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    12.
    发明专利
    未知

    公开(公告)号：DE19624808A1

    公开(公告)日：1998-01-02

    申请号：DE19624808

    申请日：1996-06-21

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS-PETER DR ,  SZABO LASZLO DR

    IPC: C07D403/04 ,  A61K31/495

    Abstract: Pyrrolyl quinoxalindiones of formula (I) and their tautomeric and isomeric forms and their physiologically acceptable salts, in which R is hydrogen, C1-C6 alkyl, substituted by hydroxyl or carboxyl, R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, a chlorine, fluorine or bromine atom, a trihalogen methyl, cyano, or nitro group or SO2C1C4 alkyl, R is COOH or a radical hydrolysable to form the carboxyl group, and n is 1 or 2.

    15.
    发明专利
    未知

    公开(公告)号：DE3825559A1

    公开(公告)日：1990-02-01

    申请号：DE3825559

    申请日：1988-07-28

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  RASCHACK MANFRED DR ,  PHILIPSBORN GERDA VON DR MED

    IPC: A61K31/135 ,  A61K31/13 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/06 ,  C07C217/22 ,  C07D295/08 ,  C07D295/092

    Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.

    16.
    发明专利
    未知

    公开(公告)号：AT172461T

    公开(公告)日：1998-11-15

    申请号：AT93107984

    申请日：1993-05-17

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS PETER DR

    IPC: A61K31/495 ,  A61K31/498 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D403/04 ,  C07D487/12 ,  C07D487/14

    Abstract: Quinoxaline-2,3-(1H,4H)diones of the general formula I in which the variables have the following meaning: R is hydrogen; an aliphatic radical having up to 12 C atoms, which can carry one of the following substituents: phenyl, cyclopentyl, cyclohexyl or a group -CO-R , -CO-O-R or -CO-NH-R , where R denotes hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl; a cycloaliphatic radical having up to 12 C atoms, or a phenyl group, where the cyclic groups contained in R can carry up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R and -CO-NH-R ; R is a pyrrol-1-yl group which can carry up to two of the following substituents: C1-C4-alkyl, phenyl, phenylsulphonyl, nitro, cyano and one of the groups -CO-O-R , -CO-NH-R , -CH2-O-R , -O-R and -CH=NO-R ; R is identical or different radicals from the following: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and one of the groups -CO-O-R and -CO-NH-R and a fused benzene ring; n is 0 to 3. Quinoxaline-2,3-(1H,4H)diones I' in which R has the meaning mentioned. The compounds I and I' are suitable as medicines for human and veterinary medicine.

    18.
    发明专利
    未知

    公开(公告)号：DE19503825A1

    公开(公告)日：1996-04-04

    申请号：DE19503825

    申请日：1995-02-06

    Applicant: BASF AG

    Inventor： TREIBER HANS-JOERG DR ,  LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR ,  HOFMANN HANS PETER DR

    IPC: C07D487/04 ,  A61K31/495

    Abstract: Imidazoloquinoxalinones have the formula (I), in which R stands for hydrogen, branched or linear C1-5-alkyl or a phenyl, pyridyl or thienyl group possibly substituted by one to two chlorine atoms, a trifluoromethyl, a nitrodioxy or a methylene dioxy group; R stands for hydrogen, C1-5-alkyl or C3-8-dialkylaminoalkyl; R stands for a chlorine or bromine atom, a trifluoromethyl, cyano or nitro group; A stands for a five-membered heterocycle with 1-4 nitrogen atoms or 1-2 nitrogen atoms and one oxygen or sulphur atom possible substituted by R and R ; the radicals R and R , that may be the same or different, stand for hydrogen, C1-5-alkyl, C1-5-hydroxyethyl, phenyl, phenyl substituted by a chlorine atom, a trifluoromethyl or nitro group, -CHO, -COOH, -COO-C1-5-alkyl, -CH2-NR R (in which R = H, C1-5-alkyl, R = H, C1-5-alkyl), -CH2-NH-CO-R (in which R = C1-5-alkyl, phenyl, a phenyl group or an heteroaryl group possibly substituted by a chlorine atom of a nitro or trifluoromethyl group) or -CH2-NHCONHR ; and B stands for a bond or a C1-5-alkylene chain. Also disclosed are the tautomer and isomer forms of these compounds, as well as their physiologically compatible salts. These new substances have good glutamate antagonistic effects and are useful for controlling neurodegenerative diseases.

    20.
    发明专利
    未知

    公开(公告)号：DE58908517D1

    公开(公告)日：1994-11-24

    申请号：DE58908517

    申请日：1989-07-21

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  RASCHACK MANFRED DR ,  VON PHILIPSBORN GERDA DR

    IPC: A61K31/135 ,  A61K31/13 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/06 ,  C07C217/22 ,  C07D295/08 ,  C07D295/092

    Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.

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