公开(公告)号：DE19536891A1

公开(公告)日：1997-04-10

申请号：DE19536891

申请日：1995-10-04

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  RIECHERS HARTMUT DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: A61K31/00 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/505 ,  A61K31/53 ,  A61P5/24 ,  A61P5/36 ,  A61P5/42 ,  A61P9/12 ,  C07D213/74 ,  C07D239/10 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/50 ,  C07D239/52 ,  C07D239/58 ,  C07D251/46 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052 ,  C07D491/056 ,  C07D251/12 ,  C07D405/06 ,  C07D403/06 ,  C07D491/044 ,  C07C229/02 ,  A61K31/495

Abstract: The invention relates to amino acid derivatives of formula (I), in which the groups have the meaning given in the description. It also relates to the use thereof as inhibitors for endothelin receptors.

公开(公告)号：DE4415998A1

公开(公告)日：1995-11-09

申请号：DE4415998

申请日：1994-05-06

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANITSCHKE LOTHAR DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR ,  MUELLER STEFAN DR ,  POTZOLLI BERND DE DR ,  RITTER KURT DR ,  ZIERKE THOMAS DR ,  THYES MARCO DR

IPC: A61K38/00 ,  A61P35/00 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: Compounds of formula (I) are disclosed, wherein R , R , R , and R have the meanings indicated in the description, as well as a process for the production of these compounds. The compounds are suitable for use as starting material for the synthesis of substances which have anti-tumour properties.

公开(公告)号：DE4415997A1

公开(公告)日：1995-11-09

申请号：DE4415997

申请日：1994-05-06

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANITSCHKE LOTHAR DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR ,  MUELLER STEFAN DR ,  POTZOLLI BERND DE DR ,  RITTER KURT DR ,  ZIERKE THOMAS DR ,  THYES MARCO DR

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: Disclosed is the compound Me2Val-Val-MeVal-Pro-Pro-NHBzl. HCl. The compound is produced from Z-Val-Val-MeVal-Pro-OR , wherein Z and R have the meanings indicated in the description. The compound disclosed has anti-neoplastic properties.

公开(公告)号：HU0004234A2

公开(公告)日：2001-05-28

申请号：HU0004234

申请日：1998-07-07

Applicant: BASF AG

Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS ,  JANSSEN BERND ,  KLING ANDREAS DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K7/06 ,  C12P19/34

Abstract: Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L  (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and r are each, independently, 0 or 1. L is a monovalent radical, such as, for example, an amino group, an N-substituted amino group, a &bgr;-hydroxylamino group, a hydrazido group, an alkoxy group, a thioalkoxy group, an aminoxy group, or an oximato group. The present invention also includes a method for treating cancer in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound of Formula I in a pharmaceutically acceptable composition.

公开(公告)号：DE19724983A1

公开(公告)日：1998-12-17

申请号：DE19724983

申请日：1997-06-13

Applicant: BASF AG

Inventor： PUHL MICHAEL DR ,  ADIDA SERGE ,  KLINGE DAGMAR DR ,  KLING ANDREAS DR

IPC: G01N33/50 ,  C07B61/00 ,  C07D239/96 ,  C40B40/04 ,  C40B50/00 ,  G01N33/15 ,  G01N37/00 ,  C07D401/06 ,  C07D265/26 ,  A01N43/54 ,  A61K31/495

Abstract: The invention relates to a method for producing quinazoline-dione derivatives and the use of said derivatives.

公开(公告)号：CZ184698A3

公开(公告)日：1998-09-16

申请号：CZ184698

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BARLOZZARI TERESA ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  HEGE HANS-GUENTHER DR ,  JANSSEN BERND DR ,  KLING ANDREAS DR ,  LIETZ HELMUT ,  RITTER KURT DR ,  ULRICH MARTINA DR ,  WEYMANN JURGEN DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：CZ24398A3

公开(公告)日：1998-07-15

申请号：CZ24398

申请日：1996-07-12

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  RITTER KURT DR ,  ZIERKE THOMAS DR

IPC: C07K1/02 ,  C07K1/12 ,  C07K5/06 ,  C07K5/078 ,  C07K5/08 ,  C07K5/083 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03073 Sec. 371 Date Jan. 13, 1998 Sec. 102(e) Date Jan. 13, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05162 PCT Pub. Date Feb. 13, 1997A process for preparing pentapeptides of the formula I where A and R1-R3 have the stated meanings, comprises assembling the pentapeptide stepwise starting from a prolinamide of the formula II where R1 and R2 have the abovementioned meanings, and eliminating the group -NR1R2 by hydrolysis where appropriate the peptide obtained in this way.

公开(公告)号：DE19614542A1

公开(公告)日：1997-10-16

申请号：DE19614542

申请日：1996-04-12

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  KLING ANDREAS DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  BAUMANN ERNST DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  HERGENROEDER STEFAN ,  SCHULT SABINE DR

IPC: A61K31/00 ,  A61K31/47 ,  A61K31/505 ,  A61P9/00 ,  A61P9/12 ,  A61P13/00 ,  A61P13/12 ,  C07D215/22 ,  C07D215/227 ,  C07D239/34 ,  C07D239/60 ,  C07D401/12 ,  C07D403/12 ,  C07D239/32 ,  C07D213/60 ,  C07C215/16 ,  C07C217/22 ,  C07D227/08 ,  C07D247/02 ,  A61K31/44

Abstract: The present invention relates to carboxylic acid derivatives of formula (I) in which the radicals have the meaning given in the description, and the production of these substances and their use as medicaments.

公开(公告)号：DE19614534A1

公开(公告)日：1997-10-16

申请号：DE19614534

申请日：1996-04-12

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  HILLEN HEINZ DR ,  UNGER LILIANE DR ,  ELGER BERND DR

IPC: C07D251/30 ,  A61K31/00 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/53 ,  A61P7/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/12 ,  A61P13/00 ,  A61P13/08 ,  A61P13/12 ,  C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D251/48 ,  C07D403/12 ,  C07D491/044 ,  C07D251/26

Abstract: Carboxylic acid derivatives having the formula (I) are disclosed, as well as the production of these compounds and their use as medicaments. In the formula, the radicals have the meanings defined in the description.

公开(公告)号：CZ326096A3

公开(公告)日：1997-04-16

申请号：CZ326096

申请日：1995-04-26

Applicant: BASF AG

Inventor： AMBERG WILHELM DR ,  BERNARD HARALD DR ,  BUSCHMANN ERNST DR ,  HAUPT ANDREAS DR ,  JANITSCHKE LOTHAR DR ,  JANSSEN BERND DR ,  KARL ULRICH DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  DE POTZOLLI BERND DR ,  RITTER KURT DR ,  THYES MARCO DR ,  ZIERKE THOMAS DR

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  C07K7/06 ,  C07K14/52

Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.