公开(公告)号：NZ545421A

公开(公告)日：2010-03-26

申请号：NZ54542104

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN GERARD ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  WEINTRAUB PHILIP MARVIN ,  DU YAN ,  DHARANIPRAGADA RAMALINGA M ,  PARKAR ASHFAQ AHMED

IPC: C07D495/04 ,  A61P11/06 ,  C07D519/00

Abstract: Disclosed is a compound of formula I wherein X is N, or C-R7; X1 is N, or C-R1 and wherein the rest of the substituents are disclosed within the specification. Also disclosed is the use of a compound of formula I in the manufacture of a medicament for treating a patient with a pathological condition related to overproduction of Th2 cytokine, such as asthma.

公开(公告)号：BRPI0414215A

公开(公告)日：2006-11-07

申请号：BRPI0414215

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK GERARD JOHN ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  WEINTRAUB PHILIP MARVIN ,  DU YAN ,  DHARANIPRAGADA RAMALINGA M ,  PARKAR ASHFAP AHMED

IPC: C07D495/04 ,  C07D519/00

Abstract: Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

公开(公告)号：ECSP066411A

公开(公告)日：2006-09-18

申请号：ECSP066411

申请日：2006-03-06

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN GERARD ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  WEINTRAUB PHILIP MARVIN ,  DU YAN ,  DHARANIPRAGADA RAMALINGA M ,  PARKAR ASHFAQ AHMED

IPC: C07D495/04 ,  C07D519/00

Abstract: Tienopirazoles, su preparación, composiciones farmacéuticas que comprenden estos compuestos, y sus usos farmacéuticos en el tratamiento de estados de enfermedad capaces de ser modulados por la inhibición de las proteína quinasas, en particular la tirosina quinasa inducible por interleuquina-2 (ITK).

公开(公告)号：AU2004272507B2

公开(公告)日：2011-05-12

申请号：AU2004272507

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： DHARANIPRAGADA RAMALINGA M ,  BARRAGUE MATTHIEU ,  DU YAN ,  MUSICK KWON YON ,  PARKAR ASHFAQ AHMED ,  EDWARDS MICHAEL LOUIS ,  JURCAK JOHN GERARD ,  GILLESPY TIMOTHY ALAN ,  WEINTRAUB PHILIP MARVIN

IPC: C07D495/04 ,  C07D519/00

Abstract: Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

公开(公告)号：PL1682553T3

公开(公告)日：2010-10-29

申请号：PL04779049

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN GERARD ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  WEINTRAUB PHILIP MARVIN ,  DU YAN ,  DHARANIPRAGADA RAMALINGA M ,  PARKAR ASHFAQ AHMED

IPC: C07D495/04 ,  C07D519/00

公开(公告)号：RS20060162A

公开(公告)日：2008-06-05

申请号：YUP20060162

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN GERARD ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  DU YAN ,  DHARANIPRAGADA RAMALINGA ,  PARKAR ASHFAQ AHMED ,  WEINTRAUB PHILIP MARVIN

IPC: C07D495/04 ,  C07D519/00

Abstract: Tienopirazoli, njihova priprema, farmaceutski preparati koji sadrže ova jedinjenja, i njihova farmaceutsko upotreba u lečenju bolesnih stanja koja se mogu menjati inhibicijom protein kinaze, naročito tirozin kinaze koja se može indukovati interleukinom-2.

公开(公告)号：BRPI0509391A

公开(公告)日：2007-09-18

申请号：BRPI0509391

申请日：2005-03-29

Applicant: AVENTIS PHARMA INC

Inventor： WEINTRAUB PHILIP MARVIN ,  EASTWOOD PAUL R ,  MEHDI SHUJAATH ,  STEFANY DAVID W ,  MUSICK KWON YON ,  MOORCROFT NEIL ,  LIM SUNGTAEK ,  JIANG JOHN Z ,  RUTTEN HARTMUT ,  PEUKERT STEFAN ,  SCHWAHN UWE

IPC: C07D213/62 ,  A61K31/44 ,  A61P9/00 ,  C07D213/64 ,  C07D217/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14 ,  C07D413/04 ,  C07D417/14

Abstract: The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

公开(公告)号：CA2538032A1

公开(公告)日：2005-03-24

申请号：CA2538032

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  JURCAK JOHN GERARD ,  DHARANIPRAGADA RAMALINGA M ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  DU YAN ,  WEINTRAUB PHILIP MARVIN ,  PARKAR ASHFAQ AHMED

IPC: C07D495/04 ,  C07D519/00

Abstract: Thienopyrazoles, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

公开(公告)号：AU2004272507A1

公开(公告)日：2005-03-24

申请号：AU2004272507

申请日：2004-07-23

Applicant: AVENTIS PHARMA INC

Inventor： DHARANIPRAGADA RAMALINGA M ,  BARRAGUE MATTHIEU ,  DU YAN ,  MUSICK KWON YON ,  PARKAR ASHFAQ AHMED ,  EDWARDS MICHAEL LOUIS ,  JURCAK JOHN GERARD ,  GILLESPY TIMOTHY ALAN ,  WEINTRAUB PHILIP MARVIN

IPC: C07D495/04 ,  C07D519/00

Abstract: Thienopyrazoles of formula I, their preparation, pharmaceutical compositions comprising these compounds, and their pharmaceutical uses in the treatment of disease states capable of being modulated by the inhibition of the protein kinases, in particular interleukin-2 inducible tyrosine kinase (ITK).

公开(公告)号：CY1110743T1

公开(公告)日：2015-06-10

申请号：CY101100762

申请日：2010-08-17

Applicant: AVENTIS PHARMA INC

Inventor： JURCAK JOHN GERARD ,  BARRAGUE MATTHIEU ,  GILLESPY TIMOTHY ALAN ,  EDWARDS MICHAEL LOUIS ,  MUSICK KWON YON ,  WEINTRAUB PHILIP MARVIN ,  DU YAN ,  DHARANIPRAGADA RAMALINGA M ,  PARKAR ASHFAQ AHMED

IPC: C07D495/04

Abstract: Θειενοπυραζόλια, ηπαρασκευήτους, φαρμακευτικέςσυνθέσειςπουπεριέχουντιςενλόγωενώσειςκαιοιφαρμακευτικέςτουςχρήσειςστηθεραπευτικήαντιμετώπισηπαθήσεωνπουείναισεθέσηναρυθμιστούνδιατηςαναστολήςπρωτεϊνικώνκινασών, ιδίωςτηςεπαγώγιμηςδιαιντελευκίνης-2 τυροσινικήςκινάσης (ΙΤΚ).