公开(公告)号：ZA765510B

公开(公告)日：1977-08-31

申请号：ZA765510

申请日：1976-09-14

Applicant: ABBOTT LAB

Inventor： KYNCL J ,  LALL A ,  FUNG A ,  MARTIN Y ,  JONES P ,  BARIANA D

IPC: A61K31/41 ,  A61K31/19 ,  A61P9/12 ,  C07C45/46 ,  C07C45/67 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/90 ,  C07C67/00 ,  C07C205/45 ,  C07D257/04 ,  C07D

Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.

公开(公告)号：SE7609886A

公开(公告)日：1977-03-12

申请号：SE7609886

申请日：1976-09-07

Applicant: ABBOTT LAB

Inventor： JONES P H ,  OURS C W ,  KYNCL J

IPC: A61K31/225 ,  A61K31/235 ,  A61P9/08 ,  A61P9/12 ,  C07C237/08 ,  C07C271/22 ,  C07C103/50

CPC classification number: C07C271/22

公开(公告)号：SE431208B

公开(公告)日：1984-01-23

申请号：SE8008533

申请日：1980-12-04

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：AU506347B2

公开(公告)日：1979-12-20

申请号：AU1790676

申请日：1976-09-20

Applicant: ABBOTT LAB

Inventor： JONES P H ,  BARIANA D S ,  FUNG A K L ,  MARTIN Y C ,  KYNCL J ,  LALL A

IPC: A61K31/19 ,  A61K31/41 ,  A61P9/12 ,  C07C45/46 ,  C07C45/67 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/90 ,  C07C67/00 ,  C07C205/45 ,  C07D257/04 ,  C07C59/26 ,  C07C59/25

Abstract: This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R1 is -CH2COOH or methyl tetrazole, and X1 and X2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.

公开(公告)号：ZA7605510B

公开(公告)日：1977-08-31

申请号：ZA7605510

申请日：1976-09-14

Applicant: ABBOTT LAB

Inventor： KYNCL J ,  LALL A ,  FUNG A ,  MARTIN Y ,  JONES P ,  BARIANA D

IPC: A61K31/19 ,  A61K31/41 ,  A61P9/12 ,  C07C45/46 ,  C07C45/67 ,  C07C49/84 ,  C07C51/00 ,  C07C59/125 ,  C07C59/90 ,  C07C67/00 ,  C07C205/45 ,  C07D257/04 ,  C07D

CPC classification number: C07D257/04 ,  C07C45/46 ,  C07C45/673 ,  C07C49/84 ,  C07C59/90 ,  C07C205/45 ,  Y10S514/869 ,  C07C49/83

公开(公告)号：ZA765071B

公开(公告)日：1977-04-27

申请号：ZA765071

申请日：1975-08-06

Applicant: ABBOTT LAB ,  CHAMBER OF MINES SERVICES LTD

Inventor： GLOSSOP M ,  JONES P ,  OURS C ,  KYNCL J

IPC: C07C20060101 ,  C07C

公开(公告)号：ZA7605071B

公开(公告)日：1977-04-27

申请号：ZA7605071

申请日：1975-08-06

Applicant: ABBOTT LAB ,  CHAMBER OF MINES SERVICES LTD

Inventor： GLOSSOP M ,  JONES P ,  OURS C ,  KYNCL J

IPC: C07C20060101 ,  C07C

公开(公告)号：SE7611379L

公开(公告)日：1977-04-15

申请号：SE7611379

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：SE7413303L

公开(公告)日：1975-04-24

申请号：SE7413303

申请日：1974-10-22

Applicant: ABBOTT LAB

Inventor： JONES P H ,  KYNCL J ,  OURS C W ,  SOMANI P

IPC: A61K31/195 ,  A01N37/44 ,  A61K31/198 ,  A61K31/22 ,  A61P9/08 ,  C07C237/08 ,  C07C103/50

Abstract: Covers the esters of gamma -glutamyl amide of dopamine selected from the group consisting of -CH2-CH2-NHO ¦ PARALLEL C-CH2-CH2-CH-C-OR PARALLEL ¦ ONH2 where R is a C1-C20 alkyl radical, and a pharmaceutically acceptable acid addition salt thereof. Also covers the use of said esters of gamma -glutamyl amide of dopamine to increase renal blood flow by administering said amide to warm-blooded mammals by clinically acceptable routes of administration such as oral, parenteral, rectal, etc.