公开(公告)号：AU655898B2

公开(公告)日：1995-01-12

申请号：AU4751393

申请日：1993-09-21

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W ,  KEBABIAN JOHN W ,  MARTIN YVONNE C ,  DENINNO MICHAEL P ,  PERNER RICHARD J ,  STOUT DAVID M ,  HSIAO CHI-NUNG W

IPC: A61K31/135 ,  A61K31/35 ,  A61K31/40 ,  A61K31/535 ,  C07C215/52 ,  C07C217/60 ,  C07C219/28 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C271/58 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D207/16 ,  C07D209/44 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/96 ,  C07D319/20 ,  C07D335/06 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/10 ,  C07D493/10 ,  C07K5/06

公开(公告)号：AU5818290A

公开(公告)日：1991-01-07

申请号：AU5818290

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W ,  DEBERNARDIS JOHN F ,  BASHA FATIMA Z ,  MEYER MICHEAL D ,  DE BISWANATH ,  KEBABIAN JOHN W ,  MARTIN YVONNE C ,  DENINNO MICHAEL P ,  PERNER RICHARD J ,  STOUT DAVID M ,  HSIAO CHI-NUNG W ,  DIDOMENICO STANLEY JR ,  EHRLICH PAUL P ,  CAMPBELL JAMES R ,  MORTON HOWARD E ,  LIJEWSKI LINDA M

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/335 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/30 ,  C07C41/02 ,  C07C215/48 ,  C07C215/64 ,  C07C217/56 ,  C07C217/74 ,  C07C219/28 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D209/08 ,  C07D209/62 ,  C07D221/06 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D313/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D493/10 ,  C07K5/06 ,  C07D409/04 ,  C07D209/56 ,  C07D211/00 ,  C07C69/76 ,  A01N43/32 ,  A01N43/16 ,  A61K31/395 ,  A61K31/235 ,  C07D311/74 ,  C07D487/00 ,  A01N43/42 ,  A01N43/62 ,  A01N33/00

Abstract: Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

公开(公告)号：CA2056995A1

公开(公告)日：1990-12-01

申请号：CA2056995

申请日：1990-05-22

Applicant: ABBOTT LAB

Inventor： SCHOENLEBER ROBERT W ,  KEBABIAN JOHN W ,  MARTIN YVONNE C ,  DENINNO MICHAEL P ,  PERNER RICHARD J ,  STOUT DAVID M ,  HSIAO CHI-NUNG W ,  DIDOMENICO STANLEY JR ,  DEBERNARDIS JOHN F ,  BASHA FATIMA Z ,  MEYER MICHAEL D ,  DE BISWANATH ,  EHRLICH PAUL P ,  CAMPBELL JAMES R ,  MORTON HOWARD E ,  LIJEWSKI LINDA M

IPC: A61K31/13 ,  A61K31/135 ,  A61K31/16 ,  A61K31/335 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K38/00 ,  A61P9/00 ,  A61P25/00 ,  A61P25/18 ,  A61P25/30 ,  C07C41/02 ,  C07C215/48 ,  C07C215/64 ,  C07C217/56 ,  C07C217/74 ,  C07C219/28 ,  C07C233/18 ,  C07C237/08 ,  C07C271/16 ,  C07C271/44 ,  C07C309/65 ,  C07C323/60 ,  C07D207/08 ,  C07D209/08 ,  C07D209/62 ,  C07D221/06 ,  C07D221/10 ,  C07D221/20 ,  C07D311/76 ,  C07D311/78 ,  C07D311/96 ,  C07D313/08 ,  C07D405/04 ,  C07D405/06 ,  C07D405/12 ,  C07D407/04 ,  C07D407/12 ,  C07D493/10 ,  C07K5/06 ,  C07D493/04 ,  C07D413/06 ,  A61K31/35 ,  A61K31/395 ,  C07D209/60

Abstract: 2056995 9015056 PCTABS00002 Novel compounds are provided of formula (I), or a pharmaceutically acceptable salt, ester or amide thereof, wherein A is O, S, CHR2, CR2 or C when n is 0 and A and R6 taken together form a nitrogen-containing 5-, 6- or 7-membered ring, and n is zero or 1. The dotted lines represent optional double bonds. R1 is selected from hydrogen and a readily cleavable group. R2 is selected from hydrogen, alkyl, substituted alkyl, alkenyl and alkynyl. R3 is selected from alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic aryl, carbocyclic arylalkyl and heterocycle. R4 is selected from hydrogen and alkyl or, taken together with R3 and the carbon atom to which they are attached, forms a spirocycloalkyl ring of from 3 to 7 carbons. R5 is selected from hydrogen, alkyl and substituted alkyl or, taken together with R3 and the carbon atoms to which they are attached forms a cycloalkyl ring of from 5 to 7 carbons. R6 is selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, carbocyclic arylalkyl, alkanoyl of from 1 to 8 carbons, amino acid and dipeptide or, taken together with A when A is C and when n is 0, forms a nitrogen-containing 5-, 6-, or 7-membered ring. R7 is hydrogen or alkyl or, taken together with R6 or R8, forms a nitrogen-containing 5-, 6- or 7-membered ring, provided that when R6 is carbocyclic arylalkyl, R7 is not alkyl. R8 is hydrogen or alkyl or, taken together with R6 or R7, forms a nitrogen-containing 5-, 6-, or 7-membered ring or, taken together with the catechol ring at the 8-position and the carbon atoms to which they are attached, forms a 5-, 6- or 7-membered ring. The compounds of the invention are useful for treating dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of cognitive impairment, attention deficit disorder, and substance abuse and other addictive behavior disorders.

公开(公告)号：BG107145A

公开(公告)日：2003-05-30

申请号：BG10714502

申请日：2002-09-24

Applicant: ABBOTT LAB

Inventor： HILL DAVID R ,  HSIAO CHI-NUNG W ,  KURUKULASURIYA RAVI ,  WITTENBERGER STEVEN J

IPC: C07D233/74 ,  C07C239/10 ,  C07C259/06 ,  C07D277/34 ,  C07D317/28 ,  C07C231/02

Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines. 11 claims

公开(公告)号：PT971919E

公开(公告)日：2002-04-29

申请号：PT98904979

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：DK0971919T3

公开(公告)日：2002-01-28

申请号：DK98904979

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：AT207920T

公开(公告)日：2001-11-15

申请号：AT98904979

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：AU724353B2

公开(公告)日：2000-09-21

申请号：AU6271898

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

公开(公告)号：BG103737A

公开(公告)日：2000-06-30

申请号：BG10373799

申请日：1999-09-16

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: The invention relates to a method for the preparation of compounds with the formula where R1, R2, R3, R4 & R5 have the meanings listed in the description, from enamine by extending the chain and closing of a ring followed by additional production of derivatives, treatment with 3-alkoxyacryloyl compound, yet another closing of a ring and conversion of the hydroxy group into a splitting one. 10 claims

公开(公告)号：PL335373A1

公开(公告)日：2000-04-25

申请号：PL33537398

申请日：1998-02-06

Applicant: ABBOTT LAB

Inventor： WANG WEI-BO ,  KERDESKY FRANCIS A J ,  HSIAO CHI-NUNG W ,  LI QUN ,  CHU DANIEL T

IPC: C07D455/02

Abstract: A process for the preparation of a compound having the formula: wherein R1, R2, R3, R4, and R5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.