCENT ,  PARVIZ BABAK A ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  SIA SAMUEL K

    IPC: B01L3/00 ,  G01N21/05 ,  G01N21/53 ,  G01N21/59 ,  G01N33/53 ,  G01N33/58

    Abstract: An assay device and method are described. The assay may involve immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.

    117.
    发明专利
    未知

    公开(公告)号：DE60228943D1

    公开(公告)日：2008-10-30

    申请号：DE60228943

    申请日：2002-04-10

    Applicant: HARVARD COLLEGE

    Inventor： WU MING-HSIEN ,  WHITESIDES GEORGE M ,  PAUL KATERI E

    IPC: G02B3/00 ,  G03F7/00 ,  G03F7/20

    Abstract: Methods and systems for effecting responses on surfaces utilizing microlens arrays including microoptical components embedded or supported by a support element and positioned from the surface at a distance essentially equal to the image distance of the microoptical component with spacer elements are disclosed. Microlens arrays can be used to manipulate incident energy or radiation having a distribution in characteristic property(s) defining an object pattern to form a corresponding image pattern on a substrate surface. The energy can be light having a pattern or a specific wavelength, intensity or polarization or coherence alignment. The image pattern can have features of order 100 nm in size or less produced from corresponding object patterns having features in the order millimeters. The size of the object pattern can be reduced by the microlens arrays described by a factor of 100 or more using a single step process to form the image patterns.

Patent Agency Ranking