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    THERMAL CYCLER WITH VAPOR CHAMBER FOR RAPID TEMPERATURE CHANGES
    11.
    发明专利
    THERMAL CYCLER WITH VAPOR CHAMBER FOR RAPID TEMPERATURE CHANGES 未知

    公开(公告)号：CA2832759A1

    公开(公告)日：2012-11-15

    申请号：CA2832759

    申请日：2012-05-01

    Applicant: BIO RAD LABORATORIES

    Inventor： GUO KUN ,  CHU DANIEL Y ,  PATT PAUL J ,  SADRI AMIR ,  TONG ROGER

    IPC: B01L7/00

    Abstract: Rapid and uniform temperature changes in the wells of a microplate or any thin-walled plate that contains an array of reaction wells or sample receptacles are achieved by the use of heating and cooling elements with a vapor chamber interposed between such elements and the microplate. The upper surface of the vapor chamber and the underside of the sample plate in certain embodiments are complementary in shape, i.e., they have identical but oppositely directed contours in the areas around each of the sample receptacles, to provide continuous surface contact along the surface of each receptacle. In other embodiments, an intermediary plate is placed between the vapor chamber and the well plate, with the top surface of the intermediary plate being complementary in shape to the underside of the well plate.

    PLANAR REGISTRATION OF MULTI-WELL PLATE FROM WELL SIDE
    13.
    发明专利
    PLANAR REGISTRATION OF MULTI-WELL PLATE FROM WELL SIDE 未知

    公开(公告)号：CA2635999C

    公开(公告)日：2011-05-17

    申请号：CA2635999

    申请日：2007-01-12

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y

    IPC: B01L9/00

    Abstract: A multi-well plate such as a microtiter plate is secured from its well side in a manner that corrects or compensates for any deviations of the plate base from a planar configuration. This is achieved by an apparatus that includes an array of posts with exposed tips that define a plane, a plurality of movable collets that, when appropriately actuated, seize the walls of selected wells, and a biasing means to urge the collets in a direction that forces the wells of the microtiter plate against the exposed tips of the posts.

    SLAB ELECTROPHORESIS SYSTEM WITH IMPROVED SAMPLE WELLS AND COOLING MECHANISM
    16.
    发明专利
    SLAB ELECTROPHORESIS SYSTEM WITH IMPROVED SAMPLE WELLS AND COOLING MECHANISM 未知

    公开(公告)号：CA2042641A1

    公开(公告)日：1991-11-17

    申请号：CA2042641

    申请日：1991-05-15

    Applicant: BIO RAD LABORATORIES

    Inventor： CHU DANIEL Y ,  BARICH JOHN J

    IPC: C25B9/00 ,  B01D57/02 ,  G01N27/26 ,  G01N27/447 ,  G01N27/453

    Abstract: 14 SLAB ELECTROPHORESIS SYSTEM WITH IMPROVED SAMPLE WELLS AND COOLING MECHANISM A gel enclosure and buffer tank for vertical slab gel electrophoresis are disclosed. The gel enclosure is formed from two flat plates, one of which contains angled troughs extending off to one side to serve as extensions of the sample wells, thereby increasing the volumetric capacity of each sample well, and improving the ease of loading it with sample. The buffer tank is constructed in such a manner as to hold one flat plate of the gel enclosure in contact with a flat heat transfer wall of the buffer tank, with cooling applied to the outside of the wall by thermoelectric means. Buffer solution below the gel enclosure is also cooled by the cooling wall, and bubbles generated at an electrode, also positioned below the gel enclosure, agitate the cooled buffer solution, extending the cooling effect over the entire surface of the other flat plate of the gel enclosure.

    MICROPLATES WITH ULTRA-THIN WALLS BY TWO-STAGE FORMING
    17.
    发明专利
    MICROPLATES WITH ULTRA-THIN WALLS BY TWO-STAGE FORMING 未知

    公开(公告)号：CA2732433C

    公开(公告)日：2016-09-13

    申请号：CA2732433

    申请日：2009-07-31

    Applicant: BIO-RAD LABORATORIES INC

    Inventor： CHU DANIEL Y ,  DU HUI

    IPC: B29C49/06 ,  B01L3/00 ,  B29C45/00 ,  B29C55/08

    Abstract: A multi-well plate with wells having ultra-thin walls and yet with sufficient structural rigidity to allow reliable use of the plate in automated instrumentation is formed by first forming a plate blank by injection molding, the blank being of a thickness that provides the desired rigidity, and then subjecting the blank to vacuum forming to stretch designated areas in the blank to form wells or to extend wells already formed, the stretching resulting in a reduction in thickness of the molded resin at the walls of the wells only.

    Compact automated cell counter
    20.
    发明专利
    Compact automated cell counter 未知

    公开(公告)号：AU2010286499A1

    公开(公告)日：2012-03-15

    申请号：AU2010286499

    申请日：2010-08-30

    Applicant: BIO RAD LABORATORIES

    Inventor： MCCOLLUM TOM ,  PATT PAUL ,  SHEN FRANK ,  CHU DANIEL Y ,  FLORY DON ,  GRIFFIN MIKE ,  HENG XIN ,  HEFNER ELI

    IPC: G06K9/00 ,  C12M1/34

    Abstract: Biological cells in a liquid suspension are counted in an automated cell counter that focuses an image of the suspension on a digital imaging sensor that contains at least 4,000,000 pixels each having an area of 2 x 2 μm or less and that images a field of view of at least 3 mm. The sensor enables the counter to compress the optical components into an optical path of less than 20 cm in height when arranged vertically with no changes in direction of the optical path as a whole, and the entire instrument has a footprint of less than 300 cm. Activation of the light source, automated focusing of the sensor image, and digital cell counting are all initiated by the simple insertion of the sample holder into the instrument. The suspension is placed in a sample chamber in the form of a slide that is shaped to ensure proper orientation of the slide in the cell counter.

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