公开(公告)号：NZ285092A

公开(公告)日：1998-01-26

申请号：NZ28509295

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKTE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  A61K38/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K5/02

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：FI964446A

公开(公告)日：1997-01-03

申请号：FI964446

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K

Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

公开(公告)号：FI964448A0

公开(公告)日：1996-11-05

申请号：FI964448

申请日：1996-11-05

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：ZA953584B

公开(公告)日：1996-11-04

申请号：ZA953584

申请日：1995-05-04

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  AMBERG WILHELM ,  BERNARD HARALD ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  JANITSCHKE LOTHAR ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS ,  POTZOLLI BERND DE

IPC: A61K38/08 ,  A61P35/00 ,  A61K38/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52 ,  C07K ,  A61K

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：PL312609A1

公开(公告)日：1996-04-29

申请号：PL31260994

申请日：1994-06-28

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  THYES MARCO

IPC: C07D471/08

Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.

公开(公告)号：MX9405030A

公开(公告)日：1995-01-31

申请号：MX9405030

申请日：1994-07-01

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  THYES MARCO

IPC: C07D471/08 ,  C07D211/14

Abstract: Described is an improved method of preparing N,N'-dibenzylbispidine by reacting N-benzylpiperidone with benzylamine and subsequent reduction.

公开(公告)号：DE3774850D1

公开(公告)日：1992-01-09

申请号：DE3774850

申请日：1987-12-17

Applicant: BASF AG

Inventor： THYES MARCO ,  STEINER GERD

IPC: B01J27/125 ,  C07B31/00 ,  C07B41/06 ,  C07B61/00 ,  C07C45/00 ,  C07C45/46 ,  C07C45/65 ,  C07C49/675 ,  C07C49/697 ,  C07C49/755 ,  C07C67/00

Abstract: Prodn. of 5H-dibenzo(a,d)cyclohepten-5-ones of formula (I) is effected by (a) reacting a (Z)-2-(arylvinyl) arylcarboxylic acid of formula (II) with a halogenating agent at -30 to +120 deg. C, and (b) cyclising the resulting acid halide (III) at 0-100 deg. C in the presence of a Lewis acid: A and B complete aromatic ring systems; X = halogen.

公开(公告)号：AT69796T

公开(公告)日：1991-12-15

申请号：AT87118716

申请日：1987-12-17

Applicant: BASF AG

Inventor： THYES MARCO ,  STEINER GERD

IPC: B01J27/125 ,  C07B31/00 ,  C07B41/06 ,  C07B61/00 ,  C07C45/00 ,  C07C45/46 ,  C07C45/65 ,  C07C49/675 ,  C07C49/697 ,  C07C49/755 ,  C07C67/00

公开(公告)号：CS254969B2

公开(公告)日：1988-02-15

申请号：CS50984

申请日：1984-01-23

Applicant: BASF AG

Inventor： ROSSY PHILIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENING HORST ,  LEHMANN HANS D ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：AU563974B2

公开(公告)日：1987-07-30

申请号：AU2366084

申请日：1984-01-20

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  A61K31/495

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.