公开(公告)号：CA2374641A1

公开(公告)日：2000-11-30

申请号：CA2374641

申请日：2000-05-24

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  SONG YONGHONG ,  ZHU BING-YAN ,  SU TING ,  ZHAOZHANG JON JIA

IPC: A61P7/02 ,  A61K31/167 ,  A61K31/18 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/472 ,  A61K31/4725 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  C07C311/16 ,  C07C311/18 ,  C07C311/40 ,  C07C311/44 ,  C07C311/46 ,  C07D207/16 ,  C07D217/22 ,  C07D401/06

Abstract: Novel compounds, their salts and compositions related thereto having activit y against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：ES2147729T3

公开(公告)日：2000-10-01

申请号：ES92906305

申请日：1992-01-28

Applicant: COR THERAPEUTICS INC ,  UNIV CALIFORNIA

Inventor： ESCOBEDO JAIME A ,  WILLIAMS LEWIS T ,  WOLF DAVID ,  TOMLINSON JAMES E ,  FRETTO LARRY J ,  GIESE NEILL A

IPC: A61K39/395 ,  A61K38/00 ,  C07K7/04 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K16/28 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/475 ,  A61K38/18

Abstract: Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues.

公开(公告)号：NZ321304A

公开(公告)日：2000-08-25

申请号：NZ32130496

申请日：1996-10-18

Applicant: COR THERAPEUTICS INC

Inventor： PHILIPS DAVID ,  LAW DEBBIE A ,  ALAIMO LISA N

IPC: G01N33/53 ,  A61K38/00 ,  A61K45/00 ,  A61P7/02 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07K14/705 ,  C12N5/06 ,  C12N11/02 ,  C12N15/09 ,  C07K14/00 ,  A61K39/00 ,  G01N33/574 ,  A61K39/38 ,  A01N37/18

Abstract: Use of an agent particularly a phosphorylated peptide which blocks the binding of a cytoplasmic signaling partner to an integrin having a phosphorylated tyrosine in the cytoplasmic domain of the beta subunit or a fragment thereof comprising the phosphorylated cytoplasmic domain in the preparation of a medicament for blocking the interaction of an integrin with a cytoplasmic signaling partner in a patient, like thrombosis, inflammation and tumor metastasis. The signalling partner is selected from the src-family of tyrosine kinases and the non-src family of tyrosine kinases. Further disclosed is an in vitro method for identifying agents which block the interaction of an integrin with a cytoplasmic signalling partner by: a) incubating a peptide comprising the phosphorylated cytoplasmic domain of the beta subunit of the integrin with the signalling partner and with an agent and; b) determining whether the agent blocks the binding of the signalling partner to the peptide.

公开(公告)号：CA2362375A1

公开(公告)日：2000-08-17

申请号：CA2362375

申请日：2000-02-11

Applicant: COR THERAPEUTICS INC

Inventor： SONG YOUNGHONG ,  SCARBOROUGH ROBERT M ,  ZHU BING-YAN

IPC: C07D295/14 ,  A61K31/18 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/341 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/505 ,  A61K31/517 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07D213/56 ,  C07D213/58 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D217/22 ,  C07D231/12 ,  C07D233/61 ,  C07D239/42 ,  C07D239/94 ,  C07D257/04 ,  C07D295/16 ,  C07D307/54 ,  C07D401/12 ,  C07D521/00

Abstract: Published without an

公开(公告)号：CA2361428A1

公开(公告)日：2000-08-17

申请号：CA2361428

申请日：2000-02-11

Applicant: COR THERAPEUTICS INC

Inventor： TENG WILLY ,  SU TING ,  CLIZBE LANE ,  JIA ZHAOZHONG JON ,  SCARBOROUGH ROBERT M ,  ZHU BING-YAN ,  SONG YONGHONG

IPC: C07D295/14 ,  A61K31/18 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/341 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4174 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/495 ,  A61K31/505 ,  A61K31/517 ,  A61P7/00 ,  A61P7/02 ,  A61P7/04 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P31/04 ,  A61P43/00 ,  C07C257/18 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07D213/56 ,  C07D213/58 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D217/22 ,  C07D231/12 ,  C07D233/61 ,  C07D239/42 ,  C07D239/94 ,  C07D257/04 ,  C07D295/16 ,  C07D307/54 ,  C07D401/12 ,  C07D521/00 ,  A61K31/16 ,  A61K31/33 ,  C07D231/56

Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammali an Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：AT190625T

公开(公告)日：2000-04-15

申请号：AT93917028

申请日：1993-07-08

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M

IPC: A61K38/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P29/00 ,  C07K5/062 ,  C07K5/065 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K7/02 ,  C07K7/06 ,  C07K7/08 ,  C07K5/06 ,  C07K5/10

公开(公告)号：AU717123B2

公开(公告)日：2000-03-16

申请号：AU4530997

申请日：1997-11-19

Applicant: COR THERAPEUTICS INC

Inventor： SINHA UMA ,  WOLF DAVID L

IPC: A61K38/36 ,  A61K38/00 ,  A61K38/17 ,  A61K38/37 ,  A61K38/43 ,  A61K38/46 ,  A61K38/47 ,  A61K38/48 ,  A61K39/395 ,  A61K39/44 ,  A61P7/02 ,  A61P29/00 ,  C07K14/42 ,  C07K14/745 ,  C07K16/36 ,  C12N9/64 ,  C12N9/99 ,  A61K35/80

公开(公告)号：CA2337693A1

公开(公告)日：2000-02-17

申请号：CA2337693

申请日：1999-08-04

Applicant: COR THERAPEUTICS INC

Inventor： RAMAKRISHNAN VANITHA ,  PHILLIPS DAVID R

IPC: A01K67/027 ,  C07K14/705 ,  C12N5/10 ,  C12N15/09 ,  C12N15/85 ,  C12Q1/02 ,  C12N15/00 ,  A61K49/00 ,  C12N15/12

Abstract: The present invention relates to nonhuman transgenic animals in which the GP V gene has been modified. The invention is also useful for identifying agents that modulate the biological functions of GP V, including the screening and identification of potential therapeutic agents.

公开(公告)号：FI104364B

公开(公告)日：2000-01-14

申请号：FI915919

申请日：1991-12-16

Applicant: COR THERAPEUTICS INC

Inventor： SCARBOROUGH ROBERT M ,  WOLF DAVID LAWRENCE ,  CHARO ISRAEL F

IPC: A61K38/00 ,  A61K35/58 ,  A61K38/02 ,  A61K38/12 ,  A61K38/17 ,  A61K38/36 ,  A61K38/57 ,  A61P7/02 ,  C07K1/14 ,  C07K1/20 ,  C07K7/00 ,  C07K7/06 ,  C07K7/64 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/745 ,  C07K14/75 ,  C07K14/755 ,  C07K14/78 ,  C12N1/21 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/56 ,  C12R1/19 ,  G01N33/86 ,  A61K38/54 ,  C07K1/00 ,  C07K2/00 ,  G01N33/566

Abstract: An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samples was accomplished. The isolated and purified PAI from several of these active snake venoms is described and characterized. In addition, PAIs lacking the Arg-Gly-Asp (RGD) adhesion sequence but containing K*-(G/Sar)-D wherein K* is a modified lysyl residue of the formula R 2 N(CH2)4CHNHCO- wherein each R is independently H, alkyl(1-6C) or at most one R is R -C=NR wherein R is H, alkyl(1-6C), phenyl or benzyl, or is NR 2 in which each R is independently H or alkyl(1-6C) and R is H, alkyl(1-6C), phenyl or benzyl, or R -C=NR is a radical selected from the group consisting of: where m is an integer of 2-3, and each R is independently H or alkyl(1-6C); and wherein one or two (CH2) may be replaced by O or S provided said O or S is not adjacent to another heteroatom are prepared and shown to specifically inhibit the binding of fibrinogen or von Willebrand Factor to GP IIb-IIIa.

公开(公告)号：AU3646299A

公开(公告)日：1999-11-01

申请号：AU3646299

申请日：1999-04-15

Applicant: COR THERAPEUTICS INC

Inventor： LAW DEBORAH ANN ,  PHILLIPS DAVID R

IPC: A01K67/027 ,  A61K45/00 ,  A61P7/02 ,  C07K14/705 ,  C12N15/09 ,  C12N15/85 ,  C12N5/10 ,  A61K49/00