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    11.
    发明专利
    未知

    公开(公告)号：DK552074A

    公开(公告)日：1975-07-07

    申请号：DK552074

    申请日：1974-10-22

    Applicant: ABBOTT LAB

    Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

    IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

    Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.

    13.
    发明专利
    未知

    公开(公告)号：SE364272B

    公开(公告)日：1974-02-18

    申请号：SE1211069

    申请日：1969-09-02

    Applicant: ABBOTT LAB

    Inventor： JONES P H ,  WIEGAND R G ,  CHUN A

    IPC: C07H17/08

    Abstract: 1,258,352. Erythromycin salts. ABBOTT LABORATORIES. 3 Sept., 1969 [4 Sept., 1968], No. 43710/69. Heading C2A. Novel erythromycin aliphatic sulphate salts having the general formula wherein Ery represents the erythronolide and cladinose moieties of erythromycin A or B and n is zero or an integer from 1 to 4, are prepared by adding to a solution of erythromycin A or B in a suitable solvent (e.g. aqueous acetone) a molar equivalent of an alkali metal salt of an aliphatic sulphate, of formula CH 3 (CH 2 ) (10 +2n) .CH 2 OSO 2 (O-Alkali metal) wherein n is as above, together with an excess of an acid or acid salt over that required to react with the alkali metal from said alkali metal salt. The acid or acid salt (e.g. acetic acid, HC1, sodium dihydrogen phosphate or sodium hydrogen sulphate) is preferably added in sufficient quantity to bring the pH to 5.5 to 6.5. The mixture is preferably warmed to aid the reaction, and the product is precipitated by adding water to the reaction mixture. Pharmaceutical compositions having antibiotic activity comprise an erythromycin aliphatic sulphate salt of Formula I as defined above together with a pharmaceutically acceptable carrier. They are preferably in forms for oral administration, e.g. tablets, chewable tablets or reconstitutable powders or granules.

    14.
    发明专利
    未知

    公开(公告)号：SE8008533L

    公开(公告)日：1980-12-04

    申请号：SE8008533

    申请日：1980-12-04

    Applicant: ABBOTT LAB

    Inventor： WINN M ,  KYNCL J ,  DUNNINGAN D A ,  JONES P H

    IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

    Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

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