公开(公告)号：KR100969564B1

公开(公告)日：2010-07-12

申请号：KR1020080065534

申请日：2008-07-07

Applicant: (주)아모레퍼시픽

Inventor： 김은주 ,  김수정 ,  노호식 ,  문은정 ,  조가영 ,  김덕희 ,  김한곤 ,  노민수

IPC: A61B10/00

Abstract: 본 발명은 후보 물질의 피부 보습력을 측정하는 방법으로서, 상기 후보물질을 청포묵에 도포한 후, 청포묵의 수분 보유력을 측정하는 단계를 포함하는 것을 특징으로 하는 후보 물질의 피부 보습력 측정방법을 제공한다.
본 발명에 따르면, 후보 물질에 대한 피부 보습력을 측정하는 경우, 특정 기기로 후보 물질이 도포된 피부층을 측정하는 경우에 한하여 소정의 수치로 표현 가능하던 종래의 피부 보습력 측정 방법과 달리, 청포묵을 통한 비교적 간단한 방법을 통해 후보 물질에 대한 피부의 보습력을 수치적으로 평가할 수 있다.
피부 보습력 측정방법, 청포묵

公开(公告)号：KR1020100055733A

公开(公告)日：2010-05-27

申请号：KR1020080114594

申请日：2008-11-18

Applicant: (주)아모레퍼시픽

Inventor： 박준성 ,  박혜윤 ,  김동현 ,  이상민 ,  신동욱 ,  김신형 ,  노민수 ,  김덕희 ,  김한곤

IPC: A61K31/366 ,  A61K31/352 ,  A61P17/00

CPC classification number: A61K31/352 ,  A61K9/0014 ,  A61K31/366

Abstract: PURPOSE: An external use skin composition containing ortho-dihydroxyisoflavone derivative is provided to improve expression of DKK3 proein and FZD1 protein and to suppress hyperproliferation. CONSTITUTION: An external use skin composition for suppressing epidermis hyperproliferation and treating inflammatory skin diseases contains 0.001-30 weight% of ortho-dihydroxyisoflavone derivative, 4'6,7-trihydroxy isoflavone, 3',4'7-trihydroxyisoflavone, or mixture thereof as an active ingredient. The composition is used in the form of skin softener, astringent, lotion, eye cream, massage cream, cleansing cream, cleansing foam, cleansing water, powder, essence, or pack.

Abstract translation: 目的：提供含有邻二羟基异黄酮衍生物的外用皮肤组合物，以改善DKK3 proein和FZD1蛋白的表达，抑制过度增殖。 构成：用于抑制表皮过度增殖和治疗炎性皮肤病的外用皮肤组合物含有0.001-30重量％的邻二羟基异黄酮衍生物，4'6,7-三羟基异黄酮，3'，4,7-二羟基异黄酮，或其混合物 活性成分。 该组合物以皮肤柔软剂，收敛剂，洗剂，眼霜，按摩霜，清洁霜，清洁泡沫，清洁水，粉末，精华或包装的形式使用。

公开(公告)号：KR1020100042708A

公开(公告)日：2010-04-27

申请号：KR1020080101820

申请日：2008-10-17

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  신동욱 ,  이찬우 ,  김한성 ,  김진웅 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K31/352 ,  A61Q19/00

Abstract: PURPOSE: A composition containing amentoflavone as an active ingredient is provided to increase alpha-6 integrin and to promote kerationcyte stem cell proliferation. CONSTITUTION: A composition for promoting skin regeneration contains amentoflavone as an active ingredient of formula 1. The composition is a cosmetic composition. A cosmetic composition contains 0.001-10 weight% of amentoflavone. The cosmetic composition is contained in lotion type, cream type, and pack type formulation. The composition also is a pharmaceutical composition. The pharmaceutical composition contains 0.001-10 weight% of amentoflavone. The pharmaceutical composition is contained in soft capsule, tablet, or granule.

Abstract translation: 目的：提供含有黄酮黄酮作为活性成分的组合物以增加α-6整联蛋白并促进细胞干细胞增殖。 构成：用于促进皮肤再生的组合物含有作为式1的有效成分的黄酮黄酮。组合物是化妆品组合物。 化妆品组合物含有0.001-10重量％的叶黄酮。 化妆品组合物包含在洗剂型，奶油型和包装型制剂中。 组合物也是药物组合物。 药物组合物含有0.001-10重量％的黄酮黄酮。 药物组合物包含在软胶囊，片剂或颗粒中。

公开(公告)号：KR1020100012076A

公开(公告)日：2010-02-05

申请号：KR1020080073605

申请日：2008-07-28

Applicant: (주)아모레퍼시픽

Inventor： 박선미 ,  신동욱 ,  이상민 ,  송민정 ,  김신형 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61K35/28 ,  A61Q19/08

CPC classification number: A61K8/97 ,  A61K35/28 ,  A61Q19/08

Abstract: PURPOSE: A composition containing medicinal herb extract for skin care or plastic surgery is provided to promote differentiation of human mesenchymal stem cells to adipocytes and improve adipose. CONSTITUTION: A composition for promoting differentiation of adipocytes contains Crassirhizomae Rhizoma, Linderae Radix, Cinnamomum cassia, and Saphora flavescens extract as an active ingredient. The medicinal herb extract is obtained using organic solvent such as water and ethanol. The composition enhances adipose. The composition promotes differentiation of human mesenchymal stem cells to adipocytes. The composition is used in the form of skin softener, nutrition lotion, massage cream, pack, gel, or skin viscosity type cosmetic product.

Abstract translation: 目的：提供含有用于护肤或整形手术的药用草药提取物的组合物，以促进人类间充质干细胞向脂肪细胞分化并改善脂肪。 构成：用于促进脂肪细胞分化的组合物含有Crassirhizomae Rhizoma，Linderae Radix，Cinnamomum Cassia和Saphora flavescens提取物作为活性成分。 使用有机溶剂如水和乙醇获得草药提取物。 组合物增强脂肪。 该组合物促进人间充质干细胞向脂肪细胞的分化。 该组合物以皮肤柔软剂，营养乳液，按摩霜，包装，凝胶或皮肤粘度型化妆品的形式使用。

公开(公告)号：KR1020100008541A

公开(公告)日：2010-01-26

申请号：KR1020080069083

申请日：2008-07-16

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  신동욱 ,  박선미 ,  송민정 ,  노민수 ,  김한곤

IPC: A61K36/428 ,  A61K36/60 ,  A61P3/10

Abstract: PURPOSE: A composition promoting adipocyte differentiation of human mesenchymal stem cells is provided to ensure volume and elasticity of the skin and effectively prevent or treat diabetes type 2. CONSTITUTION: A composition for promoting adipocyte differentiation contains Trichosanthis Semen extract or Cannabis Semen extract as an active ingredient. A composition for preventing or treating diabetes contains the Trichosanthis Semen extract or Cannabis Semen extract as an active ingredient. The composition promotes differentiation of human mesenchymal stem cells to adipocytes. The human mesenchymal stem cells are derived from human bone marrow.

Abstract translation: 目的：提供促进人类间充质干细胞脂肪细胞分化的组合物，以确保皮肤的体积和弹性，并有效预防或治疗2型糖尿病。构成：用于促进脂肪细胞分化的组合物含有Trichosanthis精液提取物或大麻精液提取物作为活性成分 成分。 用于预防或治疗糖尿病的组合物含有Trichosanthis Semen提取物或大麻精液提取物作为活性成分。 该组合物促进人间充质干细胞向脂肪细胞的分化。 人类间充质干细胞来自人骨髓。

公开(公告)号：KR1020090126692A

公开(公告)日：2009-12-09

申请号：KR1020080052915

申请日：2008-06-05

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  송민정 ,  신동욱 ,  박선미 ,  노민수 ,  김한곤

IPC: A61K36/185 ,  A61P3/10 ,  A61P3/00

Abstract: PURPOSE: A composition for promoting adipocyte differentiation, containing Torreya nucifera extract is provided to use in skin cosmetic or plastic surgery, prevent and treat diabetes. CONSTITUTION: A composition for promoting adipocyte differentiation contains Torreya nucifera extract as an active ingredient. The composition has function of increasing adipose tissue through differentiation of the adipocytes. The adipocyte is differentiated adipocyte from preadipocyte or mesenchymal stem cell of mammal. The mesenchymal stem cell of mammal is human mesenchymal stem cell derived from human bone marrow. The composition increases adipose tissue for skin cosmetic or plastic surgery. The composition is used in preventing or treating diabetes type 2. The daily dose of an active ingredient is 0.0001mg/kg/day~2000g/kg/day.

Abstract translation: 目的：提供用于促进脂肪细胞分化的组合物，其含有Torreya Nucifera提取物用于皮肤美容或整形手术，预防和治疗糖尿病。 构成：用于促进脂肪细胞分化的组合物含有作为活性成分的Torreya Nucifera提取物。 该组合物具有通过脂肪细胞分化增加脂肪组织的功能。 脂肪细胞是哺乳动物前脂肪细胞或间充质干细胞分化的脂肪细胞。 哺乳动物的间充质干细胞来自人骨髓的人间充质干细胞。 组合物增加皮肤美容或整形手术的脂肪组织。 该组合物用于预防或治疗2型糖尿病。活性成分的日剂量为0.0001mg / kg /天〜2000g / kg /天。

公开(公告)号：KR1020090125948A

公开(公告)日：2009-12-08

申请号：KR1020080052041

申请日：2008-06-03

Applicant: (주)아모레퍼시픽

Inventor： 이상민 ,  송민정 ,  신동욱 ,  노민수 ,  김한곤

IPC: A61K8/97 ,  A61Q19/00

CPC classification number: A61K8/97 ,  A61K36/74 ,  A61K2800/92 ,  A61Q19/08

Abstract: PURPOSE: A composition conaining Oldenlandia diffusa extract for skin cosmetic or beauty as an active ingredient is provided to promote differentiation of human mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for differentiation of adipocyte contains Oldenlandia diffusa extract as an active ingredient. The composition is for increasing adipose tissue. The composition promotes differentiation of human mesenchymal stem cells to adipocyte. The human mesenchymal stem cells are mesenchymal stem cells from human bone marrow. The cosmetic composition is used in the form of massage cream, nutrition cream, pack, and gel.

Abstract translation: 目的：为了促进人类间充质干细胞向脂肪细胞的分化，提供了一种赋予皮肤美容或美容作为活性成分的奥兰达氏锥体提取物的组合物。 构成：用于分化脂肪细胞的组合物含有苦参提取物作为活性成分。 该组合物用于增加脂肪组织。 该组合物促进人间充质干细胞向脂肪细胞的分化。 人类间充质干细胞是人骨髓间充质干细胞。 化妆品组合物以按摩霜，营养霜，包装和凝胶的形式使用。

公开(公告)号：KR100903974B1

公开(公告)日：2009-06-25

申请号：KR1020070097553

申请日：2007-09-27

Applicant: 한국화학연구원 ,  (주)아모레퍼시픽

Inventor： 공영대 ,  조희영 ,  전문국 ,  이태호 ,  최길돈 ,  공재양 ,  정대영 ,  황순희 ,  김정주 ,  이창훈 ,  고재영 ,  노민수 ,  한은실 ,  김형준 ,  김혁 ,  윤준원 ,  모주현 ,  김도훈

IPC: C07D277/44 ,  C07D417/04 ,  C07D417/12 ,  A61K31/426

CPC classification number: C07D277/46 ,  C07D417/04 ,  C07D417/12

Abstract: 본 발명은 하기 화학식 1로 표시되는 2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용 가능한 그의 염, 그의 제조방법 및 그를 유효성분으로 함유하는 SPC 수용체 활성으로 유발되는 염증관련 질환에 유용한 그의 용도에 관한 것이다.
본 발명의 2,4,5-삼중치환-1,3-티아졸 유도체는 사람으로부터 유래된 진피세포 및 마우스를 이용한 동물실험을 통하여 항염증 효과를 검색한 결과, SPC 수용체에 대한 우수한 억제활성을 규명함으로써, 상기 2,4,5-삼중치환-1,3-티아졸 유도체 및 약제학적으로 허용 가능한 그의 염을 유효성분으로 함유하여 SPC 수용체 활성으로 유발되는 아토피성 피부염, 기타 질환에서 나타나는 염증, 소양증 또는 피부 감염증에 유효한 염증관련 질환 치료제로서 유용하게 활용될 수 있다.


(상기 식에서, R
1 , R
2 , 및 R
3 는 명세서에서 정의한 바와 같다.)
1,3-티아졸, 스핀고실포스포릴콜린, 아토피 피부염, 염증치료제

公开(公告)号：KR1020090032373A

公开(公告)日：2009-04-01

申请号：KR1020070097554

申请日：2007-09-27

Applicant: 한국화학연구원 ,  (주)아모레퍼시픽

Inventor： 공영대 ,  조희영 ,  전문국 ,  이태호 ,  최길돈 ,  공재양 ,  박우규 ,  황순희 ,  김정주 ,  이창훈 ,  고재영 ,  노민수 ,  한은실 ,  김혁 ,  윤준원 ,  모주현 ,  김도훈

IPC: C07D401/12 ,  A61K31/498 ,  A61P29/00

CPC classification number: C07D401/12

Abstract: Provided is a 3-chloro-5-substituted-quinoxaline-2-amine derivative and a therapeutic agent using the 3-chloro-5-substituted-quinoxaline-2-amine derivative so as to treat diseases associated with inflammation. A 3-chloro-5-substituted-quinoxaline-2-amine derivative is represented by the formula 1. In the formula 1, R∧1 indicates hydrogen, linear or branched C1-C10 alkyl group, C1-C10 alkoxy group or halogen; R∧2 shows linear or branched C1-C10 alkyl group, C1-C10 alkoxy group, hydroxyl group, halogen group, amine group or substituted amine group, amide group, carbamate group or urea group. In the formula 1, the substituted group indicates a substituted phenyl group wherein one or four groups selected from the group consisting of a linear or branched C1-C10 alkyl group, halogen, nitro group, C1-C10 alkyl group, C1-C10 alkoxy group and C1-C10 haloalkyl group are substituted.

Abstract translation: 本发明提供3-氯-5-取代喹喔啉-2-胺衍生物和使用3-氯-5-取代喹喔啉-2-胺衍生物的治疗剂，以治疗与炎症相关的疾病。 3-氯-5-取代喹喔啉-2-胺衍生物由式1表示。在式1中，R 1表示氢，直链或支链C 1 -C 10烷基，C 1 -C 10烷氧基或卤素; R 2表示直链或支链C 1 -C 10烷基，C 1 -C 10烷氧基，羟基，卤素基，胺基或取代胺基，酰胺基，氨基甲酸酯基或脲基。 在式1中，取代基表示取代的苯基，其中选自直链或支链C 1 -C 10烷基，卤素，硝基，C 1 -C 10烷基，C 1 -C 10烷氧基中的一个或四个基团 和C 1 -C 10卤代烷基被取代。

公开(公告)号：KR1020080051201A

公开(公告)日：2008-06-11

申请号：KR1020060121861

申请日：2006-12-05

Applicant: (주)아모레퍼시픽

Inventor： 김형준 ,  김혁 ,  성기사 ,  김대권 ,  조선아 ,  김광미 ,  노민수 ,  이창훈 ,  김정주

IPC: A61K31/685 ,  A61K31/661

CPC classification number: A61K31/688 ,  Y10S514/863 ,  Y10S514/886

Abstract: A pharmaceutical composition comprising sphingosylphosphorylcholine or derivatives thereof is provided to inhibit proliferation and promote differentiation of keratinocyte, inhibit proliferation of splenocyte and T cell, induce reduction of leucocyte, and reduce mouse ear swelling induced by TPA(tetradecanoyl phorbol acetate), so that the composition is useful for treating psoriasis. A pharmaceutical composition for treating psoriasis comprises sphingosylphosphorylcholine(SPC) represented by the formula(1) or derivatives thereof and is formulated as tablet, pill, powder, sachet, elixir, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, sterile injection or sterile powder, wherein the daily dosage is 1-100 mg/kg, preferably 5-70 mg/kg.

Abstract translation: 提供包含鞘氨醇磷酰胆碱或其衍生物的药物组合物，以抑制角质形成细胞的增殖和促进分化，抑制脾细胞和T细胞的增殖，诱导白细胞的减少，并减少TPA（十四酰基佛波醇乙酸酯）诱导的小鼠耳肿胀，使组合物 可用于治疗牛皮癣。 用于治疗牛皮癣的药物组合物包含由式（1）表示的鞘糖基磷酰胆碱（SPC）或其衍生物，并配制成片剂，丸剂，粉末，小药囊，酏剂，悬浮液，乳剂，溶液，糖浆，气雾剂，软或硬明胶胶囊 无菌注射或无菌粉末，其中日剂量为1-100mg / kg，优选5-70mg / kg。