公开(公告)号：SI9520061B

公开(公告)日：2002-02-28

申请号：SI9520061

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：AU7919600A

公开(公告)日：2001-04-23

申请号：AU7919600

申请日：2000-10-13

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  PFEIFFER THOMAS

IPC: C07D277/30 ,  C07D277/56

公开(公告)号：PL180652B1

公开(公告)日：2001-03-30

申请号：PL32115995

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MUELLER STEFAN ,  DE POTZOLLI BERND ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  A61K38/00 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：HRP950271B1

公开(公告)日：2000-08-31

申请号：HRP950271

申请日：1995-05-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  HARALD BERNARD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND ,  KARL ULRICH ,  KLING ANDREAS ,  MULLER STEFAN ,  POTZOLLI BERND DE ,  RITTER KURT ,  THYES MARCO ,  ZIERKE THOMAS

IPC: A61K38/08 ,  A61K38/00 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.

公开(公告)号：CA2347757A1

公开(公告)日：2000-04-27

申请号：CA2347757

申请日：1999-10-13

Applicant: BASF AG

Inventor： MUNSCHAUER RAINER ,  VIERGUTZ WOLFGANG ,  BUSCHMANN ERNST ,  STEINER GERD ,  BISCHOF NORBERT ,  PFEIFFER THOMAS ,  KREI GEORG ARNOLD ,  HENNINGSEN MICHAEL

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3-azabicycl o- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds are characterized in that a bisallyl ammonium salt of formula (II), in which R has the above- mentioned meanings and X- represents an anion, is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+) - exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystallized out of an alcohol/water mixture.

公开(公告)号：AT185349T

公开(公告)日：1999-10-15

申请号：AT96925744

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：HU9900089A2

公开(公告)日：1999-05-28

申请号：HU9900089

申请日：1996-10-30

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  DE ARRUDA MONIKA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS ,  MUELLER STEFAN ,  RITTER KURT ,  ROBINSON SIMON ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  C07K7/06 ,  A61K38/08

Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.

公开(公告)号：AU705143B2

公开(公告)日：1999-05-13

申请号：AU6615496

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANSSEN BERND ,  ULRICH KARL ,  KLING ANDREAS ,  MULLER STEFAN ,  RITTER KURT ,  ZIERKE THOMAS

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：ES2126279T3

公开(公告)日：1999-03-16

申请号：ES95917962

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  JANITSCHKE LOTHAR ,  JANSSEN BERND

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.

公开(公告)号：PL175612B1

公开(公告)日：1999-01-29

申请号：PL30057893

申请日：1993-10-04

Applicant: BASF AG

Inventor： KLEIN ULRICH ,  BUSCHMANN ERNST ,  KEIL MICHAEL ,  GOETZ NORBERT ,  HARTMANN HORST

IPC: C07C239/20 ,  C07C217/06

Abstract: O-Substituted hydroxylammonium salts are prepared by hydrolysis of acetone oxime ethers with acid in the presence of an additive and removal of acetone and water by distillation with the aid of the additive.