-
公开(公告)号：WO1993017682A1
公开(公告)日：1993-09-16
申请号：PCT/US1993001177
申请日：1993-02-09
Applicant: ABBOTT LABORATORIES
Inventor： ABBOTT LABORATORIES , ZYDOWSKY, Thomas, M. , DE, Biswanath , SHIOSAKI, Kazumi , BASHA, Fatima, Z. , WINN, Martin , DeBERNARDIS, John, F. , VON GELDERN, Thomas, W. , YAMAMOTO, Diane, M. , KERKMAN, Daniel, J. , BOYD, Steven, A. , FUNG, Anthony, K., L.
IPC: A61K31/415
CPC classification number: C07D257/04 , A61K31/44 , A61K31/47 , A61K31/505 , C07D401/12 , C07D403/12 , C07D471/04 , C07D475/06
Abstract: Compounds are disclosed having formula (I). The compounds of the invention are angiotensin II receptor antagonists.
Abstract translation: 式（I）化合物是血管紧张素II受体拮抗剂。
-
公开(公告)号：EP0776324A1
公开(公告)日：1997-06-04
申请号：EP95928323.0
申请日：1995-08-04
Applicant: Abbott Laboratories
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VONGELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K.
IPC: C07D , A61K31 , A61P9 , A61P29 , A61P35 , A61P43 , C07D207 , C07D401 , C07D403 , C07D405 , C07D413 , C07D419 , C07D471 , C07F9
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Abstract translation: 公开了式（I）化合物或其药学上可接受的盐，以及其制备方法和中间体以及拮抗内皮素的方法。
-
13.发明授权ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权金刚衍生物作为11-β羟类固醇脱氢酶-1酶抑制剂
公开(公告)号：EP1846363B1
公开(公告)日：2012-04-25
申请号：EP06717418.5
申请日：2006-01-05
Applicant: Abbott Laboratories
Inventor： PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D257/04 , C07D233/54 , C07D261/08 , C07D213/64 , C07D207/48 , A61K31/4402 , A61P3/10
CPC classification number: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
-
14.发明公开4-(BENZO-1,3-DIOXOLYL)-PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AS ENDOTHELIN ANTAGONISTS 失效4-（苯并-1,3-二氧杂环戊烯） - 吡咯烷-3-羧酸衍生物AS内皮素拮抗剂
公开(公告)号：EP0888340A1
公开(公告)日：1999-01-07
申请号：EP97905897.0
申请日：1997-02-10
Applicant: Abbott Laboratories
Inventor： TASKER, Andrew, S. , BOYD, Steven, A. , SORENSEN, Bryan, K. , WINN, Martin , JAE, Hwan-Soo , VON GELDERN, Thomas, W. , HENRY, Kenneth, J.
IPC: C07D , A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P25 , A61P35 , A61P43 , C07D207 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417 , C07D419 , C07D453 , C07F9
CPC classification number: C07D405/04 , A61K9/2059 , A61K9/4866
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
-
公开(公告)号：EP0776324B1
公开(公告)日：2002-06-12
申请号：EP95928323.5
申请日：1995-08-04
Applicant: Abbott Laboratories
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VONGELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K.
IPC: C07D405/04 , C07D207/16 , A61K31/40 , C07D405/14 , C07F9/59 , C07F9/572
CPC classification number: C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
-
Patent Agency Ranking16.发明公开
公开(公告)号：EP1165505A1
公开(公告)日：2002-01-02
申请号：EP00921654.0
申请日：2000-04-03
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Thomas, W. , WINN, Martin , XIN, Zhili , WANG, Sheldon , BOYD, Steven, A. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A. , JAE, Hwan-Soo , LYNCH, John, K.
IPC: C07C323/62 , C07D233/61 , C07D207/26 , C07D295/18 , C07D213/74 , C07D211/22 , C07D207/14 , C07D211/46 , C07D211/62 , C07D211/60 , C07D401/04 , C07D217/02 , C07D307/68 , C07D295/26 , C07D317/66 , C07D209/08 , C07D295/205 , C07D401/12 , A61K31/165 , A61K31/33 , A61P29/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07D205/04 , C07D207/09 , C07D207/14 , C07D207/16 , C07D209/08 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/40 , C07D213/74 , C07D213/81 , C07D217/02 , C07D217/06 , C07D231/12 , C07D233/56 , C07D241/04 , C07D249/08 , C07D295/185 , C07D295/26 , C07D307/68 , C07D317/66 , C07D401/04 , C07D401/12
Abstract: The present invention relates to cinnamide compounds of formula (I), in which at least one of R1 to R5 is a "cis-cinnamide" (a) or a "trans-cinnamide" (b) and the other variables are as defined in the claims, that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds and to methods of inhibiting inflammation or suppressing immune response in a mammal.
-
17.发明公开PYRROLIDINE-3-CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ENDOTHELIN ANTAGOISTS 失效吡咯烷-3-羧酸衍生物及其作为内皮素拮抗剂的用途
公开(公告)号：EP1003740A2
公开(公告)日：2000-05-31
申请号：EP98937139.8
申请日：1998-07-27
Applicant: Abbott Laboratories
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , von GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: C07D405/00
CPC classification number: C07D207/27 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
-
18.发明公开ADAMANTYL DERIVATIVES AS INHIBITORS OF THE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ENZYME 有权ADAMANTYL-DERIVATE ALS INHIBITOREN DES 11-BETA-HYDOXOSTEROID-DEHYDROGENASE-1-ENZYMS
公开(公告)号：EP1846363A2
公开(公告)日：2007-10-24
申请号：EP06717418.5
申请日：2006-01-05
Applicant: ABBOTT LABORATORIES
Inventor： PATEL, Jyoti, R. , SHUAI, Qi , LINK, James, T. , ROHDE, Jeffrey, J. , DINGES, Jurgen , SORENSEN, Bryan, K. , WINN, Martin , YONG, Hong , YEH, Vince, S.
IPC: C07C235/14 , C07C317/16 , C07C323/41 , C07D257/04 , C07D233/54 , C07D261/08 , C07D213/64 , C07D207/48 , A61K31/4402 , A61P3/10
CPC classification number: C07C233/23 , C07C235/14 , C07C237/24 , C07C255/31 , C07C255/47 , C07C259/16 , C07C311/08 , C07C311/29 , C07C311/46 , C07C311/51 , C07C317/22 , C07C317/30 , C07C317/44 , C07C323/41 , C07C323/60 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D207/48 , C07D213/64 , C07D233/64 , C07D257/04 , C07D261/08
Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.
Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。
-
19.发明授权NOVEL BENZO-1,3-DIOXOLYL- AND BENZOFURANYL SUBSTITUTED PYRROLIDINE DERIVATIVES AS ENDOTHELIN ANTAGONISTS 失效新苯并-1,3-二唑和取代的苯并呋喃PYRROLIDINEDERIVATE ALS内皮素拮抗剂
公开(公告)号：EP0885215B1
公开(公告)日：2006-04-19
申请号：EP97905816.1
申请日：1997-02-12
Applicant: ABBOTT LABORATORIES
Inventor： WINN, Martin , BOYD, Steven, A. , HUTCHINS, Charles, W. , JAE, Hwan-Soo , TASKER, Andrew, S. , VON GELDERN, Thomas, W. , KESTER, Jeffrey, A. , SORENSEN, Bryan, K. , SZCZEPANKIEWICZ, Bruce, G. , HENRY, Kenneth, J., Jr. , LIU, Gang , WITTENBERGER, Steven, J. , KING, Steven, A.
IPC: C07D405/04 , C07D207/16 , A61K31/40 , C07D405/14 , C07F9/59 , C07F9/572 , C07D401/04
CPC classification number: C07D401/04 , C07D207/16 , C07D405/04 , C07D405/12 , C07D405/14 , Y02P20/55
Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
-
20.发明授权CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS 有权ZELLADHÄSION-和抗炎免疫CONNECTIONS
公开(公告)号：EP1140814B1
公开(公告)日：2005-05-25
申请号：EP99966709.0
申请日：1999-12-29
Applicant: ABBOTT LABORATORIES
Inventor： LINK, James , LIU, Gang , PEI, Zhonghua , VON GELDERN, Tom , WINN, Martin , XIN, Zhili , BOYD, Steven, A. , JAE, Hwan-Soo , LYNCH, John, K. , ZHU, Gui-Dong , FREEMAN, Jennifer, C. , GUNAWARDANA, Indrani, W. , STAEGER, Michael, A.
IPC: C07C323/00
CPC classification number: C07D207/27 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D207/09 , C07D207/14 , C07D207/20 , C07D207/22 , C07D207/26 , C07D209/08 , C07D209/18 , C07D211/22 , C07D211/26 , C07D211/42 , C07D211/46 , C07D211/54 , C07D211/60 , C07D211/62 , C07D211/74 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/36 , C07D217/06 , C07D235/26 , C07D239/42 , C07D241/04 , C07D241/24 , C07D243/08 , C07D265/30 , C07D295/13 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32 , C07D307/52 , C07D307/68 , C07D317/58 , C07D317/62 , C07D319/18 , C07D319/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.039 seconds)
