公开(公告)号：HK1122291A1

公开(公告)日：2009-05-15

申请号：HK09101287

申请日：2009-02-11

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D20060101

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：AT541844T

公开(公告)日：2012-02-15

申请号：AT06848055

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID ,  DEGOEY DAVID ,  MARING CLARENCE ,  KRUEGER ALLAN ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD ,  COOPER CURT ,  ANDERSON DAVID ,  DONNER PAMELA ,  GREEN BRIAN ,  KEMPF DALE ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD ,  MOTTER CHRISTOPHER ,  PRATT JOHN ,  SHANLEY JASON ,  TUFANO MICHAEL ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI ,  MASSE SHERIE ,  CARRICK ROBERT ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：CA2633760A1

公开(公告)日：2007-07-05

申请号：CA2633760

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： TUFANO MICHAEL D ,  KRUEGER ALLAN C ,  SHANLEY JASON P ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  LU LIANGJUN ,  ANDERSON DAVID D ,  HE WEPING ,  MOLLA AKHTERUZZAMAN ,  ZHANG RONG ,  COOPER CURT S ,  IWASAKI NOBUHIKO ,  PILOT-MATIAS TAMI ,  MASSE SHERIE VL ,  BETEBENNER DAVID A ,  CARRICK ROBERT J ,  ROCKWAY TODD W ,  WAGNER ROLF ,  MO HONGMEI ,  KEMPF DALE J

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (HCV) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：NZ569817A

公开(公告)日：2011-10-28

申请号：NZ56981706

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  COOPER CURT S ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE V L ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J

IPC: C07D471/04 ,  A61K31/4375 ,  A61K31/519 ,  A61P31/12

Abstract: Disclosed is a pyrido[2,3-d]pyrimidin-4-yl compound, a tautomer of the compound, or a pharmaceutically acceptable salt of the compound or tautomer, wherein the compound has Formula I, wherein: W1, W2 and W3 are each N, and W4 is C(R33); Z is a bond, -CR41R41'- or -NR41-, wherein R41 and R41 ' are each independently selected from the group consisting of hydrogen, alkyl, alkenyl and alkynyl; A is a carbocyclyl or heterocyclyl, R10 is hydrogen or halogen; R17, R33 and R35, X, R22, R50 are defined in the specification, e.g. 4-(4-Amino-3-methyl-phenoxy)-N-(4-bromo-phenyl)-3-(7-isopropy-1-pyrido[2,3-d]pyrimidin-4-ylamino)-benzamide for the treatment of HCV infection.

公开(公告)号：ES2348557T3

公开(公告)日：2010-12-09

申请号：ES06848056

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： ZHANG RONG ,  CARRICK ROBERT J ,  KEMPF DALE J ,  MO HONGMEI ,  KRUEGER ALLAN C ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  LU LIANGJUN ,  ANDERSON DAVID D ,  MOLLA AKHTERUZZAMAN ,  BETEBENNER DAVID A ,  MASSE SHERIE VL ,  MOTTER CHRISTOPHER E ,  HE WEPING ,  ROCKWAY TODD W ,  MADIGAN DAROLD L ,  IWASAKI NOBUHIKO ,  PILOT-MATIAS TAMI ,  COOPER CURT S ,  WAGNER ROLF

IPC: C07D471/04

Abstract: Un compuesto, un tautómero del compuesto, o una sal farmacéuticamente aceptable del compuesto o tautómero, donde el compuesto tiene la Fórmula II(a) o II(b), donde: 10 R 2 y R 3 se seleccionan independientemente del grupo que consiste en hidrógeno, alquilo, alcoxicarbonilo, y alcoxialquilaminocarbonilo; R 4 se selecciona del grupo que consiste en hidrógeno, alcoxicarbonilo, y alcoxicarbonilalquilo; 15 R 7 se selecciona del grupo que consiste en hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, alcoxicarbonilalquilo, alcoxicarbonilalquilamino, cianoalcoxicarbonilalquilo, cianoalquilo, hidroxialquilo, morfolino, hidrazino, alquilaminoalcoxi, alcoxialquilamino, y arilo; R 9 se selecciona del grupo que consiste en arilalquilamino, N-[alquilarilamino(arilsulfanil)arilalquil]-N-[(alcoxicarbonil)alquil] amino, alcoxiarilalcoxi, haloarilalcoxi, nitroarilalcoxi, cianoarilalcoxi, ariloxialquilo, haloariloxialquilo, arilalcoxi, alquilarilalcoxi, haloalquilaril- aminocarbonilo, alquilaminoarilaminocarbonilo, y arilalcoxi; R 11 se selecciona del grupo que consiste en hidrógeno, hidroxi, haloariloxi, y alquilo; R 12 se selecciona del grupo que consiste en arilsulfanilo, arilsulfinilo, ariloxi, arilaminocarbonilo, arilo, alcoxiarilo, arilalcoxi, y alquilcarbonilaminoarilo; donde R 12 está sustituido opcionalmente con uno o más sustituyentes seleccionados independientemente entre R 16 ; R 16 se selecciona del grupo que consiste en hidrógeno, halógeno, alquilo, alcoxi, hidroxi, aminocarbonilo, alquilaminocarbonilo, amino, alquilcarbonilamino, alquilheteroarilcarbonilamino, heteroarilcarbonilamino, hidroxiheteroarilcarbonilamino, hidroxialquilheteroarilcarbonilamino, heteroarilcarbonilaminoalquilcarbonilamino, heteroarilalquilcarbonilamino, ariloxiarilalquilcarbonilamino, alilaminocarbonilo, alcoxicarbonilo, hidroxialquilo, arilaminocarbonilo, hidroxiarilaminocarbonilo, alcoxialquilo, alcoxiarilaminocarbonilo, azidoalquilo, alquilaminoarilsulfoniloxi, alquilsulfoniloxi, arilalquilsulfoniloxi, alcoxicarbonilalcoxi, hidroxicarbonilalcoxi, cicloalquilcarbonilamino,arilalcoxicarbonilheterociclocarbonilamino, ariloxi, iminoalquilo, alquiltiona, arilalquilcarbonilamino, alquilariloxialquilcarbonilamino, arilalcoxialquilcarbonilamino, heteroarilcarbonilaminoalquilcarbonilamino, heteroarilalquilcarbonilamino, alquilcarbonilheterociclocarbonilamino, amino, aminocarbonilo, alquilaminocarbonilo, hidroxialquilo, aminoalquilo, alcoxialquilaminocarbonilo, hidroxiiminoalquilo, heteroarilo sustituido con alquilo, y heteroarilo; R 13 se selecciona del grupo que consiste en hidrógeno, halógeno, alquilo, alquilcarbonilaminoarilsulfonilo, aminoarilsulfanilo, arilalcoxi, haloarilalcoxi, alquilcarbonilaminoariloxi, alquilaminoariloxi, hidroxiariloxi, alquilaminocarbonilarilalcoxi, y alquilcarbonilaminoarilalcoxi.

公开(公告)号：DE602006015861D1

公开(公告)日：2010-09-09

申请号：DE602006015861

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： ROCKWAY TODD W ,  BETEBENNER DAVID A ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  COOPER CURT S ,  ANDERSON DAVID D ,  KEMPF DALE J ,  MADIGAN DAROLD L ,  MOTTER CHRISTOPHER E ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN

IPC: C07D471/04

公开(公告)号：BRPI0620440A2

公开(公告)日：2010-06-29

申请号：BRPI0620440

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： BETEBENNER DAVID A ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  KRUEGER ALLAN C ,  IWASAKI NOBUHIKO ,  ROCKWAY TODD W ,  ANDERSON DAVID D ,  DONNER PAMELA L ,  GREEN BRIAN E ,  KEMPF DALE J ,  LIU DACHUN ,  MCDANIEL KEITH F ,  MADIGAN DAROLD ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  SHANLEY JASON P ,  TUFANO MICHAEL D ,  WAGNER ROLF ,  ZHANG RONG ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  PILOT-MATIAS TAMI J ,  MASSE SHERIE VL ,  CARRICK ROBERT J ,  HE WEPING ,  LU LIANGJUN ,  GRAMPOVNIK DAVID J ,  COOPER CURT S

IPC: C07D471/04

公开(公告)号：CA2633757A1

公开(公告)日：2007-07-05

申请号：CA2633757

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KRUEGER ALLAN C ,  DEGOEY DAVID A ,  MARING CLARENCE J ,  ROCKWAY TODD W ,  WAGNER ROLF ,  ANDERSON DAVID D ,  IWASAKI NOBUHIKO ,  DONNER PAMELA L ,  ZHANG RONG ,  HE WEPING ,  MOTTER CHRISTOPHER E ,  GRAMPOVNIK DAVID J ,  MOLLA AKHTERUZZAMAN ,  LU LIANGJUN ,  BETEBENNER DAVID A ,  GREEN BRIAN E ,  CARRICK ROBERT J ,  COOPER CURT S ,  KEMPF DALE J ,  PILOT-MATIAS TAMI J ,  LIU DACHUN ,  MO HONGMEI ,  SHANLEY JASON P ,  MASSE SHERIE VL ,  MADIGAN DAROLD L ,  MCDANIEL KEITH F ,  PRATT JOHN K ,  TUFANO MICHAEL D

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

公开(公告)号：AU2006330924A1

公开(公告)日：2007-07-05

申请号：AU2006330924

申请日：2006-12-20

Applicant: ABBOTT LAB

Inventor： KEMPF DALE J ,  WAGNER ROLF ,  KRUEGER ALLAN C ,  GREEN BRIAN E ,  PILOT-MATIAS TAMI J ,  ANDERSON DAVID D ,  GRAMPOVNIK DAVID J ,  PRATT JOHN K ,  MCDANIEL KEITH F ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  MADIGAN DAROLD L ,  LU LIANGJUN ,  TUFANO MICHAEL D ,  ZHANG RONG ,  MASSE SHERIE VL ,  HE WEPING ,  MOLLA AKHTERUZZAMAN ,  MO HONGMEI ,  SHANLEY JASON P ,  COOPER CURT S ,  CARRICK ROBERT J ,  ROCKWAY TODD W ,  LIU DACHUN ,  DONNER PAMELA L ,  IWASAKI NOBUHIKO ,  DEGOEY DAVID A ,  BETEBENNER DAVID A

IPC: C07D471/04

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.