12.
    发明专利
    未知

    公开(公告)号:DE10145223A1

    公开(公告)日:2003-04-03

    申请号:DE10145223

    申请日:2001-09-13

    Applicant: BASF AG

    Abstract: Preparation of meso-zeaxanthin (A) involves separating a racemic mixture of 1-ethynyl-2,2,6-trimethyl-cyclohexane-1,4-diols (I) into the R- and S-antipodes, then converting them into sterically uniform (A) by four further stages including two Wittig reactions. Several classes of intermediate compounds are new. Preparation of meso-zeaxanthin of formula (A) involves: (a) separating a racemic mixture of acetylenic diols of formulae R-(I) and S-(I) into its antipodes; (b) converting R-(I) and S-(I) into the corresponding 15C phosphonium salts of formulae R-(II) and S-(II) respectively; (c) subjecting R-(II) or S-(II) to Wittig reaction with a 10C dial monoacetal of formula (III), to give a 25C acetal of formula R-(IV) or S-(IV); (d) converting R-(IV) or S-(IV) into the 25C aldehyde of formula R-(V) or S-(V) respectively; and (e) subjecting R-(V) and S-(II) or S-(V) and R-(II) to Wittig reaction to give sterically uniform (A). Ar = aryl; X = 1 equivalent of an anion of an (in)organic acid; R1, R2 = 1-8C alkyl, or R1 + R2 = CH2CR3R4CH2 or CHR5CH2, and R3-R5 = H or 1-4C alkyl. Independent claims are also included for: (i) the production of optically pure R-(I) and S-(I), by conversion of a racemic mixture of R-(I) and S-(I) into a diastereomer mixture using an optically active auxiliary reagent (AR), separating the diastereomers and cleaving AR, and (ii) S-(I), protected S-(I) derivatives of formula S-(XI), cyclohexane derivatives of formulae R-(VI) and S-(VI) and acetylene compounds of formula S-(VII) as new compounds. R6 = optically active urethane, carbonate, sulfonate or acyl residue; R7 = H, 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group; R8 = H or C(Me)(OR9)-CH-CH2; R9 = H or Li, and R10 = non-chiral 1-12C acyl or a hydrolytically cleavable acetal or ether protecting group.

    13.
    发明专利
    未知

    公开(公告)号:DK0801683T3

    公开(公告)日:2002-06-17

    申请号:DK96900601

    申请日:1996-01-20

    Applicant: BASF AG

    Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.

    19.
    发明专利
    未知

    公开(公告)号:DK0847384T3

    公开(公告)日:2000-07-17

    申请号:DK96929327

    申请日:1996-08-26

    Applicant: BASF AG

    Abstract: PCT No. PCT/EP96/03755 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Aug. 26, 1996 PCT Pub. No. WO97/08138 PCT Pub. Date Mar. 6, 1997Carbamoylcarboxamides of the general formula I (R1=unsubstituted or substituted alkyl, alkenyl, alkynyl; R2=hydrogen, halogen, cyano, nitro, or unsubstituted or substituted alkyl, alkoxy, alkylthio, or an unsubstituted or substituted phenyl group which is bonded via oxygen or sulfur) and compositions comprising them, processes for their preparation, and the use of the compounds I and of the compositions.

    20.
    发明专利
    未知

    公开(公告)号:DE59604905D1

    公开(公告)日:2000-05-11

    申请号:DE59604905

    申请日:1996-09-09

    Applicant: BASF AG

    Abstract: PCT No. PCT/EP96/03948 Sec. 371 Date Jan. 27, 1998 Sec. 102(e) Date Jan. 27, 1998 PCT Filed Sep. 9, 1996 PCT Pub. No. WO97/10201 PCT Pub. Date Mar. 20, 1997The present invention relates to a process for cleaving optically active amides to carboxylic acids and optically active amines with retention of the center of chirality, wherein the amides are hydrolyzed in the presence of a polyol or of an amino alcohol and of an alkali metal or alkaline earth metal hydroxide.

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