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公开(公告)号:EE200200268A
公开(公告)日:2003-06-16
申请号:EEP200200268
申请日:2000-11-13
Applicant: BASF AG
Inventor: DITRICH KLAUS , SIEGEL WOLFGANG
IPC: C12P41/00 , C07B55/00 , C07B57/00 , C07C209/58 , C07C209/86 , C07C213/00 , C07C213/08 , C07C213/10 , C07C215/08 , C07C217/10 , C07C235/08 , C12P13/00
Abstract: A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described.
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公开(公告)号:DE10145223A1
公开(公告)日:2003-04-03
申请号:DE10145223
申请日:2001-09-13
Applicant: BASF AG
Inventor: ERNST HANSGEORG , HENRICH KLAUS , DITRICH KLAUS
IPC: A61K31/045 , C07B61/00 , C07C29/74 , C07C35/17 , C07C35/18 , C07C43/196 , C07C47/21 , C07C47/225 , C07C69/013 , C07C69/14 , C07C69/16 , C07C69/63 , C07C69/65 , C07C403/08 , C07C403/24 , C07C29/09 , C07C29/78
Abstract: Preparation of meso-zeaxanthin (A) involves separating a racemic mixture of 1-ethynyl-2,2,6-trimethyl-cyclohexane-1,4-diols (I) into the R- and S-antipodes, then converting them into sterically uniform (A) by four further stages including two Wittig reactions. Several classes of intermediate compounds are new. Preparation of meso-zeaxanthin of formula (A) involves: (a) separating a racemic mixture of acetylenic diols of formulae R-(I) and S-(I) into its antipodes; (b) converting R-(I) and S-(I) into the corresponding 15C phosphonium salts of formulae R-(II) and S-(II) respectively; (c) subjecting R-(II) or S-(II) to Wittig reaction with a 10C dial monoacetal of formula (III), to give a 25C acetal of formula R-(IV) or S-(IV); (d) converting R-(IV) or S-(IV) into the 25C aldehyde of formula R-(V) or S-(V) respectively; and (e) subjecting R-(V) and S-(II) or S-(V) and R-(II) to Wittig reaction to give sterically uniform (A). Ar = aryl; X = 1 equivalent of an anion of an (in)organic acid; R1, R2 = 1-8C alkyl, or R1 + R2 = CH2CR3R4CH2 or CHR5CH2, and R3-R5 = H or 1-4C alkyl. Independent claims are also included for: (i) the production of optically pure R-(I) and S-(I), by conversion of a racemic mixture of R-(I) and S-(I) into a diastereomer mixture using an optically active auxiliary reagent (AR), separating the diastereomers and cleaving AR, and (ii) S-(I), protected S-(I) derivatives of formula S-(XI), cyclohexane derivatives of formulae R-(VI) and S-(VI) and acetylene compounds of formula S-(VII) as new compounds. R6 = optically active urethane, carbonate, sulfonate or acyl residue; R7 = H, 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group; R8 = H or C(Me)(OR9)-CH-CH2; R9 = H or Li, and R10 = non-chiral 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group.
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公开(公告)号:DK0801683T3
公开(公告)日:2002-06-17
申请号:DK96900601
申请日:1996-01-20
Applicant: BASF AG
Inventor: BALKENHOHL FRIEDHELM , DITRICH KLAUS , NUEBLING CHRISTOPH
Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.
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公开(公告)号:AU2183102A
公开(公告)日:2002-05-21
申请号:AU2183102
申请日:2001-11-09
Applicant: BASF AG
Inventor: BLASCO JORDI TORMO I , DITRICH KLAUS , SAUTER HUBERT , CULLMANN OLIVER , GEWEHR MARKUS , GRAMMENOS WASSILIOS , MULLER BERND , GROTE THOMAS , GYPSER ANDREAS , RHEINHEIMER JOACHIM , ROSE INGO , SCHAFER PETER , SCHIEWECK FRANK , AMMERMANN EBERHARD , STRATHMANN SIEGFRIED , LORENZ GISELA , STIERL REINHARD
IPC: A01N43/90 , C07B53/00 , C07C209/62 , C07C211/03 , C07D487/04 , C07D487/00
Abstract: 7-(R)-Aminotriazolopyrimidines of the formula I where the substituents and the index are as defined below: R 1 is hydrogen or methyl; R 2 is methyl; R 3 is C 2 -C 1 o-alkyl, C 1 -C 4 -alkoxymethyl, C 3 -C 1 o-cycloalkyl; R 4 is halogen, Cl-C 4 -alkyl, C 1 -C 4 -haloalkyl or Cl-C 4 -alkoxy; n is a number from 1 to 5; Y is halogen, cyano, Cl-C 4 -alkyl or C l -C 4 -alkoxy; where * is a center of chirality in the R configuration, processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi are described.
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公开(公告)号:HU0004734A2
公开(公告)日:2001-05-28
申请号:HU0004734
申请日:1998-09-18
Applicant: BASF AG
Inventor: DITRICH KLAUS , ERHARDT MELANIE , HERGENROEDER STEFAN , HILLEN HEINZ , KOHL TANJA , MARKERT CLAUS OTTO , PUHL MICHAEL , ZECHEL JOHANN-CHRISTIAN
IPC: C07D333/40 , A61K31/198 , A61K31/27 , A61K31/381 , A61K31/4704 , A61K31/498 , A61P1/04 , A61P1/18 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/08 , A61P13/12 , A61P25/06 , A61P35/00 , C07C271/12 , C07C271/20 , C07C323/56 , C07D215/48 , C07D241/44 , C07D333/38 , C07D333/16
Abstract: Pharmaceutically active compounds are prepared as described and used to produce pharmaceutical preparations for treating diseases.
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公开(公告)号:GR3033333T3
公开(公告)日:2000-09-29
申请号:GR20000401017
申请日:2000-04-26
Applicant: BASF AG
Inventor: WETTERICH FRANK , WAGNER OLIVER , EICKEN KARL , DITRICH KLAUS , AMMERMANN EBERHARD , LORENZ GISELA , STRATHMANN SIEGFRIED
IPC: C07C269/04 , A01N47/12 , C07C269/06 , C07C271/22
Abstract: PCT No. PCT/EP96/03755 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Aug. 26, 1996 PCT Pub. No. WO97/08138 PCT Pub. Date Mar. 6, 1997Carbamoylcarboxamides of the general formula I (R1=unsubstituted or substituted alkyl, alkenyl, alkynyl; R2=hydrogen, halogen, cyano, nitro, or unsubstituted or substituted alkyl, alkoxy, alkylthio, or an unsubstituted or substituted phenyl group which is bonded via oxygen or sulfur) and compositions comprising them, processes for their preparation, and the use of the compounds I and of the compositions.
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公开(公告)号:DE19913256A1
公开(公告)日:2000-09-28
申请号:DE19913256
申请日:1999-03-24
Applicant: BASF AG
Inventor: DITRICH KLAUS , LADNER WOLFGANG , MELDER JOHANN-PETER
IPC: C07B53/00 , C07C209/62 , C07C211/27 , C07C211/29 , C07C51/06 , C07C211/06 , C07C59/125
Abstract: The invention relates to a method for hydrolyzing optically active amides to carboxylic acids and optically active amines with retention of the center of chirality. The hydrolysis of the amides is carried out with an alkali or alkaline earth hydroxide in the presence of 5 - 30 wt.- %, based on the amide used, of a polyol or an amine alcohol.
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公开(公告)号:SI0847384T1
公开(公告)日:2000-08-31
申请号:SI9630162
申请日:1996-08-26
Applicant: BASF AG
Inventor: WETTERICH FRANK , WAGNER OLIVER , EICKEN KARL , DITRICH KLAUS , AMMERMANN EBERHARD , LORENZ GISELA , STRATHMANN SIEGFRIED
IPC: A01N47/12 , C07C271/22
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公开(公告)号:DK0847384T3
公开(公告)日:2000-07-17
申请号:DK96929327
申请日:1996-08-26
Applicant: BASF AG
Inventor: WETTERICH FRANK , WAGNER OLIVER , EICKEN KARL , DITRICH KLAUS , AMMERMANN EBERHARD , LORENZ GISELA , STRATHMANN SIEGFRIED
IPC: C07C269/04 , A01N47/12 , C07C269/06 , C07C271/22
Abstract: PCT No. PCT/EP96/03755 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Aug. 26, 1996 PCT Pub. No. WO97/08138 PCT Pub. Date Mar. 6, 1997Carbamoylcarboxamides of the general formula I (R1=unsubstituted or substituted alkyl, alkenyl, alkynyl; R2=hydrogen, halogen, cyano, nitro, or unsubstituted or substituted alkyl, alkoxy, alkylthio, or an unsubstituted or substituted phenyl group which is bonded via oxygen or sulfur) and compositions comprising them, processes for their preparation, and the use of the compounds I and of the compositions.
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公开(公告)号:DE59604905D1
公开(公告)日:2000-05-11
申请号:DE59604905
申请日:1996-09-09
Applicant: BASF AG
Inventor: DITRICH KLAUS , BALKENHOHL FRIEDHELM , LADNER WOLFGANG
IPC: C12M1/40 , B01J23/04 , C07B53/00 , C07B61/00 , C07C69/708 , C07C209/62 , C07C211/27
Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.
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