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公开(公告)号：DE69710662D1
公开(公告)日：2002-04-04
申请号：DE69710662
申请日：1997-08-20
Applicant: ABBOTT LAB
Inventor： ARNQUIST DAVID C , BARNES III , BUTTON RICHARD D , DUNN CHADWICK M , EAST JR , FRITCHIE PATRICK P , GALITZ CHARLES M , GRANDONE CASS J , GARDNER GREGORY E , GRAY ROBERT C , HOLEN JAMES T , LUOMA II , MCCORY JIMMY D , MITCHELL JAMES E , MURRAY ADRIAN JOHN , MURRAY DAVID W , RAMSEY JACK F , SLESZYNSKI NEAL T , TOTH JULIUS J
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公开(公告)号：CA2249779A1
公开(公告)日：1998-03-19
申请号：CA2249779
申请日：1997-08-28
Applicant: ABBOTT LAB
Inventor： FRITCHIE PATRICK P , DUNN CHADWICK M , GRANDONE CASS J , SLESZYNSKI NEAL T , MITCHELL JAMES E , BARNES GRADY III , BUTTON RICHARD D , MURRAY ADRIAN J , EAST RICHARD C JR , MURRAY DAVID W , ARNQUIST DAVID C , MCCOY JIMMY D , GALITZ CHARLES M , GRAY ROBERT C , GARDNER GREGORY E , TOTH JULIUS J , HOLEN JAMES T , LUOMA ROBERT P II , RAMSEY JACK F
Abstract: A method of constructing at least a first process lane and a second process lane, both for determining an item of interest in a sample; the method includes the steps of: (a) defining an effective length representing a total traveled distance of a container, in which the item of interest in the sample is determined, along a process lane where a process step comprises a process for determining the item of interest in the sample is performed; (b) constructing the first process lane to have a first physical length and the effective length; and (c) constructing the second process lane to have a second physical length different from the first physical length and the effective length; the sample is in particular a body fluid, for example, blood, on which tests are to be carried out for a component in the fluid, as part of the determination of the health of a person from whom the sample is obtained.
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公开(公告)号：CA2529886C
公开(公告)日：2013-12-31
申请号：CA2529886
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL G , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
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公开(公告)号：CA2214125C
公开(公告)日：2003-08-05
申请号：CA2214125
申请日：1997-08-28
Applicant: ABBOTT LAB
Inventor： GRANDONE CASS J , GRAY ROBERT C , TOTH JULIUS J , RAMSEY JACK F , MURRAY DAVID W , FRITCHIE PATRICK P , MCCOY JIMMY D , SLESZYNSKI NEAL T , MURRAY ADRIAN J , GALITZ CHARLES M , ARNQUIST DAVID C , MITCHELL JAMES E , BARNES GRADY III , BUTTON RICHARD D , GARDNER GREGORY E , EAST RICHARD C JR , HOLEN JAMES T , DUNN CHADWICK M , LUOMA ROBERT P II
IPC: G01N35/02
Abstract: The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent; the embodiments disclosed also related to determination of an item of interestin a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent; embodiments also described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. An effective length of the process lane is maintained constant while a physical length of the process lane is selectively varied.
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公开(公告)号：CA2249779C
公开(公告)日：2003-02-18
申请号：CA2249779
申请日：1997-08-28
Applicant: ABBOTT LAB
Inventor： MCCOY JIMMY D , BUTTON RICHARD D , EAST RICHARD C JR , DUNN CHADWICK M , MITCHELL JAMES E , GRANDONE CASS J , GARDNER GREGORY E , MURRAY ADRIAN J , GRAY ROBERT C , ARNQUIST DAVID C , LUOMA ROBERT P II , MURRAY DAVID W , FRITCHIE PATRICK P , RAMSEY JACK F , GALITZ CHARLES M , BARNES GRADY III , HOLEN JAMES T , TOTH JULIUS J , SLESZYNSKI NEAL T
Abstract: A method of constructing at least a first process lane and a second process lane, both for determining an item of interest in a sample; the method includes the steps of: (a) defining an effective length representing a total traveled distance of a container, in which the item of interest in the sample is determined, along a process lane where a process for determining the item of interest in the sample is performed; (b) constructing the first process lanefor determining an item of interest in a sample, said first process lane having a first physical length, said first physical length being less than the effective lengthof said first process lane; and (c) constructing the second process lane for determining an item of interest in a sample, said second process lane having a second physical length different from the first physical length, said second physical length being less than the effective length of said second process lane; the sample is in particular a body fluid, for example, blood, on which tests are to be carried out for a component in the fluid, as part of the determination of the health of a person from whom the sample is obtained.
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Patent Agency Ranking
公开(公告)号：AT213839T
公开(公告)日：2002-03-15
申请号：AT97114411
申请日：1997-08-20
Applicant: ABBOTT LAB
Inventor： ARNQUIST DAVID C , BARNES GRADY III , BUTTON RICHARD D , DUNN CHADWICK M , EAST RICHARD C JR , FRITCHIE PATRICK P , GALITZ CHARLES M , GRANDONE CASS J , GARDNER GREGORY E , GRAY ROBERT C , HOLEN JAMES T , LUOMA ROBERT P II , MCCORY JIMMY D , MITCHELL JAMES E , MURRAY ADRIAN JOHN , MURRAY DAVID W , RAMSEY JACK F , SLESZYNSKI NEAL T , TOTH JULIUS J
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公开(公告)号：ES2345211T3
公开(公告)日：2010-09-17
申请号：ES06111128
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E
Abstract: Una zona de procesado para un dispositivo de manipulación de muestras, comprendiendo dicha zona de procesado: un soporte (30, 32) para una pluralidad de recipientes de reacción (26), que tiene aberturas de drenaje (92) en sus partes inferiores, estando adaptadas dichas aberturas para soportar una altura seleccionada de fluido en dichos recipientes; pasajes (80, 82) adaptados para comunicarse con las aberturas de drenaje inferiores de los recipientes de reacción soportados; y una fuente de aire a presión distinta de la atmosférica adaptado para drenar selectivamente el fluido a través de las aberturas de drenaje en los recipientes de reacción soportados, estando dicho soporte adaptado para soportar la pluralidad de recipientes de reacción en al menos dos filas, teniendo cada fila un espacio definido desde al menos una fila adyacente, caracterizado por que dicho espacio definido entre filas comprende una ranura longitudinal generalmente vertical (46, 48, 50); y comprende adicionalmente un imán (60, 62, 64), que se extiende generalmente horizontalmente y que está soportado para el movimiento vertical seleccionado en dicha ranura.
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公开(公告)号：ES2315998T3
公开(公告)日：2009-04-01
申请号：ES06111116
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL , SAFRA SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E
Abstract: Un mecanismo de manipulación de fluido para un dispositivo de ensayo de analitos, incluyendo dicho dispositivo de ensayo una placa de soporte con una zona de procesado (20, 22) que tiene una pluralidad de recipientes de reacción (26) soportados en su interior con aberturas orientadas hacia arriba, comprendiendo dicho mecanismo de manipulación de fluido: un primer suministro a granel (230) de un primer fluido y un segundo suministro a granel (232) de un segundo fluido; un cabezal dosificador (200) que tiene X aberturas de descarga (204, 206) situadas selectivamente con cada una de dichas aberturas de descarga sobre dichas aberturas orientadas hacia arriba de X recipientes de reacción seleccionados (26), en el que X es al menos cuatro; un mecanismo de bomba dosificadora (220) adaptada para medir selectivamente X unidades de una cantidad de fluido seleccionada desde uno de dichos primero y segundo suministros a granel seleccionados (230, 232) y bombear selectivamente dichas X unidades de cantidades seleccionadas medidas de fluido a través de dichas aberturas de descarga (204, 206) hacia dichos recipientes de reacción seleccionados (26), en el que dicho mecanismo de bomba dosificadora (220) incluye X bombas de pistón (222) y que comprende adicionalmente X estructuras de válvulas, caracterizado porque cada estructura de válvula comprende una primera válvula (280), una segunda válvula (282), y una tercera válvula (284), cada una de las tres válvulas puede interrumpirse selectivamente entre una primera trayectoria (A) y una segunda trayectoria (B), con lo que la primera válvula (280), la segunda válvula (282) y la segunda válvula (284) pueden hacerse funcionar de manera que el primer fluido desde el primer suministro a granel (230) puede introducirse mediante la primera trayectoria A hacia las bombas de pistón (222) y la primera válvula (280), la segunda válvula (282) y la tercera válvula (284) pueden hacerse funcionar de manera que el primer fluido puede introducirse mediante la segunda trayectoria (B) hacia una primera salida de descarga (206) y la primera válvula (280), la segunda válvula (282), y la tercera válvula (284) pueden hacerse funcionar de manera que el segundo fluido desde el segundo suministro a granel (232) puede introducirse mediante la primera trayectoria (A) hacia las bombas de pistón (222) de la primera válvula (280) para que la segunda válvula (282), y la tercera válvula (284) puedan hacerse funcionar de manera que el primer fluido pueda introducirse mediante la segunda trayectoria (B) en la segunda salida de descarga (204).
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公开(公告)号：DE602004017635D1
公开(公告)日：2008-12-18
申请号：DE602004017635
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL , SAFRA SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels.; Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included
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公开(公告)号：CA2529886A1
公开(公告)日：2004-12-29
申请号：CA2529886
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： SHAIN ERIC B , TOTH JULIUS J , HERCHENBACH STEPHEN , GALITZ CHARLES M , KUKLA RONALD E , DUNN CHADWICK M , SAFAR SCOTT , LOWREY MICHAEL
Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movemen t between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
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