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    USE OF RE-DISPERSIBLE POLYMERIC POWDER OR POLYMERIC GRANULE AS BINDER AND SOLID PHARMACEUTICAL DOSAGE FORM
    13.
    发明专利
    USE OF RE-DISPERSIBLE POLYMERIC POWDER OR POLYMERIC GRANULE AS BINDER AND SOLID PHARMACEUTICAL DOSAGE FORM 失效

    公开(公告)号：JPH10298111A

    公开(公告)日：1998-11-10

    申请号：JP5764598

    申请日：1998-03-10

    Applicant: BASF AG

    Inventor： KOLTER KARL DR ,  TIEFENSEE KRISTIN DR ,  ZEITZ KATRIN DR

    IPC: A61K47/04 ,  A61K9/20 ,  A61K9/32 ,  A61K47/12 ,  A61K47/32 ,  A61K47/38

    Abstract: PROBLEM TO BE SOLVED: To obtain a polymeric powder or polymeric granules comprising a water-insoluble polymer and a water-soluble polymer, suitable as a binder for production of solid pharmaceutical dosage forms and capable of rapidly releasing active substance(s). SOLUTION: This polymeric powder or granules as binder comprise(s) 10-95 wt.% of polyvinyl acetate, 5-90 wt.% of an N-vinylpyrrolidone-contg. polymer, 0-20 wt.% of another water-soluble or water-swellable substance and 0-20 wt.% of a water-insoluble pulverizing agent, and in some cases, other additive(s). The content of the binder in the other objective dosage form is 0.5-20 wt.%. This polymeric powder or granules has (have) remarkable binding action, and does not disintegrate the dose form and also does not virtually affect the release of the active substance(s) included in the preparation within the concentration range of 0.5-20 wt.%, based on the whole weight of the prescribed preparation as the dosage form.

    PREPARATION OF AQUEOUS POLYMER DISPERSION, POLYMER DISPERSION PREPARED THEREBY, USE THEREOF, AND SOLID DRUG DOSAGE FORM PREPARED THEREWITH
    17.
    发明专利
    PREPARATION OF AQUEOUS POLYMER DISPERSION, POLYMER DISPERSION PREPARED THEREBY, USE THEREOF, AND SOLID DRUG DOSAGE FORM PREPARED THEREWITH 失效

    公开(公告)号：JP2000178311A

    公开(公告)日：2000-06-27

    申请号：JP35418699

    申请日：1999-12-14

    Applicant: BASF AG

    Inventor： ANGEL MAXIMILIAN DR ,  KOLTER KARL DR ,  SANNER AXEL DR

    IPC: A61K9/32 ,  C08F2/16 ,  C08F2/22 ,  C08F2/38 ,  C08F20/10 ,  C08F220/14 ,  C08F220/18

    Abstract: PROBLEM TO BE SOLVED: To obtain a polymer dispersion having a low monomer content and excellent storage stability by adjusting the pH of a starting aqueous dispersion by adding at least two basic reagents thereto in a plurality of stages in the course of polymerizing a free-radical-polymerizable ethylenically unsaturated monomer in an aqueous system in the presence of a polymerization initiator. SOLUTION: At least one free-radical-polymerizable ethylenically unsaturated monomer is polymerized in the presence of an acidic polymerization initiator in an aqueous system whose pH has been adjusted at a constant value in the range of 1-7.5 by the addition of a reagent 1 being a salt of an acid selected from the group consisting of carbonic acid, boric acid, acetic acid, citric acid, and phosphoric acid. After the polymerization initiator is consumed, the polymerization is continued in the presence of a redox catalyst, and reagent 1 is further added to the aqueous dispersion to buffer it. The aqueous dispersion is adjusted to a pH of 6-10 by the addition of a reagent 2 being a base selected from the group consisting of an alkali (alkaline earth) metal hydroxide, ammonia, and a primary to tertiary amine to obtain an aqueous polymer dispersion having a residual monomer content of 100 ppm or below.

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