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    돼지 소모성 질병의 치료 또는 예방을 위한 젖소 초유 항체 조성물
    5.
    发明授权
    돼지 소모성 질병의 치료 또는 예방을 위한 젖소 초유 항체 조성물 有权
    用于治疗或预防卵磷脂疾病的牛血清的抗体组合物

    公开(公告)号：KR101411995B1

    公开(公告)日：2014-06-24

    申请号：KR1020130166017

    申请日：2013-12-27

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장) ,  주식회사 삼양애니팜

    Inventor： 이경기 ,  현방훈 ,  박최규 ,  김성희 ,  엄재구 ,  김연희 ,  이명헌 ,  전용수 ,  민필홍 ,  홍창호 ,  김정은 ,  김우영

    IPC: A61K39/395 ,  C07K16/04 ,  C07K16/18

    CPC classification number: A61K39/39533 ,  A61K2039/552 ,  Y10S424/815 ,  Y10S424/825

    Abstract: The present invention comprises antibodies which are obtained by vaccinating the antigen of a pig epidemic diarrhea disease, the antigen of pig epidemic gastroenteritis, the antigen of a pig rotaviral infection, the antigen of a pig circovirus infection, the antigen of pig colibacillosis, and the antigen of pig salmonellosis to a milk cow. The present invention relates to an antibody composition for treating or preventing wasting diseases of a pig such as the pig epidemic diarrhea disease, pig epidemic gastroenteritis, pig rotaviral infection, pig circovirus infection, pig colibacillosis, and pig salmonellosis. The antibody composition according to the present invention is a high incidence antibody composition which treats and/or prevents the wasting diseases of pigs which cause death and growth delays.

    Abstract translation: 本发明包括通过疫苗接种猪流行性腹泻病的抗原，猪流行性胃肠炎的抗原，猪轮状病毒感染的抗原，猪圆环病毒感染的抗原，猪大肠杆菌病的抗原和 将猪沙门氏菌病的抗原转移至奶牛。 本发明涉及用于治疗或预防诸如猪流行性腹泻病，猪流行性胃肠炎，猪轮状病毒感染，猪圆环病毒感染，猪大肠杆菌病和猪沙门氏菌病的猪的浪费疾病的抗体组合物。 根据本发明的抗体组合物是治疗和/或预防引起死亡和生长延迟的猪的消耗性疾病的高发病率抗体组合物。

    중탄산염을 포함하는 염소 흔들이병 치료용 약학적 조성물
    6.
    发明公开
    중탄산염을 포함하는 염소 흔들이병 치료용 약학적 조성물 有权
    药用组合物，包括用于山羊痘痘综合征的二碳酸酯

    公开(公告)号：KR1020130036474A

    公开(公告)日：2013-04-12

    申请号：KR1020110100569

    申请日：2011-10-04

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 정병열 ,  김대근 ,  변재원 ,  김하영 ,  신동호 ,  엄재구 ,  조윤상 ,  박최규 ,  문운경 ,  이오수

    IPC: A61K33/14 ,  A61K33/10 ,  A61P43/00

    Abstract: PURPOSE: A pharmaceutical composition for goat floppy kid syndrome treatment including bicarbonate is provided to apply the composition to goats in a large scale farm by orally applying to the goats. CONSTITUTION: A pharmaceutical composition for goat floppy kid syndrome treatment including bicarbonate comprises 5-95 weight% of bicarbonate and 5-95 weight% of pharmaceutically approved excipient. The pharmaceutical composition for the goat floppy kid syndrome treatment including bicarbonate comprises 5-94 weight% of bicarbonate, 5-90 weight% of pharmaceutically approved excipient, and 1-10 weight% of additive. The pharmaceutical composition for the goat floppy kid syndrome is orally applied to goats. [Reference numerals] (AA) Before injection; (BB) After 4-5 hours; (CC) After 9-12 hours; (DD) After 24-28 hours;

    Abstract translation: 目的：提供山羊软鼠综合征治疗包括碳酸氢盐的药物组合物，通过口服施用于山羊将组合物施用于大型农场的山羊。 构成：包括碳酸氢盐的山羊软皮综合征治疗药物组合物包含5-95重量％的碳酸氢盐和5-95重量％的药学上认可的赋形剂。 用于包括碳酸氢盐的山羊软皮综合征治疗药物组合物包含5-94重量％的碳酸氢盐，5-90重量％的药学上认可的赋形剂和1-10重量％的添加剂。 山羊软蛋白综合征的药物组合物口服施用于山羊。 （附图标记）（AA）注射前; （BB）4-5小时后; （CC）9-12小时后; （DD）24-28小时后;

    비감염성 돼지수포병 바이러스 유사입자와 하이브리도마세포주가 분비하는 단클론항체를 이용한 돼지수포병바이러스 항체 진단방법
    8.
    发明公开
    비감염성 돼지수포병 바이러스 유사입자와 하이브리도마세포주가 분비하는 단클론항체를 이용한 돼지수포병바이러스 항체 진단방법 无效
    使用非感染性糖尿病病毒颗粒抗原和混合抗体制备的单克隆抗体来检测开裂性病毒性病毒抗体的方法

    公开(公告)号：KR1020070025122A

    公开(公告)日：2007-03-08

    申请号：KR1020050080908

    申请日：2005-08-31

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 최강석 ,  고영준 ,  나진주 ,  엄재구 ,  조남인

    IPC: C12N5/00 ,  G01N33/53

    Abstract: A novel method for diagnosing swine vesicular disease virus antibody is provided to rapidly detect the swine vesicular disease virus antibody in a swine serum sample using swine vesicular disease virus-like particle protein antigen, which could be safely produced in a general laboratory. The hybridoma cell line is prepared by inoculating an inactivated swine vesicular disease virus UKG/27/72 strain into mouse and fusing immune cells collected therefrom into cancer cells, and is deposited as a deposition number of KCLRF-BP-00116. The monoclonal antibody against swine vesicular disease is expressed from the hybridoma cell line. The method for diagnosing swine vesicular disease is characterized in that swine vesicular disease is detected by using swine vesicular disease virus-like particle antigen and the monoclonal antibody.

    Abstract translation: 提供了一种用于诊断猪水疱病病毒抗体的新方法，以便在猪血清样品中使用猪水疱病病毒样颗粒蛋白抗原快速检测猪水疱病病毒抗体，这可以在一般实验室中安全生产。 通过将灭活的猪囊泡病病毒UKG / 27/72菌株接种到小鼠中并将从其收集的免疫细胞融合到癌细胞中并将其沉积为KCLRF-BP-00116的沉积数来制备杂交瘤细胞系。 针对猪水泡病的单克隆抗体由杂交瘤细胞系表达。 猪血囊炎诊断方法的特征在于，通过使用猪水疱病病毒样颗粒抗原和单克隆抗体检测猪水泡病。

    곤충세포 발현 재조합 3ＡＢＣ 비구조단백질 항원 및 단클론항체를 이용한 구제역 진단방법
    9.
    发明授权
    곤충세포 발현 재조합 3ＡＢＣ 비구조단백질 항원 및 단클론항체를 이용한 구제역 진단방법 有权
    AB세포발현재조합3ABC비구조단백질항원및단클론항체를이용한구제역진단방곤충

    公开(公告)号：KR100430934B1

    公开(公告)日：2004-05-14

    申请号：KR1020010082976

    申请日：2001-12-21

    Applicant: 대한민국(농림축산식품부 농림축산검역본부장)

    Inventor： 권창희 ,  현방훈 ,  고영준 ,  이광녕 ,  구복경 ,  엄재구 ,  나진주 ,  남향미 ,  박지용 ,  계수정 ,  김인중 ,  이세영 ,  최광석 ,  손현주 ,  주이석

    IPC: C12N15/33

    Abstract: PURPOSE: Diagnostic methods of foot-and-mouth disease using recombinant 3ABC non-structural protein expressed in insect cells and a monoclonal antibody is provided, thereby more rapidly and accurately diagnosing the foot-and-mouth disease than the prior methods. CONSTITUTION: A gene encoding a recombinant 3ABC non-structural protein derived from Korean foot-and-mouth disease virus O/SKR/2000 has the nucleotide sequence of SEQ ID NO: 1. A recombinant baculovirus to be expressed in insect cells is prepared by co-transfection with a recombinant vector containing the recombinant 3ABC non-structural protein gene of SEQ ID NO: 1. The recombinant 3ABC non-structural protein is expressed by infection of the insect cells with the recombinant baculovirus. A hybridoma cell line 3F-11(KCTC 10138BP) is prepared by introducing the recombinant 3ABC non-structural protein expressed in E. coli into an animal, collecting an immunized cell from the animal and fusing the immunized cell with a cancer cell. A monoclonal antibody is produced from the hybridoma cell line 3F-11(KCTC 10138BP). A diagnostic method of foot-and-mouth disease comprises the steps of: (1) diluting the recombinant 3ABC non-structural protein in a coating buffer solution and pouring the diluate on a plate; (2) reacting the testing serum with the plate; (3) reacting a conjugate, which binds with an antibody for foot-and-mouth disease virus in the testing serum and has an enzyme, a radioactive material or a fluorescent material, with the testing serum; and (4) measuring intensity of the enzyme reaction, fluorescence reaction or radiation reaction with the conjugate.

    Abstract translation: 目的：提供使用在昆虫细胞和单克隆抗体中表达的重组3ABC非结构蛋白的口蹄疫诊断方法，从而比现有方法更快速和准确地诊断口蹄疫。 构成：编码来源于韩国口蹄疫病毒O / SKR / 2000的重组3ABC非结构蛋白的基​​因具有SEQ ID NO：1的核苷酸序列。在昆虫细胞中表达的重组杆状病毒由 用含有SEQ ID NO：1的重组3ABC非结构蛋白基因的重组载体共转染。通过用重组杆状病毒感染昆虫细胞表达重组3ABC非结构蛋白。 通过将在大肠杆菌中表达的重组3ABC非结构蛋白导入动物中，从动物中收集免疫的细胞并将免疫的细胞与癌细胞融合来制备杂交瘤细胞系3F-11（KCTC 10138BP）。 从杂交瘤细胞系3F-11（KCTC 10138BP）产生单克隆抗体。 一种口蹄疫诊断方法，包括以下步骤：（1）将重组3ABC非结构蛋白稀释于包被缓冲液中，并将稀释液倒入平板中; （2）使测试血清与平板反应; （3）使与试验血清中的口蹄疫病毒抗体结合的缀合物与测试血清具有酶，放射性物质或荧光物质; 和（4）测量酶反应的强度，荧光反应或与缀合物的辐射反应。

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