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公开(公告)号：AU2013315167A1
公开(公告)日：2015-04-30
申请号：AU2013315167
申请日：2013-09-13
Applicant: LIFE TECHNOLOGIES CORP
Inventor： MAJUMDAR NIVEDITA SUMI , WESSEL THOMAS , WOO DAVID C , SIKORA MARCIN , JANAWAY GORDON , RAIZADA SHWETA , LANKESTER JOANNA , MARKS JEFFREY , WESSEL DANIEL
IPC: G06F19/24
Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.
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公开(公告)号：SG10202107223QA
公开(公告)日：2021-08-30
申请号：SG10202107223Q
申请日：2018-02-16
Applicant: LIFE TECHNOLOGIES CORP
Inventor： MAJUMDAR NIVEDITA , GEORGE WALLACE , MARKS JEFFREY , JIANG MING , CHANG SYLVIA , WOO DAVID
Abstract: Embodiments implementing selected automated quality control operations in sample processing instruments that analyze dye-labeled samples are disclosed. In some embodiments, temperature and/or pressure parameters are measured and compared to thresholds to determine whether warning should be provided and/or actions taken. Embodiments for implementing automated correction of spectral error during the instrument's normal runtime operation without requiring the user to conduct a special, separate calibration run are also disclosed.
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公开(公告)号：SG11201908549RA
公开(公告)日：2019-10-30
申请号：SG11201908549R
申请日：2018-02-16
Applicant: LIFE TECHNOLOGIES CORP
Inventor： MAJUMDAR NIVEDITA , GEORGE WALLACE , MARKS JEFFREY , JIANG MING , CHANG SYLVIA , WOO DAVID
IPC: G01N27/447
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 23 August 2018 (23.08.2018) WIPO I PCT oimiolo VIII °nolo OH Em OH mo mil mu° X11 ois (10) International Publication Number WO 2018/151843 A2 (51) International Patent Classification: G01N 27/447 (2006.01) (21) International Application Number: PCT/US2018/000058 (22) International Filing Date: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) 16 February 2018 (16.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,700 17 February 2017 (17.02.2017) US 62/463,551 24 February 2017 (24.02.2017) US (71) Applicant: LIFE TECHNOLOGIES CORPORATION [US/US]; 5823 Newton Drive, Carlsbad, CA 92008 (US). (72) Inventors: MAJUMDAR, Nivedita; c/o Life Technolo- gies Corporation, 5823 Newton Drive, Carlsbad, CA 92008 (US). GEORGE, Wallace; c/o Life Technologies Corpo- ration, 5823 Newton Drive, Carlsbad, CA 92008 (US). MARKS, Jeffrey; c/o Life Technologies Corporation, 5823 Newton Drive, Carlsbad, CA 92008 (US). JIANG, Ming; c/o Life Technologies Corporation, 5823 Newton Drive, Carlsbad, CA 92008 (US). CHANG, Sylvia; c/o Life Tech- nologies Corporation, 5823 Newton Drive, Carlsbad, CA 92008 (US). WOO, David; c/o Life Technologies Corpo- ration, 5823 Newton Drive, Carlsbad, CA 92008 (US). (74) Agent: MAURIEL, Michael; Mauriel Kapouytian Woods LLP, 15 W. 26th Street 7th Floor, New York, NY 10010 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 71' MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 00 1-1 00 (54) Title: AUTOMATED QUALITY CONTROL AND SPECTRAL ERROR CORRECTION FOR SAMPLE ANALYSIS INSTRU- MENTS \" (57) : Embodiments implementing selected automated quality control operations in sample processing instruments and systems C are disclosed. Embodiments for implementing automated correction of spectral error in such instruments and systems are also disclosed. These and other embodiments are further disclosed herein.
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公开(公告)号：RU2702577C2
公开(公告)日：2019-10-08
申请号：RU2017131209
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor： CHU YONG , MARKS JEFFREY , FREUDENTHAL JACOB , CHEN MINGSONG , TOH TIONG HAN , AGUANNO MAURO , LAU LIK SENG , LOH LIAN SENG , TEO KOK SIONG , CHU ZENG WEI , MATHERS XIN , UY MICHAEL , YEO HUEI STEVEN , BOO KUAN MOON , LEE WAY XUANG , KOO CHIN YONG , TEO WEI FUH , LAU SOO YONG , SHIN HON SIU , TAN ZEQI , WESSEL THOMAS , WOO DAVID
Abstract: Изобретениев целомкасаетсясистем, устройстви способовнаблюдения, испытанияи/илианализаодногоилинесколькихбиологическихпроб. Системадлябиологическогоанализа, содержащая: узелблокапробоподготовки, которыйсодержитблокпробоподготовки, выполненныйс возможностьювмещениядержателяпроб, причемдержательпробвыполненс возможностьюприемамножествапроб; системууправления, выполненнуюс возможностьюциклированиямножествапробпорядутемператур; иавтоматизированныйлоток, содержащийподвижныйузел, причемлотоквыполненс возможностьюреверсивногоскользящегоперемещенияузлаблокапробоподготовкииззакрытойв открытуюпозициюдляобеспечениядоступапользователякомножествудержателейпроб; лотокилиузелблокапробоподготовкидополнительносодержитпластинку, выполненнуюс возможностьюблокированиясвета, излучаемогоотпозиционногодатчика. Техническийрезультат– повышениеэффективностианализабиологическихпроб. 3 н. и 15 з.п. ф-лы.
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Patent Agency Ranking
公开(公告)号：SG11201706352QA
公开(公告)日：2017-09-28
申请号：SG11201706352Q
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor： CHU YONG , FREUDENTHAL JACOB , MARKS JEFFREY
Abstract: Some embodiments describe a computer-implemented method for calibrating a fluorescent dye. The method can comprise imaging a sample holder, loaded into an instrument, at more than one channel. The sample holder can comprise a plurality of reaction sites and more than one dye type, with each dye occupying more than one reaction site. The method can further comprise identifying a peak channel for each dye on the sample holder, normalizing each channel to the peak channel for each dye, and producing a dye matrix that can comprise a set of dye reference values.
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公开(公告)号：SG11201706332RA
公开(公告)日：2017-09-28
申请号：SG11201706332R
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor： CHU YONG , MARKS JEFFREY , FREUDENTHAL JACOB , WESSEL THOMAS , WOO DAVID
Abstract: In one exemplary embodiment, a method for calibrating an instrument is provided. The instrument includes an optical system capable of imaging fluorescence emission from a plurality of reaction sites. The method includes performing a region-of-interest (ROI) calibration to determine reaction site positions in an image. The method further includes performing a pure dye calibration to determine the contribution of a fluorescent dye used in each reaction site by comparing a raw spectrum of the fluorescent dye to a pure spectrum calibration data of the fluorescent dye. The method further includes performing an instrument normalization calibration to determine a filter normalization factor. The method includes performing an RNase P validation to validate the instrument is capable of distinguishing between two different quantities of sample.
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公开(公告)号：SG11201506481QA
公开(公告)日：2015-09-29
申请号：SG11201506481Q
申请日：2014-02-24
Applicant: LIFE TECHNOLOGIES CORP
Inventor： CHEN MINGSONG , AGUANNO MAURO , BOO KUAN MOON , SOH WOON LIANG TERENCE , FREUDENTHAL JACOB , MARKS JEFFREY
IPC: G01N21/27
Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.
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公开(公告)号：RU2716171C2
公开(公告)日：2020-03-06
申请号：RU2017131046
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor： CHU YONG , MARKS JEFFREY , FREUDENTHAL JACOB , WESSEL THOMAS , WOO DAVID
IPC: G01N21/27
Abstract: Группаизобретенийотноситсяк областиизмерительнойтехники. Способдлякалибровкиприбора, включающегов себяоптическуюсистемус возможностьювизуализациифлуоресцентногоизлученияотмножествареакционныхучастков, такихкаклункидержателяпроб, включает: проведениекалибровкиобластиинтереса (ОИ) дляопределенияпозицийреакционныхучастковнаизображении, причемкалибровкаОИуменьшаетошибкиопределенияреакционныхучастковпутемминимизациипоменьшеймереодногофактораизследующейгруппы: насыщениекрасителявомножествереакционныхучастков, вращениесетки, вариациякоэффициентовусиленияи оптическаярадиальнаядисторсия; проведениекалибровкичистогокрасителядляопределениявкладафлуоресцентногокрасителя, применяемогов каждомреакционномучастке, путемсравненияисходногоспектрафлуоресцентногокрасителяс калибровочнымиданнымичистогоспектрафлуоресцентногокрасителя, приэтомреакционныеучасткисодержатодинаковыеконцентрациикрасителя, чтобыобеспечитьполучениечистыхспектральныхзначенийдлякаждойлункидержателяпроб, адержательпробпредставляетсобойкалибровочныйпланшетс шахматнойконфигурацией; проведениекалибровкинормализацииприборадляопределениякоэффициентанормализациидляфильтра; ипроведениевалидациис помощьюРНКазыР длявалидациивозможностиприбораразличатьдваразныхколичестваоднойпробы. Техническийрезультатзаключаетсяв обеспеченииустойчивостик принятиюсубоптимальныхкалибровок, улучшенииобъективностии единообразиявовремяосуществлениятакойдеятельности. 4 н. и 35 з.п. ф-лы, 23 ил., 1 табл.
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公开(公告)号：SG11201706355YA
公开(公告)日：2017-09-28
申请号：SG11201706355Y
申请日：2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor： MARKS JEFFREY
Abstract: The present teachings relate to a method and system for normalizing spectra across multiple instruments. In an embodiment of the present invention, the method comprises at least one reference instrument and a test instrument. Each instrument comprises at least one excitation filter and at least one emission filter arranged in pairs. Each instrument further comprises a pure dye plate comprising a plurality of wells. Each well contains a plurality of dyes where each dye comprises a fluorescent component. Fluorescent spectra are obtained from each instrument for each dye across multiple filter combinations to contribute to a pure dye matrix Mref for the reference instrument and pure dye matrix M for the test instrument. The pure dye spectra can then be multiplied by correction factors for each filter pair to result in corrected pure dye spectra, then normalized and the multicomponenting data can be extracted.
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