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公开(公告)号：KR1020120075677A
公开(公告)日：2012-07-09
申请号：KR1020100137437
申请日：2010-12-29
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/288 , A61P25/28 , A61P25/00
Abstract: PURPOSE: A composition containing Taraxacum officinale extract is provided to suppress BSE-modified prion production or remove the prion and to prevent or treat BSE. CONSTITUTION: A veterinary composition for preventing or treating BSE contains Taraxacum officinale extract. The composition is manufactured in the form of powder, granules, capsules, suspension, emulsion, solution, syrup, aerosol, soft or hard gelatin capsule, suppository, sterilized injection solution, and sterilized external use formulation. The extract is prepared using water, low carbon number alcohol of C1-C4, and a mixture solvent thereof. A feed additive composition for preventing or treating BSE contains the extract.
Abstract translation: 目的：提供含有蒲公英提取物的组合物以抑制BSE修饰的朊病毒产生或去除朊病毒并预防或治疗疯牛病。 组成：用于预防或治疗疯牛病的兽用组合物含有蒲公英提取物。 组合物以粉末，颗粒，胶囊，悬浮液，乳液，溶液，糖浆，气溶胶，软或硬明胶胶囊，栓剂，灭菌注射溶液和灭菌外用制剂的形式制造。 提取物是使用C1-C4的低碳数醇及其混合溶剂制备的。 用于预防或治疗BSE的饲料添加剂组合物含有提取物。
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公开(公告)号：KR1020110009967A
公开(公告)日：2011-01-31
申请号：KR1020090067436
申请日：2009-07-23
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: PURPOSE: A monoclonal antibody for specifically detecting abnormal prion of spongiform encephalopathy is provided. CONSTITUTION: A fusion cell line of deposit number KCLRF-BP-00213 produces monoclonal antibody for detecting abnormal prion of spongiform encephalopathy. A method for preparing fusion cell line comprises: a step of inoculating a peptide of sequence number 1 to a knock-out mouse; a step of isolating B cells from the mouse; and a step of fusing the B cells and mouse myeloma-derived cells. The abnormal prion of spongiform encephalopathy is detected by western blotting using the monoclonal antibody.
Abstract translation: 目的：提供特异性检测海绵状脑病异常朊病毒的单克隆抗体。 构成：存在编号为KCLRF-BP-00213的融合细胞系产生用于检测海绵状脑病异常朊病毒的单克隆抗体。 制备融合细胞系的方法包括：将序列号1的肽接种到敲除小鼠的步骤; 从小鼠中分离出B细胞的步骤; 以及融合B细胞和小鼠骨髓源性细胞的步骤。 使用单克隆抗体通过western印迹检测海绵状脑病的异常朊病毒。
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公开(公告)号：KR1020040073034A
公开(公告)日：2004-08-19
申请号：KR1020030008750
申请日：2003-02-12
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C07K7/08
CPC classification number: C07K7/08 , G01N33/56983 , G01N2333/115
Abstract: PURPOSE: A peptide specifically reactive with antibodies against rinderpest virus and uses thereof are provided, thereby reducing the detection time and improving detection activity of rinderpest virus antibodies by using the peptide with bovine serum albumin. CONSTITUTION: The peptide specifically reactive with antibodies against rinderpest virus has the amino acid sequence set forth in SEQ ID NO:1, wherein the peptide further contains cysteine in the N-terminal and amino group(-NH2) in the C-terminal. A composition for detecting antibodies against rinderpest virus contains the peptide of SEQ ID NO:1. A kit for detecting antibodies against rinderpest virus contains the peptide of SEQ ID NO:1.
Abstract translation: 目的：提供与抗牛瘟病毒抗体特异性反应的肽及其用途，通过使用牛血清白蛋白的肽，减少检测时间，提高牛瘟病毒抗体检测活性。 构成：与牛瘟病毒抗体特异性反应的肽具有SEQ ID NO：1所示的氨基酸序列，其中肽在N-末端还含有C-末端的氨基（-NH 2）。 用于检测针对牛瘟病毒的抗体的组合物含有SEQ ID NO：1的肽。 用于检测针对牛瘟病毒的抗体的试剂盒含有SEQ ID NO：1的肽。
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14.发明公开
公开(公告)号：KR1020030052858A
公开(公告)日：2003-06-27
申请号：KR1020010082976
申请日：2001-12-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N15/33
CPC classification number: C12N15/866 , C07K14/005 , C07K16/1009 , C07K2317/14 , C12N5/163 , C12N2770/32131 , G01N33/56983 , G01N33/577 , G01N2333/09
Abstract: PURPOSE: Diagnostic methods of foot-and-mouth disease using recombinant 3ABC non-structural protein expressed in insect cells and a monoclonal antibody is provided, thereby more rapidly and accurately diagnosing the foot-and-mouth disease than the prior methods. CONSTITUTION: A gene encoding a recombinant 3ABC non-structural protein derived from Korean foot-and-mouth disease virus O/SKR/2000 has the nucleotide sequence of SEQ ID NO: 1. A recombinant baculovirus to be expressed in insect cells is prepared by co-transfection with a recombinant vector containing the recombinant 3ABC non-structural protein gene of SEQ ID NO: 1. The recombinant 3ABC non-structural protein is expressed by infection of the insect cells with the recombinant baculovirus. A hybridoma cell line 3F-11(KCTC 10138BP) is prepared by introducing the recombinant 3ABC non-structural protein expressed in E. coli into an animal, collecting an immunized cell from the animal and fusing the immunized cell with a cancer cell. A monoclonal antibody is produced from the hybridoma cell line 3F-11(KCTC 10138BP). A diagnostic method of foot-and-mouth disease comprises the steps of: (1) diluting the recombinant 3ABC non-structural protein in a coating buffer solution and pouring the diluate on a plate; (2) reacting the testing serum with the plate; (3) reacting a conjugate, which binds with an antibody for foot-and-mouth disease virus in the testing serum and has an enzyme, a radioactive material or a fluorescent material, with the testing serum; and (4) measuring intensity of the enzyme reaction, fluorescence reaction or radiation reaction with the conjugate.
Abstract translation: 目的：提供使用在昆虫细胞中表达的重组3ABC非结构蛋白和单克隆抗体的口蹄疫诊断方法，从而比现有方法更快速，准确地诊断口蹄疫。 构成：编码来自韩国口蹄疫病毒O / SKR / 2000的重组体3ABC非结构蛋白的基因具有SEQ ID NO：1的核苷酸序列。在昆虫细胞中表达的重组杆状病毒通过 用含有SEQ ID NO：1的重组3ABC非结构蛋白基因的重组载体共转染。重组体3ABC非结构蛋白用重组杆状病毒感染昆虫细胞表达。 通过将在大肠杆菌中表达的重组3ABC非结构蛋白质导入动物中，从动物中收集免疫的细胞并将免疫的细胞与癌细胞融合来制备杂交瘤细胞系3F-11（KCTC 10138BP）。 从杂交瘤细胞系3F-11（KCTC 10138BP）产生单克隆抗体。 口蹄疫的诊断方法包括以下步骤：（1）在包被缓冲溶液中稀释重组体3ABC非结构蛋白，将稀释液倒入平板上; （2）使测试血清与板反应; （3）使与测试血清中的口蹄疫病毒抗体结合并具有酶，放射性物质或荧光材料的缀合物与测试血清反应; 和（4）测量酶反应的强度，荧光反应或与缀合物的辐射反应。
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15.发明授权흑염소의 프리온 단백질을 코딩하는 유전자를 포함하는 발현 벡터 및 이에 의하여 형질도입된 세포 有权表达载体，其包含来自Capra aegagrus hircus的编码朊病毒蛋白的基因和通过其转染的细胞
公开(公告)号：KR101491813B1
公开(公告)日：2015-02-16
申请号：KR1020120151209
申请日：2012-12-21
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 흑염소의 프리온 단백질을 코딩하는 유전자를 포함하는 발현 벡터 및 상기 벡터에 의해 형질도입된 세포에 관한 것으로, 이를 이용하여 국내 사육되는 흑염소를 대표하는 다형성을 가진 세포 및 형질전환 마우스를 제조할 수 있고, 염소과 동물에서 발생하는 스크래피질병(Scrapie)을 포함하는 프리온 질병의 진단을 포함하는 연구를 위한 실험동물모델 개발 및 국내 TSE 질병의 종간전파여부를 확인하는데 유용하게 이용될 수 있다.
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Patent Agency Ranking
公开(公告)号：KR101315261B1
公开(公告)日：2013-10-10
申请号：KR1020100137437
申请日：2010-12-29
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/288 , A61P25/28 , A61P25/00
Abstract: 본 발명은 민들레 추출물을 포함하는 소해면상뇌증(Bovine Spongiform Encephalopathy, BSE)의 예방 또는 치료용 조성물에 관한 것이다. 보다 구체적으로, 본 발명은 민들레 추출물을 포함하는 소해면상뇌증의 예방 또는 치료용 수의학적 조성물, 동물사료 첨가제용 조성물, 또는 동물사료용 조성물에 관한 것이다. 본 발명의 조성물은 세포에 지속적으로 감염된 소해면상뇌증 변형 프리온의 생산을 억제 또는 제거시킴으로써 소해면상뇌증을 예방 또는 치료하는 효과가 있다.
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17.发明公开백일홍 추출물을 포함하는 소해면상뇌증의 예방 또는 치료용 조성물 有权包含ZINNIA ELEGANS提取物的组合物，用于预防或治疗BOVINE SPUNIFORM ENCEPHALOPATHY
公开(公告)号：KR1020130052804A
公开(公告)日：2013-05-23
申请号：KR1020110118056
申请日：2011-11-14
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: A61K36/28 , A61K36/61 , A61K36/185 , A61P25/28
Abstract: PURPOSE: A composition containing a Zinnia elegans extract for preventing or treating BSE(bovine spongiform encephalopathy) is provided to suppress abnormal prion, and to be used as an eco-friendly preservative or therapeutic agent for BSE. CONSTITUTION: A veterinary composition for preventing or treating BSE contains a Zinnia elegans extract. The extract is prepared using a solvent selected from a group consisting of water, C1-C4 alcohol, and a mixture thereof. The concentration of the extract is 12.5 microgram/ml. A feed additive composition for preventing or treating BSE contains the extract. A feed composition for preventing or treating BSE contains the extract.
Abstract translation: 目的：提供含有用于预防或治疗疯牛病（牛海绵状脑病）的百日草属元素提取物以抑制异常朊病毒的组合物，并用作BSE的环保型防腐剂或治疗剂。 构成：用于预防或治疗疯牛病的兽用组合物含有百日草属提取物。 提取物使用选自水，C 1 -C 4醇及其混合物的溶剂制备。 提取物的浓度为12.5微克/毫升。 用于预防或治疗BSE的饲料添加剂组合物含有提取物。 用于预防或治疗疯牛病的饲料组合物含有提取物。
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18.发明授权
公开(公告)号：KR101149396B1
公开(公告)日：2012-06-27
申请号：KR1020090067453
申请日：2009-07-23
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
Abstract: 본 발명은 사슴의 PrP 펩타이드 중 특정부위를 선발하여 이를 유전자 적중 마우스에 접종하여 면역시킨 후 여기에서 분리한 면역 B 세포와 마우스 골수종유래세포를 융합하여 제조한 융합세포주; 상기 융합세포주로부터 생산되고 사슴만성소모성질병의 변형프리온(PrP
sc )을 사슴의 정상프리온 및 소해면상뇌증 및 스크래피(Scrapie) 등의 다른 전염성해면상뇌증의 변형프리온과 감별하여 검출해 내는 단클론항체 및 그 용도에 관한 것이다.
사슴만성소모성질병, 변형프리온, 단클론항체, 융합세포주, PrP 펩타이드, 전염성해면상뇌증-
公开(公告)号：KR1020110057733A
公开(公告)日：2011-06-01
申请号：KR1020090114269
申请日：2009-11-25
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N5/10 , C12N15/12 , C12N15/867
CPC classification number: C12N7/00 , C12N2740/15043 , C12N2790/10051
Abstract: PURPOSE: A method for preparing TSE(transmissible spongiform encephalopathy) sensitive cells is provided to develop novel drugs. CONSTITUTION: A method for preparing TSE-sensitive cells comprises: a step of isolating normal prion protein gene from the brain of an animal which infected by TSE and cloning; a step of inserting the gene to a lentivirus transfer vector to prepare infectious recombinant lentivirus; and a step of inoculating the infectious recombinant lentivirus to non-animal mammal cell line to prepare transformed cells which express a normal prion protein.
Abstract translation: 目的：提供一种制备TSE（传染性海绵状脑病）敏感细胞的方法开发新药。 构成：用于制备TSE敏感细胞的方法包括：从TSE感染的动物的脑中分离正常的朊病毒蛋白基因和克隆的步骤; 将该基因插入慢病毒转移载体以制备感染性重组慢病毒的步骤; 以及将感染性重组慢病毒接种到非动物哺乳动物细胞系以制备表达正常朊病毒蛋白的转化细胞的步骤。
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公开(公告)号：KR1020000021058A
公开(公告)日：2000-04-15
申请号：KR1019980039989
申请日：1998-09-25
Applicant: 대한민국(농림축산식품부 농림축산검역본부장)
IPC: C12N1/20
Abstract: PURPOSE: The development of a diagnostic kit of Neosporosis, which is a major cause of abortion in cattle, rapidly and accurately is provided which promotes diagnostic efficiency. CONSTITUTION: The development of a diagnostic kit is provided for diagnosing Neosporosis which is a major cause of abortion in cattle rapidly and accurately. The kit is produced by separating bovine Neospora protozoal strains from a newborn baby' brain of dairy kettle, which is incapable of standing up immediately after a birth, and culturing in large quantities by cell culturing and attaching to a Teflon-coated slide.
Abstract translation: 目的：提供快速准确地开发牛血清流产的主要原因的新孢子虫病诊断试剂盒，从而提高诊断效率。 规定：开发诊断试剂盒用于诊断新孢子虫病，这是导致牛流产的主要原因。 该试剂盒通过从新生婴儿的乳壶脑中分离牛新胞子虫原生动物菌株而产生，其不能在出生后立即站立，并通过细胞培养大量培养并附着在特氟隆涂覆的载玻片上。
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