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    METHODS AND SYSTEMS FOR BIOLOGICAL INSTRUMENT CALIBRATION
    1.
    发明申请
    METHODS AND SYSTEMS FOR BIOLOGICAL INSTRUMENT CALIBRATION 审中-公开
    生物仪器校准的方法和系统

    公开(公告)号：WO2016127124A3

    公开(公告)日：2016-09-29

    申请号：PCT/US2016016882

    申请日：2016-02-05

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHU YONG ,  MARKS JEFFREY ,  FREUDENTHAL JACOB ,  WESSEL THOMAS ,  WOO DAVID

    IPC: G01N21/27 ,  C12Q1/68 ,  G01N21/64

    CPC classification number: G01N21/6428 ,  C12Q1/6851 ,  C12Q1/686 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2201/127 ,  G01N2201/13 ,  G01N2333/922

    Abstract: In one exemplary embodiment, a method (100) for calibrating an instrument is provided. The instrument includes an optical system capable of imaging florescence emission from a plurality of reaction sites. The method includes performing a region-of-interest (ROI) calibration (102) to determine reaction site positions in an image. The method further includes performing a pure dye calibration (108) to determine the contribution of a fluorescent dye used in each reaction site by comparing a raw spectrum of the fluorescent dye to a pure spectrum calibration data of the fluorescent dye. The method further includes performing an instrument normalization calibration (110) to determine a filter normalization factor. The method includes performing an RNase P validation (112) to validate the instrument is capable of distinguishing between two different quantities of sample.

    Abstract translation: 在一个示例性实施例中，提供了一种用于校准仪器的方法（100）。 该仪器包括能够成像来自多个反应位点的荧光发射的光学系统。 该方法包括执行感兴趣区域（ROI）校准（102）以确定图像中的反应位置位置。 该方法还包括通过将荧光染料的原始光谱与荧光染料的纯光谱校准数据进行比较来执行纯染料校准（108）以确定在每个反应位点中使用的荧光染料的贡献。 该方法还包括执行仪器归一化校准（110）以确定滤波器归一化因子。 该方法包括执行RNase P验证（112）以验证仪器能够区分两种不同数量的样品。

    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS
    3.
    发明申请
    OPTICAL SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS 审中-公开
    光学系统和生物分析方法

    公开(公告)号：WO2014130970A3

    公开(公告)日：2015-12-03

    申请号：PCT/US2014018110

    申请日：2014-02-24

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： CHEN MINGSONG ,  AGUANNO MAURO ,  BOO KUAN MOON ,  SOH WOON LIANG TERENCE ,  FREUDENTHAL JACOB ,  MARKS JEFFREY

    IPC: G01N21/27 ,  G01N21/64

    CPC classification number: G01N21/6486 ,  G01N21/0332 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2201/061 ,  G01N2201/0624 ,  G01N2201/0627 ,  G01N2201/121

    Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.

    Abstract translation: 用于处理和/或测量生物过程的仪器包括样品处理系统，激发源，激发光学系统，光学传感器和发射光学系统。 样品处理系统被配置为保持第一样品保持器和第二样品保持器，其中样品池的数量对于每个样品保持器是不同的，或者第一样品池的特征尺寸与第二样品保持器的特征尺寸不同。 仪器还包括激发源温度控制器，其包括耦合到激发源的温度传感器。 温度控制器被配置为当第一样品保持器被仪器保持时产生第一目标温度，并且当第二样品保持器被仪器保持时产生第二目标温度。

    VISUALIZATION TOOLS FOR DIGITAL PCR DATA
    4.
    发明申请
    VISUALIZATION TOOLS FOR DIGITAL PCR DATA 审中-公开
    用于数字PCR数据的可视化工具

    公开(公告)号：WO2014074735A3

    公开(公告)日：2014-08-07

    申请号：PCT/US2013068984

    申请日：2013-11-07

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： LEONG HARRISON ,  MAJUMDAR NIVEDITA SUMI ,  MARKS JEFFREY ,  STRAUB THEODORE ,  TALBOT RYAN ,  BODNER KEVIN ,  HOARD DAVID

    IPC: G06F19/26

    CPC classification number: G06T11/206 ,  G06F19/26 ,  G06T11/203

    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

    Abstract translation: 提供了一种用于生成数据可视化的方法。 该方法包括将来自衬底的检测数据的一部分的表示显示给用户。 该方法进一步包括产生用于该部分检测数据的数据质量值，并与该部分检测数据的表示一起显示该部分检测数据的数据质量值的指示。 该方法进一步包括由用户选择质量值阈值，并显示针对满足质量值阈值的部分检测数据的数据质量值的调整指示。

    Visualization tools for digital PCR data
    5.
    发明专利
    Visualization tools for digital PCR data 未知

    公开(公告)号：AU2013341089A1

    公开(公告)日：2015-06-18

    申请号：AU2013341089

    申请日：2013-11-07

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： LEONG HARRISON ,  MAJUMDAR NIVEDITA SUMI ,  MARKS JEFFREY ,  STRAUB THEODORE ,  TALBOT RYAN ,  BODNER KEVIN ,  HOARD DAVID

    IPC: G16B45/00

    Abstract: A method for generating a data visualization is provided. The method includes displaying a representation of a portion of detected data from a substrate to a user. The method further includes generating a data quality value for the portion of detected data and displaying, along with the representation of the portion of detected data, an indication of data quality value for the portion of detected data. The method further includes selecting, by the user, a quality value threshold, and displaying an adjusted indication of data quality value for the portion of detected data meeting the quality value threshold.

    METHODS AND SYSTEMS FOR A DIGITAL PCR EXPERIMENT DESIGNER
    7.
    发明专利
    METHODS AND SYSTEMS FOR A DIGITAL PCR EXPERIMENT DESIGNER 未知

    公开(公告)号：SG11201502797PA

    公开(公告)日：2015-05-28

    申请号：SG11201502797P

    申请日：2013-09-13

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： MAJUMDAR NIVEDITA SUMI ,  WESSEL THOMAS ,  WOO DAVID C ,  SIKORA MARCIN ,  JANAWAY GORDON ,  RAIZADA SHWETA ,  LANKESTER JOANNA ,  MARKS JEFFREY ,  WESSEL DANIEL

    IPC: G06F19/24

    Abstract: A computer-implemented method for designing a digital PCR (dPCR) experiment is provided. The method includes receiving, from a user, a selection of optimization type. The optimization type may be maximizing the dynamic range, minimizing the number of substrates including reaction sites needed for the experiment, determining a dilution factor, or determining the lower limit of detection, for example. The method further includes receiving, from the user, a precision measure for an experiment, and a minimum concentration of a target in a reaction site for the experiment. The method also includes determining a set of dPCR experiment design factors for the experiment based on the optimization type. The set of dPCR experiment design factors is then displayed to the user.

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