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    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    2.
    发明申请
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
    光学系统和生物分析方法

    公开(公告)号：WO2014130970A3

    公开(公告)日：2015-12-03

    申请号：PCT/US2014018110

    申请日：2014-02-24

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHEN MINGSONG ,  AGUANNO MAURO ,  BOO KUAN MOON ,  SOH WOON LIANG TERENCE ,  FREUDENTHAL JACOB ,  MARKS JEFFREY

    IPC: G01N21/27 ,  G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2201/061 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/121

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样品保持器被仪器保持时产生第一目标温度，并且当第二样品保持器被仪器保持时产生第二目标温度。

    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES
    5.
    发明专利
    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES 未知

    公开(公告)号：SG10202103903UA

    公开(公告)日：2021-06-29

    申请号：SG10202103903U

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHEN MINGSONG ,  BOO KUAN MOON ,  TOH TIONG HAN ,  AGUANNO MAURO ,  LAU SOO YONG ,  YEO HUEI STEVEN ,  TEO WEI FUH

    Abstract: An instrument 100 for biological analysis, comprising an excitation source 402 , an optical sensor 490 configured to receive emissions from one or more biological samples 310 in response to the excitation source, an excitation optical system disposed along an excitation optical path and an emission optical system disposed along an emission optical path. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. A cover 102 is disposed in the excitation path immediately adjacent to the sample, the cover comprising a surface which is illuminated by the excitation light and which reflects radiation from the excitation source. A radiation shield 475 including a sensor aperture 478 disposed along an emission optical path and a blocking structure 480 disposed to cooperate with the sensor aperture, whereby the radiation shield ensures that only radiation which is reflected by the illuminated surface and which is also additionally reflected by another surface of the instrument housing is able to reach the optical sensor.

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    6.
    发明专利
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 未知

    公开(公告)号：IN3441DEN2014A

    公开(公告)日：2015-06-05

    申请号：IN3441DEN2014

    申请日：2014-04-29

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAHER KEVIN ,  CHEN MINGSONG ,  FREUDENTHAL JACOB ,  BOO KUAN MOON ,  LAU SOO YONG ,  FORTESCUE DAVID ,  SHEN MING ,  SOH WOON LIANG TERENCE

    IPC: G01N21/64

    Abstract: An instrument (1000) for processing and/or measuring a biological process contains an excitation source (110) a sample holder (204) an optical sensor (118) an excitation optical system (120) and an emission optical system (125). The sample holder (204) is configured to receive a plurality of biological samples. The optical sensor (118) is configured to receive an emission from the biological samples. The excitation optical system (120) is disposed along an excitation optical path (126) and is configured to direct the electromagnetic radiation from the excitation source (110) to the biological samples. The emission optical system (125) is disposed along an emission optical path (128) and is configured to direct electromagnetic emissions from the biological samples to the optical sensor (118). The instrument further contains a plurality of filter assemblies (130 132) configured to be interchangeably located along at least one of the optical paths. The plurality of filter components (131) includes a first filter component (138) characterized by a first optical power and a first filter (140) having a first filter function the first filter function characterized by at least one of a first low pass wavelength or a first high pass wavelength. The second filter assembly (142) is characterized by a second optical power and a second filter (145) having a second filter function the second filter function comprising at least one of a second low pass wavelength that is different than the first low pass wavelength or a second high pass wavelength that is different than the first high pass wavelength. The second optical power differs from the first optical power by an amount sufficient to at least partially compensate for an aberration introduced by the second filter (145) relative to the first filter (140).

    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES
    8.
    发明专利
    SYSTEMS AND METHODS FOR ASSESSING BIOLOGICAL SAMPLES 未知

    公开(公告)号：SG10201811725SA

    公开(公告)日：2019-02-27

    申请号：SG10201811725S

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHEN MINGSONG ,  BOO KUAN MOON ,  TOH TIONG HAN ,  AGUANNO MAURO ,  LAU SOO YONG ,  YEO HUEI STEVEN ,  TEO WEI FUH

    Abstract: Systems and Methods for Assessing Biological Samples of the Disclosure An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument. Fig. 10

    СИСТЕМЫ И СПОСОБЫ ОЦЕНКИ БИОЛОГИЧЕСКИХ ПРОБ
    9.
    发明专利
    СИСТЕМЫ И СПОСОБЫ ОЦЕНКИ БИОЛОГИЧЕСКИХ ПРОБ 未知

    公开(公告)号：RU2708542C2

    公开(公告)日：2019-12-09

    申请号：RU2017131221

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHEN MINGSONG ,  BOO KUAN MOON ,  TOH TIONG HAN ,  AGUANNO MAURO ,  LAU SOO YONG ,  YEO HUEI STEVEN ,  TEO WEI FUH

    IPC: G01N21/64

    Abstract: Изобретениеотноситсяк системам, устройствами способамнаблюдения, тестированияи/илианализабиологическихпроб. Инструментдлябиологическогоанализасодержитбазу, источниквозбуждения, оптическийдатчик, оптическуюсистемувозбужденияи оптическуюсистемуэмиссии. Базавыполненас возможностьюприемадержателяпроб, содержащегомножествобиологическихпроб. Оптическийдатчиквыполненс возможностьюприемаэмиссийотбиологическихпробв ответнаисточниквозбуждения. Инструментможетдополнительносодержатьлинзудатчика, заключеннуюв корпуслинзы, имеханизмфокусировки, содержащиймеханизм, которыйзацепляеткорпуслинзы, гдемеханизмфокусировкидоступенснаружикорпусадлярегулированияфокуса, атакжеотверстиедлядатчика, расположенноевдольоптическогопутиэмиссии, иблокирующуюконструкцию, расположеннуюдлявзаимодействияс отверстиемдлядатчикатак, чтооптическимдатчикомнепринимаетсяникакоеотраженноеизлучениеотосвещеннойповерхностиоколодержателяпроб, котороетакженебылоотраженодругойповерхностьюинструмента. 14 з.п. ф-лы, 20 ил., 2 табл.

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    10.
    发明专利
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 未知

    公开(公告)号：SG11201401919TA

    公开(公告)日：2014-10-30

    申请号：SG11201401919T

    申请日：2012-09-28

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAHER KEVIN ,  CHEN MINGSONG ,  FREUDENTHAL JACOB ,  BOO KUAN MOON ,  LAU SOO YONG ,  FORTESCUE DAVID ,  SHEN MING ,  SOH WOON LIANG TERENCE

    IPC: G01N21/64

    Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.

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