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公开(公告)号:WO2013049702A3
公开(公告)日:2013-10-10
申请号:PCT/US2012058096
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: FREUDENTHAL JACOB K , DAHLHOFF GEOFFREY , MAHER KEVIN , CHEN MINGSONG , LIM GARY , DANEHY RONALD , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE , CHENG FRANCIS , WU RUOYUN , LEE THIAM CHYE , CHAPPELL GARY , LIM CHEE KIONG , DERE JEFF , STRAUB TED , FONSECA JORGE , BOO KUAN MOON , LAU SOO YONG
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样本保持器中的任何一个的可互换组件,每个相应样本保持器被配置为接收多个样本。 该系统还包括配置成循环多个样品通过一系列温度的控制系统。 该系统还包括配置成检测从多个样品发射的荧光信号的光学系统。 该光学系统尤其可以包括单个场透镜,激励源,光学传感器和多个滤波器组件。 激发源可以是一个或多个发光二极管。 场镜可以是双凸透镜。
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公开(公告)号:WO2012078930A3
公开(公告)日:2012-11-01
申请号:PCT/US2011064036
申请日:2011-12-08
Applicant: LIFE TECHNOLOGIES CORP , YEO HUEI , LAU SOO YONG , CONG JIANG
Inventor: YEO HUEI , LAU SOO YONG , CONG JIANG
IPC: B01L7/00
CPC classification number: B01L7/52 , B01L2200/0689 , B01L2200/142 , B01L2300/0829 , B01L2300/1827
Abstract: A thermal cycler (100) is provided. The thermal cycler (100) comprises a tray assembly (110) The tray assembly (110) comprises a main body (120) made of a first material having a first thermal conductivity. The tray assembly (110) further comprises an adaptor (125) made of a second material having a thermal conductivity that is greater than the thermal conductivity of the first material. The thermal cycler (100) also includes a control block (135) configured to control the temperature of the one or more nucleotide samples. The thermal cycler (100) further includes a thermal cover (130) sized and positioned to at least partially cover the plurality of vessels. The thermal cycler (100) further includes a sample block (132) including one or more depressions configured to receive a plurality of vessels containing one or more nucleotide samples.
Abstract translation: 提供热循环仪(100)。 热循环器(100)包括托盘组件(110)。托盘组件(110)包括由具有第一导热性的第一材料制成的主体(120)。 托盘组件(110)还包括由第二材料制成的适配器(125),其具有大于第一材料的热导率的导热率。 热循环仪(100)还包括被配置为控制一个或多个核苷酸样品的温度的控制块(135)。 热循环器(100)还包括尺寸和定位成至少部分覆盖多个容器的热盖(130)。 热循环仪(100)还包括样品块(132),其包括一个或多个凹陷,其被配置为接收含有一个或多个核苷酸样品的多个容器。
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公开(公告)号:WO2016127107A3
公开(公告)日:2016-11-03
申请号:PCT/US2016016856
申请日:2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor: CHU YONG , MARKS JEFFREY , FREUDENTHAL JACOB , CHEN MINGSONG , TOH TIONG HAN , AGUANNO MAURO , LAU LIK SENG , LOH LIAN SENG , TEO KOK SIONG , CHU ZENG WEI , MATHERS XIN , UY MICHAEL , YEO HUEI STEVEN , BOO KUAN MOON , LEE WAY XUANG , KOO CHIN YONG , TEO WEI FUH , LAU SOO YONG , SHIN HON SIU , TAN ZEQI , WESSEL THOMAS , WOO DAVID
CPC classification number: B01L7/52 , B01L2200/145 , B01L2300/18 , B01L2300/1822 , C12Q1/6806 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/026 , G01N2021/6439 , G01N2035/00316 , G01N2035/00366 , G01N2201/061 , G01N2201/12
Abstract: A biological analysis system (100) is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block (114) configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray (160) comprising a slide assembly, the tray (160) configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
Abstract translation: 提供生物分析系统(100)。 该系统包括样品块组件。 样品块组件包括被配置为容纳样品架的样品块(114),样品保持器被配置为接收多个样品。 该系统还包括配置成使多个样品循环通过一系列温度的控制系统。 所述系统还包括自动托盘(160),其包括滑动组件,所述托盘(160)构造成可将样品块组件从关闭位置可逆地滑动到打开位置,以允许用户接近所述多个样品保持器。
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公开(公告)号:WO2013049702A2
公开(公告)日:2013-04-04
申请号:PCT/US2012058096
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: FREUDENTHAL JACOB K , DAHLHOFF GEOFFREY , MAHER KEVIN , CHEN MINGSONG , LIM GARY , DANEHY RONALD , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE , CHENG FRANCIS , WU RUOYUN , LEE THIAM CHYE , CHAPPELL GARY , LIM CHEE KIONG , DERE JEFF , STRAUB TED , FONSECA JORGE , BOO KUAN MOON , LAU SOO YONG
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件,每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地,光学系统可以包括单个场透镜,激发源,光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号:RU2708542C2
公开(公告)日:2019-12-09
申请号:RU2017131221
申请日:2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor: CHEN MINGSONG , BOO KUAN MOON , TOH TIONG HAN , AGUANNO MAURO , LAU SOO YONG , YEO HUEI STEVEN , TEO WEI FUH
IPC: G01N21/64
Abstract: Изобретениеотноситсяк системам, устройствами способамнаблюдения, тестированияи/илианализабиологическихпроб. Инструментдлябиологическогоанализасодержитбазу, источниквозбуждения, оптическийдатчик, оптическуюсистемувозбужденияи оптическуюсистемуэмиссии. Базавыполненас возможностьюприемадержателяпроб, содержащегомножествобиологическихпроб. Оптическийдатчиквыполненс возможностьюприемаэмиссийотбиологическихпробв ответнаисточниквозбуждения. Инструментможетдополнительносодержатьлинзудатчика, заключеннуюв корпуслинзы, имеханизмфокусировки, содержащиймеханизм, которыйзацепляеткорпуслинзы, гдемеханизмфокусировкидоступенснаружикорпусадлярегулированияфокуса, атакжеотверстиедлядатчика, расположенноевдольоптическогопутиэмиссии, иблокирующуюконструкцию, расположеннуюдлявзаимодействияс отверстиемдлядатчикатак, чтооптическимдатчикомнепринимаетсяникакоеотраженноеизлучениеотосвещеннойповерхностиоколодержателяпроб, котороетакженебылоотраженодругойповерхностьюинструмента. 14 з.п. ф-лы, 20 ил., 2 табл.
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公开(公告)号:SG11201401919TA
公开(公告)日:2014-10-30
申请号:SG11201401919T
申请日:2012-09-28
Applicant: LIFE TECHNOLOGIES CORP
Inventor: MAHER KEVIN , CHEN MINGSONG , FREUDENTHAL JACOB , BOO KUAN MOON , LAU SOO YONG , FORTESCUE DAVID , SHEN MING , SOH WOON LIANG TERENCE
IPC: G01N21/64
Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.
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公开(公告)号:SG10202001197UA
公开(公告)日:2020-03-30
申请号:SG10202001197U
申请日:2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor: CHU YONG , MARKS JEFFREY , FREUDENTHAL JACOB , CHEN MINGSONG , TOH TIONG HAN , AGUANNO MAURO , LAU LIK SENG , LOH LIAN SENG , TEO KOK SIONG , CHU ZENG WEI , MATHERS XIN , UY MICHAEL , YEO HUEI STEVEN , BOO KUAN MOON , LEE WAY XUANG , KOO CHIN YONG , TEO WEI FUH , LAU SOO YONG , SHIN HON SIU , TAN ZEQI , WESSEL THOMAS , WOO DAVID
Abstract: A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.
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公开(公告)号:SG10201811725SA
公开(公告)日:2019-02-27
申请号:SG10201811725S
申请日:2016-02-05
Applicant: LIFE TECHNOLOGIES CORP
Inventor: CHEN MINGSONG , BOO KUAN MOON , TOH TIONG HAN , AGUANNO MAURO , LAU SOO YONG , YEO HUEI STEVEN , TEO WEI FUH
Abstract: Systems and Methods for Assessing Biological Samples of the Disclosure An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument. Fig. 10
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公开(公告)号:SG11201606590UA
公开(公告)日:2016-09-29
申请号:SG11201606590U
申请日:2015-02-04
Applicant: LIFE TECHNOLOGIES CORP
Inventor: LIM CHEE KIONG , LEE WAY XUANG , LOH WUH KEN , CHING CHEE WEE , KOO CHIN YONG , KOH SIEW YING , TOH TIONG HAN , BOO KUAN MOON , LAU SOO YONG
IPC: B01L7/00
Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.
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公开(公告)号:SG11202108157WA
公开(公告)日:2021-08-30
申请号:SG11202108157W
申请日:2020-01-30
Applicant: LIFE TECH HOLDINGS PTE LIMITED , LIFE TECHNOLOGIES CORP
Inventor: BOO KUAN MOON , TEO WEI FUH , TAN ZEQI , LAU SOO YONG , SIA MING TIONG , SOH WOON LIANG , LAM CHING YEE , DONG SHAN HUA , HABERSTROH MARC , PALLAS MICHAEL , SANGHA HARDEEP
Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.
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